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supported by the national natural science foundation of china(Nos.62172051,61772085,and 61877005)and Jiangsu Agriculture science and Technology Innovation Fund(***(18)3054).

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Tsinghua science and Technology 2023年第1期28卷 82-92页

作者： Jinghui Zhang Yuchen Wang Tianyu Huang Fang Dong Wei Zhao Dian Shen School of Computer science and Engineering Southeast UniversityNanjing 211189China Hefei Comprehensive national science Center Hefei 231299China School of Computer science and Technology Anhui University of TechnologyHefei 230026China Department of Computer science&Engineering The Chinese University of Hong KongHong Kong 999077China

Numerous neural network(NN)applications are now being deployed to mobile *** applications usually have large amounts of calculation and data while requiring low inference latency,which poses challenges to the computing ability of mobile ***,devices’life and performance depend on ***,in many scenarios,such as industrial production and automotive systems,where the environmental temperatures are usually high,it is important to control devices’temperatures to maintain steady *** this paper,we propose a thermal-aware channel-wise heterogeneous NN inference *** contains two parts,the thermal-aware dynamic frequency(TADF)algorithm and the heterogeneous-processor single-layer workload distribution(HSWD)*** on a mobile device’s architecture characteristics and environmental temperature,TADF can adjust the appropriate running speed of the central processing unit and graphics processing unit,and then the workload of each layer in the NN model is distributed by HSWD in line with each processor’s running speed and the characteristics of the layers as well as heterogeneous *** experimental results,where representative NNs and mobile devices were used,show that the proposed method can considerably improve the speed of the on-device inference by 21%–43%over the traditional inference method.

关键词： neural network inference mobile device temperature adjustment channel-wise parallelization

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Achievements in cancer research supported by national natural science foundation of china

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Chinese science Bulletin 2013年第1期58卷 39-43页

作者： HONG Wei LI Cui ZHANG LiPing XU YanYing ZHANG Jun HU Hai DONG ErDan Department of Health sciences National Natural Science Foundation of China

For the past two decades,great achievements have been made in cancer research of china and the majority of them were supported by the national natural science foundation of china(NSFC).In this article,we reviewed the funding history of NSFC including the number of proposals,the amount of grants,distribution of supported program categories during the period of 1987 to 2012 and the representative achievements made by continuous support of ***,the impacts of NSFC support on discipline development and talent fostering were *** 1987 to 2012,a total of 8738 proposals related to cancer research were funded by *** percentages of the Research Program,Talent-Training Program,and the Research Environment Program were 61.19%,36.32%,and 2.49%,*** the support of NSFC,cancer research in china has achieved a significantly rapid and balanced development in both disciplines and scientist resources.

关键词：国家自然科学基金委员会癌症中国 NSFC 人才培养环境计划人才培训科学家

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This work was supported by grants from the national natural science foundation of china(Nos.81625020,81402736,and 81902791)and the Key Research and Development Program of Shaanxi Province(No.2019sf-079).

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International Journal of Dermatology and Venereology 2021年第3期4卷 152-162页

作者： Jia-Hui Jin Yu-Yan Jiang Yan Wang Zhao-Wei Meng Di-Hua Li Lei Zhang Hao Wang Yan-Jun Zhang Graduate School Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Nuclear General Tianjin Medical University General HospitalTianjin 300052China College of Pharmaceutical Engineering of Traditional Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Research Institute Tianjin NanKai HospitalTianjin 300100China Research and Development Department Tianjin ShangMei Cosmetics Co.Ltd.Tianjin 300380China School of Chinese Materia Medica Tianjin University of Traditional Chinese MedicineTianjin 301617China

Objective:This study was performed to investigate the relationship between the human melanogenesis and antioxidant systems and to further confirm the synergistic effect of oxyresveratrol(OXYR)and resveratrol(RES)in human epidermal melanocyte cell ***:The human epidermal melanocyte line PIG1 cells were divided into the UV groups and control group,treated with different doses of UVB and without UVB,*** assay and flow cytometry were used to detect cell viability and *** expression of Nrf2/HO-1 and melanogenesis-associated proteins/genes was measured by Western blotting and real-time qPCR(RT-qPCR).pCMV6-XL5-Nrf2 was used to upregulate the expression of ***,the proteins/genes levels of Nrf2/HO-1 and tyrosinase(TYR),melanin/eumelanin content,and reactive oxygen species(ROS)were *** analysis and cell experiment were used to analyze whether OXYR and RES inhibit TYR *** blotting,RT-qPCR,and NaOH splitting method were used to determine the Nrf2/HO-1 and melanogenesis-associated proteins/genes expression and melanin content to evaluate the efficacy of OXYR and ***:The activated Nrf2 and HO-1 eliminated ROS produced by UVB *** melanogenesis-associated proteins/genes of melanocyte-inducing transcription factor(MITF,P<0.01 on protein expression),TYR(both P<0.01),TYR-related protein(TRP)-1(both P<0.05),and TRP2(P<0.05 on mRNA expression)were activated in PIG1 cells by UVB ***,the upregulation of Nrf2 significantly reduced melanogenesis formation(P<0.001)and TYR level(P<0.01 on protein expression).Moreover,OXYR and RES synergistically inhibited TYR activity(P<0.001)and reduced melanin content(P<0.001).Conclusions:A microbalance exists between Nrf2/HO-1 signaling and melanogenesis production in the UVBinduced responses of ***,OXYR enhances the ability of RES to inhibit melanin production.

关键词： melanin Nrf2/HO-1 oxyresveratrol reactive oxygen species resveratrol tyrosinase

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Aortic Dissection Research in china:Analysis of Studies Funded by the national natural science foundation of china

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Current Medical science 2023年第1期43卷 206-212页

作者： Zhang YUE Da-shuai WANG Sheng LE Jia-hong XIA Ping YE Xiao-fan HUANG Department of Cardiovascular Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Department of Cardiovascular Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou450052China Department of Cardiology The Central Hospital of WuhanTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430014China

Objective The national natural science foundation of china(NSFC)has made great progress in promoting the development of aortic dissection research in recent *** study aimed to examine the development and research status of aortic dissection research in china so as to provide references for future *** The NSFC projects data from 2008 to 2019 were collected from the Internet-based science Information System and other websites utilized as search *** publications and citations were retrieved by Google Scholar,and the impact factors were checked by the InCite Journal Citation Reports *** investigator’s degree and department were identified from the institutional faculty *** A total of 250 grant funds totaling 124.3 million Yuan and resulting in 747 publications were *** funds in economically developed and densely populated areas were more than those in underdeveloped and sparsely populated *** was no significant difference in the amount of funding per grant between different departments’***,the funding output ratios of the grants for cardiologists were higher than those for basic science *** amount of funding for clinical researchers and basic scientific researchers in aortic dissection was also *** researchers were better in terms of the funding output *** These results suggest that the medical and scientific research level of aortic dissection in china has been greatly ***,there are still some problems that urgently need to be solved,such as the unreasonable regional allocation of medical and scientific research resources,and the slow transition from basic science to clinical practice.

关键词： national natural science foundation of china aortic dissection grant funding funding output ratio

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Controlled cationic ring-opening polymerization of L-lactide by organic ion pair: novel approach to isotactic-rich and crystalline polylactide

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science china Chemistry 2025年第1期68卷 394-402页

作者： Zhiqiang Ding Mingqian Wang Zijing Zhou Bin Wang Yuesheng Li Tianjin Key Laboratory of Composite & Functional Materials School of Materials Science and Engineering Tianjin University

Living/controlled cationic ring-opening polymerization （ROP） of L-lactide is a promising approach to isotactic-rich and crystalline poly（L-lactide）.In contrast with the unsubstituted lactones,L-LA can not be polymerized by organic Lewis acids or carbenium ions,and the state of the art in this field is the cationic ROP of L-LA catalyzed by Br?nsted acid/alcohol system via activated monomer ***,we reported the first example of controlled cationic ROP of L-LA by using Meerweintype ion pair[Me3O]+[B（C6F5）4]-as the catalyst.[Me3O]+[B（C6F5）4]-promoted rapid L-LA cationic polymerization in the absence of alcohol,producing isotactic-rich and crystalline PLLA without transesterification and epimerization side *** activated chain end mechanism,involving twice SN2 substitution and configuration-inversion （S→R→S） with the assistance of released Me2O,was proposed and further verified by density functional theory and control *** work expands the catalytic toolbox of isotactic-rich and crystalline polylactide *** represents a unique example of cationic-controlled polymerization of L-LA catalyzed by an organic ion pair.

关键词： organic ion pair controlled cationic ring-opening polymerization activated chain end mechanism isotactic-rich polylactide

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Direct and rapid detection of serum amino acid and monoamine neurotransmitters to assist the diagnosis of panic disorder

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science china Chemistry 2025年第1期68卷 377-384页

作者： Shiwen Liu Xuerui Wan Meng Zhao Jiaqi Wang Weilan Wu Linlin You Yonggui Yuan Qian Xu Rong Gao Key Laboratory of Environmental Medicine Engineering Ministry of Education School of Public Health Southeast University Key Laboratory of Modern Toxicology of Ministry of Education Department of Hygienic Analysis and Detection School of Public HealthNanjing Medical University Department of Psychosomatics and Psychiatry Zhongda Hospital School of Medicine Southeast University

The measurement of amino acid and monoamine neurotransmitters（NTs） in serum plays a central role in the identification and monitoring of clinical panic disorder（PD）. However, the strong polarity and chemical heterogeneity of NTs make direct extraction and rapid detection extremely challenging. Herein, we developed a strategy that integrated solid phase extraction based on magnetic Fe3O4coated with polydopamine（Fe3O4@PDA） and direct analysis of mass spectrometry in real time（DART-MS） for quantification of 10 NTs. We systematically investigated the optimal conditions of this strategy to achieve good accuracy and precision. Compared with existing magnetic solid phase extraction methods for NTs detection in biological samples, this strategy could adsorb more targets while having similar adsorption efficiencies, and the total process time was reduced by an average of 69.42%. We rapidly determined the metabolic abnormality of 6 types of NTs in the serum of PD patients and demonstrated their diagnostic accuracy. In addition, an outstanding feature of PD in which tryptophan was more metabolized by the KYN pathway and the 5-hydroxytryptamine pathway was inhibited could be elucidated by this strategy. Our results highlighted the potential ability of Fe3O4@PDA coupled with DART-MS to assist in the clinical diagnosis of PD.

关键词： neurotransmitters panic disorder magnetic solid phase extraction direct analysis of mass spectrometry in real time

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Potassium ions and cyano group modified g-C3N4 for effective generation of H2O2 through two-electron oxygen reduction

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science china Chemistry 2025年第1期68卷 192-200页

作者： Dongying Wang Shulan Pu Yongmin Chen Ke Lei Yujie Duan Linjiao Mao Xuhui Zeng Xi Luo Yuntao Zhang Yuqin Dong Jin Zhong Zhang Yan Sun School of Mechanical Engineering Chengdu University Department of Chemistry and Biochemistry University of California

Potassium ions （K+） doped graphitic carbon nitride （g-C3N4） was prepared by a thermal etching method using potassium hydroxide （KOH） as an ion *** transform infrared spectroscopy （FTIR） and X-ray photoelectron spectroscopy （XPS）results showed that the generation of the cyano group was detected while introducing K+.Under simulated sunlight irradiation,the sample with a K+doping amount of 10%showed the highest hydrogen peroxide （H2O2） generation rate of2,140.2μmol *** apparent quantum yield （AQY） at 400 nm and the solar-to-chemical conversion （SCC） are 4.35%and1.23%,respectively.K+acted as a bridge between g-C3N4layers,which enhanced charge transfer ***,the cyano group enhanced the adsorption capacity of protons （H+） and promoted the yield of *** catalyst exhibited excellent photocatalytic stability based on four-cycle *** addition,a mechanism study showed that superoxide radicals （·O2-）were the most important active species in the reaction *** production of H2O2was achieved through consecutive single-electron *** study deepens the understanding of the oxygen reduction reaction process and opens up a new venue for improving H2O2generation.

关键词： photocatalysis hydrogen peroxide oxygen reduction reaction potassium doping cyano group

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Numerical Simulation of Radiation Transport to Improve Microalgae Cultivation in an Air-Lift Photobioreactor

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Journal of Thermal science 2025年第1期34卷 62-76页

作者： ZHANG Xianbin LI Mingjia HUNG Tzuchen ZHANG Zixun Key Laboratory of Thermo-Fluid science and Engineering of Ministry of Education School of Energy and Power EngineeringXi'an Jiaotong University School of Mechanical Engineering Beijing Institute of Technology Department of Mechanical Engineering Taipei University of Technology

A comprehensive numerical model is developed to simulate the growth of microalgae under light/dark cycling *** purpose of this study is to predict the growth rate of Chlorella vulgaris cultivated in photobioreactors(PBRs) in order to improve the light conditions for microalgae and enhance the photosynthetic *** fluid dynamics(CFD) is used to simulate its internal hydrodynamic *** Lagrangian method is employed to track the movement of microalgae *** radiative transfer equation(RTE)is used to obtain light intensity *** combination of light radiation field and microalgae cell motions is used to construct the light history and they are integrated into the model of the photosynthetic units(PSU) to calculate the microalgae growth *** numerical results demonstrate that enhanced light/dark cycling frequency with ordered mixing can promote efficient microalgae *** effect of the vortex flow field generated by the baffles in an air-lift PBR is analyzed for increasing microalgae growth *** using the 1:1 baffle spacing,the biomass production of microalgae is increased by 41.8% compared to the original PBR.

关键词： light distribution particle tracking photobioreactor structure optimization

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Progress in osteoarthritis research by the national natural science foundation of china

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Bone Research 2022年第3期10卷 409-420页

作者： Yusheng Li Wenqing Xie Wenfeng Xiao Dou Dou Deparment of Orthopedics Xiangya HospitalCentral South UniversityChangsha 410008 HunanChina national Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangsha 410008 HunanChina Department of Health sciences National Natural Science Foundation of ChinaBeijing 100085China

Osteoarthritis(OA) in china is gradually becoming an important scientific research area that has had a significant impact on research and development(R&D) activities in the OA field worldwide. This article summarizes the R&D progress related to OA in china in recent years. The national natural science foundation of china(NSFC) is a national funding institution for basic research and plays a critical role in promoting and supporting Chinese scholars’ R&D activities. We collected and analyzed information on NSFC funding in the field of OA from 2010 to 2019, including the amount, the level and the program categories of the funded projects. The data fully demonstrate the important and positive role of the NSFC in supporting free exploration, cultivating research teams and young talent, and boosting OA R&D. In this article, we outline and discuss hot topics in focused areas, key advances in this field and the prospects for progress in OA research in china.

关键词： NSFC supporting becoming

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Separation of the ionospheric and thermospheric contributions in the data from the Triple Ionosophere Photo Meter onboard the Feng-Yun 3E satellite

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science china Earth sciences 2025年第1期68卷 172-184页

作者： Fang JIANG Tian MAO Jin-Song WANG Xiu-Qing HU Xiao-Xin ZHANG Liping FU Nan JIA Tianfang WANG national Space science Center Chinese Academy of Sciences Beijing Key Laboratory of Space Environment Exploration Key Laboratory of Environmental Space Situation Awareness Technology national Satellite Meteorological Center China Meteorological Administration

The Triple Ionosphere Photo Meter （TRIPM） is a far ultraviolet nadir-view photometer that is onboard the secondgeneration,polar-orbiting Chinese meteorological satellite Feng-Yun 3E （FY-3E）,which was launched on July 5,*** has three channels,and each is used to measure different types of emissions:（1） 135.6 nm airglow produced by the recombination of the O+ions and electrons in the absence of sunlight （nighttime channel）;（2） 135.6 nm airglow from the OI when sunlight is present （daytime/dusk-dawn 135.6 nm channel）;and （3） Airglow in the N2LBH of the TRIPM （daytime/dusk-dawn N2LBH channel）.FY-3E is a satellite operating in the early morning ***,the data are mostly distributed on the dawndusk side or at times when the solar zenith angle is relatively *** this study,combined with simulation calculations,the data are *** further explore the application value of the data products,a model is used to separate the ionospheric radiative recombination contribution from the thermosphere photoelectron impact excitation contribution in the data from the daytime/dusk-dawn 135.6 nm *** approach not only improves the accuracy of O/N2derived from the 135.6 nm channel and N2LBH channel but also provides the ionospheric 135.6 nm radiance at the same time as the *** results show that the 135.6 nm radiance originating from the combination of O+and electrons extracted from the measurement data exhibits similar equatorial anomaly peak structure characteristics and seasonal variations as the corresponding GPS total electron content （TEC） *** the other hand,the separated 135.6 nm radiance generated from the thermosphere photoelectron collision excitation does not contain radiative recombination contributions;thus,the ionosphere influence is greatly avoided when the O/N2is obtained.

关键词： Far ultraviolet 135.6 nm emission intensity Photoelectron impact excitation Radiative recombination excitation

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