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The aflatoxin B1 isolating potential of two lactic acid bacteria

Asian Pacific Journal of Tropical Biomedicine 2013年第9期3卷 732-736页

作者： Adel Hamidi Reza Mirnejad Emad Yahaghi Vahid Behnod Ali Mirhosseini Sajad Amani Sara Sattari Ebrahim Khodaverdi Darian Department of Microbiology Razi Vaccine and Serum Research Institute Molecular Biology research Center Baqiyatallah University of Medical Sciences Young researchers and Elite Club Damghan BranchIslamic Azad University Department of Microbiology Dameghan BranchIslamic Azad University Applied microbiology research center baqiyatallah university of medical sciences Young researchers and Elite Club Tonkabon BranchIslamic Azad University Department of Microbiology Science and research BranchIslamic Azad University Young researchers and Elite Club Karaj BranchIslamic Azad University

Objective:To determine lactic acid bacteria's capability to enhance the process of binding and isolating aflatoxin B1 and to utilize such lactic acid bacteria as a food supplement or probiotic products for preventing absorption of aflatoxin Bl in human and animal ***:In the present research,the bacteria were isolated from five different *** surveying the capability of the bacteria in isolating aflatoxin Bl,ELISA method was implemented,and for identifying the resultant strains through 16S rRNA sequencing method,universal primers were ***:Among the strains which were isolated,two strains of Lactobacillus pentosus and Lactobacillus beveris exhibited the capability of absorbing and isolating aflatoxin Bl by respectively absorbing and discharging 17.4%and 34.7%of the aforementioned toxin existing in the experiment ***:Strains of Lactobacillus pentosus and Lactobacillus beveris were isolated from human feces and local milk samples,*** both strains has the ability to isolate or bind with aflatoxin Bl.

关键词： Mycotoxin Aflatoxin Lactic acid Bacteria ELISA test

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Design of a heterosubtypic epitope-based peptide vaccine fused with hemokinin-1 against influenza viruses

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Virologica Sinica 2015年第3期30卷 200-207页

作者： Shahla Shahsavandi Mohammad Majid Ebrahimi Kaveh Sadeghi Homayoon Mahravani razi vaccine & serum research institute Karaj 31975 Iran

Influenza viruses continue to emerge and re-emerge, posing new threats for public health. Control and treatment of influenza depends mainly on vaccination and chemoprophylaxis with approved antiviral drugs. Identification of specific epitopes derived from influenza viruses has significantly advanced the development of epitope-based vaccines. Here, we explore the idea of using HLA binding data to design an epitope-based vaccine that can elicit heterosubtypic T-cell responses against circulating H7N9, H5N1, and H9N2 subtypes. The hemokinin-1(HK-1) peptide sequence was used to induce immune responses against the influenza viruses. Five conserved high score cytotoxic T lymphocyte(CTL) epitopes restricted to HLA-A*0201-binding peptides within the hemagglutinin(HA) protein of the viruses were chosen, and two HA CTL/HK-1 chimera protein models designed. Using in silico analysis, which involves interferon epitope scanning, protein structure prediction, antigenic epitope determination, and model quality evaluation, chimeric proteins were designed. The applicability of one of these proteins as a heterosubtypic epitopebased vaccine candidate was analyzed.

关键词： epitope-based vaccine hemokinin-1 heterosubtypic immunity influenza virus

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