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Advanced nano-based strategies for mRNA tumor vaccine

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Acta Pharmaceutica Sinica B 2024年第1期14卷 170-189页

作者： Yangqi Qu Jingjing Xu Tong Zhang Qinjun Chen Tao Sun Chen Jiang Key Laboratory of Smart Drug Delivery(Ministry of Education) Minhang HospitalState Key Laboratory of Medical NeurobiologyDepartment of PharmaceuticsSchool of PharmacyFudan UniversityShanghai 201203China

Tumor vaccine is a promising strategy for cancer immunotherapy by introducing tumor antigens into the body to activate specific anti-tumor immune *** with the technological breakthroughs in genetic engineering and delivery systems,messenger ribonucleic acid(mRNA)technology has achieved unprecedented development and application over the last few years,especially the emergency use authorizations of two mRNA vaccines during the COVID-19 pandemic,which has saved countless lives and makes the world witness the powerful efficacy of mRNA technology in ***,unlike infectious disease vaccines,which mainly induce humoral immunity,tumor vaccines also need to activate potent cellular immunity to control tumor growth,which creates a higher demand for mRNA delivery to the lymphatic organs and antigen-presenting cells(APCs).Here we review the existing bottlenecks of mRNA tumor vaccines and advanced nano-based strategies to overcome those challenges,as well as future considerations of mRNA tumor vaccines and their delivery systems.

关键词： mRNA vaccine Nanoparticle Tumor vaccine Delivery system Stability Targeting Transfection Immunogenicity

Modelling and mechanical characteristics of PDC cutter-rock interaction by combining mixed fragmentation modes with dynamic rock strength

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Petroleum 2024年第3期10卷 474-482页

作者： Guangjian Dong Ping Chen Xudong Wang Jianhong Fu Yingxin Yang State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum UniversityChengdu610500China School of Petroleum Engineering Southwest Petroleum UniversityChengdu610500China Periodical Office of Southwest Petroleum University Southwest Petroleum UniversityChengdu610500China School of Mechatronic Engineering Southwest Petroleum UniversityChengdu610500China

Polycrystalline diamond compact(PDC)bit is one of the most widely used drill bits for improving the rate of penetration in deep oil and gas well and geothermal ***,the dynamic rock fragmentation mechanics characteristics of PDC bits are still unclearly.A coupled fragmentation mechanics model of PDC cutter-rock interaction is established by combining the mixed fragmentation modes with dynamic *** coupling influence laws of cutter angle,cutting depth,dynamic strength ratio,breaking modes on the horizontal force coefficient(HFC),vertical force coefficient(VFC)and specific energy are *** model of this paper can optimize cutter inclination angle,cutting depth and minimum specific *** the increase of the cutter inclination angle,the dynamic VFC changes into two *** definition of the dynamic modes depends on the dynamic strength *** the cutting angle increases,the cutting force *** cutting force increases nonlinearly with increasing cutting *** specific energy of rock fragmentation increases nonlinearly with increasing cutting *** the increase of dynamic strength,the specific energy of rock fragmentation increases *** the input-energy increases,the rate of penetration response is divided into three *** results have important guiding significance for the PDC bit design and drilling parameters optimization to increase the rate of penetration and the efficiency of exploration and development.

关键词： Mechanical characteristics PDC cutter-rock inter action Mixed fragmentation modes Dynamic rock strength

Encouraging Solution to the Problem of Synthesizing Protein α-Thioester

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Chinese Journal of Chemistry 2024年第10期42卷 1114-1120页

作者： Xinliang Liu Zijun Gao Jie Zhao Farong Ye Ping Huang Ping Wang Center for Chemical Glycobiology Shanghai Key Laboratory for Molecular Engineering of Chiral DrugsFrontiers Science Center for Transformative MoleculesSchool of Chemistry and Chemical EngineeringZhangjiang Institute for Advanced StudyShanghai JiaoTongUniversityShanghai 200240China Shenzhen Research Institute of Shanghai Jiao Tong University ShenzhenGuangdong 518057China

Expressed protein ligation(EPL)provides a powerful tool to access large-size proteins with precise *** methods for constructing the critical protein thioester for EPL have predominantly relied on the recombinant intein fusion expressed in Escherichia coli(***).Despite its powerful applications,the expression of thioester derived from eukaryotic protein in *** inherently suffers from its limited solubility,the inactivity of intein,premature hydrolysis and low *** overcome these obstacles,we present herein the facile one-flask synthesis of inaccessible proteinα-thioester via a SUMO-protein-intein(SPI)sandwich *** utility of SUMO enhances the protein fusion yield and solubility,prevents premature hydrolysis and simplifies the purification *** inaccessible protein thioester with internal Cys residues can be readily produced and is compatible with the EPL-desulfurization protocol used to prepare complex proteins,which is otherwise difficult to obtain using traditional *** utility has been highlighted through the synthesis of human granulocyte colony-stimulating factor(G-CSF).

关键词： Desulfurization Glycoproteins Glycopeptides Protein expression Peptide thioester

Enhanced homing of mesenchymal stem cells for in situ niche remodeling and bone regeneration

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Nano Research 2024年第8期17卷 7449-7460页

作者： Yin Yuan Lijun Chen Jing Yang Sining Zhou Yangxin Fang Qi Zhang Ning Zhang Yifei Li Li Yuan Fan Jia Shuo Ni Charlie Xiang State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesNational Medical Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Biology The David H.Koch Institute for Integrative Cancer Research at MITMassachusetts Institute of TechnologyCambridgeMA 02139USA Research Units of Infectious disease and Microecology Chinese Academy of Medical SciencesHangzhou 310003China Innovative Precision Medicine(IPM)Group Hangzhou 311215China MOE Key Laboratory of Macromolecule Synthesis and Functionalization of Ministry of Education Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province Department of CardiologySir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016China Department of Cancer Immunology and Virology Dana-Farber Cancer InstituteBostonMA 02215USADepartment of ImmunologyHarvard Medical SchoolBoston MA 02115USA Department of Orthopedic Surgery and Shanghai Institute of Microsurgery on Extremities Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiaotong University School of MedicineShanghai 200233China

Mesenchymal stem cells(MSCs)transplantation is a promising strategy for osteoporosis ***,limited sources and poor tissue-homing efficiency limit their clinical *** this study,we isolated a kind of MSCs from women’s menstrual blood(MenSCs)noninvasively and established a novel MSCs bone marrow-targeted delivery system by utilizing waterin-oil-in-water droplet *** were encapsulated withinβ-cyclodextrin-functionalized alginate microcapsules loaded with zoledronates,which has a high affinity for *** this delivery system,MenSCs could be preferentially delivered to the bone marrow tissues via intravenous infusion,and restored bone mass by remodeling the bone marrow niche in situ in ovariectomized mouse ***,scRNA-seq analysis demonstrated that those MenSCs homed to the bone marrow recruited CD4^(+)FOXP3^(+)natural regulatory T(nT_(reg))cells by secreting *** recruited nTreg promoted CD8^(+)T cells to secret Wnt family member 10B(WNT10B),activating the Wnt signaling in osteoblasts and thus promoting bone formation in situ in the bone *** study reveals a promising application of MenSCs in postmenopausal osteoporosis treatment and highlights the clinical value of MenSCs by encouraging women to reserve autologous MenSCs before menopause to prevent and alleviate postmenopausal osteoporosis.

关键词： mesenchymal stem cells microfluidics bone marrow homing stem cell niche postmenopausal osteoporosis

Superior and safer lithium sulfur batteries realized by robust polysulfides-retarding dam with high flame retardance

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Journal of Energy Chemistry 2024年第2期89卷 471-486,I0011页

作者： Junling Wang Yanfang Cao Zhirong Wang Yinquan Zhao Chuang He Fudong Zhao Chaoling Han Shui Yu Jiangsu Key Laboratory of Hazardous Chemicals Safety and Control College of Safety Science and EngineeringNanjing Tech UniversityNanjing 211816JiangsuChina Department of Architecture and Civil Engineering City University of Hong KongHong Kong 999077China School of Mechanical and Power Engineering Nanjing Tech UniversityNanjing 211816JiangsuChina

The unparalleled energy density has granted lithium-sulfur batteries(LSBs)with attractive ***,LSBs still face some unsurpassed challenges in industrialization,with polysulfides shuttling,dendrite growth and thermal hazard as the major problems triggering the cycling instability and low *** the merit of convenience,the method of designing functional separator has been ***,the carbon aerogel confined with CoS_(2)(CoS_(2)-NCA)is constructed and coated on Celgard separator surface,acquiring CoS_(2)-NCA modified separator(CoS_(2)-NCA@C),which holds the promoted electrolyte affinity and flame *** revealed,CoS_(2)-NCA@C cell gives a high discharge capacity 1536.9 mAh/g at 1st cycle,much higher than that of Celgard cell(987.1 mAh/g).Moreover,the thermal runaway triggering time is dramatically prolonged by 777.4 min,corroborating the promoted thermal safety of ***,the higher coulombic efficiency stability and lower overpotential jointly confirm the efficacy of CoS_(2)-NCA@C in suppressing the lithium dendrite ***,this work can provide useful inspirations for designing functional separator,coping with the vexing issues of LSBs.

关键词： Lithium-sulfur batteries Thermal safety Flame retardancy Separator

Acetaminophen overdose-induced acute liver injury can be alleviated by static magnetic field

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Zoological Research 2024年第3期45卷 478-490页

作者： Han-Xiao Chen Xin-Yu Wang Biao Yu Chuan-Lin Feng Guo-Feng Cheng Lei Zhang Jun-Jun Wang Ying Wang Ruo-Wen Guo Xin-Miao Ji Wen-Jing Xie Wei-Li Chen Chao Song Xin Zhang CAS Key Laboratory of High Magnetic Field and Ion Beam Physical Biology High Magnetic Field LaboratoryHefei Institutes of Physical ScienceChinese Academy of SciencesHefeiAnhui 230031China Science Island Branch of Graduate School University of Science and Technology of ChinaHefeiAnhui 230026China Institutes of Physical Science and Information Technology Anhui UniversityHefeiAnhui 230601China

Acetaminophen(APAP),the most frequently used mild analgesic and antipyretic drug worldwide,is implicated in causing 46%of all acute liver failures in the USA and between 40%and 70%in *** predominant pharmacological intervention approved for mitigating such overdose is the antioxidant N-acetylcysteine(NAC);however,its efficacy is limited in cases of advanced liver injury or when administered at a late *** the current study,we discovered that treatment with a moderate intensity static magnetic field(SMF)notably reduced the mortality rate in mice subjected to high-dose APAP from 40%to 0%,proving effective at both the initial liver injury stage and the subsequent recovery *** the early phase of liver injury,SMF markedly reduced APAPinduced oxidative stress,free radicals,and liver damage,resulting in a reduction in multiple oxidative stress markers and an increase in the antioxidant glutathione(GSH).During the later stage of liver recovery,application of vertically downward SMF increased DNA synthesis and hepatocyte ***,the combination of NAC and SMF significantly mitigated liver damage induced by high-dose APAP and increased liver recovery,even 24 h post overdose,when the effectiveness of NAC alone substantially ***,this study provides a noninvasive non-pharmaceutical tool that offers dual benefits in the injury and repair stages following APAP *** note,this tool can work as an alternative to or in combination with NAC to prevent or minimize liver damage induced by APAP,and potentially other toxic overdoses.

关键词： Acetaminophen Acute liver injury Static magnetic fields Oxidative stress DNA synthesis

DYNAMICS FOR A CHEMOTAXIS MODEL WITH GENERAL LOGISTIC DAMPING AND SIGNAL DEPENDENT MOTILITY

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Acta Mathematica Scientia 2024年第3期44卷 1046-1063页

作者：涂馨予穆春来邱蜀燕张静 School of Mathematics and Statistics Southwest UniversityChongqing400715China Department of Applied Mathematics The Hong Kong Polytechnic UniversityHung HomHong KongChina College of Mathematics and Statistics Chongqing UniversityChongqing401331China School of Sciences Southwest Petroleum UniversityChengdu610500China

In this paper,we consider the fully parabolic Chemotaxis system with the general logistic source{ut=Δ(γ(v)u)+λu-μu^(k),x∈Ω,t>0,vt=△v+wz,x∈Ω,t>0,wt=-wz,x∈Ω,t>0,zt=△z-z+u,x∈Ω,t>0 whereΩ⊂ℝn(n≥1)is a smooth and bounded domain,λ≥0,μ≥0,κ>1,and the motility function satisfies thatγ(v)∈C3([0,∞)),γ(v)>0,γ′(v)≤0 for all v≥*** the Neumann boundary condition,we obtain the global boundedness of solutions if one of the following conditions holds:(i)λ=μ=0,1≤nλ3;(ii)λ>0,μ>0,combined withκ>1,1≤n≤3 or k>n+2/4,,n>***,we prove that the solution (u, v, w, z) exponentially converges to the constant steady state ((λ/μ)1/k-1,∫Ωv0dx+∫Ωw0dx/|Ω|,0,(λ/μ)1/k-1).

关键词： chemotaxis signal-dependent motility logistic source boundedness asymptotic behavior

Enhancing visible-light-driven NO oxidation through molecular‐level insights of dye-loaded sea sands

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Rare Metals 2024年第2期43卷 543-554页

作者： Yu-Han Li Bang-Fu Chen Sónia A.C.Carabineiro You-Yu Duan Ping Tan Wing-Kei Ho Fan Dong Engineering Research Center for Waste Oil Recovery Technology and Equipment Ministry of EducationChongqing Key Laboratory of Catalysis and New Environmental MaterialsChongqing Technology and Business UniversityChongqing400067China Nanchang Institute of Technology Nanchang33044China LAQV-REQUIMTE Department of ChemistryNOVA School of Science and TechnologyUniversidade NOVA de Lisboa2829-516CaparicaPortugal College of Physics and Center of Quantum Materials and Devices Chongqing UniversityChongqing401331China Department of Science and Environmental Studies The Education University of Hong KongHong Kong999077China

Natural minerals,abundant and easily obtained through simple physical processing,offer a cost-effective and environmentally friendly solution for dyeing wastewater disposal and air pollution *** study investigates the photocatalytic removal of NO using natural different types of dyes,loaded on natural sand,under visible light *** examining various coating concentrations of dyes and sand weights,we discovered that sand loaded with Rhodamine B(RhB)exhibits high activity for the photo-oxidation of NO.A combination results of X-ray diffraction(XRD),X-ray photoelectron spectroscopy(XPS),Fourier transform infrared spectroscopy(FTIR)and thermogravimetric(TG)analyses confirm the presence of SiO_(2),CaCO_(3),Al_(2)O_(3)and iron oxides as the main components of the ***,studying RhB-loaded individual components reveals that CaCO_(3)plays a crucial role in enhancing the NO removal *** results and theoretical calculations demonstrate the establishment of a directional charge transfer channel from CaCO_(3)to RhB,facilitating the adsorption and activation of molecular NO and O_(2).This work not only promotes the utilization of natural mineral resources but also enriches the fields of environmental photochemistry and semiconductor photocatalysis.

关键词： Sand dyes Rhodamine B Photo-oxidation of NO Visible light illumination

利用纳米气泡控制农业废水灌溉系统复合污垢的机制

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Engineering 2024年第4期35卷 214-225页

作者： Yang Xiao Bo Zhou Siyuan Tan Lei Li Tahir Muhammad Buchun Si Changjian Ma Sunny C.Jiang Yunkai Li College of Water Resources and Civil Engineering China Agricultural UniversityBeijing 100083China Engineering Research Center for Agricultural Water-Saving and Water Resources(Ministry of Education of the People’s Republic of china) China Agricultural UniversityBeijing 100083China School of Environment and Civil Engineering Dongguan University of TechnologyDongguan 523808China State Key Laboratory of Nutrient Use and Management Institute of Agricultural Resources and EnvironmentShandong Academy of Agricultural SciencesJinan 250100China Department of Civil and Environmental Engineering University of California-IrvineIrvineCA 92617USA

The increasing demand for wastewater treatment has become a notable trend for addressing global water ***,fouling is a significant challenge for wastewater distribution engineering *** study provides an approach using nanobubbles(NBs)to control *** antifouling capacities of three types of NBs,six oxygen concentrations,and two application procedures(prevention and removal)are *** results show that NBs effectively mitigate composite fouling—including biofouling,inorganic scaling,and particulate fouling—in comparison with the non-NBs *** specifically,hydroxyl radicals generated by the self-collapse of NBs oxidize organics and kill microorganisms in *** negatively charged surfaces of the NBs transform the crystalline form of CaCO_(3)from calcite to looser aragonite,which reduces the likelihood of ion ***,the NBs gas-liquid interfaces act as gas"bridges"between colloidal particles,enhancing the removal of particles from ***,although the NBs inhibit the growth of fouling,they do not significantly remove the already adhered fouling in non-NBs treated *** study anticipates that the application of NBs will address the significant fouling issue for various wastewater distribution engineering systems in order to meet the global challenge of sustainable water supplies.

关键词： Biofouling Scaling Colloidal fouling Wastewater Antifouling mechanism