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Neuropathic pain-like symptoms and pre-surgery radiographic severity contribute to patient satisfaction 4.8 years post-total joint replacement

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World Journal of Orthopedics 2017年第10期8卷 761-769页

作者： Sophie C Warner Helen Richardson Wendy Jenkins Thomas Kurien Michael Doherty Ana M Valdes Academic Rheumatology University of NottinghamClinical Sciences BuildingNottingham City Hospital Department of Cardiovascular Sciences University of Leicester and National Institute for Health Res-earchLeicester Cardiovascular Biomedical Research Unit Arthritis Research UK Pain Centre Academic Division of Trauma and Orthopaedics Queens Medical Centre

AIM To investigate a comprehensive range of factors that contribute to long-term patient satisfaction post-total joint replacement(TJR) in people who had undergone knee or hip replacement for *** Participants(n = 1151) were recruited from nottinghamshire post-total hip or knee replacement. Questionnaire assessment included medication use, the pain-DETECT questionnaire(PDQ) to assess neuropathic pain-like symptoms(NP) and TJR satisfaction measured on average 4.8 years post-TJR. Individual factors were tested for an association with post-TJR satisfaction, before incorporating all factors into a full model. Data reduction was carried out using LASSO and receiveroperator characteristic(ROC) curve analysis was used to quantify the contribution of variables to post-TJR *** After data reduction, the best fitting model for post-TJR satisfaction included various measures of pain, history of revision surgery, smoking, pre-surgical X-ray severity, WOMAC function scores and various comorbidities. ROC analysis of this model gave AUC = 0.83(95%CI: 0.80-0.85). PDQ scores were found to capture much of the variation in post-TJR satisfaction outcomes: AUC = 0.79(0.75-0.82). Pre-surgical radiographic severity was associated with higher post-TJR satisfaction: OR_(satisfied) = 2.06(95%CI: 1.15-3.69), P = *** These results highlight the importance of pre-surgical radiographic severity, post-TJR function, analgesic medication use and NP in terms of post-TJR satisfaction. The PDQ appears to be a useful tool in capturing factors that contribute to post-TJR satisfaction.

关键词： Osteoarthritis Patient satisfaction Total joint arthroplasty Neuropathic pain Surgery outcomes

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Machine Learning and Deep Learning Methods for Enhancing Building Energy Efficiency and Indoor Environmental Quality – A Review

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Energy and AI 2022年第4期10卷 262-289页

作者： Paige Wenbin Tien Shuangyu Wei Jo Darkwa Christopher Wood John Kaiser Calautit Department of Architecture and Built Environment University of NottinghamNottingham NG72RDUK

The built environment sector is responsible for almost one-third of the world’s final energy consumption. Hence, seeking plausible solutions to minimise building energy demands and mitigate adverse environmental impacts is necessary. Artificial intelligence (AI) techniques such as machine and deep learning have been increasingly and successfully applied to develop solutions for the built environment. This review provided a critical summary of the existing literature on the machine and deep learning methods for the built environment over the past decade, with special reference to holistic approaches. Different AI-based techniques employed to resolve interconnected problems related to heating, ventilation and air conditioning (HVAC) systems and enhance building performances were reviewed, including energy forecasting and management, indoor air quality and occupancy comfort/satisfaction prediction, occupancy detection and recognition, and fault detection and diagnosis. The present study explored existing AI-based techniques focusing on the framework, methodology, and performance. The literature highlighted that selecting the most suitable machine learning and deep learning model for solving a problem could be challenging. The recent explosive growth experienced by the research area has led to hundreds of machine learning algorithms being applied to building performance-related studies. The literature showed that existing research studies considered a wide range of scope/scales (from an HVAC component to urban areas) and time scales (minute to year). This makes it difficult to find an optimal algorithm for a specific task or case. The studies also employed a wide range of evaluation metrics, adding to the challenge. Further developments and more specific guidelines are required for the built environment field to encourage best practices in evaluating and selecting models. The literature also showed that while machine and deep learning had been successfully applied in

关键词： Artificial intelligence Building energy management Deep learning Heating,ventilation and air conditioning (HVAC) Indoor environmental quality(IEQ) Machine learning Occupancy detection Thermal comfort

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Insecticide resistance in malaria-transmitting mosquitoes in Zimbabwe: a review

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Infectious Diseases of Poverty 2015年第1期4卷 359-370页

作者： White Soko Moses J.Chimbari Samson Mukaratirwa School of Nursing and Public Health University of KwaZulu-NatalHoward CampusDurban 4001South Africa College of Health Sciences University of KwaZulu-NatalDurbanSouth Africa School of Life Sciences University of KwaZulu-NatalKwaZulu-NatalSouth Africa Ministry of Health and Child Care National Institute of Health ResearchP.O.Box CY 573CausewayZimbabwe

Malaria is a global public health problem,with about 3.2 billion people at risk of *** populations at risk mainly reside in Africa,Asia and America,with African populations accounting for the largest burden of the *** 2013,close to 198 million malaria cases were reported,leading to 584,000 ***(90%)of the mortality rates were recorded from the World Health Organization(WHO)database in the African region and 78%of these occurred in children under the age of *** Zimbabwe,approximately half of the population is at risk of infection with *** residual spraying(IRS)has been documented as an effective way to control malaria and has been adopted globally by the WHO and national ***,both insecticide resistance and climate change threaten to reverse the progress made by IRS in malaria *** has been reported in all four classes of insecticides approved by the WHO for vector control *** of environmental temperature is suspected to complicate the situation through alteration in the genetic structure,and enzyme and protein profiles of *** Zimbabwe,little research has been done on the interaction between climate change,temperature variability and insecticide resistance in malarial mosquitoes over *** information is important for informing policies on insecticide selection for *** reviewed literature on insecticide sensitivity among malarial mosquitoes in Zimbabwe from 1972 to *** peer-reviewed articles on insecticide sensitivity in Zimbabwe,published in English in this time period,were searched using MEDLINE®(PubMed),Google Scholar,Google and grey *** publications were eligible for the present study,with one of the articles being a review *** articles covered insecticide resistance,while the other two articles,published in 2000,were about the absence of *** resistance results were reported in *** insecticide s

关键词： Malaria Mosquitoes Vector control Insecticide resistance Insecticide sensitivity Zimbabwe

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综述前苏联关于地表沉陷的煤炭地下气化经验（英文）

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Journal of Zhejiang university-Science A(Applied Physics & Engineering) 2015年第10期16卷 839-850页

作者： Yury DERBIN James WALKER Dariusz WANATOWSKI Alec MARSHALL Department of Civil Engineering University of Nottingham Faculty of Engineering University of Nottingham

1.相比于传统的煤矿开采方法,煤炭地下气化的适用范围更广,但同时也可能引起地下水污染和地表沉陷。2.前苏联在煤炭地下气化方面拥有一段很长的研究和使用历史,由于当时的国际环境,前苏联的研究相对比较封闭,所以对其研究成果的综述目... 详细信息

1.相比于传统的煤矿开采方法,煤炭地下气化的适用范围更广,但同时也可能引起地下水污染和地表沉陷。2.前苏联在煤炭地下气化方面拥有一段很长的研究和使用历史,由于当时的国际环境,前苏联的研究相对比较封闭,所以对其研究成果的综述目前仍然很有价值。3.综述了不同煤层参数(如煤层深度、倾斜度、高度、宽度、含灰量和地质剖面等)和气化燃烧相关参数(如岩土材料导热性、热损耗、热冲击和体积变化等)与地表沉陷的相关性研究。

关键词：煤炭地下气化地表沉陷岩土材料热性能煤矿开采苏联煤田

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Exploration on Research Methods for Exploring Human Response to Luminous Environment with Chromogenic Windows Applied

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Journal of Electronic Research and Application 2021年第3期5卷 34-39页

作者： Runqi Liang Yupeng Wu Jiawei Yao Yongming Zhang College of Architecture and Urban Planning Tongji UniversityShanghai 200092China Department of Architecture and Built Environment University of NottinghamNottingham NG72 RDUK Sino-German Institute of Engineering Tongji University Shanghai 200092China

Chromogenic windows enable both energy-saving and daylighting ***,the human response to the luminous environment affected by them is difficult to test,since their features of dynamic change and tinting *** study explores the research methods,including experimental design and statistical analysis,by literature review and an experiment *** results show that a proper size of the test room is significant to obtain desired data,and the advanced VR technologies have the potential to be applied for testing these dynamic *** approaches are recommended to be tried and get more accurate interference about the experimental results.

关键词： Chromogenic windows Building luminous environment Human response Statistical analysis Experimental design

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New perspectives on epigenetic modifications and PARP inhibitor resistance in HR-deficient cancers

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Cancer Drug Resistance 2023年第1期6卷 35-44页

作者： Rachel Bayley Ellie Sweatman Martin R.Higgs Institute of Cancer and Genomic Sciences University of BirminghamBirmingham B152TTUK

The clinical treatment of DNA-repair defective tumours has been revolutionised by the use of poly(ADP)ribose polymerase(PARP)***,the efficacy of these compounds is hampered by resistance,which is attributed to numerous mechanisms including rewiring of the DNA damage response to favour pathways that repair PARP inhibitor-mediated ***,we comment on recent findings by our group identifying the lysine methyltransferase SETD1A as a novel factor that conveys PARPi *** discuss the implications,with a particular focus on epigenetic modifications and H3K4 *** also deliberate on the mechanisms responsible,the consequences for the refinement of PARP inhibitor use in the clinic,and future possibilities to circumvent drug resistance in DNA-repair deficient cancers.

关键词： Double strand break repair histone methylation PARP inhibitor resistance SETD1A BOD1L H3K4

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