检索结果-南通市图书馆

Transglutaminase 2 serves as a pathogenic hub gene of KRAS mutant colon cancer based on integrated analysis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2024年第5期16卷 2074-2090页

作者： Wei-Bin Peng Yu-Ping Li Yong Zeng Kai Chen First People’s Hospital of Foshan Foshan 528000Guangdong ProvinceChina Department of Radiation Oncology Cancer Hospital of Shantou University Medical CollegeShantou 515031Guangdong ProvinceChina

BACKGROUND Colon cancer is acknowledged as one of the most common malignancies worldwide,ranking third in United States regarding incidence and ***,approximately 40%of colon cancer cases harbor oncogenic KRAS mutations,resulting in the continuous activation of epidermal growth factor receptor *** To investigate the key pathogenic genes in KRAS mutant colon cancer holds considerable *** Weighted gene co-expression network analysis,in combination with additional bioinformatics analysis,were conducted to screen the key factors driving the progression of KRAS mutant colon ***,various in vitro experiments were also conducted to explore the biological function of transglutaminase 2(TGM2).RESULTS Integrated analysis demonstrated that TGM2 acted as an independent prognostic factor for progression-free *** analysis on tissue microarrays revealed that TGM2 was associated with an elevated probability of perineural invasion in patients with KRAS mutant colon ***,biological roles of the key gene TGM2 was also assessed,suggesting that the downregulation of TGM2 attenuated the proliferation,invasion,and migration of the KRAS mutant colon cancer cell *** This study underscores the potential significance of TGM2 in the progression of KRAS mutant colon *** insight not only offers a theoretical foundation for therapeutic approaches but also highlights the need for additional clinical trials and fundamental research to support our preliminary findings.

关键词： Colon cancer KRAS mutation Transglutaminase 2 Weighted gene co-expression network analysis

Variable projection algorithms with sparse constraint for separable nonlinear models

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Control Theory and Technology 2024年第1期22卷 135-146页

作者： Hui-Lang Xu Guang-Yong Chen Si-Qing Cheng Min Gan Jing Chen College of Computer and Data science Fuzhou UniversityFuzhou350116FujianChina Fujian Key Laboratory of Network Computing and Intelligent Information Processing Fuzhou UniversityFuzhou350116FujianChina Key Laboratory of Intelligent Metro of Universities in Fujian Fuzhou UniversityFuzhou350116FujianChina Engineering Research Center of Big Data Intelligence Ministry of EducationFuzhou UniversityFuzhou350116FujianChina School of science Jiangnan UniversityWuxi214122JiangsuChina

Separable nonlinear models are widely used in various fields such as time series analysis, system modeling, and machine learning, due to their flexible structures and ability to capture nonlinear behavior of data. However, identifying the parameters of these models is challenging, especially when sparse models with better interpretability are desired by practitioners. Previous theoretical and practical studies have shown that variable projection (VP) is an efficient method for identifying separable nonlinear models, but these are based on \(L_2\) penalty of model parameters, which cannot be directly extended to deal with sparse constraint. Based on the exploration of the structural characteristics of separable models, this paper proposes gradient-based and trust-region-based variable projection algorithms, which mainly solve two key problems: how to eliminate linear parameters under sparse constraint;and how to deal with the coupling relationship between linear and nonlinear parameters in the model. Finally, numerical experiments on synthetic data and real time series data are conducted to verify the effectiveness of the proposed algorithms.

关键词： Variable projection(VP) Non-smooth constraint Separable nonlinear models

Nomogram based on liver stiffness and spleen area with ultrasound for posthepatectomy liver failure:A multicenter study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2024年第27期30卷 3314-3325页

作者： Guang-Wen Cheng Yan Fang Li-Yun Xue Xiao-Hui Qiao Xue-Qi Li Yan Zhang Jia Guo Xiao-Yan Xie Hong Ding Department of Ultrasound Huashan HospitalFudan UniversityShanghai 200040China Department of Ultrasound Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203China Department of Medical Ultrasonics Institute of Diagnostic and Interventional UltrasoundSun Yat-sen University First Affiliated HospitalGuangzhou 510080Guangdong ProvinceChina Institute of Ultrasound in Medicine and Engineering Shanghai Cancer CenterShanghai 200040China Department of Ultrasound Eastern Hepatobiliary Surgical HospitalSecond Military Medical UniversityShanghai 200433China Department of Ultrasound National Clinical Research Center for Aging and MedicineHuashan HospitalFudan UniversityShanghai 200040China

BACKGROUND Liver stiffness(LS)measurement with two-dimensional shear wave elastography(2D-SWE)correlates with the degree of liver fibrosis and thus indirectly reflects liver function *** size of the spleen increases due to tissue proliferation,fibrosis,and portal vein congestion,which can indirectly reflect the situation of liver fibrosis/*** was reported that the size of the spleen was related to posthepatectomy liver failure(PHLF).So far,there has been no study combining 2D-SWE measurements of LS with spleen size to predict *** prospective study aimed to investigate the utility of 2D-SWE assessing LS and spleen area(SPA)for the prediction of PHLF in hepatocellular carcinoma(HCC)patients and to develop a risk prediction *** To investigate the utility of 2D-SWE assessing LS and SPA for the prediction of PHLF in HCC patients and to develop a risk prediction *** This was a multicenter observational study prospectively analyzing patients who underwent hepatectomy from October 2020 to March *** 1 wk before partial hepatectomy,ultrasound examination was performed to measure LS and SPA,and blood was drawn to evaluate the patient’s liver function and other *** absolute shrinkage and selection operator logistic regression and multivariate logistic regression analysis was applied to identify independent predictors of PHLF and develop a *** performance was validated *** diagnostic performance of the nomogram was evaluated with receiver operating charac-teristic curve compared with the conventional models,including the model for end-stage liver disease(MELD)score and the albumin-bilirubin(ALBI)*** A total of 562 HCC patients undergoing hepatectomy(500 in the training cohort and 62 in the validation cohort)were enrolled in this *** independent predictors of PHLF were LS,SPA,range of resection,blood loss,international normalized ratio,and total *** diagnostic performanc

关键词： Shear-wave elastography Spleen Hepatectomy Posthepatectomy liver failure Hepatocellular carcinoma

Genomic alterations in oral multiple primary cancers

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Oral science 2024年第1期16卷 145-153页

作者： Wen Wang Qian Wang Shiying Sun Pengfei Zhang Yuyu Li Weimin Lin Qiwen Li Xiao Zhang Zhe Ma Haiyan Lu Hebei Key Laboratory of Stomatology Hebei Clinical Research Center for Oral DiseasesHebei Medical UniversityShijiazhuangChina Department of Orthodontics School and Hospital of StomatologyHebei Medical UniversityShijiazhuangChina State Key Laboratory of Oral Diseases&national Center for Stomatology&national Clinical Research Center for Oral Diseases&West china Hospital of Stomatology Sichuan UniversityChengduChina Department of Preventive Dentistry School and Hospital of StomatologyHebei Medical UniversityShijiazhuangHebeiChina

Oral squamous cell carcinoma (OSCC) is the predominant type of oral cancer, while some patients may develop oral multiple primary cancers (MPCs) with unclear etiology. This study aimed to investigate the clinicopathological characteristics and genomic alterations of oral MPCs. Clinicopathological data from patients with oral single primary carcinoma (SPC, n=202) and oral MPCs (n=34) were collected and compared. Copy number alteration (CNA) analysis was conducted to identify chromosomal-instability differences among oral MPCs, recurrent OSCC cases, and OSCC patients with lymph node metastasis. Whole-exome sequencing was employed to identify potential unique gene mutations in oral MPCs patients. Additionally, CNA and phylogenetic tree analyses were used to gain preliminary insights into the molecular characteristics of different primary tumors within individual patients. Our findings revealed that, in contrast to oral SPC, females predominated the oral MPCs (70.59%), while smoking and alcohol use were not frequent in ***, long-term survival outcomes were poorer in oral MPCs. From a CNA perspective, no significant differences were observed between oral MPCs patients and those with recurrence and lymph node metastasis. In addition to commonly mutated genes such as CASP8, TP53 and MUC16, in oral MPCs we also detected relatively rare mutations, such as HS3ST6 and RFPL4A. Furthermore, this study also demonstrated that most MPCs patients exhibited similarities in certain genomic regions within individuals, and distinct differences of the similarity degree were observed between synchronous and metachronous oral MPCs.

关键词： alterations metastasis oral

A method to interpret fracture aperture of rock slope using adaptive shape and unmanned aerial vehicle multi-angle nap-of-the-object photogrammetry

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journal of Rock Mechanics and Geotechnical Engineering 2024年第3期16卷 924-941页

作者： Mingyu Zhao Shengyuan Song Fengyan Wang Chun Zhu Dianze Liu Sicong Wang College of Construction Engineering Jilin UniversityChangchun130026China College of Geo-Exploration science and Technology Jilin UniversityChangchun130026China Institute of Engineering Geology and Geohazards Hohai UniversityNanjing210098China

The aperture of natural rock fractures significantly affects the deformation and strength properties of rock masses,as well as the hydrodynamic properties of fractured rock *** conventional measurement methods are inadequate for collecting data on high-steep rock slopes in complex mountainous *** study establishes a high-resolution three-dimensional model of a rock slope using unmanned aerial vehicle(UAV)multi-angle nap-of-the-object photogrammetry to obtain edge feature points of *** opening morphology is characterized using coordinate projection and *** central axis is determined using vertical measuring lines,allowing for the interpretation of aperture of adaptive fracture *** feasibility and reliability of the new method are verified at a construction site of a railway in southeast Tibet,*** study shows that the fracture aperture has a significant interval effect and size *** optimal sampling length for fractures is approximately 0.5e1 m,and the optimal aperture interpretation results can be achieved when the measuring line spacing is 1%of the sampling *** fractures in the study area generally have larger apertures than shear fractures,and their tendency to increase with slope height is also greater than that of shear *** aperture of tensile fractures is generally positively correlated with their trace length,while the correlation between the aperture of shear fractures and their trace length appears to be *** of different orientations exhibit certain differences in their distribution of aperture,but generally follow the forms of normal,log-normal,and gamma *** study provides essential data support for rock and slope stability evaluation,which is of significant practical importance.

关键词： Unmanned aerial vehicle(UAV) photogrammetry High-steep rock slope Fracture aperture Interval effect Size effect Parameter interpretation

Dilute Aqueous-Aprotic Electrolyte Towards Robust Zn-Ion Hybrid Supercapacitor with High Operation Voltage and Long Lifespan

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano-Micro Letters 2024年第9期16卷 1-12页

作者： Shuilin Wu Yibing Yang Mingzi Sun Tian Zhang Shaozhuan Huang Daohong Zhang Bolong Huang Pengfei Wang Wenjun Zhang Key Laboratory of Catalysis and Energy Materials Chemistry of Ministry of Education&Hubei Key Laboratory of Catalysis and Materials science South-Central Minzu UniversityWuhan 430074People’s Republic of China Department of Materials science and Engineering and Center of Super‑Diamond and Advanced FilmsCity University of Hong Kong83 Tat Chee AvenueKowloon TongHong Kong SARPeople’s Republic of China Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijingPeople’s Republic of China

With the merits of the high energy density of batteries and power density of supercapacitors,the aqueous Zn-ion hybrid supercapacitors emerge as a promising candidate for applications where both rapid energy delivery and moderate energy storage are ***,the narrow electrochemical window of aqueous electrolytes induces severe side reactions on the Zn metal anode and shortens its *** also limits the operation voltage and energy density of the Zn-ion hybrid ***'water in salt'electrolytes can effectively broaden their electrochemical windows,but this is at the expense of high cost,low ionic conductivity,and narrow temperature compatibility,compromising the electrochemical performance of the Zn-ion hybrid ***,designing a new electrolyte to balance these factors towards high-performance Zn-ion hybrid supercapacitors is urgent and *** developed a dilute water/acetonitrile electrolyte(0.5 m Zn(CF_(3)SO_(3))_(2)+1 m LiTFSI-H_(2)O/AN)for Zn-ion hybrid supercapacitors,which simultaneously exhibited expanded electrochemical window,decent ionic conductivity,and broad temperature *** this electrolyte,the hydration shells and hydrogen bonds are significantly modulated by the acetonitrile and *** a result,a Zn-ion hybrid supercapacitor with such an electrolyte demonstrates a high operating voltage up to 2.2 V and long lifespan beyond 120,000 cycles.

关键词： Zn-ion supercapacitors Zn metal anode Electrolyte engineering Hydrogen bonds Solvation structures

Interorgan communication in neurogenic heterotopic ossification: the role of brain-derived extracellular vesicles

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Bone Research 2024年第1期12卷 137-152页

作者： Weicheng Lu Jianfei Yan Chenyu Wang Wenpin Qin Xiaoxiao Han Zixuan Qin Yu Wei Haoqing Xu Jialu Gao Changhe Gao Tao Ye Franklin R.Tay Lina Niu Kai Jiao Department of Stomatology Tangdu Hospital&State Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration&School of StomatologyThe Fourth Military Medical UniversityXi’anShaanxiChina State Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration&national Clinical Research Center for Oral Diseases&Shaanxi Key Laboratory of Stomatology School of StomatologyThe Fourth Military Medical UniversityXi’anShaanxiChina The Dental College of Georgia Augusta UniversityAugustaGAUSA

Brain-derived extracellular vesicles participate in interorgan communication after traumatic brain injury by transporting pathogens to initiate secondary ***-related proteins encapsulated in brain-derived extracellular vesicles can cross the blood‒brain barrier to reach distal *** proteins initiate inflammatory dysfunction,such as neurogenic heterotopic *** recurrent condition is highly debilitating to patients because of its relatively unknown pathogenesis and the lack of effective prophylactic intervention ***,a rat model of neurogenic heterotopic ossification induced by combined traumatic brain injury and achillotenotomy was developed to address these two *** examination of the injured tendon revealed the coexistence of ectopic calcification and fibroblast *** relationships among brain-derived extracellular vesicles,fibroblast pyroptosis and ectopic calcification were further investigated in vitro and in *** injection of the pyroptosis inhibitor Ac-YVAD-cmk reversed the development of neurogenic heterotopic ossification in *** present work highlights the role of brain-derived extracellular vesicles in the pathogenesis of neurogenic heterotopic ossification and offers a potential strategy for preventing neurogenic heterotopic ossification after traumatic brain injury.

关键词： neurogenic ossification pathogenesis

Interpretability of Neural Networks Based on Game-theoretic Interactions

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Machine Intelligence Research 2024年第4期21卷 718-739页

作者： Huilin Zhou Jie Ren Huiqi Deng Xu Cheng Jinpeng Zhang Quanshi Zhang School of Electronic Information and Electrical Engineering Shanghai Jiao Tong UniversityShanghai 200240China XLAB The Second Academy of China Aerospace Science and Industry CorporationBeijing 100854China

This paper introduces the system of game-theoretic interactions,which connects both the explanation of knowledge encoded in a deep neural networks(DNN)and the explanation of the representation power of a *** this system,we define two gametheoretic interaction indexes,namely the multi-order interaction and the multivariate *** crucially,we use these interaction indexes to explain feature representations encoded in a DNN from the following four aspects:(1)Quantifying knowledge concepts encoded by a DNN;(2)Exploring how a DNN encodes visual concepts,and extracting prototypical concepts encoded in the DNN;(3)Learning optimal baseline values for the Shapley value,and providing a unified perspective to compare fourteen different attribution methods;(4)Theoretically explaining the representation bottleneck of ***,we prove the relationship between the interaction encoded in a DNN and the representation power of a DNN(e.g.,generalization power,adversarial transferability,and adversarial robustness).In this way,game-theoretic interactions successfully bridge the gap between“the explanation of knowledge concepts encoded in a DNN”and"the explanation of the representation capacity of a DNN"as a unified explanation.

关键词： Model interpretability and transparency explainable AI game theory interaction deep learning.

Prevalence and influencing factors of social alienation among elderly patients undergoing radical prostatectomy for prostate cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Current Urology 2024年第2期18卷 98-103页

作者： Xiao Fang Kong Ren Yan Li QiaoMeng Mingyue Li Miao Miao Jing Zhan Xia Wang FeiWu Meixia Zhang Department of Urology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityShandong First Medical University and Shandong Academy of Medical SciencesJinanChina Department of Urology The Second Clinical Medical College of Binzhou Medical UniversityYantaiChina Department of Hematology The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan HospitalJinanChina

Objectives:This study aims to not only investigate the prevalence of social alienation among elderly patients undergoing radical prostatectomy for prostate cancer but also identify the contributing *** and methods:A total of 245 elderly patients diagnosed with prostate cancer and undergoing radical prostatectomy at a tertiary care general hospital in Jinan were included in this *** assess the patients,several questionnaires were *** included the General Situation Questionnaire,General Alienation Scale,Social Impact Scale,Modified Memorial Anxiety Scale for Prostate Cancer,and Perceived Social Support *** correlation analysis was conducted to examine the relationships between variables,whereas multiple linear regression was used to identify the factors influencing social alienation among patients who underwent radical ***:Patients who underwent radical prostatectomy had a mean total score of 44.13±7.24 on the Social Alienation *** results of the Pearson correlation analysis indicated that social alienation showed an inverse association with social support(r=−0.627,p<0.05)and positive associations with age,disease stigma,and anxiety(r=0.325,0.575,0.421,all p’s<0.01)among patients who underwent radical *** findings frommultiple linear regression analysis demonstrated that educational level,age,urinary incontinence,disease stigma,anxiety,and social support significantly influenced social alienation among elderly patients who underwent radical prostatectomy(p<0.05).Conclusions:Elderly patients who undergo radical prostatectomy often experience social *** study found that social alienation was associated with factors such as educational level,age,urinary incontinence,social support,anxiety,and disease ***,healthcare providers should actively monitor the degree of social alienation in elderly patients after radical prostatectomy and provide suitable psychological care to f

关键词： Prostate cancer Social alienation Disease stigma Social support Nursing