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Xiangshao Granules Ameliorate Post-stroke Depression by Inhibiting Activation of Microglia and IDO1 Expression in Hippocampus and Prefrontal Cortex

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Chinese Journal of Integrative Medicine 2025年第1期31卷 28-38页

作者： LI Cheng-gang XU Lu-shan SUN Liang XU Yu-hao CAO Xiang ZHAO Chen-chen XIA Sheng-nan ZHANG Qing-xiu XU Yun Department of Neurology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjing210008China State Key Laboratory of Pharmaceutical Biotechnology and institute of Translational Medicine for Brain Critical Diseases Nanjing UniversityNanjing210008China Jiangsu Key Laboratory for Molecular Medicine Medical School of Nanjing UniversityNanjing210008China Nanjing Neurology medical Center Nanjing210008China

Objective To investigate the therapeutic effect of Xiangshao Granules(XSG)on post-stroke depression(PSD)and explore the underlying *** Forty-three C57BL/6J mice were divided into 3 groups:sham(n=15),PSD+vehicle(n=14),and PSD+XSG(n=14)groups according to a random number *** PSD models were constructed using chronic unpredictable mild stress(CUMS)after middle cerebral artery occlusion(MCAO).The sham group only experienced the same surgical operation,but without MACO and CUMS *** XSG group received XSG(60 mg/kg per day)by gavage for 4 *** mice in the sham and vehicle groups were given the same volume of 0.9%saline at the same *** body weight and behavior tests including open field test,sucrose preference test,tail suspension test,and elevated plus-maze test,were used to validate the PSD mouse ***-time fluorescence quantitative polymerase chain reaction(RT-qPCR),enzyme-linked immunosorbent assay(ELISA),and immunofluorescence staining were used to evaluate the anti-inflammatory effects of *** potential molecular mechanisms were explored and verified through network pharmacology analysis,Nissl staining,Western blot,ELISA,and RT-qPCR,*** The body weight and behavior tests showed that MCAO combined with CUMS successfully established the PSD *** alleviated neuronal damage,reduced the expressions of pro-apoptotic proteins Caspase-3 and B-cell lymphoma-2(BCL-2)-associated X(BAX),and increased the expression of anti-apoptotic protein BCL-2 in PSD mice(P<0.05 or P<0.01).XSG inhibited microglial activation and the expressions of pro-inflammatory cytokines including tumor necrosis factor-α,interleukin(IL)-1β,and IL-6 via the toll-like receptor 4/nuclear factor kappa-B signaling pathway in PSD mice(P<0.05 or P<0.01).Furthermore,XSG decreased the expression of indoleamine 2,3-dioxygenase1(IDO1)and increased the concentration of 5-hydroxytryptamine in PSD mice(P<0.05 or P<0.01).Conclusion XSG could reverse

关键词： post-stroke depression Xiangshao Granules indoleamine 2,3-dioxygenase 1 Chinese medicine

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General Automatic Solution Generation for Social Problems

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Machine Intelligence research 2025年第1期22卷 145-159页

作者： Tong Niu Haoyu Huang Yu Du Weihao Zhang Luping Shi Rong Zhao Center for Brain-Inspired Computing research(CBICR) Optical Memory National Engineering Research Centerand Department of Precision InstrumentTsinghua UniversityBeijing100084China IDG/McGovern institute for Brain research Tsinghua UniversityBeijing100084China THU-CET HIK Joint research Center for Brain-Inspired Computing Beijing100084China

Given the escalating intricacy and multifaceted nature of contemporary social systems,manually generating solutions to address pertinent social issues has become a formidable *** response to this challenge,the rapid development of artificial intelligence has spurred the exploration of computational methodologies aimed at automatically generating ***,current methods for the auto-generation of solutions mainly concentrate on local social regulations that pertain to specific ***,we report an automatic social operating system(ASOS)designed for general social solution generation built upon agent-based models that enables both global and local analyses and regulations of social problems across spatial and temporal *** adopts a hypergraph with extensible social semantics for a comprehensive and structured representation of social *** also incorporates a generalized protocol for standardized hypergraph operations and a symbolic hybrid framework that delivers interpretable solutions,yielding a balance between regulatory efficacy and functional *** demonstrate the effectiveness of the ASOS,we apply it to the domain of averting extreme events within international oil futures *** generating a new trading role supplemented by new mechanisms,ASOS can adeptly discern precarious market conditions and make front-running interventions for nonprofit *** study demonstrated that ASOS provides an efficient and systematic approach for generating solutions for enhancing our society.

关键词： General automatic generation global-local regulation hypergraph social representation symbolic hybrid scheme generalized operation protocol

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A polynomial resultant approach to algebraic constructions of extremal graphs

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Science China Mathematics 2025年第2期68卷 485-506页

作者： Tao Zhang Zixiang Xu Gennian Ge institute of Mathematics and Interdisciplinary Sciences Xidian UniversityXi’an 710071China School of Mathematical Sciences Capital Normal UniversityBeijing 100048China

The Turán problem asks for the largest number of edges ex(n,H)in an n-vertex graph not containing a fixed forbidden subgraph H,which is one of the most important problems in extremal graph ***,the order of magnitude of ex(n,H)for bipartite graphs is known only in a handful of *** particular,giving explicit constructions of extremal graphs is very challenging in this *** this paper,we develop a polynomial resultant approach to the algebraic construction of explicit extremal graphs,which can efficiently decide whether a specified structure exists.A key insight in our approach is the multipolynomial resultant,which is a fundamental tool of computational algebraic *** main results include the matched lower bounds on the Turán number of 1-subdivision of K3,t1and the linear Turán number of the Berge theta hypergraph■_(3,t_(2))^(B).where t_(1)=25 and t_(2)=***,the constant t1improves the random algebraic construction of Bukh and Conlon(2018)and makes the known estimation better on the smallest value of t1concerning a problem posed by Conlon et al.(2021)by reducing the value from a magnitude of 10^(56)to the number 25,while the constant t_(2)improves a result of He and Tait(2019).

关键词： Turan number resultant algebraic construction subdivision Berge theta hypergraph

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Zosurabalpin like petrichor:a novel antibiotic class with unprecedented target towards Acinetobacter baumannii

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Science Bulletin 2025年第1期70卷 7-9页

作者： Yajin Wen Yongye Huang Zhenwei Xia Min Wu Yinghao Zhi The Department of Pediatrics Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Key Laboratory of Bioresource research and development of Liaoning Province College of Life and Health SciencesNortheastern UniversityShenyang 110169China Wenzhou institute University of Chinese Academy of SciencesWenzhou 325000China Wenzhou Traditional Chinese Medicine Hospital of Zhejiang Chinese medical University Wenzhou 325000China

A recent paper published in Nature[1]by Bradley and colleagues reports that zosurabalpin,an optimized tethered macrocyclic peptide(MCP)antibiotic,can kill Acinetobacter baumannii by inhibiting Lpt B2FGC transport of lipopolysaccharide(LPS)from the bacterial plasma membrane to its outer membrane(Fig.1).This breakthrough in the search for new antibiotics,like petrichor after a long drought,breathes new life into the prospect of treating drug-resistant bacterial like carbapenem-resistant Acinetobacter baumannii(CRAB).

关键词： breakthrough outer drought

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Bioelectronic medicine in modulation of cortical spreading depolarization and beyond

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Neural Regeneration research 2025年第2期20卷 481-482页

作者： Khaled Alok Timothy G.White Chunyan Li Department of Neurosurgery Donald and Barbara Zucker School of Medicine at Hofstra/NorthwellHempsteadNYUSA Translational Brain research Laboratory The Feinstein Institutes for Medical ResearchManhassetNYUSA

Bioelectronic interventions,specifically trigeminal nerve st imulat ion(TNS),have attracted considerable attention in conditions where cortical spreading depolarizations(CSDs)accompanied by compromised cerebral perfusion may exacerbate neurological *** pharmacological interventions have demonstrated initial potential in addressing CSDs,a standardized treatment approach has not yet been *** objective of this perspective is to explore emerging bioelectronic methodologies for addressing CSDs,particularly emphasizing TNS,and to underscore TNS’s capacity to enhance neurovascular coupling and cerebral perfusion.

关键词： cerebral perfusion electronic

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Functions of transcription factor superfamilies in rice immunity

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The Crop Journal 2025年第1期13卷 5-22页

作者： Sang Ryeol Park Yujeong Jeong Seungmin Son national institute of Agricultural Sciences Rural Development AdministrationJeonju 54874Republic of Korea Department of Crop Science and Biotechnology Jeonbuk National UniversityJeonju 54896Republic of Korea

The emergence of novel phytopathogens and the accelerated spread of plant diseases to new regions,driven by global climate change,constitute significant threats to agricultural ***,a major tropical staple crucial for global food security,possesses six transcription factor superfamilies-AP2/ERF,bHLH,bZIP,MYB,NAC,and WRKY-that function in innate immunity against *** review their biological functions and regulatory mechanisms in rice immunity.

关键词： Biotic stress Crop resilience Immune response Rice Transcription factor

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Planar Hall plateau in magnetic Weyl semimetals

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Science Bulletin 2025年第2期70卷 187-192页

作者： Lei Li Chaoxi Cui Run-Wu Zhang Zhi-Ming Yu Yugui Yao Centre for Quantum Physics Key Laboratory of Advanced Optoelectronic Quantum Architecture and Measurement(MOE)School of PhysicsBeijing Institute of TechnologyBeijing 100081China Beijing Key Lab of Nanophotonics&Ultrafine Optoelectronic Systems School of PhysicsBeijing Institute of TechnologyBeijing 100081China International Center for Quantum Materials Beijing Institute of TechnologyZhuhai 519000China

Despite the rapid progress in the study of planar Hall effect(PHE)in recent years,all the previous works only showed that the PHE is connected to local geometric quantities,such as Berry ***,for the first time,we point out that the PHE in magnetic Weyl semimetals is directly related to a global quantity,namely,the Chern number of the Weyl *** leads to a remarkable consequence that the PHE observation predicted here is robust against many system details,including the Fermi *** main difference between non-magnetic and magnetic Weyl points is that the latter breaks time-reversal symmetry T,thus generally possessing an energy *** semiclassical Boltzmann theory,we investigate the PHE in generic magnetic Weyl models with energy tilt and arbitrary Chern *** find that by aligning the magnetic and electric fields in the same direction,the trace of the PHE conductivity contributed by Berry curvature and orbital moment is proportional to the Chern number and the energy tilt of the Weyl points,resulting in a previously undiscovered quantized PHE plateau by varying the Fermi *** further confirm the existence of PHE plateaus in a more realistic lattice model without T *** proposing a new quantized physical quantity,our work not only provides a new tool for extracting the topological character of the Weyl points but also suggests that the interplay between topology and magnetism can give rise to intriguing physics.

关键词： Magnetic Weyl semimetals Planar Hall effect Quantized plateau Chern number

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Localizing base stations with measured data:a concatenated image-based deep learning approach

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Science China(Information Sciences) 2025年第2期68卷 385-386页

作者： Yang CHEN Ziyuan LIU Feng JIANG Hong SHEN Wei XU Mengyu LI Ritao CHENG national Mobile Communications research Laboratory Southeast University China Mobile Group Design institute Co. Ltd.

Localization has become an indispensable function of modern cellular communication systems [1]. In a cloud radio access network(C-RAN), the remote radio head(RRH) is the actual signal transmitter, whose location can assist in wireless network layout optimization and wireless resource management. The measurement of the RRH location can only be done manually on-site due to the lack of global positioning systems(GPS) at the RRH side, which is thus not a cost-effective solution for the widely used C-RAN with a large number of RRH units.

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Integration of perioperative features and intragraft TCF7L2 expression to predict lipid metabolic disorder in liver transplant recipients

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Science China(Life Sciences) 2025年第1期68卷 297-299页

作者： Junbin Zhou Rongli Wei Guanghan Fan Zhengxing Lian Xuanyu Zhang Linsong Tang Zhetuo Qi Haiyang Xie Shusen Zheng Qiang Wei Xiao Xu Department of Hepatobiliary and Pancreatic Surgery People’s Hospital of LishuiAffiliated Lishui Hospital of Wenzhou Medical UniversityThe First Affiliated Hospital of Lishui UniversityLishui 323000China NHFPC Key Laboratory of Combined Multi-Organ Transplantation Hangzhou 310003China Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province Department of Hepatobiliary and Pancreatic SurgeryHangzhou First People’s HospitalHangzhou 310006China Department of Hepatobiliary and Pancreatic Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Urology The Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China Department of Hepatobiliary and Pancreatic Surgery Department of Liver TransplantationShulan(Hangzhou)HospitalHangzhou 310011China Hangzhou medical College Hangzhou 310059China Zhejiang University School of Medicine Hangzhou 310058China

Dear Editor,Liver transplantation(LT)is the only curative therapy for patients with endstage liver disease(He et al.,2023;Ling et al.,2022).Post-transplant hypertriglyceridemia(PTHT),which has an incidence of up to 32.8%in 6 months after LT,is one of the major post-transplant complications(Toshima et al.,2020).With the prolongation of the recipient’s survival time,the incidence of PTHT is increasing,becoming an important factor that affects the recipient’s quality of life and survival *** with various metabolic complications,including PTHT,have a 1.78 times higher risk of atherosclerotic cardiovascular disease(ASCVD)development and death than recipients without these complications(Jiménez Pérez et al.,2016).Studies have shown that PTHT,accompanied by other posttransplant metabolic complications and immunosuppressants,are important risk factors for post-transplant ASCVD and mediate 19%–42% of nongraft-related deaths(Davis and Shadab Siddiqui,2017;Jiménez-Pérez et al.,2016).However,early prediction of PTHT remains a major challenge.

关键词： liver graft

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AAV mediated carboxyl terminus of Hsp70 interacting protein overexpression mitigates the cognitive and pathological phenotypes of APP/PS1 mice

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Neural Regeneration research 2025年第1期20卷 253-264页

作者： Zhengwei Hu Jing Yang Shuo Zhang Mengjie Li Chunyan Zuo Chengyuan Mao Zhongxian Zhang Mibo Tang Changhe Shi Yuming Xu Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina Academy of medical Sciences of Zhengzhou University ZhengzhouHenan ProvinceChina NHC Key Laboratory of Prevention and treatment of Cerebrovascular Diseases The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina Henan Key Laboratory of Cerebrovascular Diseases The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina institute of Neuroscience Zhengzhou UniversityZhengzhouHenan ProvinceChina Sino-British research Centre for Molecular Oncology National Centre for International Research in Cell and Gene TherapySchool of Basic Medical SciencesAcademy of Medical SciencesZhengzhou UniversityZhengzhouHenan ProvinceChina Department of Gerontology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina

The E3 ubiquitin ligase,carboxyl terminus of heat shock protein 70(Hsp70)interacting protein(CHIP),also functions as a co-chaperone and plays a crucial role in the protein quality control *** this study,we aimed to investigate the neuroprotective effect of overexpressed CHIP on Alzheimer’s *** used an adeno-associated virus vector that can cross the blood-brain barrier to mediate CHIP overexpression in APP/PS1 mouse *** overexpression significantly ameliorated the performance of APP/PS1 mice in the Morris water maze and nest building tests,reduced amyloid-βplaques,and decreased the expression of both amyloid-βand phosphorylated *** also alleviated the concentration of microglia and astrocytes around *** APP/PS1 mice of a younger age,CHIP overexpression promoted an increase in ADAM10 expression and inhibitedβ-site APP cleaving enzyme 1,insulin degrading enzyme,and neprilysin *** of HSP70 and HSP40,which have functional relevance to CHIP,were also *** nuclei transcriptome sequencing in the hippocampus of CHIP overexpressed mice showed that the lysosomal pathway and oligodendrocyte-related biological processes were up-regulated,which may also reflect a potential mechanism for the neuroprotective effect of *** research shows that CHIP effectively reduces the behavior and pathological manifestations of APP/PS1 ***,overexpression of CHIP could be a beneficial approach for the treatment of Alzheimer’s disease.

关键词： adeno-associated virus Alzheimer’s disease APP/PS1 mice carboxyl terminus of Hsp70 interacting protein gene therapy

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