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A complete compilation of matrix metalloproteinase expression in human malignant gliomas

world Journal of Clinical Oncology 2012年第5期3卷 67-79页

作者： Carsten Hagemann Jelena Anacker ralf-Ingo Ernestus Giles H Vince Department of Neurosurgery Tumorbiology Laboratory University of Würzburg Josef-Schneider-Str. 11 D-97080 Würzburg Germany Department of Obstetrics and Gynaecology University of Würzburg Josef-Schneider-Str. 4 D-97080 Würzburg Germany

Glioblastomas are characterized by an aggressive local growth pattern, a marked degree of invasiveness and poor prognosis. tumor invasiveness is facilitated by the increased activity of proteolytic enzymes which are involved in destruction of the extracellular matrix of the surrounding healthy brain tissue. Elevated levels of matrix metalloproteinases(MMPs) were found in glioblastoma(GBM) cell-lines, as well as in GBM biopsies as compared with low-grade astrocytoma(LGA) and normal brain samples, indicating a role in malignant progression. A careful review of the available literature revealed that both the expression and role of several of the 23 human MMP proteins is controversely discussed and for some there are no data available at all. we therefore screened a panel of 15 LGA and 15 GBM biopsy samples for those MMPs for which there is either no, very limited or even contradictory dataavailable. Hence, this is the first complete compilation of the expression pattern of all 23 human MMPs in astrocytic tumors. this study will support a better understanding of the specific expression patterns and interaction of proteolytic enzymes in malignant human glioma and may provide additional starting points for targeted patient therapy.

关键词： Astrocytic tumor Expression pattern Glioblastoma cell-lines Glioblastoma multiforme Matrix metalloproteinase

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