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Ameliorative effect of grapefruit juice on amiodarone-induced cytogenetic and testicular damage in albino rats

Asian Pacific Journal of Tropical Biomedicine 2013年第7期3卷 573-579页

作者： Saber Abdelruhman Sakr Mohamed El-said Zoil Samraa Samy El-shafey Zoology Department Faculty of Science Menoufia UniversityEgypt Zoology Department Faculty of Science Benha UniversityEgypt

Objective:To evaluate the ameliorative role of grapefruit juice on the cytogenetic and testicular damage induced by the antiarrythmic drug amiodarone in albino ***:Animals were divided into four *** I was considered as *** II was given grapefruit juice at a dose level of 27 mL/kg body *** III was orally administered amiodarone(18 mg/kg body weight)daily for 5 *** were sacrificed after 5 weeks of *** marrow was collected from the femurs for analysis of chromosomal aberrations and mitotic *** were removed and stained with H&E for histological *** were collected from epidedymis for detection of sperm head *** assay was used to detect DNA ***:Amiodarone treatment caused a significant increase in the percentage of chromosomal aberrations,decreased the mitotic index and increased DNA *** testis showed many histopathological alterations,inhibition of spermatogenesis and morphometric *** number of sperm head abnormalities was *** animals with amiodarone and grapefruit juice caused a reduction in chromosomal aberrations,mitotic index,DNA damage and testicular alterations caused by ***:The results of this study indicated that grapefruit juice ameliorates the cytotoxicty and testicular alterations induced by amiodarone in albino rats and this is may be due to the potent antioxidant effects of its components.

关键词： Amiodarone Grapefruit Chromosome Comet assay Testis

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Ameliorative effect of Morus alba leaves extract against developmental retinopathy in pups of diabetic and aluminum intoxicated pregnant albino rats

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Asian Pacific Journal of Tropical Biomedicine 2015年第4期5卷 300-309页

作者： Hassan El-Sayyed Gamal Badawy Sobhy Hassab Elnabi Ibrahim El-Elaimy Eman Al Shehari Department of Zoology Faculty of Science Mansoura University Department of Zoology Faculty of Science Menoufiya University

Objective: To investigate the possible ameliorative effect of crude water extract of Morus alba(M. alba) leaves on retinopathy of rat pups maternally subjected to diabetes and/or Al ***: Both control and experimental groups were subjected to certain integrated approaches, namely, biochemical assessments, light microscopic investigation, transmission electron microscopic investigation, single cell gel electrophoresis(comet assay) and determination of DNA ***: The retina of pups of diabetic and/or Al-intoxicated mothers exhibited abnormal alterations in retinal cell layers including retinal pigmented epithelium, photoreceptor inner segment and ganglion cells. Increased incidence of DNA fragmentation and apoptosis were evident in pups of diabetic and/or Al-intoxicated mothers. However, retina of pups maternally received M. alba extract plus diabetes or Al-intoxicated alone or in combination showed marked amelioration. Less degree of ameliorations was seen in retina of pups maternally subjected to combined treatment. Furthermore, application of crude water extract of *** resulted in amelioration of the alterations of maternal serum glucose as well as Al ***: Based on the results of the present study, M. alba extract is effective against experimentally diabetic and Al-induced developmental retinopathy.

关键词： Morus alba Retinopathy Aluminum Diabetes TEM Comet assay

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Effect of mesenchymal stem cells on anti-Thy1,1 induced kidney injury in albino rats

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Asian Pacific Journal of Tropical Biomedicine 2013年第3期3卷 174-181页

作者： Saber Sakr Laila Rashed Waheba Zarouk Rania El-Shamy Department of Zoology Faculty of ScienceMenoufia University Department of Biochemistry Faculty of MedicineCairo University Center of Human Genetics and Human Genome Research National Research Center

Objective:To evaluate the effect of mesenchymal stem cells(MSCs)in rats with anti-Thy 1,***:Female albino rats were divided into three groups,control group,anti-Thy 1,1group and treatment with *** *** were derived from bone marrow of male albino rats,Y—chromosome gene was detected by polymerase chain reaction in the *** urea and creatinine were estimated for all *** of all studied groups was examined histologically and histochemically(total carbohydrates and total proteins).DNA fragmentation and expression ofα-SMA were ***:Kidney of animals injected with anti-Thy 1,1showed inflammatory leucocytic infiltration,hypertrophied glomeruli,tubular necrosis and congestion in the renal blood *** kidney tissue also showed reduction of carbohydrates and total proteins together with increase in apoptosis and in expression ofα-***,the levels of urea and creatinine were *** animals with MSCs revealed that kidney tissue displayed an improvement in the histological and histochemical *** andα-SMA expression were decreased,and the levels of urea and creatinine ***:The obtained results demonstrated the potential of MSCs to ameliorate the structure and function of the kidney in rats with anti-Thy 1,1 nephritis possibly through the release of paracrine growth factor(s).

关键词： Anti-Thy1,1 Nephritis Mesenchymal stem cells α-SMA Apoptosis

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