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Rapid Determination of Total Content of Five Major Anthraquinones in Rhei Radix et Rhizoma by NIR Spectroscopy

Chinese Herbal Medicines 2017年第3期9卷 250-257页

作者： Hao Zhan Jing Fang Hong-wei Wu Hong-jun Yang Hua Li Zhu-ju Wang Bin Yang Li-ying Tang Mei-hong Fu Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences

Objective To establish a new method with near-infrared（NIR） spectroscopy to determine the total content of emodin, chrysophanol, rhein, aloeemodin, and physcion. NIR was used in this study to provide rapid and nondestructive analysis results. Methods In the first place, HPLC was used to measure the total content of emodin, chrysophanol, rhein, aloe-emodin and physcion in Rhei Radix et Rhizoma（RR） as a reference. In the second place, the spectral regions, regression methods, pretreatment methods, and partial least squares（PLS） factors were compared to increase the feasibility of the model. In the last, the root mean square error of calibration（RMSEC）, root mean square error of cross validation（RMSECV）, root mean square error of prediction（RMSEP）, and correlation coefficient（r） were used as assessment parameters. Results PLS with first derivative pretreatment in the ranges of 4242-5581 cm^（-1）, 5885-6233 cm^（-1） and 6394-7011 cm^（-1） provided the best results. The RMSEC and RMSEP obtained were 0.134 and 0.226 respectively. The according determination coefficients of the quantitative model were 0.99 and 0.94. Conclusion NIR spectroscopy as a quick and nondestructive analytical method may be used to determine the total content of emodin, chrysophanol, rhein, aloeemodin, and physcion for the quality control of RR.

关键词： near-infrared spectroscopy partial least squares quality control rapid determination Rhei Radix et Rhizoma

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Myocardial injury:where inflammation and autophagy meet

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Burns & Trauma 2023年第1期11卷 188-202页

作者： Chunping Liu Yanjiao Liu Huiqi Chen Xiaofei Yang Chuanjian Lu Lei Wang Jiahong Lu State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacaoChina State Key Laboratory of Dampness Syndrome of Chinese Medicine The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou51080China Guangdong-Hong Kong-Macao Joint Lab on Chinese Medicine and Immune Disease Research Guangzhou510080China

Autophagy is a highly conserved bulk degradation mechanism that degrades damaged organelles,aged proteins and intracellular contents to maintain the homeostasis of the intracellular *** of autophagy can be observed during myocardial injury,during which inflammatory responses are strongly *** can inhibit the inflammatory response and regulate the inflammatory microenvironment by removing invading pathogens and damaged *** addition,autophagy may enhance the clearance of apoptotic and necrotic cells to promote the repair of damaged *** this paper,we briefly review the role of autophagy in different cell types in the inflammatory microenvironment of myocardial injury and discuss the molecular mechanism of autophagy in regulating the inflammatory response in a series of myocardial injury conditions,including myocardial ischemia,ischemia/reperfusion injury and sepsis cardiomyopathy.

关键词： Autophagy Inflammation Myocardial injury

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Screening hepatoprotective effective components of Lonicerae japonica Flos based on the spectrum-effect relationship and its mechanism exploring

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Food Science and Human Wellness 2023年第1期12卷 283-294页

作者： Song Wang Lin Yang Ajiao Hou Songtao Liu Liu Yang Haixue Kuang Hai Jiang Key Laboratory of Chinese Materia Medica Heilongjiang University of Chinese MedicineMinistry of EducationHarbin 150040China School of Pharmacy Jiangxi University of Traditional Chinese MedicineNanchang 330004China

Lonicerae japonicae Flos(LF)is a kind of healthcare food with hepatoprotective *** study was designed to explore the spectrum-effect relationships between UPLC fingerprints and the hepatoprotective effects of *** of ten batches of LF were established by *** inhibitory levels of AST and ALT were used as pharmacological indexes,and secoxyloganin,isochlorogenic acid A and isochlorogenic acid C were screened as hepatoprotective active compounds by grey relational analysis(GRA)and partial least squares regression analysis(PLSR).Caspase-3 was obtained by network pharmacology as a key target of hepatoprotective active *** docking is used to explore the interaction between small molecules and *** work provided a general model of the combination of UPLC-PDA and hepatoprotective effect to study the spectrum-effect relationship of LF,which can be used to considerable methods and insight for the fundamental research of the material basis of similar healthcare food.

关键词： Lonicerae japonicae Flos Hepatoprotective effect Spectrum-effect relationship Molecular docking Mechanism

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