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Leveraging nano-engineered mesenchymal stem cells for intramedullary spinal cord tumor treatment

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Chinese Chemical Letters 2023年第5期34卷 449-455页

作者： Lu Tang Mengying Xie Jing Li Yijun Mei Yuqi Cao Qiaqia Xiao Haijuan Dong Yuhui Zhang Wei Wang Department of Pharmaceutics State Key Laboratory of Natural MedicinesSchool of PharmacyChina Pharmaceutical UniversityNanjing 210009China NMPA Key Laboratory for Research and Evaluation of Pharmaceutical Preparations and Excipients China Pharmaceutical UniversityNanjing 210009China The Public Laboratory Platform China Pharmaceutical UniversityNanjing 210009China Department of Spine Surgery Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China

Intramedullary spinal cord tumor(IMSCT)is comparatively rare malignant tumor in the central nervous system and is very difficult accessible by conventional chemotherapy ***,there are very limited researches for IMSCT treatment using *** fill this gap,we originally reported a targeted strategy by leveraging nano-engineered mesenchymal stem cells(MSCs)for synergistic antiIMSCT *** this study,two mode drugs paclitaxel(PTX)and metformin(MET)were co-loaded in maleimide-modified poly(lactic-co-glycolicacid)(PLGA-MAL)nanoparticles,which were further conjugated onto MSCs surface via the thioether bond formed between PLGA-MAL and MSCs without affecting the migration ability of *** to the excellent tumor tropism and penetrability of MSCs and good biodegradability of PLGA,the designed drug delivery platform could accurately target IMSCT sites to exert long-term synergistic antitumor efficacy,exhibiting promising research value for alternative IMSCT management beyond surgery.

关键词： Mesenchymal stem cell Intramedullary spinal cord tumor Metformin Nanosystem Targeted drug delivery

In-situ polarization of covalent organic frameworks in seawater enables enhanced photocatalytic hydrogen evolution under visiblelight irradiation

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Nano Research 2023年第5期16卷 6251-6259页

作者： Qihong Yue Guoqing Li Ping Fu Biao Meng Fangpei Ma Yu Zhou Jun Wang State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical EngineeringNanjing Tech UniversityNanjing 210009China

Photocatalytic hydrogen(H_(2))production from seawater over a photocatalyst is of great significance for the utilization of the earth’s abundant seawater resources and the storage of inexhaustible solar energy with low-energy ***,the designation of efficient photocatalytic systems by using seawater usually suffers from activation decline when replacing pure water with ***,we synthesized threeβ-ketoenamine-linked covalent organic frameworks(COFs),demonstrating their promotion in the photocatalytic decomposition of seawater relative to pure water under visible-light *** target COFs were synthesized via a microwave assisted solvothermal method by using 1,3,5-triformylphloroglucinol(Tp)as the aldehyde monomer to react with diamino units with different numbers of benzene *** surveying the building blocks,the constructed COF with a high density ofβ-ketoenamine units exhibited the so far highest photocatalytic H_(2) evolution rate(41.3 mmol·g^(−1)·h^(−1))in seawater,about 1.66 times higher than that in pure ***β-ketoenamine units allowed the in-situ polarization of the COF framework through the adsorption of metal salts when proceeding with the photocatalytic H_(2) production in *** polarization effect significantly increases the dielectric constant of the organic semiconductor to lower exciton dissociation energy and thus enhances the charge separation and transfer to promote the H_(2) photoproduction in seawater.

关键词： covalent organic frameworks photocatalysis hydrogen evolution reaction seawater polarization

Atomistic simulations of the lubricative mechanism of a nano-alkane lubricating film between two layers of Cu-Zn alloy

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Chinese Physics B 2021年第8期30卷 211-219页

作者： Jing Li Peng Zhu Yuan-Yuan Sheng Lin Liu Yong Luo School of Mechanical Engineering and Rail Transit Changzhou UniversityChangzhou 213164China jiangsu Key Laboratory of Green Process Equipment Changzhou UniversityChangzhou 213164China School of Materials Science and Physics University of Mining and TechnologyXuzhou 221116China

We describe simulations of lubrication by a hexadecane molecular lubricating film during the shearing process of a Cu-Zn alloy performed using the atomistic *** results indicate that with increasing Zn contents,the interface slip between the alloy wall and the lubricating film first decreases and then increases,according to variations of the radius distribution function(RDF),while the interface slip reaches its lowest value of 0.12 during the shearing of CuZn30 *** also discuss the relationship between interface roughness and the lubricating *** film lubrication,the interface's roughness effectively inhibits interfacial *** the convex contact model,the presence of the hexadecane lubricating film reduces the interfacial contact pressure from 11.9 GPa to 8.7 GPa and the friction coefficient from 0.81 to 0.52.

关键词： molecular dynamic simulation nanotribology Cu-Zn alloy interface slip

Manipulation of acoustic wavefront by transmissive metasurface based on pentamode metamaterials

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Chinese Physics B 2019年第2期28卷 306-312页

作者： Ying Liu Yi-Feng Li Xiao-Zhou Liu College of Computer Science and Technology Nanjing Tech University Key Laboratory of Modern Acoustics Ministry of EducationNanjing University Key Laboratory of Modern Acoustics Ministry of EducationInstitute of Acoustics and School of PhysicsNanjing University

An underwater acoustic metasurface with sub-wavelength thickness is designed for acoustic wavefront *** this paper, a pentamode lattice and a frequency-independent generalized acoustic Snell's law are introduced to overcome the limitations of narrow bandwidth and low transmittance. The bulk modulus and effective density of each unit cell can be tuned simultaneously, which are modulated to guarantee the achievement of refractive index profile and high transmission. Here, we actualize anomalous refraction, generation of non-diffracting Bessel beam, sub-wavelength flat focusing,and surface wave conversion by constructing inhomogeneous acoustic metasurface. This design approach has potential applications in medical ultrasound imaging and underwater acoustic communications.

关键词： metasurface frequency-independent pentamode high transmission

Acute Pesticide Poisoning in jiangsu province, China, from 2006 to 2015

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Biomedical and Environmental Sciences 2017年第9期30卷 695-700页

作者： WANG Bo Shen CHEN Lin LI Xiu Ting XU Ming ZHU Bao Li ZHANG Juan Key Laboratory of Environmental Medicine Engineering of Ministry of Education School of Public Health Southeast University Department of Prevention and Control for Occupational Disease Jiangsu Provincial Center for Disease Prevention and Control Nanjing Prevention and Treatment Center for Occupational Diseases

This study aimed to investigate the characteristics of pesticide poisoning in jiangsu province, China, and to provide a scientific basis for developing effective interventional measures and preventive strategies. From 2006 to 2015, a total of 35,308 cases of pesticide poisoning were reported in jiangsu province. Non‐occupational poisoning accounted for 73.79% of all poisoning cases. A comparison of the data collected before（2006） and after（2015） this study showed a decrease in non‐occupational pesticide poisoning. Pesticide poisoning showed an age central tendency of 30 to 44 years, area central tendency for northern jiangsu, and seasonal central tendency of occupational pesticide poisoning in autumn. Pesticide poisoning remains a major health concern in China. Government agencies together with scientists should focus their efforts on the prevention of potential threats to vulnerable groups such as the elderly, women, and children.

关键词： from 2006 to 2015 Acute Pesticide Poisoning in jiangsu province China

Non-sticky and Non-slippery Biomimetic Patterned Surfaces

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Journal of Bionic Engineering 2020年第2期17卷 326-334页

作者： Qingwen Dai Qi Chang Meng Li Wei Huang Xiaolei Wang National Key Laboratory of Science and Technology on Helicopter Transmission Nanjing University of Aeronautics and AstronauticsNanjing 210016China

In modern mechanical design,non-sticky and non-slippery surfaces are highly preferred in many *** this work,bio-inspired micro patterns of hexagonal pillar and round dimple with various geometric parameters are fabricated,and the static friction and adhesion performances of the prepared surfaces are *** is found that hexagonal pillar patterns can enhance the static friction and weaken the adhesion performances either at dry or wet *** effects of round dimple patterns on the tribological performances depend on the wetting condition,the load,and the area *** function mechanism of the designed surfaces is revealed,and a general design principle of the biomimetic patterned surface is proposed.

关键词： biomimetic static friction adhesion hexagonal pillar round dimple

Reducing dielectric confinement effect in ionic covalent organic nanosheets to promote the visible-light-driven hydrogen evolution

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Journal of Energy Chemistry 2023年第7期82卷 40-46,I0002页

作者： Guoqing Li Xiaolong Zhao Qihong Yue Ping Fu Fangpei Ma Jun Wang Yu Zhou State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical EngineeringNanjing Tech UniversityNanjing 211816JiangsuChina

Ultra-thin two-dimensional(2D)organic semiconductors are promising candidates for photocatalysts because of the short charge diffusion pathway and favorable exposure of active sites plus the versatile ***,the inherent dielectric confinement of 2D materials will induce a strong exciton effect hampering the charge ***,we demonstrated an effective way to reduce the dielectric confinement effect of 2D ionic covalent organic nanosheets(iCONs)by tailoring the functional group via molecular *** ultra-thin CONs with different functional groups and the same ionic moieties were synthesized through Schiff base condensation between ionic amino monomer triaminoguanidinium chloride(TG)and aldehyde *** integration of the hydroxyl group was found to significantly increase the dielectric constant by enhancing the polarizability of ionic moieties,and thus reduced the dielectric confinement and the corresponding exciton binding energy(E_(b)).The champion hydroxyl-functional iCON exhibited promoted exciton dissociation and in turn a high photocatalytic hydrogen production rate under visible-light *** work provided insights into the rationalization of the dielectric confinement effect of low-dimensional photocatalysts.

关键词： Photocatalysis H_(2)evolution Ionic covalent organic framework Nanosheets 2D material Polarization

Design and verification of a broadband highly-efficient plasmonic circulator

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Chinese Physics B 2021年第3期30卷 248-252页

作者： Jianfei Han Shu Zhen Weihua Wang Kui Han Haipeng Li Lei Zhao Xiaopeng Shen School of Materials Science and Physics China University of Mining and TechnologyXuzhou 221116China School of Information and Control Engineering China University of Mining and TechnologyXuzhou 221116China

Circulators play a significant role in radar and microwave communication *** paper proposes a broadband and highly efficient plasmonic circulator,which consists of spoof surface plasmon polaritons(SSPPs)waveguides and ferrite disks to support non-reciprocal mode *** simulated performance of symmetrically designed circulator shows that it has an insertion loss of roughly 0.5 dB while the isolation and return loss is more than 12 dB in the frequency range of 6.0 GHz–10.0 GHz(relative bandwidth of 50%).Equivalent circuit model has been proposed to explain the operating mechanism of the plasmonic *** equivalent circuit model,numerical simulations,and experimental results are consistent with each other,which demonstrates the good performance of the proposed plasmonic circulator.

关键词： plasmonic circulator spoof surface plasmon polaritons ferrite

Enhanced plasmonic absorption of Pt cuboctahedra-WO_(3)nanohybrids used as visible light photocatalysts for overall water splitting

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Nano Research 2023年第4期16卷 5919-5928页

作者： Qiaoling Chen Yiwei Tan State Key Laboratory of Materials-Oriented Chemical Engineering School of Chemistry and Chemical EngineeringNanjing Tech UniversityNanjing 211816China

Localized surface plasmon resonance(LSPR)effects of nanoscale plasmonic metals/semiconductor composites have been extensively applied into visible light ***,Pt nanoparticles(NPs)with the visible LSPR absorption maxima have rarely been used as a photosensitizer to facilitate photocatalytic reactions,especially the photocatalytic overall water splitting(POWS)reaction,presumably because they feature weak light ***,we present that the increased plasmonic absorption and local field enhancement can be achieved in the wide visible range by exploiting the simulated and experimental expressions of Pt nanocuboctahedra and Pt cuboctahedra-WO_(3)nanohybrids(Pt-WO3).First,monodisperse Pt cuboctahedra with different sizes,a hierarchical WO_(3)nanoarchitecture composed of radially patterned WO_(3)nanopillars,and Pt-WO_(3)were systematically ***,visible plasmonic Pt-WO_(3)photocatalysts were employed in the POWS tests and exhibited the significant activity enhancement in the visible light *** apparent quantum efficiency(AQE)of greater than 7%within the range of visible light has been achieved for the optimal Pt-WO3.

关键词： localized surface plasmon resonance plasmonic photocatalysis overall water splitting plasmonic Pt nanoparticles WO_(3)