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Bacterial and cancerous cell membrane fused liposome coordinates with PD-L1 inhibitor for cancer immunotherapy

Nano Research 2024年第9期17卷 8389-8401页

作者： Xianjin Luo Chenglong Li Zhaofei Guo Hairui Wang Penghui He Yuanhao Zhao Yi Lin Chunting He Yingying Hou Yongshun Zhang Guangsheng Du Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and sichuan Province Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial TechnologyWest China School of PharmacySichuan UniversityChengdu 610064China Pharmaceutical Biotechnology Department of PharmacyLMU MunichButenandt Strasse 5-13Munich 81377Germany Department of Biomedical Engineering College of Future TechnologyPeking UniversityBeijing 100871China

Although tumor cell membranes with broad-spectrum antigens have been explored for cancer vaccines for decades,their relatively poor capacity to stimulate immune responses,especially cellular immune responses,has limited their ***,we presented a novel bacterial and cancerous cell membrane fusogenic liposome for co-delivering cell membrane-derived antigens and ***,a programmed death-ligand 1(PD-L1)inhibitor,JQ-1,was incorporated into the formulation to tackle the up-regulated PD-L1 expression of antigen-presenting cells(APCs)upon vaccination,thereby augmenting its anti-tumor *** fusogenic liposomes demonstrated significantly improved cellular uptake by APCs and effectively suppressed PD-L1 expression in bone marrow-derived dendritic cells(BMDCs)in *** subcutaneous vaccination,the nano-vaccines efficiently drained to the tumor-draining lymph nodes(TDLNs),and significantly inhibited PD-L1 expression of both dendritic cells(DCs)and macrophages within the TDLNs and *** a result,the liposomal vaccine induced robust innate and cellular immune responses and inhibited tumor growth in a colorectal carcinoma-burden mouse *** summary,the fabricated cell membrane-based fusogenic liposomes offer a safe,effective,and easily applicable strategy for tumor immunotherapy and hold potential for personalized cancer immunotherapy.

关键词： fusogenic liposome tumor cell membrane adjuvant programmed death-ligand 1(PD-L1)inhibitor tumor draining lymph nodes

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Selenomethionine alleviates chronic heat stress-induced breast muscle injury and poor meat quality in broilers via relieving mitochondrial dysfunction and endoplasmic reticulum stress

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Animal Nutrition 2024年第1期16卷 363-375页

作者： Jinzhong Jing Jiayi Wang Xiaoyu Xiang Shenggang Yin Jiayong Tang Longqiong Wang Gang Jia Guangmang Liu Xiaoling Chen Gang Tian Jingyi Cai Bo Kang Lianqiang Che Hua Zhao Key Laboratory for Animal Disease-Resistance Nutrition of Ministry of Education of China Ministry of Agriculture and Rural Affairsof Sichuan ProvinceAnimal Nutrition InstituteSichuan Agricultural University College of Animal Science and Technology Sichuan Agricultural University

In the present study,the chronic heat stress （CHS） broiler model was developed to investigate the potential protection mechanism of organic selenium （selenomethionine,SeMet） on CHS-induced skeletal muscle growth retardation and poor meat *** hundred Arbor Acres male broilers （680±70 g,21 d old） were grouped into 5 treatments with 8 replicates of 10 broilers per *** in the control group were raised in a thermoneutral environment （22±2°C） and fed with a basal *** other four treatments were exposed to hyperthermic conditions （33±2°C,24 h in each day） and fed on the basal diet supplied with SeMet at 0.0,0.2,0.4,and 0.6 mg Se/kg,respectively,for 21 *** showed that CHS reduced （P<0.05） the growth performance,decreased （P<0.05） the breast muscle weight and impaired the meat quality of breast muscle in *** induced protein metabolic disorder in breast muscle,which increased （P<0.05） the expression of caspase 3,caspase 8,caspase 9 and ubiquitin proteasome system related genes,while decreased the protein expression of *** also decreased the antioxidant capacity and induced mitochondrial stress and endoplasmic reticulum （ER） stress in breast muscle,which increased （P<0.05） the ROS levels,decreased the concentration of ATP,increased the protein expression of HSP60 and CLPX,and increased （P<0.05） the expression of ER stress *** SeMet supplementation linearly increased （P<0.05） breast muscle Se concentration and exhibited protective effects via up-regulating the expression of the selenotranscriptome and several key selenoproteins,which increased （P<0.05） body weight,improved meat quality,enhanced antioxidant capacity and mitigated mitochondrial stress and ER ***'s more,SeMet suppressed protein degradation and improved protein biosynthesis though inhibiting the caspase and ubiquitin proteasome system and promoting the mTOR-4EBP1 *** conclusion,dietary SeMet supplementation increases the expression of

关键词： Broiler Chronic heat stress Skeletal muscle Meat quality Mitochondrial dysfunction Endoplasmic reticulum stress

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qGW11a/OsCAT8,encoding an amino acid permease,negatively regulates grain size and weight in rice

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The Crop Journal 2024年第4期12卷 1150-1158页

作者： Peng Gao Feifan Chen Haitang Liu Shijun Fan Jierui Zeng Xue Diao Yang Liu Wencheng Song Shifu Wang Jing Li Xiaobo Zhu Bin Tu Weilan Chen Ting Li Yuping Wang Bingtian Ma Shigui Li Hua Yuan Peng Qin State Key Laboratory of Crop Gene Exploration and Utilization in Southwest china Rice Research InstituteSichuan Agricultural UniversityChengdu 611130SichuanChina

Grain size is a key factor influencing grain weight in *** this study,a chromosome segment substitution line(CSSL9-17)was identified,that exhibits a significant reduction in both grain size and weight compared to its donor parent *** investigation identified two quantitative trait loci(QTL)on chromosome 11,designated qGW11a and qGW11b,which contribute to 1000-grain weight with an additive ***_Os11g05690,encoding the amino acid permease OsCAT8,is the target gene of *** of OsCAT8 resulted in decreased grain weight,while OsCAT8 knockout mutants exhibited increased grain *** 287-bp located within the OsCAT8 promoter region of 93-11 negatively regulates its activity,which is subsequently correlated with an increase in grain size and *** results suggest that OsCAT8 functions as a negative regulator of grain size and grain weight in rice.

关键词： Rice Grain size Grain weight QTL OsCAT8

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Sucrose-associated SnRK1a1-mediated phosphorylation of Opaque2 modulates endosperm filling in maize

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Molecular Plant 2024年第5期17卷 788-806页

作者： Tao Yang Yunqin Huang Longyu Liao Shanshan Wang Haoyu Zhang Jingying Pan Yongcai Huang Xiaoling Li Di Chen Tao Liu Xiaoduo Lu Yongrui Wu State Key Laboratory of Crop Gene Exploration and Utilization in Southwest china Sichuan Agricultural UniversityChengdu 611130SichuanChina National Key Laboratory of Plant Molecular Genetics CAS Center for Excellence in Molecular Plant SciencesShanghai lnstitute of Plant Physiology and EcologyChinese Academy of SciencesShanghai 200032China Institute of Molecular Breeding for Maize Qilu Normal UniversityJinanChina

During maize endosperm filling,sucrose not only serves as a source of carbon skeletons for storage-reserve synthesis but also acts as a stimulus to promote this ***,the molecular mechanisms underlying sucrose and endosperm filling are poorly *** this study,we found that sucrose promotes the expression of endosperm-filling hub gene Opaque2(O2),coordinating with storage-reserve *** showed that the protein kinase SnRK1a1 can attenuate O2-mediated transactivation,but sucrose can release this *** assays revealed that SnRK1a1 phosphorylates O2 at serine 41(S41),negatively affecting its protein stability and transactivation *** observed that mutation of SnRK1a1 results in larger seeds with increased kernel weight and storage reserves,while overexpression of SnRK1a1 causes the opposite *** of the native O2(O2-OE),phospho-dead(O2-SA),and phospho-mimetic(O2-SD)variants all increased 100-kernel *** O2-SA seeds exhibit smaller kernel size,they have higher accumulation of starch and proteins,resulting in larger vitreous endosperm and increased test weight.O2-SD seeds display larger kernel size but unchanged levels of storage reserves and test weight.O2-OE seeds show elevated kernel dimensions and nutrient storage,like a mixture of O2-SA and O2-SD ***,our study discovers a novel regulatory mechanism of maize endosperm *** of S41 as a SnRK1-mediated phosphorylation site in O2 offers a potential engineering target for enhancing storage-reserve accumulation and yield in maize.

关键词： maize Opaque2 SnRK1 endosperm phosphorylation sucrose

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Advanced strategies for 3D-printed neural scaffolds:materials,structure,and nerve remodeling

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Bio-Design and Manufacturing 2024年第5期7卷 747-770页

作者： Jian He Liang Qiao Jiuhong Li Junlin Lu Zhouping Fu Jiafang Chen Xiangchun Zhang Xulin Hu College of Basic Medicine and Forensic Medicine Henan University of Science and TechnologyLuoyang 471023China The First Affiliated Hospital College of Clinical Medicine of Henan University of Science and TechnologyLuoyang 471003China Tea Research Institute Chinese Academy of Agricultural SciencesHangzhou 310008China Clinical Medical College Affiliated Hospital of Chengdu UniversityChengdu UniversityChengdu 610081China Department of Cardiovascular Surgery Department of BiotherapyCancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China Department of Neurosurgery West China HospitalSichuan UniversityChengdu 610041China

Nerve regeneration holds significant potential in the treatment of various skeletal and neurological disorders to restore lost sensory and motor *** potential of nerve regeneration in ameliorating neurological diseases and injuries is critical to human ***-dimensional(3D)printing offers versatility and precision in the fabrication of neural *** neural structures such as neural tubes and scaffolds can be fabricated via *** reviewcomprehensively analyzes the current state of 3D-printed neural scaffolds and explores strategies to enhance their *** highlights therapeutic strategies and structural design involving neural materials and stem ***,nerve regeneration materials and their fabrication techniques are *** applications of conductive materials in neural scaffolds are reviewed,and their potential to facilitate neural signal transmission and regeneration is ***,the progress in 3D-printed neural scaffolds applied to the peripheral and central nerves is comprehensively evaluated,and their potential to restore neural function and promote the recovery of different nervous systems is *** addition,various applications of 3D-printed neural scaffolds in peripheral and neurological diseases,as well as the design strategies of multifunctional biomimetic scaffolds,are discussed.

关键词： Nerve regeneration 3D printing based neural scaffolds Biomaterials Nervous system Design strategies

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Effects of raw material extrusion and steam conditioning on feed pellet quality and nutrient digestibility of growing meat rabbits

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Animal Nutrition 2017年第2期3卷 151-155页

作者： Kuoyao Liao Jingyi Cai Zhujun Shi Gang Tian Dong Yan Delin Chen Institute of Animal Nutrition Sichuan Agricultural University

This study was conducted to investigate the effects of raw material extrusion and steam conditioning on feed pellet quality and nutrient digestibility of growing meat rabbits, in order to determine appropriate rabbit feed processing methods and processing parameters. In Exp. 1, an orthogonal design was *** temperature, material moisture content and feed rate were selected as test factors, and acid detergent fiber(ADF) content was selected as an evaluation index to research the optimum extrusion parameters. In Exp. 2. a two-factor design was adopted. Four kinds of rabbit feeds were processed and raw material extrusion adopted optimum extrusion parameters of Exp. 1. A total of 40 healthy and 42-day-old rabbits with similar weight were used in a randomized design, which consisted of 4 groups and 10 replicates in each group(1 rabbits in each replicate). The adaptation period lasted for 7 d, and the digestion trial lasted for 4 d. The results showed as follows: 1) ADF was significantly affected by barrel temperature(P < 0.05); the optimum extrusion parameters were barrel temperature 125℃, moisture content 16% and feed rate 9 Hz. 2) Raw material extrusion and steam conditioning both significantly decreased powder percentage, pulverization ratio and protein solubility(P < 0.05), significantly improved hardness and starch gelatinization degree of rabbit feed(P < 0.05). They both had significant interaction effects on the processing quality of rabbit feed(P < 0.05). 3) Extrusion significantly improved the apparent digestibility of dry matter and total energy(P < 0.05). Extrusion and steam conditioning both significantly improved the apparent digestibility of crude fiber(CF), ADF and NDF(P < 0.05), but they had no interaction effects on the apparent digestibility of rabbit feed. Thus, using extrusion and steam conditioning technology at the same time in the weaning rabbits feed processing can improve the pellet quality and nutrient apparent digestibility of rabbit

关键词： Extrusion Rabbit feed Process parameters Pellet quality Apparent digestibility

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Haplotype-based phylogenetic analysis and population genomics uncover the origin and domestication of sweetpotato

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Molecular Plant 2024年第2期17卷 277-296页

作者： Mengxiao Yan Ming Li Yunze Wang Xinyi Wang M-Hossein Moeinzadeh Dora G.Quispe-Huamanquispe Weijuan Fan Yijie Fang Yuqin Wang Haozhen Nie Zhangying Wang Aiko Tanaka Bettina Heider Jan F.Kreuze Godelieve Gheysen Hongxia Wang Martin Vingron Ralph Bock Jun Yang Shanghai Key Laboratory of Plant Functional Genomics and Resources Shanghai Chenshan Botanical GardenShanghai 201602China College of Life Sciences Chongqing Normal UniversityChongqing 401331China Biotechnology and Nuclear Technology Research Institute Sichuan Academy of Agricultural SciencesChengdu 610061China College of Life Sciences Shanghai Normal UniversityShanghai 200234China Department of Computational Molecular Biology Max Planck Institute for Molecular GeneticsIhnestraBe 63-7314195 BerlinGermany Department of Biotechnology Ghent University9000 GhentBelgium Guangdong Provincial Key Laboratory of Crops Genetics and Improvement Crop Research InstituteGuangdong Academy of Agricultural SciencesGuangzhou 510640China Graduate School of Bioagricultural Sciences Nagoya UniversityChikusaNagoya 464-8601Japan international Potato Center(CIP) LimaPeru CAS Center for Excellence of Molecular Plant Sciences Institute of Plant Physiology and EcologyChinese Academy of SciencesShanghai 200233China Max-Planck-Institut fur Molekulare Pflanzenphysiologie Am Muhlenberg 114476 Potsdam-GolmGermany

The hexaploid sweetpotato(lpomoea batatas)is one of the most important root crops ***,its genetic origin remains controversial,and its domestication history remains *** this study,we used a range of genetic evidence and a newly developed haplotype-based phylogenetic analysis to identify two probable progenitors of *** diploid progenitor was likely closely related to lpomoea ae-quatoriensis and contributed the B,subgenome,IbT-DNA2,and the lineage 1 type of chloroplast genome to *** tetraploid progenitor of sweetpotato was most likely *** 4x,which donated the B2 subgenome,IbT-DNA1,and the lineage 2 type of chloroplast *** most likely originated from reciprocal crosses between the diploid and tetraploid progenitors,followed by a subsequent whole-genome *** addition,we detected biased gene exchanges between the subgenomes;the rate of B,to B2 subgenome conversions was nearly three times higher than that of B2 to B subgenome *** analyses revealed that genes involved in storage root formation,maintenance of genome stabil-ity,biotic resistance,sugar transport,and potassium uptake were selected during the speciation and domestication of *** study sheds light on the evolution of sweetpotato and paves the way forimprovementofthiscrop.

关键词： sweetpotato origin gene conversion domestication IbT-DNA HPA

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Effects of a multi-enzyme complex on growth performance,nutrient utilization and bone mineralization of meat duck

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Journal of Animal Science and Biotechnology 2015年第4期6卷 402-409页

作者： Qiufeng Zeng Xueqin Huang Yuheng Luo Xuemei Ding Shiping Bai Jianping Wang Yue Xuan Zhuowei Su Yonggang Liu Keying Zhang Institute of Animal Nutrition Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of EducationSichuan Agricultural University Adisseo Asia Pacific Pte Ltd

Background： Previous studies with broiler have shown dietary supplementation with multi-enzyme complex containing non-starch polysaccharides （NSP） degrading enzymes and phytase is efficient in releasing phosphorus （P）, calcium （Ca）, energy and amino acids from corn-soybean meal diets or corn-sorghum diets, hence compensating considerable levels of nutrients in formulation. Notwithstanding, such potentials have not been well defined in duck nutrition. Giving china being the largest duck producing country, we conducted this study to establish adequate specifications of major nutrients along with multi-enzyme complex to meat duck from day-old to slaughter, focusing on performance, utilization of nutrients and bone mineralization. Five dietary treatments were： Positive control （PC,T1）： the nutrients concentration of diet for 1 to 14 d of age were apparent metabolizable energy（AME） 2,800 kcal/kg, crude protein （CP）1 9.39%, Ca 0.85%, available phosphorus （avP） 0.42%; for 15 to 35 d of age these parameters were AME 2,900 kcal/kg, CP 16.47%,Ca 0.76%,avP 0.38%; Negative control 1（NC1,7-2）, the AME and digestible amino acids （DAA） were reduced by 70 kcal/kg and 2.0%, avP and Ca by 1.0 g/kg from PC diet; Negative control 2（NC2,T4）, the down- spec from PC diet was AME 100 kcal/kg, DAA 2.5%, avP 1.5 g/kg and Ca 1.2 g/kg; The enzyme complex was added at the same dosage （200 mL/1,000 kg） on NC1 （T3） and NC2 （T5） diets. Results： Comparing with the ducks fed on T1, T3 and T5 diets, the birds fed on NC2 diet showed the lowest （P 〈 0.05） body weight （ d 14 and 35）, feed intake （d 35）, tibia ash, Ca and P contents （d 14 and 35）, and the utilization of nutrients （P 〈 0.05）. The supplementation with the enzyme complex to the NC diets restored growth rate, utilization of nutrients and bone mineralization to the level of the PC diet, and increased AME by 60 kcal/kg and 117 kcal/kg, respectively for the NC1 and NC2 diets. Conclusion： These results suggest that down-spec AME by 100 kcal/kg,

关键词： Formulation specification Growth Phytase Meat duck Non-starch polysaccharides enzyme

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Antibacterial Activities and Nuclease Properties of Two New Ternary Copper（ll） Complexes with 2-（4＇-Thiazolyl）- benzimidazole and 2,2＇-Bipyridine/1,10-phenanthroline

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Chinese Journal of Chemistry 2011年第7期29卷 1380-1388页

作者：任祥祥陈佳阳乐学义 Department of Applied Chemistry South China Agricultural University Guangzhou Guangdong 510642 China Guangzhou GRG Metrology and Test Technology Co. LTD. Guangzhou Guangdong 510656 China Institute of Biomaterial South China Agricultural University Guangzhou Guangdong 510642 China

Two new complexes： [Cu（TBZ）（bipy）Cl]Cl[H2O （1） and [Cu（TBZ）（phen）CI]CloH20 （2） [TBZ=2-（4＇-thiazolyl）- benzimidazole, phen = 1,10-phenanthroline and bipy =2,2＇-bipyridine] have been synthesized and characterized by elemental analysis, molar conductivity, IR, and UV-vis methods. Complex 2, structurally characterized by single-crystal X-ray crystallography, crystallizes in the monoclinic space group P21/c in a unit cell of a = 0.85257（12） nm, b=2.5358（4） nm, c=1.15151（13） nm, β=118.721（8）°, V=2.183.2（5） nm^3, Z=4, Dc=1.624 gocm 3, μ= 1.367 mm^-1. The complexes, free ligands and chloride copper（II） salt were each tested for their ability to inhibit the growth of two gram-positive （B. subtilis and S. aureus） and two gram-negative （Salmonella and E. coli） bacteria. The complexes showed good antibacterial activities against the microorganisms. The interaction between the com- plexes and calf thymus DNA in aqueous solution was investigated adopting electronic absorption spectroscopy, fluorescence spectroscopy, viscosity measurements and cyclic voltammetry. Results suggest that the two complexes can bind to DNA by intercalative mode. In addition, the result of agarose gel electrophoresis suggested that the complexes can cleave the plasmid DNA at physiological pH and room temperature. Mechanistic studies with different inhibiting reagents reveal that hydroxyl radicals, and a singlet oxygen-like copper-oxo species are all involved in the DNA scission process mediated by the complexes.

关键词： ternary copper(ll) complexes copper 2-(4'-thiazolyl)benzimidazole DNA DNA cleavage antibacterial activity

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Dietary resistant starch ameliorating lipopolysaccharide-induced inflammation in meat ducks associated with the alteration in gut microbiome and glucagon-like peptide 1 signaling

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Journal of Animal Science and Biotechnology 2022年第6期13卷 1945-1958页

作者： Simeng Qin Weiqiang Bai Todd JApplegate Keying Zhang Gang Tian Xuemei Ding Shiping Bai Jianping Wang Li Lv Huanwei Peng Yue Xuan Qiufeng Zeng Institute of Animal Nutrition Key Laboratory for Animal Disease-Resistance Nutrition of ChinaMinistry of EducationSichuan Agricultural UniversityChengdu 611130China Department of Poultry Science University of Georgia110 Cedar StAthensGA 30602USA

Background:Consumption of resistant starch(RS)has been associated with various intestinal and systemic health benefits,but knowledge of its effects on intestinal health and inflammatory response in stressed birds is ***,we examined how dietary RS supplementation from 12%raw potato starch(RPS)modulated inflammatory severity induced by lipopolysaccharide(LPS)in meat ***:LPS administration at 14,16,and 18 d(chronic challenge)decreased body weight(BW)and glucagon-like peptide 1 receptor(GLP-1R)level with higher intestinal permeability and inflammation,evident by higher proinflammatory cytokine *** 12%RPS supplementation enhanced Claudin-1 and GLP-1R expression,along with lower levels of inflammatory factors in both ileum and *** analysis showed that RS treatment shifted microbial structure reflected by enriched the proportion of Firmicutes,Bifidobacterium,Ruminococcus,*** RS addition also significantly increased the concentrations of propionate and butyrate during chronic LPS ***,response to acute challenge,the ducks received 2 mg/kg BW LPS at 14 d had higher concentrations of serum endotoxins and inflammatory cytokines,as well as upregulated transcription of toll like receptor 4(TLR4)in ileum when compared to control *** to GLP-1 agonist liraglutide,dietary RS addition decreased endotoxins and inflammation cytokines,whereas it upregulated the GLP-1 synthesis related genes ***,dietary RS supplementation suppressed the acute LPS challenge-induced TLR4 ***:These data suggest that dietary 12%RPS supplementation could attenuate the LPS-induced inflammation as well as intestinal injury of meat ducks,which might involve in the alteration in gut microbiota,SCFAs production and the signaling pathways of TLR4 and GLP-1/GLP-1R.

关键词： GLP-1 Inflammatory response Intestinal integrity Microbiota Resistant starch

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