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The interaction between KIF21A and KANK1 regulates dendritic morphology and synapse plasticity in neurons

Neural Regeneration research 2025年第1期20卷 209-223页

作者： Shi-Yan Sun Lingyun Nie Jing Zhang Xue Fang Hongmei Luo Chuanhai Fu Zhiyi Wei Ai-Hui Tang Hefei National research Center for Physical Sciences at the Microscale CAS Key Laboratory of Brain Function and DiseaseMinistry of Education Key Laboratory for Membrane-less Organelles and Cellular DynamicsDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina CAS Center for Excellence in Molecular Cell Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Neurobiology School of Life SciencesSouthern University of Science and TechnologyShenzhenGuangdong ProvinceChina Brain research Center Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina

Morphological alterations in dendritic spines have been linked to changes in functional communication between neurons that affect learning and ***-4 KIF21A helps organize the microtubule-actin network at the cell cortex by interacting with KANK1;however,whether KIF21A modulates dendritic structure and function in neurons remains *** this study,we found that KIF21A was distributed in a subset of dendritic spines,and that these KIF21A-positive spines were larger and more structurally plastic than KIF21A-negative ***,the interaction between KIF21A and KANK1 was found to be critical for dendritic spine morphogenesis and synaptic *** of either KIF21A or KANK1 inhibited dendritic spine morphogenesis and dendritic branching,and these deficits were fully rescued by coexpressing full-length KIF21A or KANK1,but not by proteins with mutations disrupting direct binding between KIF21A and KANK1 or binding between KANK1 and *** down KIF21A in the hippocampus of rats inhibited the amplitudes of long-term potentiation induced by high-frequency stimulation and negatively impacted the animals’cognitive *** together,our findings demonstrate the function of KIF21A in modulating spine morphology and provide insight into its role in synaptic function.

关键词： actin cytoskeleton dendrite KANK1 KIF21A microtubule spine morphology spine synaptic plasticity talin1

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Spin reorientation in easy-plane kagome ferromagnet Li_9Cr_3(P_2O_7)_3(PO_4)_2

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Chinese Physics B 2023年第5期32卷 153-157页

作者：董元浩付盈刘以轩郝占阳王乐刘才邓可梅佳伟 shenzhen Institute for Quantum Science and Engineering and Department of PhysicsSouthern University of Science and TechnologyShenzhen 518055China School of Physics Xi’an Jiaotong UniversityXi’an 710049China Department of Physics Southern University of Science and TechnologyShenzhen 518055China shenzhen Key Laboratory of Advanced Quantum Functional Materials and Devices Southern University of Science and TechnologyShenzhen 518055China

We report the successful growth and characterization of Li_9Cr_3(P_2O_7)_3(PO_4)_2single crystal,and investigate its magnetic properties under external magnetic fields via magnetization and heat capacity *** study reveals that Li_9Cr_3(P_2O_7)_3(PO_4)_2 is an easy-plane kagome ferromagnet with S=3/2,as evidenced by the Curie–Weiss temperature of 6 K which implies a ferromagnetic exchange coupling in the *** zero magnetic field,Li_9Cr_3(P_2O_7)_3(PO_4)_2 undergoes a magnetic transition at TC=2.7 K from a paramagnetic state to a ferromagnetically ordered state with the magnetic moment lying in the kagome *** applying a c-axis directional magnetic field to rotate the spin alignment from the kagome plane to the c-axis,we observe a reduction in the magnetic transition temperature as the field is *** construct a magnetic phase diagram as a function of temperature and magnetic field applied parallel to the c-axis of Li_9Cr_3(P_2O_7)_3(PO_4)_2 and find that the phase boundary is linear over a certain temperature *** that theoretically,the field-induced phase transition of the spin reorientation in the easy-plane ferromagnet can be viewed as the ferromagnetic magnon Bose–Einstein condensation(BEC),the phase boundary scaling of field-induced(B c)magnetic transition in Li_9Cr_3(P_2O_7)_3(PO_4)_2 can be described as the quasi-2D magnon BEC,which has been observed in other ferromagnetic materials such as K_2CuF_4.

关键词： kagome lattice flux method magnetic material spin-3/2

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Optical engineering of infrared PbS CQD photovoltaic cells for wireless optical power transfer systems

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Frontiers of Optoelectronics 2023年第2期16卷 103-113页

作者： Mengqiong Zhu Yuanbo Zhang Shuaicheng Lu Zijun Wang Junbing Zhou Wenkai Ma Ruinan Zhu Guanyuan Chen Jianbing Zhang Liang Gao Jiancan Yu Pingqi Gao Jiang Tang School of Materials Shenzhen Campus of Sun Yat-Sen UniversityShenzhen 518107China Wuhan National Laboratory for Optoelectronics(WNLO)and School of Optical and Electronic Information Huazhong University of Science and Technology(HUST)Wuhan 430074China

Infrared photovoltaic cells(IRPCs)have attracted considerable attention for potential applications in wireless optical power transfer(WOPT)*** an efcient fber-integrated WOPT system typically uses a 1550 nm laser beam,it is essential to tune the peak conversion efciency of IRPCs to this ***,IRPCs based on lead sulfde(PbS)colloidal quantum dots(CQDs)with an excitonic peak of 1550 nm exhibit low short circuit current(Jsc)due to insufcient absorption under monochromatic light ***,we propose comprehensive optical engineering to optimize the device structure of IRPCs based on PbS CQDs,for 1550 nm WOPT *** absorption by the device is enhanced by improving the transmittance of tin-doped indium oxide(ITO)in the infrared region and by utilizing the optical resonance efect in the ***,the optimized device exhibited a high short circuit current density of 37.65 mA/cm^(2)under 1 sun(AM 1.5G)solar illumination and 11.91 mA/cm^(2)under 1550 nm illumination 17.3 mW/cm^(2).Furthermore,the champion device achieved a record high power conversion efciency(PCE)of 7.17%under 1 sun illumination and 10.29%under 1550 nm *** PbS CQDs IRPCs under 1550 nm illumination can even light up a liquid crystal display(LCD),demonstrating application prospects in the future.

关键词： Wireless optical power transfer PbS CQDs Photovoltaic cells Optical engineering

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Understanding the cooperative effects in the catalysis of homodimeric fluoroacetate dehalogenase

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Science China Chemistry 2024年第7期67卷 2382-2391页

作者： Ke-Wei Chen Jia-Nan Chen Jun Zhang Chao Wang Tian-Yu Sun Yun-Dong Wu Key Laboratory of Computational Chemistry and Drug Design State Key Laboratory of Chemical OncogenomicSchool of Chemical Biology and BiotechnologyPeking University Shenzhen Graduate SchoolShenzhen 518055China Institute of Chemical Biology Shenzhen Bay LaboratoryShenzhen 518132China College of Chemistry and Molecular Engineering Peking UniversityBeijing 100871China Changping Laboratory Beijing 102200China

Fluoroacetate dehalogenases(FAcD),a homodimeric enzyme,catalyzes the conversion of fluoroacetic acid to glycolic acid(GoA).It has been proved that the enzyme has a half-of-the-site ***,its catalytic(C)subunit converts the first substrate to a covalent intermediate;then,the non-catalytic(NC)subunit binds a second substrate and promotes the conversion of the intermediate in the C subunit into the final *** the release of the product,the C subunit becomes the NC subunit,and the previous NC subunit becomes the C *** elucidate the detailed mechanism behind this cooperative catalysis,we have conducted microsecond-scale MD simulations along the reaction *** simulations indicate that the substrate in the NC subunit induces W185 and Y141 adopting an open conformation in the C *** opening of W185(C)facilitates the entry of catalytic water,enhancing the catalytic activity for product formation,while the opening of Y141(C)creates an unfavorable environment for product binding,promoting its *** interaction network analysis reveals that the substrate in the NC subunit can induce conformational changes through a conserved water chain at the interface.

关键词： enzyme catalysis molecular dynamics cooperative effect pre-reaction state

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Indications of pro-inflammatory cytokines in laparoscopic and open liver resection for early-stage hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2024年第3期23卷 257-264页

作者： Kevin Tak-Pan Ng Li Pang Jia-Qi Wang Wong Hoi She Simon Hing-Yin Tsang Chung Mau Lo Kwan Man Tan To Cheung Department of Surgery HKU-SZH&School of Clinical MedicineLi Ka Shing Faculty of MedicineThe University of Hong KongHong KongChina State Key Laboratory of Liver research The University of Hong KongHong KongChina

Background:Our clinical practice of laparoscopic liver resection(LLR)had achieved better short-term and long-term benefits for patients with hepatocellular carcinoma(HCC)over open liver resection(OLR),but the underlying mechanisms are not *** study was to find out whether systemic inflammation plays an important ***:A total of 103 patients with early-stage HCC under liver resection were enrolled(LLR group,n=53;OLR group,n=50).The expression of 9 inflammatory cytokines in patients at preoperation,postoperative day 1(POD1)and POD7 was quantified by Luminex Multiplex *** relationships of the cytokines and the postoperative outcomes were compared between LLR and ***:Seven of the circulating cytokines were found to be significantly upregulated on POD1 after LLR or OLR compared to their preoperative *** to OLR,the POD1 levels of granulocytemacrophage colony-stimulating factor(GM-CSF),interleukin-6(IL-6),IL-8,and monocyte chemoattractant protein-1(MCP-1)in the LLR group were significantly *** POD1 levels of these cytokines were significantly correlated with longer operative time and higher volume of blood loss during *** levels of these cytokines were positively associated with postoperative liver injury,and the length of hospital ***,a high level of IL-6 at POD1 was a risk factor for HCC recurrence and poor disease-free survival after liver ***:Significantly lower level of GM-CSF,IL-6,IL-8,and MCP-1 after liver resection represented a milder systemic inflammation which might be an important mechanism to offer better short-term and long-term outcomes in LLR over OLR.

关键词： Laparoscopic liver resection Open liver resection Hepatocellular carcinoma Postoperative cytokines Inflammatory responses

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Dichloromethane-Induced Poisoning from Acrylic Paint Cleaner-shenzhen City,Guangdong Province,China,2023

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China CDC weekly 2023年第43期5卷 966-969,I0004页

作者： Xiaojun Zheng Yuan Zhuang Dongmei Liang Nan Wu Tao Wei Anhua Kang Xiandong Zeng Chuanwen Dai Xiang Guo shenzhen Field Epidemiology Training program(SZFETP) Shenzhen CityGuangdong ProvinceChina shenzhen Futian District Center for Disease Control and Prevention Shenzhen CityGuangdong ProvinceChina shenzhen Baoan District Center for Public Health Service Shenzhen CityGuangdong ProvinceChina shenzhen Nanshan District Center for Disease Control and Prevention Shenzhen CityGuangdong ProvinceChina shenzhen Prevention and Treatment Center for Occupational Diseases Shenzhen CityGuangdong ProvinceChina

Summary What is already known about this topic?Dichloromethane(DCM)is a colorless and transparent organic solvent that commonly causes poisoning during occupational *** is added by this report?Unknown to teachers and students,they were utilizing an acrylic paint cleaner that contained *** the time of the poisoning incident,the art room was occupied beyond its capacity with inadequate local *** primary cause of the incident was determined to be the students’inhalation of DCM during the cleaning *** are the implications for public health practice?The unclear composition of environmental cleaning products available for purchase online presents a major obstacle for consumers trying to assess their *** is imperative that robust regulatory measures and proactive public education campaigns are implemented to mitigate instances of poisoning.

关键词： methane Clean Paint

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A novel fractal-statistical scaling model of rocks considering strain rate

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Journal of Rock Mechanics and Geotechnical Engineering 2023年第11期15卷 2831-2841页

作者： Changtai Zhou Heping Xie Zhihe Wang Tao Zhou Jianbo Zhu Guangdong Provincial Key Laboratory of Deep Earth Sciences and Geothermal Energy Exploitation and Utilization Institute of Deep Earth Sciences and Green EnergyCollege of Civil and Transportation EngineeringShenzhen UniversityShenzhen518060China shenzhen Key Laboratory of Deep Underground Engineering Sciences and Green Energy Shenzhen UniversityShenzhen518060China

The scaling-dependent behaviors of rocks are significant to the stability and safe operation of the structures built in or on rock masses for practical ***,many size effect models are employed to connect laboratory measurements at small scales and engineering applications at large ***,limited works consider the strain rate *** this study,an fractal-statistical scaling model incorporating strain rate is proposed based on a weakest-link approach,fractal theory and dynamic fracture *** proposed scaling model consists of 8 model parameters with physical meaning,***-dependent parameter,intrinsic material parameter,dynamic strain rate,quasi-static strain rate,quasi-static fracture toughness,micro-crack size,micro-crack intensity and fractal dimension,enabling the proposed scaling model to model the scaling behaviors under different external *** predictions are consistent with experimental data on red sandstone,proving the reliability and effectiveness of the proposed scaling ***,the scaling behaviors of rocks under dynamic loading conditions can be captured by the proposed fractal-statistical scaling *** sensitivity analysis indicates that the nominal strength difference becomes more obvious with a higher strain rate,larger fractal dimension,smaller micro-crack size or lower micro-crack ***,the proposed scaling model has the potential to capture the scaling behaviors considering the thermal effect,weathering effect,anisotropic characteristic etc.,as the proposed scaling model incorporated model parameters with physical *** findings of this study are of fundamental importance to understand the scaling behaviors of rock under dynamic loading condition,and thus would facilitate the appropriate design of rock engineering.

关键词： Size effect Strain rate Uniaxial compressive strength(UCS) Dynamic fracture mechanics

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Significant reduction in friction and wear of a high-entropy alloy via the formation of self-organized nanolayered structure

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Journal of Materials Science & Technology 2021年第14期73卷 1-8页

作者： Lu Yang Zhuo Cheng Weiwei Zhu Cancan Zhao Fuzeng Ren Department of Materials Science and Engineering Southern University of Science and TechnologyShenzhen 518055China Institute of Applied Physics and Materials Engineering Faculty of Science&TechnologyUniversity of MacaoMacaoChina

Sliding wear-induced nanolayering and its positive impact on wear resistance have been observed in conventional binary alloys with a matrix of high stacking fault energy(SFE),but this concept has never been reported in high-entropy alloys(HEAs)with low ***,we design and fabricate a(CoCrFeNi)_(90)Ag_(10)HEA,consisting of a face-center-cubic(fcc)CoCrFeNi HEA matrix with low SFE and uniformly dispersed Ag *** comparison with CoCrFeNi,a significant reduction in friction and wear was found in(CoCrFeNi)_(90)Ag_(10)HEA through the spontaneous formation of nanolayered subsurface microstructure during *** finding suggests a novel approach for designing HEAs that can achieve low friction and wear.

关键词： High-entropy alloy Sliding wear Nanolayering

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THEORETICAL INVESTIGATION ON THE DYNAMIC PERFORMANCE OF CMUT FOR DESIGN OPTIMIZATION

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Acta Mechanica Solida Sinica 2013年第1期26卷 99-110页

作者： Ting Yu Wenchao Zhou Peng Xu Fengqi Yu Qin Qian Department of Integrated Electronics Shenzhen Institute of Advanced TechnologyChinese Academy of Sciences The Chinese University of Hong Kong School of Civil Engineering and Mechanics Huazhong University of Sciences and Technology

Although many modeling approaches exist for analyzing the behavior of capacitive micro-machined ultrasonic transducers （CMUTs）, the relation equation between the design pa- rameters with input and output is still lacking. What there is can only be used to analyze the dynamic performance of CMUT indirectly and qualitatively, such as stiffness and sound pressure. A lumped-parameter theoretical model based on the dynamic theory is proposed in this paper. The relation equations between the design parameters with inputs and outputs are given. The results obtained by the proposed model agree well with those by finite element method （FEM） simulation. The dynamic and static behavior of CMUT can be clearly depicted, which is helpful for design and optimization iterations. This shows that the proposed model makes it easier to optimize the parameters of a CMUT with respect to output and bandwidth directly and to better understand the influence of each parameter.

关键词： CMUT dynamic theory finite element method

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rADSC-loaded tubular units composed of multilayer electrospun membranes promoted bone regeneration of critical-sized skull defects

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Materials Futures 2024年第3期3卷 178-194页

作者： Huamin Jiang Zhaoyi Lin Jinze Li Ting Song Hongyun Zang Pengwen Li Jiarun Li Wenyi Hou Jianhua Zhou Yan Li School of Biomedical Engineering Shenzhen Campus of Sun Yat-sen UniversityShenzhen 518107People’s Republic of China Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument Sun Yat-sen UniversityGuangzhou 510006People’s Republic of China Hospital of Stomatology Guangdong Provincial Key Laboratory of StomatologyInstitute of Stomatological ResearchGuanghua School of StomatologySun Yat-sen UniversityGuangzhou 510062People’s Republic of China The Third Affiliated Hospital of Sun Yat-sen University Guangzhou 510630People’s Republic of China

Adipose-derived stem cells(ADSCs)have considerable potential for bone ***,their performance is limited by a lack of scaffolds that adequately mimic the hierarchical structure of bone to promote proliferation and osteogenic differentiation of *** this study,nanofiber membranes composed of polycaprolactone,poly(lactide-co-glycolide),and hydroxyapatite(HAp)were prepared via electrospinning,and the membranes curled after responding to temperature stimuli in an aqueous *** electron microscopy and scanning electron microscopy observations indicated that needle-like HAp nanoparticles with an average diameter of 57±39 nm and a length–diameter ratio of 7.4±1.56 were entrapped in the nanofiber matrix and did not affect the surface morphology of *** cutting and deformation,the nanofibers changed from straight to bent,and the diameters increased;they were 1105±200 nm for BPLG85-H and 1120±199 nm for ***,tubular units with a single layer(BPLG-H(1.5))or multiple layers(BPLG-H(3.5))were obtained by controlling the initial shape and size of the *** on the concave surface of BPLG-H(3.5)proliferated faster and exhibited better osteogenic activity than those on the convex side of BPLG-H(3.5)and both surfaces of BPLG-H(1.5),which was correlated with the higher expressions of vascular endothelial growth factor and bone morphogenetic protein ***,rADSCs on both units maintained osteogenic activity after storage at-80◦C for 20 *** rat skull defect(diameter of 8 mm)models,rADSC-loaded BPLG-H(3.5)units fixed using gelatin hydrogel(ADSC@BHM)exhibited 84.1±6.6%BV/TV after implantation for 12 weeks,which was 155.6%higher than that of the Blank group.H&E and Masson’s staining results demonstrated that there was more bone regeneration at the defect center of ADSC@BHM than in the BHM and Blank *** conclusion,rADSC-loaded BPLG-H(3.5)with an osteon-mimic structure provides a potential strategy to repair

关键词： adipose-derived stem cells electrospinning composite fiber bone regeneration

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