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Fenton cleaning strategy for ceramic membrane fouling in wastewater treatment

Journal of Environmental Sciences 2019年第11期31卷 189-199页

作者： Shengyin Tang Lixun Zhang Yi Peng Jing Liu Zhenghua Zhang shenzhen Environmental Science and New Energy Technology Engineering Laboratory Tsinghua-Berkeley Shenzhen Institute Tsinghua University Shenzhen 518055 China Institute of Environmental Engineering & Nano-Technology Tsinghua Shenzhen International Graduate School Tsinghua UniversityShenzhen 518055 China Guangdong Provincial Engineering Research Center for Urban Water Recycling and Environmental Safety Tsinghua Shenzhen International Graduate School Tsinghua University Shenzhen 518055 China

Membrane fouling is an obstacle impeding the wide applications of ceramic membranes and organics are responsible for most of the membrane fouling issues in wastewater *** this study,Fenton cleaning strategy was firstly proposed to clean ceramic membrane fouling in wastewater ***2+ efficiently catalyzed fouling cleaning with H2O2 (1.5%) to recover the filterability of ceramic *** maximum ΔTMP recovery (over 99%) was achieved at an optimal Fe2+ dosage of 124 mg/L after 6 hr of immersion *** total residual membrane fouling resistance decreased gradually from this optimum value as the Fe2+ dosage increased above 124 mg/*** residual hydraulically reversible fouling resistance accounted for most of the membrane fouling and was basically removed (≤3.0 × 109 m-1) when Fe2+ dosages higher than 124 mg/L were *** foulants responsible for the formation of a residual hydraulically reversible fouling layer (DOC (dissolved organic carbon),proteins,polysaccharides,EEM (fluorescence excitationemission matrix spectra),SS (suspended solids),and VSS (volatile suspended solids)) were gradually removed as the Fe2+ dosage *** residual organic foulants were degraded from biopolymers (10-200 kDa) to low molecular weight substances (0.1-1 kDa),and the particle size of these residual foulants decreased significantly as a *** strong oxidation power of hydrogen peroxide/hydroxy radicals towards organic foulants was enhanced by Fe2+.Fe2+ played a significant role in the removal of hydraulically reversible fouling and irreversible fouling from the ceramic ***,Fe2+(≥124 mg/L) increased the likelihood of forming secondary iron-organics aggregates.

关键词： Membrane fouling Cleaning Ferrous Fenton Wastewater treatment

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Design,synthesis and biological evaluation of novel phthalazinone acridine derivatives as dual PARP and Topo inhibitors for potential anticancer agents

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Chinese Chemical Letters 2020年第2期31卷 404-408页

作者： Qiuzi Dai Jiwei Chen Chunmei Gao Qinsheng Sun Zigao Yuan Yuyang Jiang Department of Chemistry Tsinghua UniversityBeijing 100084China The State Key Laboratory of Chemical Oncogenomics Key Laboratory of Chemical BiologyThe Graduate School at ShenzhenTsinghua UniversityShenzhen 518055China College of Chemistry and Chemical Engineering Shenzhen UniversityShenzhen 518060China Department of Pharmacology and Pharmaceutical Sciences School of MedicineTsinghua UniversityBeijing 100084China

In this study,we designed and synthesized a series of phthalazinone acridine derivatives as dual PARP and Topo *** assays indicated that most of the compounds significantly inhibited multiple cancer cells *** addition,all the compounds displayed Topo Ⅱ inhibition activity at 10 mol/L,and also possessed good PARP-1 inhibitory *** mechanistic studies showed that compound 9 a induced remarkable apoptosis and caused prominent S cell cycle arrest in HCT116 *** study suggested that 9 a inhibiting Topo and PARP concurrently can be a potential lead compound for cancer therapy.

关键词： Topo PARP Multitarget Acridines Antitumor bioactivity

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Functional polymer passivatingFA_(0.85)PEA_(0.15)SnI_(3) for efficient and stable lead-free perovskite solar cells

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Nano Research 2023年第1期16卷 481-488页

作者： Wenzhan Xu Yu Gao Miao He Shuyan Chen Hongyan Fu Guodan Wei Tsinghua-Berkeley shenzhen Institute(TBSI) Tsinghua Shenzhen International Graduate SchoolTsinghua UniversityShenzhen 518000China Tsinghua shenzhen International Graduate School Tsinghua UniversityShenzhen 518000China

Due to their excellent advantages such as low toxicity,superior optoelectronic properties,low-temperature fabrication,and costeffectiveness,Sn-based perovskites have become the most promising alternatives for high performance lead-free perovskite solar ***,the character of Sn ^(2+)is easily oxidized toSn ^(4+),causing unnecessary p-type self-doping and high leakage *** seriously,trap-induced non-radiative recombination from rapid crystallization causes into large energy loss with a low open circuit ***,the Sn-based solar cells have efficiency far behind the Pb-based solar ***,the polymer poly(ethylene glycol)diacrylate(PEGDA)is used to control crystal growth and passivate the defects in FA_(0.85)PEA_(0.15)SnI_(3) thin *** Sn-perovskite layer shows compact crystal with large grain size and reduced *** perovskite thin film is further processed to fabricate the inverted solar cell with device structure of ITO(indium tin oxide)/PEDOT:PSS(Poly(3,4-ethylenedioxythiophene)/poly(styrenesulfonate))/FA_(0.85)PEA_(0.15)SnI_(3)/ICBA(indene-C60 bisadduct)/BCP(bathocuproine)/Ag,which shows the power conversion efficiency(PCE)of 11.45%with voltage of 0.82 ***,corresponding perovskite solar cells exhibit an enhanced stability due to PEGDA induced compressive strain in *** work could shed light on one of successful attempts to improve Sn-based solar cell efficiency for sustainable energy conversion.

关键词： FA_(0.85)PEA_(0.15)SnI_(3) perovskites solar cells crystal growth modulation stability

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Carbon nanodots enhanced performance of Cs_(0.15)FA_(0.85)PbI_(3) perovskite solar cells

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Nano Research 2021年第7期14卷 2294-2300页

作者： Yu Gao Wenzhan Xu Fang He Pengbo Nie Qingdan Yang Zhichun Si Hong Meng Guodan Wei Tsinghua-Berkeley shenzhen Institute(TBSI) Tsinghua UniversityShenzhen 518000China Tsinghua shenzhen International Graduate School Tsinghua UniversityShenzhen 518000China School of Chemical Engineering and Light Industry Guangdong University of TechnologyGuangzhou 510080China Peking University shenzhen Graduate School Peking UniversityShenzhen 518055China

A high-quality hybrid Cs_(0.15)FA_(0.85)PbI_(3) thin film is deposited through doping of carbon nanodots(CNDs)into perovskite precursor *** corresponding inverted planar perovskite solar cells(PSCs)of ITO/PTAA/Cs_(0.15)FA_(0.85)PbI_(3)/PC_(61)BM/BCP/Ag exhibit an improvement in efficiency from 17.36%to 20.06%,which could be attributed to the passivation of the defects at the crystallized perovskite thin film and enhanced perovskite phase *** results of electron trap density indicate that the addition of CNDs significantly reduces the defects density at the perovskite thin film and the recombination of charge carriers in transport process is *** results demonstrate that low-cost CNDs are effective additives for passivating defects,further reducing charge carrier recombination and improving device efficiency.

关键词： carbon nanodots perovskite solar cells passivation power conversion efficiency

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One-nanometer-thick platinum-based nanowires with controllable surface structures

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Nano Research 2019年第7期12卷 1721-1726页

作者： Xiaokun Fan Shuiping Luo Xixia Zhao Xiaotong Wu Zhishan Luo Min Tang Wen Chen Xing Song Zewei Quan Department of Chemistry Southern University of Science and Technology (SUSTech)Shenzhen 518055China School of Chemical Biology and Biotechnology Shenzhen Graduate SchoolPeking UniversityShenzhen 518055China

Pt-based ultrathin nanowires (NWs) are considered as one of the most intriguing catalysts for fuel ***,the delicate controllability of surface structure of ultrathin NWs to regulate their catalytic performances is still a ***,two kinds of one-nanometer-thick Pt-based NWs with smooth surfaces (S-NWs) and rough surfaces (R-NWs) are demonstrated,in which the combined use of hexadecyltrimethylammonium bromide and oleylamine plays an essential role,as they could form soft-templates to direct the growth of *** to its high-density of low-coordinated sites on the surface,Pt-based R-NWs exhibit higher oxygen reduction reaction (ORR) activities but lower stabilities than corresponding ***,Pt0.78Ni0.22 R-NWs possess the highest mass activity (1.07 A-mgpt^-1) and specific activity (1.02 mA·cm^-2) among all Pt-based *** 10,000 sweeping cycles,the mass activity still exhibits 5.7-fold enhancement compared to the corresponding commercial Pt/*** work presents a new approach to delicately control the surface structure of ultrathin Pt-based NWs as advanced ORR catalysts.

关键词： platinum ultrathin nanowire surface structure oxygen reduction reaction electrtocatalyst

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Tetrabenzotriazacorrole and its derivatives as undopea hole transporting materials for perovskite solar cells:Synthesis,device fabrication,and device performance

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Journal of Energy Chemistry 2020年第4期29卷 139-147页

作者： Xian-Fu Zhang Chang Liu Jianchang Wu Baomin Xu Department of Materials Science and Engineering Southern University of Science and TechnologyShenzhen 518055GuangdongChina Institute of Applied Photochemistry Hebei Normal University of Science and TechnologyQinhuangdao 066004HebeiChina shenzhen Engineering Research and development Center for Flexible Solar Cells Southern University of Science and TechnologyShenzhen 518055GuangdongChina

Phosphorous tetrabenzotriazacorrole(TBC)and its two soluble derivatives(TBC-1 and TBC-2)were synthesized and used for the first time as undoped hole transporting materials(HTMs)in MAPbI3 perovskite solar cells(PSCs).Their performance in PSCs was measured and compared with that of SpiroOMeTAD and phthalocyanine *** fundamental properties related to HTMs are also *** novel HTMs are easily prepared,cost-effective,and solution *** materials exhibited much higher hole transport mobility and broader light absorption than pristine Spiro-OMeTAD and phthalocyanine *** can work efficiently in the absence of any dopant for devices composed of FTO/cp-TiO2/mp-TiO2/MAPbI3/HTM/*** undoped mesoscopic solar cell devices based on TBC exhibited a promising power conversion efficiency(PCE)of up to 16.2%(measured at 100 mWcm2 illumination,AM 1.5 G),together with good long-term stability under ambient *** PCE of 16.2%observed using TBC is remarkably higher than the 11.2%observed using undoped Spiro-OMeTAD and also much better than the 8.70%observed using its phthalocyanine *** to substitution effects,α-substituted TBC-1 was found to be a better HTM thanβ-substituted TBC-2(PCE 11.4%)and unsubstituted TBC-3(PCE 6.81%)under the same *** results provide the basis for further exploiting TBC compounds as a new type of low-cost and effective HTM for PSCs.

关键词： Perovskite solar cell Hole transporting material Tetrabenzotriazacorrole Phthalocyanine

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Combined inhibition of HDAC and DNMT1 induces p85α/MEKmediated cell cycle arrest by dual target inhibitor 208 in U937 cells

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Chinese Chemical Letters 2019年第6期30卷 1233-1236页

作者： Yue Ren Qinsheng Sun Zigao Yuan Yuyang Jiang Department of Chemistry Tsinghua University Beijing 100084 China State Key Laboratory of Chemical Oncogenomics Key Laboratory of Chemical Biology the Graduate School at Shenzhen Tsinghua University Shenzhen 518055 China National & Local United Engineering Lab for Personalized Anti-tumor Drugs Shenzhen Kivita Innovative Drug Discovery Institute the Graduate School at Shenzhen Tsinghua University Shenzhen 518055 China School of Life Science Tsinghua University Beijing 100084 China School of Pharmaceutical Sciences Tsinghua University Beijing 100084 China

Multiple histone deacetylase inhibitors (HDACi) and DNA methyltransferase inhibitors (DNMTi) have been developed for cancer therapy. However, the research on their mechanisms of action is not sophisticated enough. In this study, we reported a dual HDAC and DNMT inhibitor 208 and found it induced G1 cell cycle arrest and apoptosis in U937 cells. Proteome and bioinformatic analyses revealed that the combined inhibition of DNMT1 and HDAC by 208 affected the expression of a series of proteins involved in many biological processes. We observed that several proteins associated with G1 cell cycle arrest and apoptosis were down regulated after 208 treatment, including p85α, MEK, and CDK4, suggesting that 208 induces cell cycle arrest and apoptosis through the p85α/MEK-mediated pathway in U937 cells. Moreover, biological function analysis showed that the combined epigenetic inhibition influenced various processes, including the synthesis and processing of RNA, translation, protein transport, and DNA repair. These findings provide novel insight into the potential mechanisms of multifunctional epigenetic inhibitors, which supports their further improvement and development.

关键词： Proteomics Epigenetic inhibitor HDAC DNMT1 Cell cycle arrest

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Design, synthesis and antitumor evaluations of nucleoside base hydroxamic acid derivatives as DNMT and HDAC dual inhibitors

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Chinese Chemical Letters 2021年第8期32卷 2479-2483页

作者： Qinsheng Sun Qiuzi Dai Cunlong Zhang Yan Chen Lei Zhao Zigao Yuan Yuyang Jiang School of Life Science Tsinghua UniversityBeijing 100084China National&Local United Engineering Lab for Personalized Anti-tumor Drugs The State Key Laboratory of Chemical OncogenomicsKey Laboratory of Chemical BiologyTsinghua Shenzhen International Graduate SchoolTsinghua UniversityShenzhen 518055China Institute of Biomedical Health Technology and Engineering Shenzhen Bay LaboratoryShenzhen 518055China National&Local United Engineering Lab for Personalized Anti-tumor Drugs Shenzhen Kivita Innovative Drug Discovery InstituteShenzhen 518110China School of Pharmaceutical Sciences Tsinghua UniversityBeijing 100084China

DNA methyl transferase(DNMT) and histone deacetylase(HDAC) are well recognized epigenetic targets for discovery of antitumor *** this study,we designed and synthesized a series of nucleoside base hydroxamic acid derivatives as DNMT and HDAC dual *** assays and enzymatic inhibitory activity tests indicated that compound 204 exhibited potent DNMT1 and HDAC1/6 inhibitory potency simultaneously in enzymatic levels and at cellular levels,inducing hypomethylation of p16 and hyperacetylation of histones H_(3) K9 and H4 ***,204 remarkably inhibited proliferation against cancer cells U937 by prompting G0/G1 cell cycle *** docking models explained the functional mechanism of 204 inhibiting DNMT1 and *** studies on metabolic profiles revealed that 204 showed desirable stability in liver *** study suggested that 204 inhibiting DNMT and HDAC concurrently can be a potential lead compound for epigenetic cancer therapy.

关键词： Epigenetic DNMT HDAC Multitarget Antitumor bioactivity

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CHIP regulates bone mass by targeting multiple TRAF family members in bone marrow stromal cells

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Bone Research 2018年第2期6卷 145-154页

作者： Tingyu Wang Shan Li Dan Yi Guang-Qian Zhou Zhijie Chang Peter X.Ma Guozhi Xiao Di Chen Department of Pharmacy Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Department of Orthopedic Surgery Rush University Medical Center Department of Medical Cell Biology and Genetics Shenzhen Key Laboratory and the Center for Anti-Ageing and Regenerative Medicine Shenzhen University Medical School State Key Laboratory of Biomembrane and Membrane Biotechnology Tsinghua University School of Medicine Department of Biologic and Materials Science University of Michigan

Carboxyl terminus of Hsp70-interacting protein（CHIP or STUB1） is an E3 ligase and regulates the stability of several proteins which are involved in different cellular functions. Our previous studies demonstrated that Chip deficient mice display bone loss phenotype due to increased osteoclast formation through enhancing TRAF6 activity in osteoclasts. In this study we provide novel evidence about the function of CHIP. We found that osteoblast differentiation and bone formation were also decreased in Chip KO mice. In bone marrow stromal（BMS） cells derived from Chip^-/- mice, expression of a panel of osteoblast marker genes was significantly decreased. ALP activity and mineralized bone matrix formation were also reduced in Chip-deficient BMS cells. We also found that in addition to the regulation of TRAF6, CHIP also inhibits TNFα-induced NF-κB signaling through promoting TRAF2 and TRAF5 degradation. Specific deletion of Chip in BMS cells downregulated expression of osteoblast marker genes which could be reversed by the addition of NF-κB inhibitor. These results demonstrate that the osteopenic phenotype observed in Chip^-/- mice was due to the combination of increased osteoclast formation and decreased osteoblast differentiation. Taken together, our findings indicate a significant role of CHIP in bone remodeling.

关键词： CHIP regulates bone mass targeting multiple TRAF family members marrow stromal cells

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Crystallization Regulation and Morphological Evolution for HTM-free Tin-Lead (1.28eV) Alloyed Perovskite Solar Cells

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Energy & Environmental Materials 2023年第2期6卷 113-119页

作者： Hang Hu Xianyong Zhou Jiabang Chen Deng Wang Dongyang Li Yulan Huang Luozheng Zhang Yuanjun Peng Feng Wang Jingxia Huang Naichao Chen Liang Sun Xuesong Liu Xingzhu Wang Jianyong Ouyang Baomin Xu Department of Materials Science and Engineering Southern University of Science and TechnologyShenzhen 518055China Department of Materials Science and Engineering National University of SingaporeSingapore 117576Singapore shenzhen Engineering Research and development Center for Flexible Solar Cells Southern University of Science and TechnologyShenzhen 518055China Key Laboratory of Energy Conversion and Storage Technologies(Southern University of Science and Technology) Ministry of EducationShenzhen 518055China Guangdong-Hong Kong-Macao Joint Laboratory for Photonic-Thermal-Electrical Energy Materials and Devices Southern University of Science and TechnologyShenzhen 518055China SUSTech Academy for Advanced Interdisciplinary Studies Southern University of Science and TechnologyShenzhen 518055China shenzhen Putai Technology Co. LtdShenzhen 518110China

There have been huge achievements of all-perovskite tandem solar cells,which recently realized the highest power conversion efficiency of 24.8%.However,the complex device structure and complicated manufacture processes severely restrict the further development of all-perovskite tandem solar *** this work,we successfully fabricated high-efficiency hole transport material-free(HTM-free)Sn−Pb alloyed narrow bandgap perovskite solar cells(PSCs)by introducing guanidinium thiocyanate(GASCN)and hydroiodic acid(HI)into the perovskite precursor *** and HI play a positive synergy effect during perovskite crystallization process resulting in larger grain size,fewer surface defects,and lower trap density to suppress the Sn^(2+)oxidation ***,they could effectively adjust the energy level of perovskite materials,reduce the energy level difference between perovskite and ITO resulting in more efficiently transport of free hole charge *** a result,with adding GASCN and HI,the achieved highest power conversion efficiency of HTM-free devices increased from 12.58%to 17.85%,which is one of the highest PCEs among all values reported to date for the HTM-free narrow-bandgap(1.2-1.4 eV)Sn−Pb binary ***,the optimized device shows improved environmental *** additive strategy manifests a remarkable step towards the facile,cost-efficient fabrication of HTM-free perovskite-based tandem solar cells with both high efficiency and simple fabrication process.

关键词： crystallization regulation hole transport layer-free mixed tin-lead narrow bandgap perovskite solar cells

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