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Chinese Journal of Chemistry 2016年第6期34卷 599-608页

作者： Yehong Zhou Congli Wang Fei Wang Chenzhong Li Chuan Dong Shaomin Shuang Department of Chemistry and Chemical Engineering and Institute of Environmental Science Shanxi University Taiyuan Shanxi 030006 China Department of Biomedical Engineering Florida International University Miami Florida USA

β-Cyclodextrin （β-CD） and its derivatives functionalized magnetic nanoparticles （MNPs） with high saturated magnetism were fabricated successfully by an effective grafting method. The resultant carboxymethyl/hydroxy- propyl/sulfobutyl ether-β-CD-MNPs （CM/HP/SBE-β-CD-MNPs） nanocomposites were characterized by the TEM, FTIR, DLS, Zeta potential, XRD and VSM. In addition, the loading and release performance of the as-prepared nanocarriers for the hydrophobic anti-cancer drug curcumin was also investigated. The results revealed that the SBE-fl-CD-MNPs possessed the highest loading and release capacity in comparison with other two nanosystems. Cellular uptake and imaging suggested that the SBE-β-CD-MNPs entered into the cell, and curcumin could be suc-cessfully delivered into the cell by SBE-β-CD-MNPs nanocarrier. Moreover, cell toxicity experiments demonstrated the SBE-β-CD-MNPs were non-toxic, while curcumin loaded SBE-β-CD-MNPs showed high potential to kill the HepG2 cells. The as-prepared magnetic composites were expected to expand their potential applications in bio- medical field.

关键词： β-cyclodextrin derivatives magnetic nanoparticles targeting delivery curcumin cell imaging

Non-metallic gold nanoclusters for oxygen activation and aerobic oxidation

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Chinese Chemical Letters 2018年第5期29卷 687-693页

作者： Guomei Zhang Ruru Wang Gao Li School of Chemistry and Chemical Engineering Shanxi University State Key Laboratory of Catalysis Dalian Institute of Chemical Physics Chinese Academy of Sciences

In recent decade, Au nanoclusters of atomic precision （AunLm, where L= organic ligand： thiolate andphosphine） have been shown as a new promising nanogold catalyst. The well-defined AunLm catalystspossess unique electronic properties and frameworks, providing an excellent opportunity to correlate theintrinsic catalytic behavior with the cluster＇s framework as well as to study the catalytic mechanismsover gold nanoclusters. In this review, we only demonstrate the important roles of the gold nanoclustersin the oxygen activation （e.g., 302 to 102） and their selective oxidations in the presence of oxygen （e.g., COto C02, sulfides to sulfoxides, alcohol to aldehyde, styrene to styrene epoxide, amines to imines, andglucose to gluconic acid）. The size-specificity （Au25 （1.3 nm）, Au38 （].5 nm）, Au144 （1.9 nm）, etc.）, ligandengineering （e.g., aromatic vs aliphatic）, and doping effects （e.g., copper, silver, palladium, and platinum）are discussed in details. Finally, the proposed reactions＇ mechanism and the relationships of clusters＇structure and activity at the atomic level also are presented.

关键词： Gold nanocluster Oxygen activation Aerobic oxidation Size-specificity Ligand engineering Doping effects

A novel-green adsorbent based on betaine-modified magnetic nanoparticles for removal of methyl blue

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Science Bulletin 2017年第5期62卷 319-325页

作者： Haowei Wang Shangning Jia Haojiang Wang Bo Li Wen Liu Ningbo Li Jie Qiao Chen-Zhong Li College of Basic Medicine Shanxi Medical University Department of Biomedical Engineering Florida International University

A potential adsorbent based on betaine-modified magnetic iron oxide nanoparticles(BMNPs) was successfully synthesized by facile method, characterized and applied for methyl blue(MB) removal from aqueous solution. The characterization results of FTIR, transmission electron microscopy(TEM), X-ray diffraction(XRD) and vibrating sample magnetometer(VSM) showed that the prepared nanoparticles could be well dispersed in water and exhibited excellent superparamagnetism. These properties imply the potential to recycle BMNPs from wastewater through magnetic field. In the adsorption process, the effects of main experimental parameters such as p H of MB solution, initial concentration of MB, contact time, and adsorption capacity for MB were studied and optimized. These results demonstrated that large amounts of quaternary ammonium groups existing on the surface of BMNPs could promote absorption of MB via electrostatic forces. Additionally, the adsorption kinetics of MB was found to follow a pseudosecond-order kinetic model and the adsorption equilibrium data fitted very closely to the Langmuir adsorption isotherm model. The maximum adsorption capacity for MB was calculated to be 136 mg g 1at room temperature. Moreover, the BMNPs showed good reusability with 73.33% MB adsorption in the5 th cycle.

关键词： Iron oxide nanoparticles Betaine Adsorption Methyl blue

Studies on the Interaction Between Vanillin and β-Amyloid Protein via Fluorescence Spectroscopy and Atomic Force Microscopy

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Chemical Research in Chinese Universities 2016年第2期32卷 172-177页

作者： SONG Shengmei MA Xuewen ZHOU Yehong XU Maotian SHUANG Shaomin DONG Chuan Institute of Environmental Science Shanxi University Taiyuan 030006 P. R. China Key Laboratory of Biomolecular Recognition and Sensing of Shangqiu Normal University Shangqiu 476000 P. R. China

β-Amyloid（Afl） plaques and intracellular neurofibrillary lesions in the brain are markers of Alzheimer＇s disease（AD）. The ability to safely decrease Aft concentrations is potentially important as a preventive strategy for AD. The interactions between vanillin and Aft polypeptide were investigated via fluorescence spectroscopy and atomic force microscopy（AFM）. The results of fluorescence and synchronous spectroscopies illustrate that the intrinsic fluorescence of tyrosine（Tyr） residues in Aβ1-42 aggregates can be quenched strongly upon the formation of vanil- lin-Aβ-42 complex. Thioflavine T（ThT）-induced fluorescence changes indicated that Aβ1--42 aggregates could be disaggregated by vanillin, and the AFM images of Aβ1-42 enunciated the depolymerization of Aβ1-42 aggregates by vanillin in a dose-dependent manner. Vanillin may be a potential pharmacological agent for the treatment of AD.

关键词： β-Amyloid fibril Vanillin Interaction Fluorescence spectroscopy Atomic force microscopy

Triazole backbone ligand in an unprecedented efficient manganese catalyst for use in transfer hydrogenation

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Science China Chemistry 2023年第7期66卷 2028-2036页

作者： Qianqian Liang Chunyan Zhang Fangchao Wang Zhong Luo Wei Yang Guohui Zhang Ding Ding Guoying Zhang State Key Laboratory of Coal Conversion Institute of Coal ChemistryChinese Academy of SciencesTaiyuan 030001China College of Ecology Taiyuan University of TechnologyTaiyuan 030001China University of Chinese Academy of Sciences Beijing 100049China China College of Chemical Engineering Qingdao University of Science and TechnologyQingdao 266042China

Noble metal catalysts are generally expensive,and thus,abundant 3d metals recently received significant attention as catalysts in catalytic *** catalysts are widely applied in transfer hydrogenations,but the reported catalyst loadings remain up to three orders of magnitude higher than noble ***,catalyst consumption should be overcome before 3d metal catalytic systems may be utilized practically in ***,a catalytic system based on novel,scalable triazole N5-ligands coordinated to Mn is presented for use in transfer *** on pre-activation via dehydrohalogenation,an unprecedented,efficient catalytic system operating via synergistic H-bond auxiliary activation was *** Mn catalysts are practical at metal concentrations 0.0001 mol%,generating alcohol with turnover number(TON)up to 857,200,thus approaching loadings more conventionally observed in precious-metal-based ***,using this protocol,several pharmaceuticals may be easily synthesized in one pot.

关键词： manganese catalyst triazoles ligand transfer hydrogenation ketones alcohols

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β-Amyloid Biomarker Detection for Alzheimer’s Disease

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Journal of Analysis and Testing 2017年第2期1卷 66-76页

作者： Chen-zhong Li Shantal Grajales Shaomin Shuang Chuan Dong Madhavan Nair Nanobioengineering/Bioelectronics Laboratory Department of Biomedical EngineeringFlorida International University10555 West Flagler StreetMiamiFL 33174USA Department of Chemistry Shanxi UniversityTaiyuan030006People’s Republic of China Department of Immunology Florida International University11200 SW 8th StUniversity ParkMiamiFL 33199USA

Alzheimer’s disease(AD)is a neurodegenerative *** is a type of dementia and it mainly deals with thinking,memory and behavioral *** is a progressive disease,which in course of time damages most sections of the *** amyloid peptides(Aβ)have been recognized as potential biomarkers to monitor *** Ab protein is made up of 39–42 amino acids,which are the main components of the plaques found in the AD *** beta amyloid is toxic to the neurons and causes *** order to measure these biomarkers,nanobiosensing techniques are *** monitoring of Ab levels helps in the detection of the irreversible disease called *** techniques fall in two categories,viz.,in vitro and in *** techniques like electrochemical techniques,cantilever-based liposome biosensor,ELISA,PET scan,microdialysis,etc.,are discussed further in the *** techniques can prove to be effective methods for quantifying amyloid deposition within specific brain regions.

关键词： Alzheimer’s disease Beta amyloid Aβ In vivo Analysis In vitro Biomarker Detection

Motif-mediated Au25(SPh)5(PPh3)ioX2 nanorods with conjugated electron delocalization

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Nano Research 2019年第3期12卷 501-507页

作者： Kai Zheng Jiangwei Zhang Dan Zhao Yong Yang Zhimin Li Gao Li State Key Laboratory of Catalysis Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian 116023 China University of Chinese Academy of Sciences Beijing 100049 China Institute of Catalysis for Energy and Environment College of Chemistry and Chemical Engineering Shenyang Normal University Shenyang 110034 China Department of Materials Science & Engineering College of Engineering Peking University Beijing 100871 China

We developed a general and effective strategy to afford rod-like [Au25(SPh)5(PPh3)10X2]X2 (X = Cl/Br) nanoclusters, capped by conjugated delocalized pπ electron mediated ligands. The detailed atomic structure of these materials was resolved by synchrotron radiation X-ray diffraction (SRXRD) combined with electrospray ionization mass spectrometry (ESI-MS) and UV–vis analyses. The Au17(SR)3(PPh3)6X2minimum asymmetric unit, with exposed Au atoms at the center, can serve as an important model to understand the transformation of homogold nanoclusters into alloy nanoclusters. The conjugated delocalized pπ electrons of the thiolate ligands can effectively tune the electronic properties of the Au25 kernel, as qualitatively evidenced by the energy gaps measured by UV–vis experiments and density functional theory (DFT) calculations. The delocalized electrons distinctly flow to the orbitals of the Au25 kernel via the S atoms of the aromatic thiolates. The ESI-MS analysis indicates that Au3 clusters are formed during the etching reactions, which provide an opportunity to gain insight into the intriguing conversion pathway of the Aun(PPh3)mXy precursor to the final Au25 nanorods. Finally, the thiophenol-protected Au25 nanorods, immobilized on activated carbon, show good catalytic activity in the aerobic oxidation of glucose to gluconic acid (74% glucose conversion and 100% selectivity for gluconic acid), much higher than that of the aliphatic Au25 analogue. The Au25(SPh)5(PPh3)10X2 catalyst yields a turnover frequency (TOF) of 13.5 s^–1, higher than that of commercial catalysts such as Pd/activated carbon (AC) and Pd-Bi/AC. The insight obtained from this study will support the development and design of efficient nanogold catalysts for special oxidation reactions.

关键词： gold clusters AU25 nanorod synchrotron radiation X-ray diffraction (SRXRD) aerobic oxidation

基于乙醇和铝离子聚集诱导的铜纳米团簇（英文）

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物理化学学报 2018年第7期34卷 818-824页

作者：郭肖红周影石利红张彦张彩红董川张国梅双少敏山西大学化学化工学院环境科学研究所太原030006

金属纳米团簇(MNCs)作为一种新型的纳米材料,具有合成方法简单、光稳定性强、毒性低、生物相容性好以及发光效率高等优点。在本研究中,使用"一锅法"合成谷胱甘肽保护的铜纳米团簇。在激发波长为370 nm时,GS@CuNCs的荧光发射波长在610 n... 详细信息

金属纳米团簇(MNCs)作为一种新型的纳米材料,具有合成方法简单、光稳定性强、毒性低、生物相容性好以及发光效率高等优点。在本研究中,使用"一锅法"合成谷胱甘肽保护的铜纳米团簇。在激发波长为370 nm时,GS@CuNCs的荧光发射波长在610 nm左右。铜纳米团簇可以通过有溶剂诱导和阳离子诱导两种方法聚集诱导增强其荧光强度。通过测定在不同溶剂(乙醇、甲醇、N,N-二甲基甲酰胺)中铜纳米团簇的荧光强度,探究了溶剂极性对聚集的影响。研究结果表明:在水溶液中铜纳米团簇只发射弱的荧光,随着乙醇含量从0%到85%,其荧光强度逐渐增强。此外,我们开发了一种新的选择性好、灵敏性高的检测铝离子的荧光探针。线性范围为2-20μmol·L-1,且检测限(LOD)为33 nmol·L-1。进一步探究可得,乙醇和铝离子能使GS@CuNCs荧光强度显著增加的机理为聚集诱导荧光增强。

关键词：荧光铜纳米团簇聚集诱导发光乙醇铝离子

Microglial NLRP3 inflammasome-mediated neuroinflammation and therapeutic strategies in depression

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Neural Regeneration Research 2024年第9期19卷 1890-1898页

作者： Qiuqin Han Wenhui Li Peiqing Chen Lijuan Wang Xiwen Bao Renyan Huang Guobin Liu Xiaorong Chen Department of Scientific Research Shanghai University of Medicine&Health Sciences Affiliated Zhoupu HospitalShanghaiChina Department of Traditional Chinese Vascular Surgery Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghaiChina Department of Physiology Laboratory of Neurodegenerative DiseasesChangzhi Medical CollegeChangzhiShanxi ProvinceChina

Previous studies have demonstrated a bidirectional relationship between inflammation and *** of the nucleotide-binding oligomerization domain,leucine-rich repeat,and NLR family pyrin domain-containing 3(NLRP3)inflammasomes is closely related to the pathogenesis of various neurological *** patients with major depressive disorder,NLRP3 inflammasome levels are significantly *** the role that NLRP3 inflammasome-mediated neuroinflammation plays in the pathogenesis of depression may be beneficial for future therapeutic *** this review,we aimed to elucidate the mechanisms that lead to the activation of the NLRP3 inflammasome in depression as well as to provide insight into therapeutic strategies that target the NLRP3 ***,we outlined various therapeutic strategies that target the NLRP3 inflammasome,including NLRP3 inflammatory pathway inhibitors,natural compounds,and other therapeutic compounds that have been shown to be effective in treating ***,we summarized the application of NLRP3 inflammasome inhibitors in clinical trials related to ***,there is a scarcity of clinical trials dedicated to investigating the applications of NLRP3 inflammasome inhibitors in depression *** modulation of NLRP3 inflammasomes in microglia holds promise for the management of *** investigations are necessary to ascertain the efficacy and safety of these therapeutic approaches as potential novel antidepressant treatments.

关键词： depression microglia neuroinflammation NLRP3 inflammasome

两步升温热轧工艺对AZ31镁合金薄板各向异性及成形性能影响

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Transactions of Nonferrous Metals Society of China 2023年第4期33卷 1066-1085页

作者：王利飞潘晓锾朱星晓邢镔张华卢立伟王红霞程伟丽 Maurizio VEDANI 太原理工大学材料科学与工程学院先进镁基材料山西省重点实验室太原030024 重庆工业大数据创新中心有限公司工业大数据应用技术国家工程实验室重庆400707 上海交通大学材料科学与工程学院上海200240 烟台大学精准材料高等研究院烟台264005 湖南科技大学难加工材料高效精密加工湖南省重点实验室湘潭411201 Department of Mechanical Engineering Politecnico di Milano20156 MilanItaly

采用两步梯度升温轧制工艺对AZ31镁合金板材进行轧制,探究轧制过程对镁合金板材显微组织织演化、各向异性及成形性能的影响。第I步轧制在300℃开展,其每道次压下量为15%;第II步轧制在550℃进行,其每道次压下量为40%。经过共4道次轧制后... 详细信息

采用两步梯度升温轧制工艺对AZ31镁合金板材进行轧制,探究轧制过程对镁合金板材显微组织织演化、各向异性及成形性能的影响。第I步轧制在300℃开展,其每道次压下量为15%;第II步轧制在550℃进行,其每道次压下量为40%。经过共4道次轧制后,最终获得厚度为1 mm的镁合金薄板。结果显示,第I步低温轧制过程不更换轧制方向时,试样中生成大量剪切带;而更换轧制方向时,组织内部主要为孪晶和再结晶晶粒。随着II步轧制温度的升高,由于动态再结晶急剧激发,剪切带数量及尺寸逐渐减小,晶粒明显细化。根据IGMA分析得出,非基面滑移,特别是棱柱面滑移活动增强。轧制退火后的AZ31镁合金薄板的力学性能得到提高,各向异性减小,冲压成形性能得到明显改善。

关键词：镁合金板材两步升温热轧非基面滑移剪切带织构成形性能