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Prediction of the short-term efficacy of anti-VEGF therapy for neovascular age-related macular degeneration using optical coherence tomography angiography

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Eye and Vision 2024年第3期10卷 21-30页

作者： Huixun Jia Bing Lu Zhi Zhao Yang Yu Fenghua Wang Minwen Zhou Xiaodong Sun Department of Ophthalmology Shanghai General Hospital(Shanghai First People’s Hospital)Shanghai Jiao Tong University School of Medicine100 Hai Ning RoadShanghai200080People’s Republic of China shanghai Key Laboratory of Ocular Fundus Diseases ShanghaiChina National Clinical Research center for Eye Diseases ShanghaiChina shanghai Engineering center for Visual Science and Photomedicine ShanghaiChina shanghai Engineering center for Precise Diagnosis and Treatment of Eye Diseases ShanghaiChina Clinical Research Institute Shanghai Jiao Tong University School of MedicineShanghaiChina

Background To evaluate whether the specific choroidal neovascularization(CNV)characteristics measured using optical coherence tomography angiography(OCTA)can predict the 6-month prognosis of neovascular age-related macular degeneration(nAMD)after anti-vascular endothelial growth factor(anti-VEGF)*** Patients with type 1,type 2,or mixed-type neovascularization(NV)were prospectively *** underwent an initial loading phase of three consecutive monthly intravitreal injections of Conbercept(0.5 mg)and were switched to a pro re nata(PRN)treatment *** images were evaluated for eyes that underwent follow-up assessments for more than 6 *** lesions were manually segmented,and the CNV area,vessel area,greatest vascular caliber(GVC),and greatest linear dimension(GLD)were compared between responders and *** masked graders independently measured the above-mentioned parameters using OCTA,and consistency was assessed using the intraclass correlation coefficient(ICC)*** logistic regression analysis was performed to evaluate the effect of a 3-month change in the CNV area,GLD,and GVC on the 6-month response to anti-VEGF *** Among the 60 eyes of 60 patients with nAMD,39 were responders and 21 were *** proportion of CNV types was significantly different between responders and non-responders(P=0.009).Patients with type 2 or mixed NV seemed more likely to respond to the treatment(28.2%vs.0.0%,and 30.8%vs.23.8%,respectively).The change in GVC showed a significant difference between responders(−4.98±17.17μm)and non-responders(11.01±14.10μm)after three monthly intravitreal anti-VEGF *** logistic regression analysis showed that only the change in GVC remained significant after controlling for baseline GVC,injection number,and CNV type(adjusted OR=1.083;P=0.008).Conclusions Type 2 and mixed-type NV were significantly associated with a better response to anti-VEGF *** i

关键词： Age-related macular degeneration Choroidal neovascularization Optical coherence tomography angiography Anti-VEGF

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Pathologically successful conversion hepatectomy for advanced giant hepatocellular carcinoma after multidisciplinary therapy:A case report and review of literature

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1647-1659页

作者： Ju-Hang Chu Lu-Yao Huang Ya-Ru Wang Jun Li Shi-Long Han Hao Xi Wen-Xue Gao Ying-Yu Cui Ming-Ping Qian Department of General Surgery Shanghai Tenth People's HospitalSchool of MedicineTongji UniversityShanghai 200072China Department of Interventional and Vascular Surgery Shanghai Tenth People's HospitalSchool of MedicineTongji UniversityShanghai 200072China Department of Pathology Shanghai Tenth People's HospitalSchool of MedicineTongji UniversityShanghai 200072China Clinical Research Management Office Shanghai Tenth People’s HospitalShanghai 200072China Department of Cell Biology Institute of Medical GeneticsState Key Laboratory of CardiologyTongji University School of MedicineShanghai 200331China

BACKGROUND Hepatocellular carcinoma(HCC)is one of the leading causes of death due to its complexity,heterogeneity,rapid metastasis and easy recurrence after surgical *** demonstrated that combination therapy with transcatheter arterial chemoembolization(TACE),hepatic arterial infusion chemotherapy(HAIC),Epclusa,Lenvatinib and Sintilimab is useful for patients with advanced *** SUMMARY A 69-year-old man who was infected with hepatitis C virus(HCV)30 years previously was admitted to the hospital with abdominal *** computed tomography(CT)revealed a low-density mass in the right lobe of the liver,with a volume of 12.9 cm×9.4 cm×15 cm,and the mass exhibited a“fast-in/fast-out”pattern,with extensive filling defect areas in the right branch of the portal vein and an alpha-fetoprotein level as high as 657 ng/***,he was judged to have advanced *** treatment,the patient received three months of Epclusa,three TACE treatments,two HAIC treatments,three courses of sintilimab,and twenty-one months of *** the third month of treatment,the patient developed severe side effects and had to stop immunotherapy,and the Lenvatinib dose had to be *** pathological diagnosis indicated a complete *** patient recovered well after the operation,and no tumor recurrence was *** Multidisciplinary conversion therapy for advanced enormous HCC caused by HCV infection has a significant *** drug adjustments should be made during any treatment according to the patient's tolerance to treatment.

关键词： Hepatocellular therapy Conversion hepatectomy Interventional therapy Epclusa Lenvatinib Sintilimab Case report

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Current Mycoplasma pneumoniae epidemic among children in shanghai:unusual pneumonia caused by usual pathogen

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World Journal of Pediatrics 2024年第1期20卷 5-10页

作者： Xiao-Bo Zhang Wen He Yong-Hao Gui Quan Lu Yong Yin Jian-Hua Zhang Xiao-Yan Dong Ying-Wen Wang Ying-Zi Ye Hong Xu Jia-Yu Wang Bing Shen Dan-Ping Gu Li-Bo Wang Yi Wang Department of Respiratory Medicine Children's Hospital of Fudan University399 Wanyuan RoadShanghai 201102China State Key Laboratory of Genetic Engineering at School of Life Sciences Institute of Reproduction&DevelopmentChildren's Hospital of Fudan UniversityShanghaiChina Department of Respiratory Medicine Children's Hospital of Shanghai Jiao Tong UniversityShanghaiChina Department of Respiratory Medicine Shanghai Children's Medical CenterAffiliated to Shanghai Jiaotong University School of MedicineShanghaiChina Department of Pediatric Respiratory Xinhua HospitalAffiliated to Shanghai Jiaotong University School of MedicineShanghaiChina Department of Nursing Children's Hospital of Fudan UniversityShanghaiChina Department of Infectious Diseases Children's Hospital of Fudan UniversityShanghaiChina Department of Nephrology Children's Hospital of Fudan UniversityShanghaiChina NHC Key Laboratory of Neonatal Diseases Children's Hospital of Fudan UniversityShanghaiChina shanghai Shenkang hospital development center ShanghaiChina center for Medical Quality Control Management of shanghai ShanghaiChina Department of Neurology Children's Hospital of Fudan University399Wanyuan RoadShanghai 201102China

Mycoplasma pneumoniae(***),primarily transmitted through respiratory droplets when infected individuals cough or sneeze,is a common cause of communityacquired pneumonia,especially among school-age children and *** infection occurs endemically with an epidemic peak every few *** worldwide incidence confirmed by direct test methods was reported to be 8.61%between 2017 and 2020 across all age groups[1].

关键词： pneumonia epidemic respiratory

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Fabrication of a 3D bioprinting model for posterior capsule opacification using GelMA and PLMA hydrogel-coated resin

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Regenerative Biomaterials 2024年第4期3卷 52-65页

作者： Xin Liu Jiale Li Shuyu Liu Yan Long Ching Kang Chen Zhao Ling Wei Shaoqi Huang Yi Luo Bo Dai Xiangjia Zhu Cataract and Lens Refractive Surgery Group Department of OphthalmologyEye&ENT Hospital of Fudan UniversityShanghai 200031People’s Republic of China NHC Key Laboratory of Myopia Key Laboratory of MyopiaChinese Academy of Medical SciencesFudan UniversityShanghai 200031People’s Republic of China shanghai Key Laboratory of Visual Impairment and Restoration Shanghai 200031People’s Republic of China Engineering Research center of Optical Instrument and System the Ministry of EducationShanghai Key Laboratory of Modern Optical SystemUniversity of Shanghai for Science and TechnologyShanghai 200093China

Posterior capsule opacification(PCO)remains the predominant complication following cataract surgery,significantly impairing visual function *** this study,we developed a PCO model that closely mimics the anatomical structure of the crystalline lens capsule *** model incorporated a threaded structure for accurate positioning and observation,allowing for opening and *** 3D printing technology,a stable external support system was created using resin material consisting of a rigid,hollow base and *** replicate the lens capsule structure,a thin hydrogel coating was applied to the resin *** biocompatibility and impact on cellular functionality of various hydrogel compositions were assessed through an array of staining techniques,including calcein-AM/PI staining,rhodamine staining,BODIPY-C11 staining and EdU staining in conjunction with transwell ***,the PCO model was utilized to investigate the effects of eight drugs with anti-inflammatory and anti-proliferative properties,including 5-aminoimidazole-4-carboxamide ribonucleotide(AICAR),THZ1,sorbinil,4-octyl itaconate(4-OI),xanthohumol,zebularine,rapamycin and caffeic acid phenethyl ester,on human lens epithelial cells(HLECs).Confocal microscopy facilitated comprehensive imaging of the PCO *** results demonstrated that the GelMA 605%þPLMA 2%composite hydrogel exhibited superior biocompatibility and minimal lipid peroxidation levels among the tested ***,compared to using hydrogel as the material for 3D printing the entire model,applying surface hydrogel spin coating with parameters of 2000 rpm�2 on the resin-based 3D printed base yielded a more uniform cell distribution and reduced ***,rapamycin,4-OI and AICAR demonstrated potent antiproliferative effects in the drug intervention *** microscopy imaging revealed a uniform distribution of HLECs along the anatomical structure of the crystalline lens capsule with

关键词： posterior capsule opacification(PCO) human lens epithelial cells(HLECs) 3D bioprinting hydrogel resin

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Individualised evaluation based on pathophysiology for moyamoya vasculopathy:application in surgical revascularisation

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Stroke & Vascular Neurology 2024年第3期9卷 268-278,I0241-I0246页

作者： Xin Zhang Yu Lei Jiabin Su Chao Gao Yanjiang Li Rui Feng Ding Xia Peng Gao Yuxiang Gu Ying Mao Department of Neurosurgery Huashan Hospital Fudan UniversityShanghaiChina Department of Radiology Huashan Hospital Fudan UniversityShanghaiChina

Background Although bypass surgery is an effective treatment for moyamoya vasculopathy(MMV),the incidence of postoperative complications is still *** study aims to introduce a novel evaluating system based on individualised pathophysiology of MMV,and to assess its clinical *** This multicentre,prospective study enrolled adult patients with MMV from Huashan hospital,Fudan University and National center for Neurological Disorders,China between March 2021 and February *** neuroimages containing structural and functional information were used to evaluate personalised disease severity and fused to localise the surgical field,avoid invalid regions and propose alternative recipient *** recipient artery was further selected intraoperatively by assessing regional haemodynamic and electrophysiological *** preanastomosis and postanastomosis data were compared with assist with the postoperative *** who received such tailored revascularisations were included in the novel group and the others were included in the traditional *** 30-day surgical outcomes and intermediate long-term follow-up were *** Totally 375 patients(145 patients in the novel group and 230 patients in the traditional group)were *** overall complication rate was significantly lower in the novel group(p˂0.001).In detail,both the rates of postoperative infarction(p=0.009)and hyperperfusion syndrome(p=0.010)were significantly *** functional outcomes trended to be more favourable in the novel group,though not significantly(p=0.260).Notably,the proportion of good functional status was higher in the novel group(p=0.009).Interestingly,the preoperative statuses of perfusion and metabolism around the bypass area were significantly correlated with the occurrence of postoperative complications(P˂0.0001).Conclusions This novel evaluating system helps to identify appropriate surgical field and recipient arteries during b

关键词： surgical bypass metabolism

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Icaritin inhibits the progression of urothelial cancer by suppressing PADI2-mediated neutrophil infiltration and neutrophil extracellular trap formation

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Acta Pharmaceutica Sinica B 2024年第9期14卷 3916-3930页

作者： Zezhong Mou Yiling Chen Jinzhong Hu Yun Hu Lujia Zou Xinan Chen Shenghua Liu Qiuping Yin Jian Gong Shuchen Li Shanhua Mao Chenyang Xu Haowen Jiang Department of Urology Huashan HospitalFudan UniversityShanghai 200040China Fudan Institute of Urology Fudan UniversityShanghai 200040China National Clinical Research center for Aging and Medicine Fudan UniversityShanghai 200040China

Tumor relapse and metastasis are the major causes of mortality associated with urothelial *** the tumor microenvironment,negative regulatory molecules and various immune cell subtypes suppress antitumor *** inflammatory microenvironment,associated with neutrophils and neutrophil extracellular traps(NETs),promotes tumor ***,no drugs are currently available to specifically inhibit neutrophils and *** this study,we first demonstrated that icaritin(ICT),a Chinese herbal remedy that is a first-line treatment for advanced and incurable hepatocellular carcinoma,reduces NETs caused by suicidal NETosis and prevents neutrophil infiltration in the tumor ***,ICT binds to and inhibits the expression of PADI2 in neutrophils,thereby suppressing PADI2-mediated histone ***,ICT inhibits ROS generation,suppresses the MAPK signaling pathway,and inhibits NET-induced tumor ***,ICT inhibits tumoral PADI2-mediated histone citrullination,which consequently suppresses the transcription of neutrophil-recruiting genes such as GM-CSF and *** downregulation of IL-6 expression,in turn,forms a regulatory feedback loop through the JAK2/STAT3/IL-6 *** a retrospective study of clinical samples,we found a correlation between neutrophils,NETs,UCa prognosis,and immune *** ICT with immune checkpoint inhibitors may have synergistic *** summary,our study demonstrated that ICT could be a novel inhibitor of NETs and a novel UCa treatment.

关键词： Icaritin Neutrophil Neutrophil extracellular trap PADI2 Urothelial cancer

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Diverse functions of sox9 in liver development and homeostasis and hepatobiliary diseases

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Genes & Diseases 2024年第4期11卷 170-187页

作者： Taiyu Shang Tianyi Jiang Xiaowen Cui Yufei Pan Xiaofan Feng Liwei Dong Hongyang Wang School of Life Sciences Institute of Metabolism and Integrative BiologyFudan UniversityShanghai 200438China National center for Liver Cancer The Naval Medical UniversityShanghai 201805China International Cooperation Laboratory on Signal Transduction Eastern Hepatobiliary Surgery InstituteThe Second Military Medical UniversityShanghai 200438China Laboratory of Signaling Regulation and Targeting Therapy of Liver Cancer Second Military Medical University&Ministryof EducationShanghai 200438China

The liver is the central organ for digestion and detoxification and has unique metabolic and regenerative *** hepatobiliary system originates from the foregut endoderm,in which cells undergo multiple events of cell proliferation,migration,and differentiation to form the liver parenchyma and ductal system under the hierarchical regulation of transcription *** on liver development and diseases have revealed that SRY-related high-mobility group box 9(SOx9)plays an important role in liver embryogenesis and the progression of hepatobiliary ***9 is not only a master regulator of cell fate determination and tissue morphogenesis,but also regulates various biological features of cancer,including cancer stemness,invasion,and drug resistance,making Sox9 a potential biomarker for tumor prognosis and *** review systematically summarizes the latest findings of sox9 in hepatobiliary development,homeostasis,and *** also highlight the value of sox9 as a novel biomarker and potential target for the clinical treatment of major liverdiseases.

关键词： Biliary system Cancer Homeostasis Liver diseases SOX9

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Therapeutic robots for post-stroke rehabilitation

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Medical Review 2024年第1期4卷 55-67页

作者： Ronghua Hong Bingyu Li Yunjun Bao Lingyu Liu Lingjing Jin Neurotoxin Research center Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of EducationDepartment of NeurologyTongji HospitalSchool of MedicineTongji UniversityShanghaiChina Department of Neurology and Neurological Rehabilitation Shanghai Disabled Persons’Federation Key Laboratory of Intelligent Rehabilitation Assistive Devices and TechnologiesYangzhi Rehabilitation Hospital(Shanghai Sunshine Rehabilitation Center)School of MedicineTongji UniversityShanghaiChina Department of Neurology and Neurological Rehabilitation Shanghai Disabled Persons’Federation Key Laboratory of Intelligent Rehabilitation Assistive Devices and TechnologiesYangzhi Rehabilitation Hospital(Shanghai Sunshine Rehabilitation Center)School of MedicineTongji UniversityShanghai 200092China Neurotoxin Research center Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of EducationDepartment of NeurologyTongji HospitalSchool of MedicineTongji UniversityShanghai 200092China Collaborative Innovation center for Brain Science Tongji UniversityShanghai 200092China

Stroke is a prevalent,severe,and disabling healthcare issue on a global scale,inevitably leading to motor and cognitive *** has become one of the most significant challenges in China,resulting in substantial social and economic *** addition to the medication and surgical interventions during the acute phase,rehabilitation treatment plays a crucial role in stroke *** technology takes distinct advantages over traditional physical therapy,occupational therapy,and speech therapy,and is increasingly gaining popularity in post-stroke *** use of rehabilitation robots not only alleviates the workload of healthcare professionals but also enhances the prognosis for specific stroke *** review presents a concise overview of the application of therapeutic robots in poststroke rehabilitation,with particular emphasis on the recovery of motor and cognitive function.

关键词： therapeutic robots post-stroke rehabilitation motor function cognitive function

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Publication trends of Leber congenital amaurosis researches:a bibliometric study during 2002-2022

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International Journal of Ophthalmology(English edition) 2024年第8期17卷 1501-1509页

作者： Xiao-Xu Huang Yi-Min Wang Min-Yue Xie Yi-Qing Sun Xiao-Huan Zhao Yu-Hong Chen Jie-Qiong Chen Si-Yang Han Min-Wen Zhou Xiao-Dong Sun Department of Ophthalmology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China National Clinical Research center for Eye Disease Shanghai 200080China shanghai Key Laboratory of Ocular Fundus Diseases Shanghai 200080China shanghai Engineering center for Visual Science and Photomedicine Shanghai 200080China Department of Ophthalmology Zhongshan HospitalFudan UniversityShanghai 200030China Beijing Tongren hospital Capital Medical UniversityBeijing 100054China Eberly College of Science Penn State UniversityUniversity Park 16802-1503United States

AIM:To analyze the changes in scientific output relating to Leber congenital amaurosis(LCA)and forecast the study trends in this ***:All of the publications in the field of LCA from 2002 to 2022 were collected from Web of Science(WOS)*** analyzed the quantity(number of publications),quality(citation and H-index)and development trends(relative research interest,RRI)of published LCA research over the last two ***,VOSviewer software was applied to define the co-occurrence network of keywords in this ***:A total of 2158 publications were ultimately *** found that the focus on LCA kept rising and peaked in 2015 and 2018,which is consistent with the development trend of gene *** USA has contributed most to this field with 1162 publications,56674 citations and the highest H-index value(116).The keywords analysis was divided into five clusters to show the hotspots in the field of LCA,namely mechanism-related,genotype-related,local phenotype-related,system phenotype-related,and *** also identified gene therapy and antiretinal degeneration therapy as a major focus in recent ***:Our study illustrates historical research process and future development trends in LCA *** may help to guide the orientation for further clinical diagnosis,treatment and scientific research.

关键词： VOSviewer bibliometrics Leber congenital amaurosis gene therapy hotpots

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Anti-metabolic agent pegaspargase plus PD-1 antibody sintilimab for first-line treatment in advanced natural killer T cell lymphoma

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1665-1674页

作者： Jie Xiong Shu Cheng Xiao Gao Shan-He Yu Yu-Ting Dai Xin-Yun Huang Hui-Juan Zhong Chao-Fu Wang Hong-Mei Yi Hao Zhang Wei-Guo Cao Rong Li Wei Tang Yan Zhao Peng-Peng Xu Li Wang Wei-Li Zhao shanghai Institute of Hematology State Key Laboratory of Medical GenomicsNational Research Center for Translational Medicine at ShanghaiRuijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina Department of Nuclear Medicine Shanghai Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Pathology Shanghai Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Otolaryngology Shanghai Rujin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Radiation Shanghai Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Hematology Navy Medical Center of PLAShanghaiChina Pole de Recherches Sino-Francais en Science du Vivant et Genomique Laboratory of Molecular PathologyShanghaiChina

Natural killer T cell lymphoma(NKTCL)is highly aggressive,with advanced stage patients poorly responding to intensive *** explore effective and safe treatment for newly diagnosed advanced stage NKTCL,we conducted a phase ll study of anti-metabolic agent pegaspargase plus PD-1 antibody sintilimab(NCT04096690).Twenty-two patients with a median age of 51 years(range,24-74)were enrolled and treated with induction treatment of pegaspargase 2500 IU/m2 intramuscularly on day 1 and sintilimab 200 mg intravenously on day 2 for 6 cycles of 21 days,followed by maintenance treatment of sintilimab 200 mg for 28 cycles of 21 *** complete response and overall response rate after induction treatment were 59%(95%Cl,43-79%)and 68%(95%Cl,47-84%),*** a median follow-up of 30 months,the 2 year progression-free and overall survival rates were 68%(95%Cl,45-83%)and 86%(95%Cl,63-95%),*** most frequently grade 3/4 adverse events were neutropenia(32%,n=7)and hypofibrinogenemia(18%,n=4),which were manageable and led to no discontinuation of *** proportion score of PD-L1,peripheral blood high-density lipoprotein cholesterol,and apolipoprotein A-l correlated with good response,while PD-1 on tumor infiltrating lymphocytes and peripheral Treg cells with poor response to pegaspargase plus sintilimab *** conclusion,the chemo-free regimen pegaspargase plus sintilimab was effective and safe in newly diagnosed,advanced stage *** lipid profle and immunosuppressive signature contributed to treatment resistance,providing an alternative therapeutic approach dual targeting fatty acid metabolism and CTLA-4 in NKTCL.

关键词： killer metabolism lymphoma

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