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Acta Geologica Sinica(English Edition) 2024年第2期98卷 303-310页

作者： ZHANG Honggang YIN Yalei PEI Rui ZHOU Changfu College of Earth Science and Engineering Shandong University of Science and TechnologyQingdaoShandong 266570China College of Paleontology Shenyang Normal UniversityShenyang 110034China Key Laboratory of Evolution of Past Life in NE Asia Ministry of Natural ResourcesShenyang 110034China Key Laboratory of Evolutionary Systematics of Vertebrates Institute of Vertebrate Paleontology and PaleoanthropologyChinese Academy of SciencesBeijing 100044China CAS Center for Excellence in Life and Paleoenvironment Beijing 100044China

Three eusauropod teeth(SDUST-V1064,PMOL-AD00176,PMOL-ADt0005)are reported from the Lower Cretaceous Yixian Formation of Ningcheng,southeastern Inner Mongolia,*** of them(SDUST-V1064,PMOL-AD00176)are assigned to early-diverging titanosauriforms in having slightly mesiodistal expansion at the base of the tooth crown,a slenderness index value>2.0 and<4.0,and D-shaped cross ***,SDUST-V1064 and PMOL-AD00176 are referred as an Euhelopus-like titanosauriform on the basis of having a sub-circular boss on the lingual surface and an asymmetrical crown-root margin which slants apically,*** scan data of SDUST-V1064 reveals new dental information of early-diverging titanosauriforms,for example,the enamel on the labial side thicker than that on the lingual side,an enamel/dentine ratio of 0.26 and a boss present on the lingual side of the dentine of the crown.

关键词： teeth Titanosauriformes Lower Cretaceous Yixian Formation Ningcheng

Total synthesis of a putative yuzurimine-type Daphniphyllum alkaloid C_(14)–epi-deoxycalyciphylline H

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Chinese Chemical Letters 2024年第4期35卷 336-339页

作者： Jingping Hu Jing Xu Shenzhen Grubbs Institute and Department of Chemistry and Guangdong provincial Key Laboratory of Catalysis and Shenzhen Key Laboratory of Small Molecule Drug Discovery and Synthesis Southern University of Science and TechnologyShenzhen 518055China

One of the largest subfamilies within the famous Daphniphyllum alkaloid family is made up of the yuzurimine-type(or macrodaphniphyllamine-type) alkaloids. Their complex aza-polycyclic caged structures, several contiguous stereogenic centers, and vicinal all-carbon quaternary centers make these alkaloids formidable challenge for synthetic chemists. Recently, synthesis of these alkaloids has received extensive attention from our community. Herein, we wish to report the total synthesis of C_(14)–epideoxycalyciphylline H, a putative member of yuzurimine-type alkaloid subfamily. Key transformations employed in our approach include an intramolecular Prins reaction and a Pd-catalyzed enyne cycloisomerization. In addition, synthesis of a daphnezomine L-type alkaloid, paxdaphnidine A, was also studied.

关键词： Total synthesis Daphniphyllum alkaloids Yuzurimine-type alkaloids Prins reaction Enyne cycloisomerization

Metal nanoparticles for cancer therapy:Precision targeting of DNA damage

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1132-1149页

作者： Qian Chen Chunyan Fang Fan Xia Qiyue Wang Fangyuan Li Daishun Ling Institute of Pharmaceutics Hangzhou Institute of Innovative MedicineCollege of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Frontiers Science Center for Transformative Molecules School of Chemistry and Chemical EngineeringNational Center for Translational MedicineShanghai Jiao Tong UniversityShanghai 200240China World Laureates Association(WLA)Laboratories Shanghai 201203China Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province Hangzhou 310009China

Cancer,a complex and heterogeneous disease,arises from genomic ***,DNA damage-based cancer treatments,including radiotherapy and chemotherapy,are employed in clinical ***,the efficacy and safety of these therapies are constrained by various factors,limiting their ability to meet current clinical *** nanoparticles present promising avenues for enhancing each critical aspect of DNA damage-based cancer *** customizable physicochemical properties enable the development of targeted and personalized treatment *** this review,we delve into the design principles and optimization strategies of metal *** shed light on the limitations of DNA damage-based therapy while highlighting the diverse strategies made possible by metal *** encompass targeted drug delivery,inhibition of DNA repair mechanisms,induction of cell death,and the cascading immune ***,we explore the pivotal role of physicochemical factors such as nanoparticle size,stimuli-responsiveness,and surface modification in shaping metal nanoparticle ***,we present insights into the challenges and future directions of metal nanoparticles in advancing DNA damage-based cancer therapy,paving the way for novel treatment paradigms.

关键词： DNA damage Metal nanoparticles Nucleus-targeting DNA repair inhibition Immune response Size optimization Stimuli-responsiveness Surface modification

Optimizing 3d spin polarization of CoOOH by in situ Mo doping for efficient oxygen evolution reaction

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Carbon Energy 2024年第1期6卷 236-244页

作者： Zhichao Jia Yang Yuan Yanxing Zhang Xiang Lyu Chenhong Liu Xiaoli Yang Zhengyu Bai Haijiang Wang Lin Yang Key Laboratory of Green Chemical Media and Reactions School of Chemistry and Chemical EngineeringCollaborative Innovation Center of Henan Province for Green Manufacturing of Fine ChemicalsMinistry of EducationHenan Normal UniversityXinxiangHenanChina School of Physics Henan Normal UniversityXinxiangHenanChina Oak Ridge National Laboratory Electrification and Energy Infrastructures DivisionOak RidgeTennesseeUSA Department of Mechanical and Energy Engineering Key Laboratory of Energy Conversion and Storage TechnologiesSouthern University of Science and TechnologyShenzhenGuangdongChina

Transition-metal oxyhydroxides are attractive catalysts for oxygen evolution reactions(OERs).Further studies for developing transition-metal oxyhydroxide catalysts and understanding their catalytic mechanisms will benefit their quick transition to the next ***,Mo-doped CoOOH was designed as a high-performance model electrocatalyst with durability for 20 h at 10 mAcm−***,it had an overpotential of 260 mV(glassy carbon)or 215 mV(nickel foam),which was 78 mV lower than that of IrO_(2)(338 mV).In situ,Raman spectroscopy revealed the transformation process of *** using the density functional theory showed that during OER,doped Mo increased the spin-up density of states and shrank the spin-down bandgap of the 3d orbits in the reconstructed CoOOH under the electrochemical activation process,which simultaneously optimized the adsorption and electron conduction of oxygen-related intermediates on Co sites and lowered the OER *** research provides new insights into the methodical planning of the creation of transition-metal oxyhydroxide OER catalysts.

关键词： electrocatalyst in situ Raman Mo-doped CoOOH oxygen evolution reaction

Unveiling a Novel Insulator-to-Metal Transition in La_(N)iO_(4+δ):Challenging High-Temperature Superconductivity Claimed for Single-Layer Lanthanum Nickelates

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Chinese Physics Letters 2024年第9期41卷 93-106页

作者： Yunqi Ji Xiaohan Wang Xiaohe Li Wenting Tang Xinyang Li Xin Wang Fangfei Li Liang Li Qiang Zhou Synergetic Extreme Condition User Facility State Key Laboratory of Superhard MaterialsCollege of PhysicsJilin UniversityChangchun 130012China

La_(2)NiO_(4)has a similar structure to La_(2)CuO_(4)and was proposed as a high-temperature superconductor based on magnetic-moment measurements decades ***,with the exception for electrical resistance drop behavior of about 4 orders of magnitude that is claimed to originate from the superconductivity ever observed in Sr-doped La_(N)iO_(4),most electrical data reported to date in La_(N)iO_(4)system exhibit a trivial insulating ground ***,we definitively identify the similar electrical resistance drop behavior of more than 3 orders of magnitude in La_(2)NiO_(4+δ).However,our extensive investigations reveal that this phenomenon is a novel insulatorto-metal transition,distinct from ***,compared to the weak magnetic-field effects,pressure can significantly suppress the transition and transform from the metallic to an insulating ground state,accompanied by an isostructural phase *** work not only elucidates the fundamental properties of the metallic conducting ground state in La_(N)iO_(4)+δ,but also critically challenges the notion of superconductivity in single-layer lanthanum nickelates.

关键词： resistance electrical metallic

Application of Natural Medicinal Plants Active Ingredients in Oral Squamous Cell Carcinoma

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Chinese Journal of Integrative Medicine 2024年第9期30卷 852-864页

作者： REN Qun-li LI Xiao-lan TIAN Tian LI Shuang SHI Rong-yi WANG Qian ZHU Yuan WANG Miao HU Huan LIU Jian-guo School of Stomatology Zunyi Medical UniversityZunyiGuizhou Province563000China Microbial Resources and Drug Development Key Laboratory of Guizhou Tertiary Institution Zunyi Medical UniversityZunyiGuizhou Province563000China School of Basic Medicine Zunyi Medical UniversityZunyiGuizhou Province563000China

Oral squamous cell carcinoma(OSCC)is the most common malignant cancer of the head and neck,with high morbidity and mortality,ranking as the sixth most common cancer in the *** treatment of OSCC is mainly radiotherapy,chemotherapy and surgery,however,the prognosis of patients is still poor and the recurrence rate is *** paper reviews the range of effects of natural medicinal plant active ingredients(NMPAIs)on OSCC cancer,including the types of NMPAIs,anti-cancer mechanisms,involved signaling pathways,and clinical *** NMPAIs include terpenoids,phenols,flavonoids,glycosides,alkaloids,coumarins,and volatile *** active ingredients inhibit proliferation,induce apoptosis and autophagy,inhibit migration and invasion of OSCC cells,and regulate cancer immunity to exert anti-cancer *** mechanism involves signaling pathways such as mitogen-activated protein kinase,phosphatidylinositol 3 kinase/protein kinase B,nuclear factor kappa B,miR-22/WNT1/β-catenin and Nrf2/***,NMPAIs can inhibit the growth of OSCC,and the combined drug is more *** medicinal plants are promising candidates for the treatment of OSCC.

关键词： natural medicinal plant active ingredients oral squamous cell carcinoma mechanism signaling pathway review

Resolving controversies surrounding carbon sinks from carbonate weathering

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Science China Earth Sciences 2024年第9期67卷 2705-2717页

作者： Xiaoyong BAI Sirui ZHANG Pete SMITH Chaojun LI Lian XIONG Chaochao DU Yingying XUE Zilin LI Mingkang LONG Minghui LI Xiaoyun ZHANG Shu YANG Qing LUO Xiaoqian SHEN State Key Laboratory of Environmental Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China University of Chinese Academy of Sciences Beijing 100049China Institute of Biological and Environmental Sciences University of AberdeenAberdeen AB243UUUK College of Resources and Environmental Engineering Guizhou UniversityGuiyang 550025China School of Geography and Environmental Sciences Guizhou Normal UniversityGuiyang 550025China CAS Center for Excellence in Quaternary Science and Global Change Xi’an 710061China

The importance of carbonate weathering carbon sinks(CCSs)is almost equal to that of vegetation photosynthesis in the global carbon ***,CCSs have become controversial in formulating carbon neutral policies to deal with global climate problems in various countries,since the carbonate dissolution is *** order to address these controversies,we reviewed recent advances in understanding CCSs and examined the outstanding controversies surrounding *** have analyzed the five controversies,revealing the existence of CCSs,quantifying their magnitude,clarifying their spatiotemporal pattern,and documenting how they have increased and how they evolved under the background of global *** addressing these five controversies,we help to bring clarity to the role of CCSs in the carbon cycle of global terrestrial ecosystems.

关键词： Carbon sink Carbonate weathering Carbon cycle Climate change Anthropogenic driver

Advance in reversible Zn anodes promoted by 2D materials

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Rare Metals 2024年第4期43卷 1350-1369页

作者： Shu-Yuan Lei Jin-Xiu Feng Yu-Chao Chen Dong Zheng Wen-Xian Liu Wen-Hui Shi Fang-Fang Wu Xie-Hong Cao School of Materials Science and Engineering Zhejiang University of TechnologyHangzhou310014China Center for Membrane Separation and Water Science and Technology College of Chemical EngineeringZhejiang University of TechnologyHangzhou310014China

With the growing energy demand associated with high safety and low-cost requirement,aqueous zinc-ion batteries(AZIBs)have been considered as one of the most promising next-generation ***,some key issues,such as uncontrollable dendrites growth,severe corrosion,hydrogen evolution and side reactions of Zn anodes during charge/discharge process,have hindered its pragmatic ***-dimensional(2D)materials hold advantages of unique physical and chemical properties,large surface areas and abundant active sites,which have been successfully used to overcome the above shortcomings of Zn anodes in recent *** this review,the issues and challenges of Zn anodes are ***,the state-of-the-art progress on Zn anodes modification based on 2D materials such as graphene,2D metal carbides and nitrides(MXenes),2D metal-organic frameworks(MOFs),2D covalent organic frameworks(COFs),2D transition metal compounds and other 2D materials is discussed in ***,the perspectives of employing 2D materials in highly reversible Zn anodes are summarized and discussed.

关键词： 2D materials Aqueous zinc-ion battery Zn anodes Dendrites growth

Improved damage tolerance and oxidation resistance of (Ti_(0.2)Zr_(0.2)Hf_(0.2)Nb_(0.2)Ta_(0.2))B_(2)–SiC by introducing chopped carbon fibers

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Journal of Advanced Ceramics 2024年第1期13卷 101-112页

作者： Feilong Huang Hailong Wang Cheng Fang Mingliang Li Gang Shao Jinpeng Zhu Yanchun Zhou School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450001China

High-entropy diborides(HEBs)are considered as promising high-temperature structure materials owing to their high melting point and excellent thermal ***,the intrinsic brittleness is the main obstacle that seriously limits their practical *** overcome with this obstacle,carbon fibers(Cf)with outstanding mechanical properties are used in the present work as a first attempt to improve the damage tolerance of *** as-prepared C_(f)/(Ti_(0.2)Zr_(0.2)Hf_(0.2)Nb_(0.2)Ta_(0.2))B_(2)–SiC composite(C_(f)/HEB–SiC)shows high relative density(97.9%)and good mechanical properties with flexural strength of 411±3 MPa and fracture toughness of 6.15±0.11 MPa·m^(1/2).More importantly,the damage tolerance parameter(Dt)has increased from 0.10 m^(1/2) for HEB–SiC to 0.29 m^(1/2) for C_(f)/HEB–*** microstructural analysis and Vickers indentation of the composite,the toughening mechanisms are *** carbon fibers coated with carbon coatings demonstrate unique capacity for prolonging the crack propagation path,which promotes the reliability of the composite ***,the C_(f)/(Ti_(0.2)Zr_(0.2)Hf_(0.2)Nb_(0.2)Ta_(0.2))B_(2)–SiC composite also exhibits good static oxidation resistance in the temperature range of 1100–1500℃in air due to the formation of the protective oxide layer constituting of multicomponent oxides(Zr)HfTiO4 and(Zr)Hf_(6)Ta_(2)O_(17) embedded in a continuous SiO_(2) *** results are promising,and this primary work can be used as a reference to the synthesis of C_(f)/HEBs for thermal protection materials under hightemperature serving conditions.

关键词： high-entropy ceramics carbon fibers(Cf) toughening mechanisms oxidation resistance

Total Synthesis of Laurane and Guaiane Sesquiterpenoids via Oxidative Nazarov Reaction

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Chinese Journal of Chemistry 2024年第11期42卷 1267-1274页

作者： Yuye Chen Wenqing Chen Zhiting Zhang Jing Xu Shenzhen Grubbs Institute and Department of Chemistry and Guangming Advanced research Institute and Guangdong provincial Key Laboratory of Catalysis and Shenzhen Key Laboratory of Small Molecule Drug Discovery and Synthesis Southern University of Science and TechnologyShenzhenGuangdong518055 China

As one of the most common structural motifs in natural products,cyclopentenones usually can be fabricated by Nazarov cyclization using divinyl ketones or functionalized tertiary divinyl carbinols(TDCs)as ***,straightforward method for transforming unfunctionalized TDCs to their corresponding cyclopentenones is currently ***,we wish to report the total syntheses of four structurally distinct terpenoids,namely laurane-type marine sesquiterpenoids isolaurene,debromoaplysin and aplysin,and guaiane sesquiterpenoid guaiadienone A,all using a novel synthetic method,named oxidative Nazarov cyclization,as the key *** work demonstrated our robust method is suitable for synthesizing various highly substituted cyclopentenones.

关键词： Total synthesis Synthetic methods Sesquiterpenoids Oxidative Nazarov reaction Electrocyclization Oxoammonium salt Pericyclic reaction Annulation