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dynamic recrystallization behavior and strengthening mechanism of a novel Mo-Ti_(3)AlC_(2) alloy at ultrahigh temperature

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rare Metals 2024年第8期43卷 3946-3960页

作者： Lu Yang Xin-Yuan Zheng Yang Zhao Xi-ran Wang Fang-Nao Xiao Shi-Zhong Wei School of Materials Science and Engineering Henan University of Science and TechnologyLuoyang 471023China National Joint Engineering research Center for Abrasion Control and Molding of Metal Materials Henan University of Science and TechnologyLuoyang 471003China department of Applied Mechanics Univ.Bourgogne FrancheComteFEMTO-ST InstituteCNRS/UF/ENSMM/UTBM25000BesangonFrance

Increasing the recrystallization temperature to achieve better high-temperature performance is critical in the development of molybdenum alloys for ultrahightemperature applications,such as the newest generation of multitype high-temperature nuclear *** this study,an innovative strategy was proposed to improve the performance of molybdenum alloys at high temperature by using the two-dimensional MAX(where M is an early transition metal,A is an A-group element and X is C or N)ceramic material Ti_(3)AlC_(2).The relationships between flow stress,strain rate and temperature were *** microstructure,distribution of misorientation and evolution of dislocations in the Mo-Ti_(3)AlC_(2) alloy were *** microscopic mechanism of the Ti_(3)AlC_(2) phase in the molybdenum alloy at high temperatures was *** experimental results showed that the peak flow stress of Mo-Ti_(3)AlC_(2) at 1600℃ reached 155 MPa,which was161.8% greater than that of pure *** activation energy of thermal deformation of Mo-Ti_(3)AlC_(2) was as large as537 kJ·mol~(-1),which was 17.6% more than that of pure *** recrystallization temperature reached 1600℃ or even *** topological reaction of the Ti_(3)AlC_(2) phase consumed a large amount of energy at high temperatures,resulting in increases in the deformation activation *** structures of AlTi_3 and Ti-O Magneli-phase oxides(Ti_nO_(2n-1)) were formed in-situ,which relied on kink bands and interlayer slip,resulting in many dislocations during ***,the special two-dimensional of the structure Ti_(3)AlC_(2) ceramic inhibited the recrystallization behavior of the Mo *** results of this study can provide theoretical guidance for the development of a new generation of molybdenum alloys for use in ultrahigh-temperature environments.

关键词： Mo alloy Two-dimensional reinforcement dynamic recrystallization behavior Hot deformation Mechanical properties

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Structure optimization of pulsed electric field processor and its sterilization effect

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Food Quality and Safety 2024年第1期8卷 92-104页

作者：田野樊文硕卢伟健张冠军常正实 School of Electrical Engineering Xi’an Jiaotong UniversityXi’anChina Guangdong Xi’an Jiaotong University Academy FoshanChina

Pulsed electric field(PEF)technology is a highly promising non-thermal processing technique,which holds great potential for sterilizing liquid *** effectiveness of this treatment depends on two crucial factors:pulse parameters and the structure of the *** this study,we focus on optimizing the shape of insulators within the PEF processor to improve the sterilization *** research provides a reliable technical reference for designing industrial *** numerical simulation of multi-physics fields was employed to analyze the temperature,electric field,and fluid field distributions for different ***,the geometric structure of the insulator was optimized by embedding a 0.7-mm *** experiments were then conducted on Escherichia coli and Staphylococcus aureus suspensions with conductivities similar to those of real grapefruit *** sterilization effect of the processor with the optimized structure and the maximum applied voltage was examined at the same driving *** results indicate that compared to the original structure,there is an increase in withstanding voltage by 5–10 kV while maintaining significantly improved bactericidal effects at the same applied ***,we preliminarily discussed the sterilization mechanism by combining electroporation theory with the electroporation threshold of ***.

关键词： Pulsed electric field multi-physics field simulation cellular transmembrane voltage electroporation.

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Sorafenib sensitization in tumor therapy by iron overload and AMPK activation

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Nano research 2024年第7期17卷 6386-6399页

作者： Jun Zhu Shoujie Zhao Yejing Zhu Shouzheng Ma Tenghui Han Fenghua Xu Huichen Li Bo Wang Zhixiong Guo da Chen Yongquan Qu Zhimin Tian Junlong Zhao Lei Liu State key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers National Clinical Research Center for Digestive DiseasesXijing HospitalFourth Military Medical UniversityXi’an 710032China department of General Surgery The Southern Theater Air Force HospitalGuangzhou 510602China department of General Surgery Tangdu HospitalFourth Military Medical UniversityXi’an 710038China department of Thoracic Surgery Tangdu HospitalFourth Military Medical UniversityXi’an 710038China department of Neurology Airborne Army HospitalWuhan 430012China key Laboratory of Modern Teaching Technology(Ministry of Education) Shaanxi Normal UniversityXi’an 710062China State key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers Department of Biochemistry and Molecular BiologySchool of Basic MedicineFourth Military Medical UniversityXi’an 710032China key Laboratory of Special Functional and Smart Polymer Materials of Ministry of Industry and Information Technology School of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi’an 710072China State key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers Department of Medical Genetics and Developmental BiologyFourth Military Medical UniversityXi’an 710032China department of Pediatrics Tangdu HospitalFourth Military Medical UniversityXi’an 710000China

Sorafenib,as a first-line drug for advanced hepatocellular carcinoma(HCC),could trigger ferroptosis by inhibiting cystine/glutamate ***,low-level intracellular iron and insufficient activation of adenosine monophosphate(AMP)-activated protein kinase(AMPK)confer impaired response to *** this study,a unique sorafenib nanocomposite dexterously modified with Fe-Material of Institut Lavoisier(sora@Fe-MIL)was synthesized to escalate intracellular iron level and activate AMPK,further potentiating the ferroptotic effect of ***,this strategic deployment of sora@Fe-MIL triggered an extensive demise of cancer cells,while manifesting negligible deleterious impact on normal *** prominent ferroptosis biomarkers,glutathione peroxidase 4(GPX4)and solute carrier family 7 member 11(SLC7A11),underwent pronounced downregulation,underscoring the efficacy of this strategy in inducing ***,the bioactivity of AMPK was considerably elevated,and its downstream targets were conspicuously inhibited by the treatment with sora@*** orthotopic HCC animal models,we observed a substantial suppression of primary in situ tumor growth,and ribonucleic acid(rNA)sequencing elucidated an elevated degree of ferroptosis and AMPK activation with the treatment of sora@*** conclusion,we proposed that the meticulously designed strategy for secure and efficacious iron release and AMPK activation could significantly potentiate the ferroptotic impact of sorafenib,thus resuscitating its therapeutic response in HCC patients.

关键词： anti-tumor ferroptosis Fe-Material of Institut Lavoisier(Fe-MIL) sorafenib adenosine monophosphate(AMP)-activated protein kinase(AMPK)

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Layer by Layer Self-assembly Fiber-based Flexible Electrochemical Transistor

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Journal of Wuhan University of Technology(Materials Science) 2024年第4期39卷 937-944页

作者：谭艳 HAO Panpan HE Yang ZHU rufeng 王跃丹 School of Biomedical Engineering Hubei University of MedicineShiyan 442000China key Laboratory of Textile Fiber and Products Ministry of EducationWuhan Textile UniversityWuhan 430200China

Poly(3,4-ethylenedioxyethiophene)-polystyrene sulfonic acid(PEdOT:PSS)/polyallyl dimethyl ammonium chloride modified reduced graphene oxide(PddA-rGO)was layer by layer self-assembled on the cotton *** surface morphology and electric property was *** results confirmed the dense membrane of PEdOT:PSS and the lamellar structure of PddA-rGO on the *** has excellent electrical conductivity and mechanical *** fiber based electrochemical transistor(FECTs)prepared by the composite conductive fiber has a maximum output current of 8.7 mA,a transconductance peak of 10 mS,an on time of 1.37 s,an off time of 1.6 s and excellent switching *** importantly,the devices by layer by layer self-assembly technology opens a path for the true integration of organic electronics with traditional textile technologies and materials,laying the foundation for their later widespread application.

关键词： layer by layer self-assembly fiber based organic electrochemical transistor reduced graphene oxide PEdOT:PSS

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Vibration and noise mechanism of a 110 kV transformer under dC bias based on finite element method

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Global Energy Interconnection 2024年第4期7卷 503-512页

作者： Ziyang Li Xujun Lang Bo Yang Xiaolin Liu Hao Wang Zhang Li Shandong Electric Power Engineering Consulting Institute Co. Ltd.Jinan 250013P.R.China School of Electrical Engineering Shandong UniversityJinan 250061P.R.China

Global energy and environmental issues are becoming increasingly problematic,and the vibration and noise problem of 110 kV transformers,which are the most widely distributed,have attracted widespread attention from both inside and outside the *** bias is one of the main contributing factors to vibration noise during the normal operation of *** clarify the vibration and noise mechanism of a 110 kV transformer under a dC bias,a multi-field coupling model of a 110 kV transformer was established using the finite element *** electromagnetic,vibration,and noise characteristics during the dC bias process were compared and quantified through field circuit coupling in parallel with the power frequency of AC,harmonic,and dC power *** was found that a dC bias can cause significant distortions in the magnetic flux density,force,and displacement distributions of the core and *** contributions of the dC bias effect to the core and winding are different at Kdc=*** this point,the core approached saturation,and the increase in the core force and displacement ***,the saturation of the core increased the leakage flux,and the stress and displacement of the winding increased *** sound field distribution characteristics of the 110 kV transformer under a dC bias are related to the force *** the dC bias coefficient was 1.25,the noise sound pressure level reached 73.6 dB.

关键词： Transformer dC bias Vibration Noise

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dCVAE-adv:A Universal Adversarial Example Generation Method for White and Black Box Attacks

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Tsinghua Science and Technology 2024年第2期29卷 430-446页

作者： Lei Xu Junhai Zhai College of Mathematics and Information Science Hebei UniversityBaoding 071002China

deep neural network(dNN)has strong representation learning ability,but it is vulnerable and easy to be fooled by adversarial *** order to handle the vulnerability of dNN,many methods have been *** general idea of existing methods is to reduce the chance of dNN models being fooled by observing some designed adversarial examples,which are generated by adding perturbations to the original *** this paper,we propose a novel adversarial example generation method,called *** from the existing methods,dCVAE-adv constructs adversarial examples by mixing both explicit and implicit perturbations without using original ***,the proposed method can be applied to both white box and black box *** addition,in the inference stage,the adversarial examples can be generated without loading the original images into memory,which greatly reduces the memory *** compared dCVAE-adv with three most advanced adversarial attack algorithms:FGSM,AdvGAN,and AdvGAN++.The experimental results demonstrate that dCVAE-adv is superior to these state-of-the-art methods in terms of attack success rate and transfer ability for targeted *** code is available at https://***/xzforeverlove/dCVAE-adv.

关键词： deep neural network adversarial examples white box attack black box attack robustness

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rapid synthesis of oxygen-defected molybdenum oxides quantum dots as efficient nanozymes for healing diabetic ulcers

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Nano research 2024年第7期17卷 6376-6385页

作者： Fangjun Cao Hui Feng Jiaxin Yao Xiang Hou Tiezhi Jin Junfeng Hui shaanxi key Laboratory of Qinling Ecological Security Shaanxi Institute of ZoologyXi’an 710072China Engineering research Center of Western resource Innovation Medicine Green Manufacturing Ministry of EducationSchool of Chemical EngineeringNorthwest UniversityXi'an 710069China shaanxi key Laboratory of degradable Biomedical Materials and shaanxi r&d Center of Biomaterials and Fermentation Engineering School of Chemical EngineeringNorthwest UniversityXi'an 710069China

The continuous inflammatory response in diabetic skin wounds leads to excessive production of reactive oxygen species,which cause a vicious circle of long-term *** the therapeutic research of metal nanoenzymes for healing diabetic ulcers,it still faces the challenges in poor nanoenzymes activity and low-efficient therapeutic ***,ultrasmall oxygen-deficient MoO_(3−X)quantum dots were fabricated and employed as nanoenzymes for healing fiabetic *** PEGylation,PEGylated MoO_(3−X)quantum dots(MoO_(3−X)/PEG)with oxygen vacancies exhibits excellent photothermal,peroxidase/catalase-like *** addition,these MoO_(3−X)/PEG showed superior properties in scavenging H_(2)O_(2)and effectively inhibiting the scavenging of reactive oxygen *** importantly,such an oxygen-defected MoO_(3−X)/PEG had obvious antibacterial and skin repairing effects on alleviating hypoxia and excessive oxidative stress even in a mouse model of diabetic ulcers,inhibiting proinflammatory cytokines and significantly accelerating the healing of infected wounds,which shows great application potential for promoting wound *** work highlights that the developed oxygen defected molybdenum oxide compounds capable of peroxidaselike and catalase-like activities show great application potential for healing diabetes wound.

关键词： oxygen-defected molybdenum-based nanoenzymes antioxidant anti-inflammatory diabetes ulcer wounds

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Experimental study on the CO_(2) concentration and age of air distribution inside tiny sleeping spaces

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Building Simulation 2024年第4期17卷 591-605页

作者： Jingying Zhang Yanyan Li Haiguo Yin Linfeng Liang Songmei Zu Le Gao Ying Zhang Angui Li School of Building Services Science and Engineering Xi’an University of Architecture and TechnologyXi’anShaanxi710055China

In recent years,rapid urban development has led to capsule hotels,sleep pods,and other tiny sleeping spaces that adapt to people’s fast-paced lives,achieving maximum functionality with a very small ***,due to the small space,human metabolic pollutant(such as CO_(2))is more likely to accumulate,and the air is not easily *** this paper,a full-size experimental platform is set up with three types of ventilation modes to explore the exclusion efficiency of metabolic pollutants and the overall distribution of age of air under these ventilation *** conclusions showed that the mean values of metabolic pollutant exclusion rates for the different ventilation modalities varied very little across the spatial dimensions of the confined space but varied considerably in the area around the *** double-side attached ventilation method was the most effective in removing human metabolic pollutants,especially in the head region(CN≥0.92),while the single-wall attached ventilation method had the best air exchange efficiency(η≥0.85).This suggests an inconsistent distribution of CO_(2) and age of air,which is contrary to general common *** conclusions of this paper can guide the design of ventilation for tiny sleeping spaces.

关键词： attached ventilation mode human metabolic pollutant indoor air quality air exchange efficiency tiny sleeping spaces

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EdU-GAN:Edge Enhancement Generative Adversarial Networks with dual-domain discriminators for Inscription Images denoising

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Computers, Materials & Continua 2024年第7期80卷 1633-1653页

作者： Yunjing Liu Erhu Zhang Jingjing Wang Guangfeng Lin Jinghong duan School of Mechanical and Precision Instrument Engineering Xi’an University of TechnologyXi’an710048China department of Information Science Xi’an University of TechnologyXi’an710054China School of Faculty of Painting Packaging Engineering and Digital MediaXi’an University of TechnologyXi’an710048China School of Computer Science and Engineering Xi’an University of TechnologyXi’an710048China

recovering high-quality inscription images from unknown and complex inscription noisy images is a challenging research *** fromnatural images,character images pay more attention to stroke ***,existingmodelsmainly consider pixel-level informationwhile ignoring structural information of the character,such as its edge and glyph,resulting in reconstructed images with mottled local structure and character *** solve these problems,we propose a novel generative adversarial network(GAN)framework based on an edge-guided generator and a discriminator constructed by a dual-domain U-Net framework,i.e.,*** existing frameworks,the generator introduces the edge extractionmodule,guiding it into the denoising process through the attention mechanism,which maintains the edge detail of the restored inscription ***,a dual-domain U-Net-based discriminator is proposed to learn the global and local discrepancy between the denoised and the label images in both image and morphological domains,which is helpful to blind denoising *** proposed dual-domain discriminator and generator for adversarial training can reduce local artifacts and keep the denoised character structure *** to the lack of a real-inscription image,we built the real-inscription dataset to provide an effective benchmark for studying inscription image *** experimental results show the superiority of our method both in the synthetic and real-inscription datasets.

关键词： dual-domain discriminators inscription images denoising edge-guided generator

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Three anti-inflammatory polysaccharides from Lonicera japonica Thunb.:insights into the structure-function relationships

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Food Science and Human Wellness 2024年第4期13卷 2197-2207页

作者： Yu Liu Hongjing dong dongxiao Sun-Waterhouse Wenwen Li Bin Zhang Jinqian Yu Zhichang Qiu Zhenjia Zheng key Laboratory of Food Nutrition and Health in Universities of Shandong College of Food Science and EngineeringShandong Agricultural UniversityTai’an 271018China key Laboratory for Applied Technology of Sophisticated Analytical Instruments of Shandong province Shandong Analysis and Test CenterQilu University of Technology(Shandong Academy of Sciences)Jinan 250014China School of Chemical Sciences The University of AucklandPrivate Bag 92019New Zealand

This study demonstrates the feasibility of producing three polysaccharides(neutral LJP-1,acidic LJP-2 and acidic LJP-3)with significant in vitro and in vivo anti-inflammatory activities from the flowers of Lonicera *** three polysaccharides differed in chemical composition,molecular weight(Mw)distribution,glycosidic linkage pattern,functional groups and *** exhibited excellent protective effects(in a dose-dependent manner)in lipopolysaccharide-injured rAW264.7 macrophages and Cu SO4-damaged zebrafish via reducing NO production and inhibiting the overexpressions of inflammation-related transcription factors,inflammatory proteins and cytokines in the NF-κB/MAPK signaling *** antiinflammatory effects varied owing to their different molecular characteristics and chemical ***,LJP-2 at 400μg/m L was the most ***-2 consisted mainly of→5)-α-L-Araf(1→,→4)-α-LGalp A(1→and→2)-α-L-rhap(1→residues with terminal T-β-***,honeysuckle flowers are good sources of anti-inflammatory polysaccharides,and precise fractionation enables the production of potent antiinflammatory agents for the development of functional foods and healthcare products.

关键词： Honeysuckle polysaccharides Fractionation Molecular characteristics Anti-inflammatory properties Structure-function relationship

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