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Raman and UV-Vis Spectroscopy Applied to the Analysis of Liver Tissues from Rats with Myocardial Ischemia Induced by Isoproterenol

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Chemical Research in Chinese Universities 2011年第4期27卷 570-573页

作者： GAO Hai-cheng ZOU Ying-gang HUANG Yu-xin GAO Hai-mei CHEN Lei PEI Jin School of Pharmaceutical Sciences Jilin University Changchun 130012 P. R. China Department of Obstetrics ＆ Gynecology the Second Hospital of Jilin University Changchun 130041 P. R. China Basic Science College Changchun University of Technology Changchun 130012 P. R. China Key Laboratory for Molecular Enzymology and Engineering Ministry of Education Jilin University Changchun 130012 P. R. China

The application of the laser Raman spectroscopic（LRS） technique for the analysis of liver tissues from rats with myocardial ischemia induced by isoproterenol（ISO） was *** model of myocardial ischemia was established for rats induced by *** were randomly divided into four groups as normal group and myocardial ischemia *** observed the successful myocardial ischemia model via serum enzymes levels and hematoxylin-eosin（HE） staining,and detected the liver tissue of the rats from normal group and liver tissue of the rats from myocardial ischemia groups via UV-Vis spectroscopy（UV-Vis） and LRS,and the changes of the absorbance spectra were compared in the above four different *** results show that ISO can induce rat myocardial ischemia *** spectrum of normal liver tissue supernatant exhibits a strong absorption band at 968 nm,but no absorption band appears in the spectra of liver tissue supernatant solutions from the rats with myocardial ischemia induction after 2,12 and 72 h presented at 968 *** results show that Raman intensities of the precipitates suffered from ISO-treatment after 2,12 and 72 h were obviously increased compared with that of the precipitate of the liver tissue of the normal rats suffered from 0.9 g/L normal saline（NS） *** results indicate that LRS and UV-Vis can be harmless,nondestructive,rapid and effective methods for analyzing different pathological specimens of liver tissue from myocardial ischemia rats.

关键词： Laser Raman spectroscopy UV-Vis spectroscopy Isoproterenol Myocardial ischemia Rat Liver tissue

Bioinformatics analysis of microarray data to explore the key genes involved in HSF4 mutation-induced cataract

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International Journal of Ophthalmology(English edition) 2018年第6期11卷 910-917页

作者： Rui Tian Yang Xu Wen-Wen Dou Hui Zhang Department of Ophthalmology the Second Hospital of Jilin University Department of Oral and Maxillofacial Surgery School of Stomatology of Jilin University

AIM： To reveal the mechanisms of heat-shock transcription factor 4 （HSF4） mutation-induced ***： GSE22362, including 3 HSF4-null lens and 3 wild-type lens, was obtained from Gene Expression Omnibus database. After data preprocessing, the differentially expressed genes （DEGs） were identified using the limma package. Based on Database for Annotation, Visualization and Integrated Discovery （DAVID） tool, functional and pathway enrichment analyses were performed for the DEGs. Followed by protein-protein interaction （PPI） network was constructed using STRING database and Cytoscape software. Furthermore, the validated microRNA （miRNA）-DEG pairs were obtained from miRWalk2.0 database, and then miRNA-DEG regulatory network was visualized by Cytoscape software. RESULTS： A total of 176 DEGs were identified in HSF4-null lens compared with wild-type lens. In the PPI network, FBJ osteosarcoma oncogene （FOS）, early growth response 1 （EGR1） and heme oxygenase （decycling） 1 （HMOX1） had higher degrees and could interact with each other. Besides, mmu-miR-15a-5p and mmu-miR-26a-5p were among the top 10 miRNAs in the miRNA-DEG regulatory network. Additionally, mmu-miR-26a-5p could target EGR1 in the regulatory network. CONCLUSION： FOS, EGR1, HMOX1, mmu-miR-26a-5p and mmu-miR-15a-5p might function in the pathogenesis of HSF4 mutation-induced cataract.

关键词： cataract heat-shock transcription factor 4 differentially expressed genes protein-protein interaction network regulatory network

Microstructural evolution and aging behavior of Mg-4.5Y-2.5Nd-1.0Gd-0.5Zr alloys with different Zn additions

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Rare Metals 2021年第8期40卷 2188-2196页

作者： Zheng Tian Qiang Yang Kai Guan Zhan-Yi Cao Jian Meng Key Laboratory of Automobile Materials of Ministry of Education Department of Materials Science and EngineeringJilin UniversityChangchun130025China State Key Laboratory of Rare Earth Resources Utilization Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022China

Microstructures and mechanical properties of Mg-4.5 Y-2.5 Nd-1.0 Gd-0.5 Zr-xZn(x=0,0.5,1.0,and 1.5;wt%)alloys under as-cast and peak-aged states were investigated in this *** results indicate that the intermetallic phase components are closely dependent on Zn *** as-cast state,the dominant eutectic phase is Mg5 RE in the alloys with 0 wt%and 0.5 wt%Zn additions while Mg5 RE,18 R-and 14 H-LPSO(long period stacking ordered)phases in the alloys with 1.0 wt%and1.5 wt%Zn *** solution and peak-aging,the highest strength and hardness were obtained on the alloy with 0.5 wt%Zn *** electron microscopy(TEM)characterizations revealed that there are denser and finer precipitates on basal(β’)and prismatic(γ’)planes,***,the excellent mechanical performance of the alloy with 0.5 wt%Zn addition is mainly due to precipitation strengthening and grain boundary strengthening.

关键词： Magnesium alloy Intermetallic phase Precipitates Mechanical property

Lath-like phases formed at an extremely high temperature in a Mg-RE(RE=rare earth)-Al alloy

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Rare Metals 2024年第8期43卷 3937-3945页

作者： Bo Deng Shu-Hui Lv Qiang Yang Dong-Yue Zhao Jun-Yuan Fan Xin Qiu School of Materials Science and Engineering Changchun University of Science and TechnologyChangchun 130022China State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China Chongqing Research Institute Changchun University of Science and TechnologyChongqing 401135China

Thermal stable intermetallic particles are important for the heat resistance of magnesium(Mg)*** this work,many lath-like particles formed in α-Mg grains of a Mg-8Gd-3Sm-0.7Al casting alloy when heat-treated at 873 ***-resolution high-angle annular dark field scanning transmission electron microscopy(HAADF-STEM) characterizations indicate that most of them are Mg-containing Al_(2)(Gd,Sm),with the atomic ratio of Mg:Al:(Gd,Sm) being ~1:1:1;a small part of them with relatively wider thickness are long-period stacking ordered(LPSO) phases simultaneously containing both 14H and 18R *** followed common orientation relationships with Mg matrix as those reported in previous *** addition,many Mg laths were observed in the primary blocky Al_(2)(Gd,Sm) phase at grain boundaries,where the atomic ratio of Al:(Gd,Sm) in the Al_(2)(Gd,Sm) matrix was 2:***,density functional theory(DFT) calculations illustrated the detail structure of the re-constructed Mg/Al_(2)RE interface and simultaneously deduced the underlying reason for the re-dissolution of the newly formed Mg-containing Al_(2)(Gd,Sm) plates in α-Mg matrix.

关键词： Magnesium alloy HAADF-STEM Microstructures Intermetallic particles Orientation relationships Interfaces

Fabrication of Novel Scaffolds Containing Collagen-I/Polylactic Acid/Nanohydroxyapatite via Co-electrospinning Methods

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Chemical Research in Chinese Universities 2010年第4期26卷 662-666页

作者： ZANG Jun-ting QI Xin LI Shu-qiang LI Dong-song GONG Yu-bao YANG Chen XU Feng LIU Jian-guo Department of Bone and Joint Surgery First Hospital of Jilin University Changchun 130021 P R. China

A novel scaffold containing collagen-I/polylactic acid（PLA）/nanohydroxyapatite（nHA） was prepared via co-electrospinning method. Different target substrates were used to improve the collection efficiency of this scaffold. The properties of the novel scaffold were compared with those of conventionally prepared ones. Compared to con- ventional method, the modified method was more efficient in producing the scaffold. Moreover, the porosity, thickness, and morphology of the novel scaffold were better than those of scaffolds prepared by conventional methods. The properties of collagen-I, collagen-I/PLA and collagen-I/PLA/nHA scaffolds were also compared. Diameters of the electrospun fibers ranged from 180 to 405 nm, and roughness was present on the surface of the fibers due to the deposition of crystals of nHA along the long axis of the fibers. The fibers of the collagen-I/PLA/nHA scaffold and the fibers of natural bone tissue had similar structure.

关键词： Electrospinning Collagen-I PLA Nanohydroxyapatite

Effect of Qiangxin Huoli decoction on rats with adriamycin-induced chronic heart failure

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Journal of Traditional Chinese Medicine 2019年第1期39卷 81-88页

作者： Gao Ling Yang Ting Zhu Jiaqi Xu Lei Su Li Wang Di Encephalopathy of Internal Medicine of Trational Chinese Medicine Changchun University of Chinese MedicineJilin 130117China Department of Trational Chinese Medicine the Second People's Hospital of Chengyang District of QingdaoQingdao 266000China Reproductive Center of the First Hospital Of jilin University Jilin 130041China Department of Kidney Disease Traditional Chinese Medicine Hospital of Huangdao DistrictQingdao 266500China Department of Formulas of Chinese medicine Changchun University of Chinese MedicineJilin 130117China

OBJECTIVE: To investigate the effect of Qiangxin Huoli decoction on rats with chronic heart failure(CHF) induced by adriamycin(ADR), and to investigate the underlying mechanism of this ***: Ninety-six healthy Wistar rats were divided into six groups: control, CHF model, CHF treated by Shenfu injection, and three CHF groups treated with Qiangxin Huoli decoction at high, medium, and low doses, respectively. Qiangxin Huoli decoction was administered orally to protect the stomach in the three Qiangxin Huoli decoction groups, while the control group and the CHF model group were administered the same volume of 0.9% physiological saline, and the Shenfu group wereadministered the same volume of Shenfu injection. Ten days later, the CHF model was then induced in all groups except the control group by intraperitoneal injection of ADR at gradient dose intervals. The bodyweights were recorded on days 10, 20, 30, and 40. Hemodynamic indices were recorded, including left ventricular systolic pressure(LVSP), left ventricular end-diastolic pressure(LVEDP), maximum increase in left ventricular pressure(+dp/dt_(max)), maximum decrease in left ventricular pressure(-dp/dt_(max)), heart rate(HR), and electrocardiogram using an eight-channel physiological recorder with LabChart software monitoring. The plasma brain natriuretic peptide(BNP) concentration was determined by enzyme-linked immunosorbent adsorption. The expressions of B-cell lymphoma-2(Bcl-2) and Bcl-2-associated X protein(Bax) were detected by immunohistochemical ***: The CHF model group were in poor condition, and the mean bodyweight was significantly decreased compared with the control group. Furthermore, compared with the control group, the CHF groups had significantly decreased LVSP, +dp/dt_(max), and-dp/dt_(max), and significantly increased LVEDP. The CHF groups also showed significant increases in HR, S-T segment elevation, and plasma BNP levels compared with the control group. Compared with the C

关键词： Heart failure Hemodynamics Doxorubicin Natriuretic peptide,brain Genes,bcl-2 Bcl-2associated X protein Qiangxin Huoli decoction

Microstructures and mechanical properties of a newly developed high-pressure die casting Mg-Zn-RE alloy

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Journal of Materials Science & Technology 2020年第18期52卷 174-184页

作者： Xiru Hua Qiang Yang Dongdong Zhang Fanzhi Meng Chong Chen Zihao You Jinghuai Zhang Shuhui Lv Jian Meng Key Laboratory of Superlight Materials&Surface Technology Ministry of EducationHarbin Engineering UniversityHarbin150001China State Key Laboratory of Rare Earth Resources Utilization.Changchun Institute of Applied Chemistry Chinese Academy of SciencesChangchun130022China School of Materials Science and Engineering Changchun University of Science and TechnologyChangchun130022China

A newly developed Mg-4Zn-2La-3Y alloy with high strength was fabricated by high-pressure die casting method,and its microstructures were thoroughly studied using transmission electron *** results demonstrate that it owns fine grains and approximately highly interconnected intermetallic phase skeletons,and exhibits ultra-high strength at both room and high ***,the eutectic intermetallic skeleton of this alloys is consisted of numerous fine particles,which are mainly consisted of two intermetallic phases,namely W and ***{101}twins and SFs were found in the Mg12RE phase while a few of SFs in the W ***,minor long-period stacking ordered phase was observed in the eutectoid phase,and it probably nucleated on the Mg12RE phase following a certain OR as(0002)14H//(110)Mg12REand[1120]14H//[111]Mg12RE,or(0002)14H//(211)Mg12REand[1120]14H//[111]*** special intermetallic skeleton with many interfaces and planar faults can efficiently transfer dislocations across grain boundaries,and this is the key factor for the outstanding mechanical properties of the studied alloy.

关键词： Magnesium alloys High-pressure die casting(HPDC) Transmission electron microscopy(TEM) Intermetallic phase Mechanical properties

Characterizations on the instantaneously formed Ni-containing intermetallics in magnesium alloys

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Journal of Magnesium and Alloys 2023年第8期11卷 2991-2998页

作者： Shuhui Lv Qiang Yang Fanzhi Meng Jian Meng School of Materials Science and Engineering Changchun University of Science and Technology 130022PR China State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022PR China

Instantaneous reactions of Al,Mn,Zn,Zr and Y with Ni by mixing the prepared Mg-8Al-0.4Mn,Mg-6Zn-2Y-0.5Zr and Mg-0.6Ni melts were investigated in this work to reveal the underlying mechanisms of their effects on the removal of Ni *** results indicate three Ni-containing intermetallics,namely Al_(4)NiY,Al_(4)Ni(Y,Zr)and Al_(31)Ni_(2)Mn_(6).The former two phases present lath-like and have a relatively larger size(>20μm in length)than the latest one which is granular with the diameter of∼120 *** illustrates that Al and Y(/Zr)can efficiently remove Ni by forming Al_(4)NiY or Al_(4)Ni(Y,Zr)which would precipitate to the bottom of the ***,adding Y into Mg-Al based alloys can simultaneously remove Fe and Ni,which contributes their excellent corrosion ***,this paper proposes two methods helped to efficiently remove Ni for both Mg-Al based alloys and Al-free Mg alloys,and both of them are also benefit to improve alloys’strength.

关键词： Magnesium alloys Intermetallics Nickel Transmission electron microscopy(TEM) Impurity

A new high-pressure die casting Mg-Gd-Sm-Al alloy with high strength-ductility synergy

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Journal of Rare Earths 2024年第12期42卷 2239-2248,I0002页

作者： Shuhui Lv Youwei Cheng Bo Deng Tao Xu Xin Qiu Qiang Yang School of Materials Science and Engineering Changchun University of Science and TechnologyChangchun130022China State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022China Kashui International Holdings Limited Shenzhen518111China

A high-pressure die casting(HPDC)Mg-5Gd-1.5Sm-0.7Al alloy was newly developed and exhibits outstanding strength-ductility synergy,with the yield strength and the tensile elongation to fracture being approximately 200 MPa and 8.5%,*** alloy has two types of a-Mg grains:coarse a_(1)-Mg((46±18)μm)and fine a_(2)-Mg((9.2±2.3)μm)grains,and various Al-GS(GS=Gd and Sm)particles located at grain boundaries while clear solute-atom segregation near grain boundaries with limited or free intermetallic *** using Cs-corrected high-angle annular dark-field scanning transmission electron microscopy(HAADF-STEM)indicate the crystal structures of Al-GS *** aging,denseβ'precipitates and chain-shapedβ''-like structures precipitated near grain boundaries while a high density of ultrafineβ''-(Mg,Al)3Sm precipitates and Al-GS clusters formed in grain *** fine grains,Al-GS primary particles,solute-atom segregation near grain boundaries,and/or multiple precipitates contribute to the high strength of the studied alloy,while the multi-scale a-Mg grains,variety of intermetallic particles but discontinuous skeleton,and the multi-typed precipitated lead to its satisfactory ductility.

关键词： Magnesium alloys Strength-ductility synergy Intermetallic phases Scanning/transmission electron microscopy (STEM)Precipitate Rare earths