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Integrated multi-omics reveals the relationship between growth performance,rumen microbes and metabolic status of Hu sheep with different residual feed intakes

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Animal Nutrition 2024年第3期18卷 284-295页

作者： Yanzhen Zhang Xiaowei Zhang Dingren Cao Jinyong Yang Huiling Mao Lingling Sun Chong Wang College of Animal science and technology College of Veterinary MedicineZhejiang A&F UniversityHangzhou 311300China Key Laboratory of Applied technology on Green-Eco-Healthy Animal Husbandry of zhejiang province Hangzhou 311300China zhejiang Provincial Animal Husbandry technology Promotion and Monitoring Station of Breeding Livestock and Poultry Hangzhou 310021China Department of Animal science Shandong Vocational Animal Science and Veterinary CollegeWeifang 261061China

Residual feed intake(RFI)is a metric that provides a more accurate measure of feed *** lower the RFI,the higher the feed *** changes in the host microbiome and metabolome contribute to the greater feed efficiency of low RFI(LRFI)*** aim of this study was to explore the differences in rumen microorganisms,rumen metabolites and plasma metabolites of Hu sheep with differing RFI through the microbiome and metabolome.A total of 80 Hu sheep were *** experiment consisted of a 15-d pretrial period and a 128-d experimental *** RFI in the experimental period was calculated for all sheep,and the sheep were screened into high RFI(HRFI,n=8)and LRFI(n=8)*** HRFI and LRFI sheep did not differ in their initial and final body weights,average daily gain and body measurements,but the dry matter intake of LRFI sheep was significantly decreased(28.4%,P<0.001).The sheep with LRFI had higher digestibility of crude protein(P=0.010)and ether extract(P=0.010)compared to HRFI *** concentrations of acetate(P=0.036),propionate(P=0.010),valerate(P=0.027)and total volatile fatty acids(P=0.048)in rumen of LRFI group were higher compared to HRFI *** results of 16S rDNA sequencing indicated that the sheep with LRFI had higher proportions of Prevotella genus in rumen liquid(P=0.031).The rumen metabolome and plasma metabolome results showed that the citrate cycle,pyruvate metabolism and alanine,aspartate and glutamate metabolism processes were more active for sheep in LRFI group,which provided more energy substrate such as malic acid,oxoglutaric acid and citric *** conclusion,sheep with LRFI can utilize feed more efficiently,and the more active energy metabolism pathway and the production of energy substances may account for the higher feed efficiency.

关键词： Feed efficiency Residual feed intake Rumen microbiome and metabolome Plasma metabolome

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Multisensory Conflict Impairs Cortico-Muscular Network Connectivity and Postural Stability: Insights from Partial Directed Coherence Analysis

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Neuroscience Bulletin 2024年第1期40卷 79-89页

作者： Guozheng Wang Yi Yang Kangli Dong Anke Hua Jian Wang Jun Liu Key Laboratory for Biomedical Engineering of Ministry of Education College of Biomedical Engineering&Instrument ScienceZhejiang UniversityHangzhou 310058China Taizhou Key Laboratory of Medical Devices and Advanced Materials Research Institute of Zhejiang University-TaizhouTaizhou 318000China Department of Sports science College of EducationZhejiang UniversityHangzhou 310058China Center for Psychological science Zhejiang UniversityHangzhou 310058China

Sensory conflict impacts postural control,yet its effect on cortico-muscular interaction remains *** aimed to investigate sensory conflict's influence on the cortico-muscular network and postural *** used a rotating platform and virtual reality to present subjects with congruent and incongruent sensory input,recorded EEG(electroencephalogram)and EMG(electromyogram)data,and constructed a directed connectivity *** results suggest that,compared to sensory congruence,during sensory conflict:(1)connectivity among the sensorimotor,visual,and posterior parietal cortex generally decreases,(2)cortical control over the muscles is weakened,(3)feedback from muscles to the cortex is strengthened,and(4)the range of body sway increases and its complexity *** results underline the intricate effects of sensory conflict on cortico-muscular *** the sensory conflict,the brain adaptively decreases the integration of conflicting *** this integrated information,cortical control over muscles may be lessened,whereas the muscle feedback may be enhanced in compensation.

关键词： Cortico-muscular interaction Postural control Virtual reality Electroencephalogram Electromyography Sensory integration

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Preparation and properties of poly(ethylene glycol)-bpoly( 3-acrylamidophenylboronic acid) glucose responsive particles and their hyaluronic acid-based microneedle patches

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Journal of zhejiang University-science A(Applied Physics & Engineering) 2024年第5期25卷 395-410页

作者： Yichuan HONG Haojie YU Li WANG Xiang CHEN Di SHEN Yu WANG Shuning REN Yudi HUANG Jian YANG State Key Laboratory of Chemical Engineering College of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310058China zhejiang-Russia Joint Laboratory of Photo-Electro-Magnetic Functional Materials College of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310058China

To overcome the pain and risk of hypoglycemia in insulin administration,glucose-responsive microneedles have been developed by researchers,which could release insulin according to the blood glucose *** designed a kind of particles by a reversible addition-fragmentation chain transfer(RAFT)method containing a phenylboronic acid group as the sensor of glucose and carrier of ***(ethylene glycol)(PEG)-2-(dodecylthio(thiocarbonyl)thio)-2-methylpropionic acid(DDMAT)was synthesized as a macromolecular RAFT agent,which was then reacted with 3-acrylamidophenylboronic acid(AAPBA)to synthesize the block copolymer ***-responsive particles loaded with insulin were prepared by self-assembly based on hydrophilic-hydrophobic *** patches loaded with glucose-responsive particles were prepared using hyaluronic acid as the *** insulin release behavior of the particles in glucose solutions of 0,100,and 400 mg/dL showed significant glucose responsiveness and good *** results of blood glucose control experiments in rats indicate that a single microneedle patch can effectively maintain normal blood glucose for over 7 h.

关键词： Diabetes Hyaluronic acid Phenylboronic acid(PBA) Glucose responsive hydrogel Microneedles

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Non-Deterministic Liveness-Enforcing Supervisor Tolerant to Sensor-Reading Modification Attacks

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IEEE/CAA Journal of Automatica Sinica 2024年第1期11卷 240-248页

作者： Dan You Shouguang Wang IEEE the School of Information and Electronic Engineering Sussex Artificial Intelligence InstituteZhejiang Gongshang UniversityHangzhou 310018China

In this paper, we study the supervisory control problem of discrete event systems assuming that cyber-attacks might occur. In particular, we focus on the problem of liveness enforcement and consider a sensor-reading modification attack(SM-attack) that may disguise the occurrence of an event as that of another event by intruding sensor communication channels. To solve the problem, we introduce non-deterministic supervisors in the paper, which associate to every observed sequence a set of possible control actions offline and choose a control action from the set randomly online to control the system. Specifically, given a bounded Petri net(PN) as the reference formalism and an SMattack, an algorithm that synthesizes a liveness-enforcing nondeterministic supervisor tolerant to the SM-attack is proposed for the first time.

关键词： Cyber-attacks cyber-physical system(CPS) liveness non-deterministic supervisors Petri net(PN)

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Balancing Exploration–Exploitation of Multi-verse Optimizer for Parameter Extraction on Photovoltaic Models

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Journal of Bionic Engineering 2024年第2期21卷 1022-1054页

作者： Yan Han Weibin Chen Ali Asghar Heidari Huiling Chen Xin Zhang College of Computer science and Artificial Intelligence Wenzhou UniversityWenzhou325035China School of Surveying and Geospatial Engineering College of EngineeringUniversity of TehranTehranIran School of Biomedical Engineering National Engineering Research Center of Ophthalmology and OptometryEye HospitalWenzhou Medical UniversityWenzhou325027China Key Lab of Biohealth Materials and Chemistry of Wenzhou Wenzhou UniversityWenzhouChina Key Laboratory of Intelligent Informatics for Safety&Emergency of zhejiang province Wenzhou UniversityWenzhouChina

Extracting photovoltaic(PV)model parameters based on the measured voltage and current information is crucial in the simulation and management of PV *** accurately and reliably extract the unknown parameters of different PV models,this paper proposes an improved multi-verse optimizer that integrates an iterative chaos map and the Nelder–Mead simplex method,*** experiments verified that the proposed INMVO fueled by both mechanisms has more affluent populations and a more reasonable balance between exploration and ***,to verify the feasibility and competitiveness of the proposal,this paper employed INMVO to extract the unknown parameters on single-diode,double-diode,three-diode,and PV module four well-known PV models,and the high-performance techniques are selected for *** addition,the Wilcoxon signed-rank and Friedman tests were employed to test the experimental results *** evaluation metrics,such as root means square error,relative error,absolute error,and statistical test,demonstrate that the proposed INMVO works effectively and accurately to extract the unknown parameters on different PV models compared to other *** addition,the capability of INMVO to stably and accurately extract unknown parameters was also verified on three commercial PV modules under different irradiance and *** conclusion,the proposal in this paper can be implemented as an advanced and reliable tool for extracting the unknown parameters of different PV *** that the source code of INMVO is available at https://***/woniuzuioupao/INMVO.

关键词： Photovoltaic models Multi-verse optimizer Nelder-Mead simplex Iterative chaos map

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Influences of divalent ion substitution on the magnetic and dielectric properties of W-type barium ferrite

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Chinese Physics B 2024年第6期33卷 480-486页

作者：何诗悦刘若水刘煦婕叶先平王利晨沈保根 School of Rare Earths University of Science and Technology of ChinaHefei 230026China Ganjiang Innovation Academy Chinese Academy of SciencesGanzhou 341119China Ningbo Institute of Materials technology&Engineering Chinese Academy of SciencesNingbo 315201China Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China

Saturation magnetization,magneto-crystalline anisotropy field,and dielectric properties are closely related to microwave devices applied at different *** regulating the magnetic and dielectric properties of W-type barium ferrites,single-phase BaMe_(2)Fe_(16)O_(27)(Me=Fe,Mn,Zn,Ni,Co) with different Me ions were synthesized by the high-temperature solid-state *** saturation magnetization(Ms) range from 47.77 emu/g to 95.34 emu/g and the magnetic anisotropy field(H_a) range from 10700.60 Oe(1 Oe=79.5775 A·m^(-1)) to 13739.57 Oe,depending on the type of cation substitution in the hexagonal *** dielectric permittivity and dielectric loss decrease with increasing frequency of the AC electric field in the low-frequency region,while they almost remain constant in the high-frequency *** charac teristics of easy regulation and preparation make it a potential candidate for use in microwave device applications.

关键词： W-type hexaferrite Raman spectra magnetic properties dielectric properties

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Epidemiology and prognostic nomogram for locally advanced gastric signet ring cell carcinoma:A population-based study

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2610-2630页

作者： Ze-Hao Yu Lei-Ming Zhang Zhi-Qi Dai Meng-Na Zhang Si-Ming Zheng Health science Center The First Affiliated Hospital of Ningbo UniversityNingbo 315000Zhejiang ProvinceChina Health science Center Ningbo UniversityNingbo 315211Zhejiang ProvinceChina College of Medicine The First Affiliated Hospital of Zhejiang UniversityHangzhou 310058Zhejiang ProvinceChina

BACKGROUND Gastric signet ring cell carcinoma(GSRC)represents a specific subtype of gastric cancer renowned for its contentious epidemiological features,treatment principles,and prognostic *** To investigate the epidemiology of GSRC and establish an improved model for predicting the prognosis of patients with locally advanced GSRC(LAGSRC)after *** The annual rates of GSRC incidence and mortality,covering the years 1975 to 2019,were extracted from the Surveillance,Epidemiology,and End Results(SEER)database to explore the temporal trends in both disease incidence and mortality rates using Joinpoint *** clinical data of 3793 postoperative LAGSRC patients were collected from the SEER database for the analysis of survival *** Cox regression model was used to explore the independent prognostic factors for overall survival(OS).The risk factors extracted were used to establish a prognostic *** The overall incidence of GSRC increased dramatically between 1975 and 1998,followed by a significant downward trend in incidence after *** recent years,there has been a similarly optimistic trend in GSRC mortality *** trend in GSRC showed discrepancies based on age and *** operating characteristic curves,calibration curves,and decision curve analysis for 1-year,3-year,and 5-year OS demonstrated the high discriminative ability and clinical utility of this *** area under the curve indicated that the performance of the new model outperformed that of the pathological staging *** The model we established can aid clinicians in the early prognostication of LAGSRC patients,resulting in improved clinical outcomes by modifying management strategies and patient health care.

关键词： Signet ring cell carcinoma Locally advanced gastric cancer Adjuvant chemotherapy Nomogram Epidemiology Overall survival

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In-situ growth of MIL-53(Fe)on charcoal sponge as a highly efficient and recyclable photocatalyst for removal of Cr(Ⅵ)

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Rare Metals 2024年第9期43卷 4344-4355页

作者： Zhuo-Fan Yu Ye Yang Hai-Feng Zhuang Sheng-Dao Shan Mihail-Simion Beldean-Galea Qing-Quan Xue Xiao-Feng Shen Shi-Jie Li Key Laboratory of Recycling and Eco-Treatment of Waste Biomass of zhejiang province School of Environmental and Natural ResourcesZhejiang University of Science and TechnologyHangzhou 310023China Faculty of Environmental science and Engineering Babes-Bolyai University400294 Cluj-NapocaRomania Key Laboratory of Pollution Exposure and Health Intervention of zhejiang province Interdisciplinary Research Academy(IRA)Zhejiang Shuren UniversityHangzhou 310015China National Engineering Research Center for Marine Aquaculture Institute of Innovation&ApplicationZhejiang Ocean UniversityZhoushan 316022China

The application of metalDorganic frameworks(MOFs)is hindered by several crucial factors,including low photocatalytic efficiency,poor stability and challenges in *** this study,MIL-53(Fe)was grown in situ on a charcoal sponge(CS)with a large surface area,excellent mechanical properties,and high photocatalytic efficiency using a solvothermal method,thus addressing the above-mentioned shortcomings of MOF ***,CS/MIL-53(Fe)has an amazing light-harvesting capacity in the visible range,leading to a significant improvement in the utilization of *** results of the experiments indicate that CS/MIL-53(Fe)displays a higher photocatalytic activity(87%Cr(Ⅵ))when exposed to visible light than CS(58%)or MIL-53(Fe)(27%),attributing to the increased separation of photogenerated carriers.e-is the main reactive radical and dominates the photocatalytic reduction process,rooting from that e-can reduce Cr(Ⅵ)to low-toxicity Cr(Ⅲ).This study presents a novel method for constructing photocatalysts with large surface areas,superior mechanical characteristics,and enhanced photocatalytic ***,it achieves the resource utilization of agricultural and forestry waste.

关键词： Cr(Ⅵ) Charcoal sponge MIL-53(Fe) Photocatalysis Light absorption

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CALTM:A Context-Aware Long-Term Time-Series Forecasting Model

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Computer Modeling in Engineering & sciences 2024年第4期139卷 873-891页

作者： Canghong Jin Jiapeng Chen Shuyu Wu Hao Wu Shuoping Wang Jing Ying School of Computer and Computing science Hangzhou City UniversityHangzhou310015China School of Computer science and Engineering Macao University of Science and TechnologyMacao999078China College of Computer science and technology Zhejiang UniversityHangzhou310058China

Time series data plays a crucial role in intelligent transportation *** flow forecasting represents a precise estimation of future traffic flow within a specific region and time *** approaches,including sequence periodic,regression,and deep learning models,have shown promising results in short-term series ***,forecasting scenarios specifically focused on holiday traffic flow present unique challenges,such as distinct traffic patterns during vacations and the increased demand for long-term ***,the effectiveness of existing methods diminishes in such ***,we propose a novel longterm forecasting model based on scene matching and embedding fusion representation to forecast long-term holiday traffic *** model comprises three components:the similar scene matching module,responsible for extracting Similar Scene Features;the long-short term representation fusion module,which integrates scenario embeddings;and a simple fully connected layer at the head for making the final *** results on real datasets demonstrate that our model outperforms other methods,particularly in medium and long-term forecasting scenarios.

关键词： Traffic volume forecasting scene matching multi module fusion

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Dynamic Response of A Group of Cylindrical Storage Tanks with Baffles Considering the Effect of Soil Foundation

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china Ocean Engineering 2024年第1期38卷 129-143页

作者： SUN Ying WANG Jia-dong HUO Rui-li ZHOU Ding GU Zhen-yuan QIAN Wang-ping School of Transportation and Civil Engineering Nantong UniversityNantong 226019China Faculty of Civil Engineering and Mechanics Jiangsu UniversityZhenjiang 212013China College of Civil Engineering Nanjing Tech UniversityNanjing 211816China

The sloshing in a group of rigid cylindrical tanks with baffles and on soil foundation under horizontal excitation is studied *** solutions for the velocity potential are derived out by the liquid subdomain *** models with mass-spring oscillators are established to replace continuous *** with the least square technique,Chebyshev polynomials are employed to fit horizontal,rocking and horizontal-rocking coupling impedances of soil,respectively.A lumped parameter model for impedance is presented to describe the effects of soil on tank structures.A mechanical model for the soil-foundation-tank-liquid-baffle system with small amount of calculation and high accuracy is proposed using the substructure *** analytical solutions are in comparison with data from reported literature and numerical codes to validate the effectiveness and correctness of the *** dynamic properties and seismic responses of the soil-tank system are given for the baffle number,size and location as well as soil parameter.

关键词： cylindrical tanks multiple annular baffles equivalent analytical model soil−structure interaction subdomain method dynamic response

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