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High mobility group box 1 in the central nervous system:regeneration hidden beneath inflammation

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Neural Regeneration Research 2025年第1期20卷 107-115页

作者： Hanki Kim Bum Jun Kim Seungyon Koh Hyo Jin Cho Xuelian Jin Byung Gon Kim Jun Young Choi Department of Brain science Ajou University School of MedicineSuwonSouth Korea Department of Biomedical sciences Ajou University Graduate School of MedicineSuwonSouth Korea Department of Neurology Ajou University School of MedicineSuwonSouth Korea Department of Geriatrics The Affiliated Suqian First People’s Hospital of Nanjing Medical UniversitySuqianJiangsu ProvinceChina

High-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields,including neurology and ***-mobility group box 1 in the extracellular space functions as a pro-inflammatory damage-associated molecular pattern,which has been proven to play an important role in a wide variety of central nervous system disorders such as ischemic stroke,Alzheimer’s disease,frontotemporal dementia,Parkinson’s disease,multiple sclerosis,epilepsy,and traumatic brain *** drugs that inhibit high-mobility group box 1 as a damage-associated molecular pattern,such as glycyrrhizin,ethyl pyruvate,and neutralizing anti-high-mobility group box 1 antibodies,are commonly used to target high-mobility group box 1 activity in central nervous system *** it is commonly known for its detrimental inflammatory effect,high-mobility group box 1 has also been shown to have beneficial pro-regenerative roles in central nervous system *** this narrative review,we provide a brief summary of the history of high-mobility group box 1 research and its characterization as a damage-associated molecular pattern,its downstream receptors,and intracellular signaling pathways,how high-mobility group box 1 exerts the repair-favoring roles in general and in the central nervous system,and clues on how to differentiate the pro-regenerative from the pro-inflammatory *** targeting high-mobility group box 1 in the central nervous system may benefit from differentiating between the two functions rather than overall suppression of high-mobility group box 1.

关键词： central nervous system damage-associated molecular pattern ethyl pyruvate glycyrhizzin high mobility group box 1 inflammation neural stem cells neurodevelopment oligodendrocyte progenitor cells redox status regeneration

Effects of nano-sized Ag reinforcing particulates on the microstructure of Sn-0.7Cu solder joints

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International Journal of Minerals,Metallurgy and Materials 2009年第6期16卷 677-684页

作者： Feng Tai Fu Guo Zhi-dong Xia Yong-ping Lei Yao-wu Shi College of Materials science and Engineering Beijing University of Technology Beijing 100124 China

Composite solders were prepared by mechanically dispersing different volumes of nano-sized Ag particles into the Sn-0.7Cu eutectic solder. The effects of Ag particle addition on the microstructure of Sn-0.7Cu solder joints were investigated. Besides, the effects of isothermal aging on the microstructural evolution in the interfacial intermetallic compound （IMC） layer of the Sn-0.7Cu solder and the composite solder reinforced with 1vol% Ag particles were analyzed, respectively. Experimental results indicate that the growth rate of the interfacial IMC layer in the Ag particles reinforced composite solder joint is much lower than that in the Sn-0.7Cu solder joint during isothermal aging. The Ag particles reinforced composite solder joint exhibits much lower layer-growth coefficient for the growth of the IMC layer than the corresponding solder joint.

关键词： lead-free solder composite solder intermetallic compounds microstructure isothermal aging

Quantitative reconstruction of formation paleo-pressure in sedimentary basins and case studies

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science China Earth sciences 2020年第6期63卷 808-821页

作者： Nansheng QIU Yifeng LIU Wen LIU Jingkun JIA State Key Laboratory of Petroleum Resources and Prospecting China University of Petroleum(Beijing)Beijing 102249China College of Geosciences China University of Petroleum(Beijing)Beijing 102249China College of Ocean Zhejiang UniversityZhoushan 316021China Institute of Geomechanics Chinese Academy of Geological ScienceBeijing 100081China

Paleo-pressure reconstruction in sedimentary basins is one of the most important aspects of hydrocarbon accumulation *** view of the advantages and disadvantages of the current methods for paleo-pressure research,a new method to reconstruct the paleo-pressure is presented in this *** to the geological background,quantitative analyses of the factors that might control overpressure were first conducted to clarify the contributions of each mechanism during different geological *** evolution was reconstructed by fluid-compaction modelling with constraints imposed by the paleo-pressures obtained from fluid inclusions or differential stress *** the mechanisms responsible for overpressures during geological history is the basic prerequisite for paleo-pressure ***,quantitative studies were conducted of the contributions of disequilibrium compaction,gas charging,oil cracking,temperature reduction,and tectonic uplift and subsidence to *** case studies of paleo-pressure reconstruction were performed for the Sinian strata in the Sichuan Basin,Ordovician strata in the north uplift in the Tarim Basin and the Permian strata in the Sulige Gas Field in the Ordos Basin,where these three study sites are normally pressured,weakly over-pressured and abnormally low pressured at present,*** new method developed in this paper is very important for the practical reconstruction of the paleopressure in marine strata and ancient strata in deep basins.

关键词： Formation pressure Fluid inclusion Differential stress Basin modelling Overpressure Marine basin

STUDY ON DYNAMIC J-INTEGRAL OF MECHANICAL HETEROGENEOUS WELDED JOINT

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Acta Metallurgica Sinica(English Letters) 2004年第6期17卷 934-939页

作者： F.Q.Tian D.Y.He X.Y.Li Y.W.Shi D.Zhang InstituteofCompositeMaterials ShanghaiJiaotongUniversityShanghai200030China SchoolofMaterialsscienceandEngineering BeijingPolytechnicUniversityBeijing100022China

Welded joint is a mechanical heterogeneous body, and mechanical heterogeneity has great effect on dynamic fracture behaviour of welded joints. In the present investigation, dynamic response curve and dynamic J-integral of practical undermatched welded joint and whole base and whole weld three-point-bend (TPB) models containing longitudinal crack are com- puted. Dynamic J-integral is evaluated using virtual crack extension (VCE) method and the computation is performed using MARC finite element code. Because of the effect of inertia, dynamic load response curve of computed model waves periodically. Dynamic J-integral evaluated by VCE method is path independent. The effect of inertia has little influence on dynamic J-integral curve. The value of dynamic J-integral of undermatched welded joint is lower than that of whole base metal and higher than that of whole weld metal. The results establish the foundation of safety evaluation for dynamic loaded welded structures.

关键词： virtual crack extension welded joint dynamic response curve dynamic J-integral

Hydrodynamic behavior of an internally circulating fluidized bed with tubular gas distributors

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Particuology 2013年第6期11卷 664-672页

作者： Wenli Zhao Tiefeng Wang Chenjing Wang Zuoliang Sha Beijing Key Laboratory of Green Reaction Engineering and technology Department of Chemical EngineeringTsinghua University Tianjin Key Laboratory of Marine Resources and Chemistry Tianjin University of Science and Technology

To better understand the hydrodynamic behavior of an internally circulating fluidized bed, solids holdup in the down-comer （Eso）, solids circulation rate （Gs） and gas bypassing fraction （from down-comer to riser y^R, and from riser to down-comer yRD） were experimentally studied. The effects of gas velocities in the riser and in the down-comer （UR and UD）, orifice diameter in the draft tube （dor）, and draft tube height （HR） were investigated. Experimental results showed that increase of gas velocities led to increase in Gs and yDR, and slight decrease in yeD. Larger orifice diameter on the draft tube led to higher 8sD, Gs and yDR, but had insignificant influence on YRD. with increasing draft tube height, both Gs and YDR first increased and then decreased, while yRD first decreased and then increased. Proposed correlations for predicting the hydrodynamic parameters agreed reasonably well with experimental values.

关键词： Internally circulating fluidized bed Solids holdup Solids circulation rate Gas bypassing fraction

Diagnostic performance of Neutrophil CD64 index,procalcitonin,and C-reactive protein for early sepsis in hematological patients

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World Journal of Clinical Cases 2022年第7期10卷 2127-2137页

作者： Yu-Xi Shang Zhi Zheng Min Wang Hui-Xia Guo Yi-Juan Chen Yue Wu Xing Li Qian Li Jian-Ying Cui Xiao-Xiao Ren Li-Ru Wang Department of Hematology Fuxing HospitalEighth Clinical Medical CollegeCapital Medical UniversityBeijing 100038China Department of General Surgery Xuanwu HospitalCapital Medical UniversityBeijing 100053China

BACKGROUND Patients with hematological diseases are immunosuppressed due to various factors,including the disease itself and treatments,such as chemotherapy and immunotherapy,and are susceptible to *** in these patients often progress rapidly to sepsis,which is *** To evaluate the diagnostic efficacy of the neutrophil CD64(nCD64)index,compared to procalcitonin(PCT)and high-sensitivity C-reactive protein(hs-CRP),for the identification of early sepsis in patients with hematological *** This was a prospective analysis of patients with hematological diseases treated at the Fuxing Hospital affiliated with Capital Medical University,between March 2014 and December *** nCD64 index was quantified by flow cytometry and the Leuko64 assay *** factors which may affect the nCD64 index levels were compared between patients with different infection statuses(local infection,sepsis,and no infection),and the control group and the nCD64 index levels were compared among the *** diagnostic efficacy of the nCD64 index,PCT,and hs-CRP for early sepsis was evaluated among patients with hematological *** A total of 207 patients with hematological diseases(non-infected group,n=50;locally infected group,n=67;sepsis group,n=90)and 26 healthy volunteers were *** to the absolute neutrophil count(ANC),patients with hematological diseases without infection were divided into the normal ANC,ANC reduced,and ANC deficiency *** was no statistically significant difference in the nCD64 index between these three groups(P=0.586).However,there was a difference in the nCD64 index among the non-infected(0.74±0.26),locally infected(1.47±1.10),and sepsis(2.62±1.60)groups(P<0.001).The area under the diagnosis curve of the nCD64 index,evaluated as the difference between the sepsis and locally infected group,0.777,which was higher than for PCT(0.735)and hs-CRP(0.670).The positive and negative likelihood ratios w

关键词： CD64 index Hematological diseases Sepsis Procalcitonin C-reactive protein

Stochastic response of an axially moving viscoelastic beam with fractional order constitutive relation and random excitations

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Acta Mechanica Sinica 2013年第3期29卷 443-451页

作者： Di Liu Wei Xu Yong Xu Department of Applied Mathematics Northwestern Polytechnical University

A convenient and universal residue calculus method is proposed to study the stochastic response behaviors of an axially moving viscoelastic beam with random noise excitations and fractional order constitutive relationship, where the random excitation can be decomposed as a nonstationary stochastic process, Mittag-Leffler internal noise, and external stationary noise excitation. Then, based on the Laplace transform approach, we derived the mean value function, variance function and covariance function through the Green＇s function technique and the residue calculus method, and obtained theoretical results. In some special case of fractional order derivative α , the Monte Carlo approach and error function results were applied to check the effectiveness of the analytical results, and good agreement was found. Finally in a general-purpose case, we also confirmed the analytical conclusion via the direct Monte Carlo simulation.

关键词： Axially moving beam Fractional derivatives Kelvin constitutive relationship Stationary nonstationary noise Residue calculus method Stochastic response

Optimization study of spherical tuyere based on BP neural network and new evaluation index

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Building Simulation 2024年第2期17卷 223-234页

作者： Mengchao Liu Ran Gao Yi Wang Angui Li School of Building Services science and Engineering Xi’an University of Architecture and TechnologyXi’an710055China

The energy consumption of heating,ventilation,and air conditioning(HVAC)systems holds a significant position in building energy usage,accounting for about 65%of the total energy ***,with the advancement of building automation,the energy consumption of ventilation systems continues to *** study focuses on improving the performance of spherical tuyeres in HVAC *** primarily utilizes neural networks and multi-island genetic algorithms(MIGA)for multi-parameter *** employing methods such as structural parameterization,accurate and fast computational fluid dynamics(CFD)simulations,a minimized sample space,and a rational optimization strategy,the time cycle of the optimization process is ***,a new comprehensive evaluation index is proposed in this research to describe the performance of spherical tuyeres,which can be used to more accurately assess spherical tuyeres with different *** results show that by establishing a neural network prediction model and combining it with the multi-island genetic algorithm,a novel spherical tuyere design was successfully *** optimized novel spherical tuyeres achieved a 27.05%reduction in the spherical tuyeres effective index(STEI)compared to the traditional spherical ***,the resistance decreased by 15.68%,and the jet length increased by 7.57%.The experimental results demonstrate that our proposed optimization method exhibits high accuracy,good generalization capability,and excellent agreement at different Reynolds numbers.

关键词： spherical tuyeres STEI CFD ventilation

Research on the navigation method of large-scale differential tail-control improvised guided munitions based on rotational speed constraints

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Defence technology（防务技术） 2024年第8期38卷 155-170页

作者： Ning Liu Wenjiang Zhao Yao Wang Kai Shen Zhong Su Wenhao Qi Yuedong Xie Beijing Key Laboratory of High Dynamic Navigation technology Beijing Information Science and Technology UniversityBeijing100192China Hua an Industry Group Co. Ltd.Qiqihar161006China Integrated Navigation and Intelligent Navigation Laboratory Beijing Institute of TechnologyBeijing100081China Beijing Institute of technology Beijing100081China

In the process of launching guided projectile under the conventional system, it is difficult to effectively obtain the precise navigation parameters of the projectile in the high dynamic environment. Aiming at this problem, this paper describes a new system of guided ammunition based on tail spin reduction. After analyzing the mechanism of the ammunition's tail spin reduction, a navigation method of large scale difference tail control simple guided ammunition based on speed constraint is proposed. In this method,the corresponding navigation constraints can be carried out by combining the rotation speed state of the ammunition itself, and the optimal solution of navigation parameters during the flight of the missile can be obtained by Extended Kalman Filter(EKF). Finally, the performance of the proposed method was verified by the simulation environment, and the hardware-in-the-loop simulation test and flight test were carried out to verify the performance of the method in the real environment. The experimental results show that the proposed method can achieve the optimal estimation of navigation parameters for simple guided ammunition with large-scale difference tail control. Under the conditions of simulation test and hardware-in-loop simulation test, the position and velocity errors calculated by the method in this paper converged. Under the condition of flight test, the spatial average error calculated by the method described in this paper is 6.17 m, and the spatial error of the final landing point is 3.50 *** this method, the accurate acquisition of navigation parameters in the process of projectile launching is effectively realized.

关键词： Guided projectiles Tail spin reduction RPM constraints Combined navigation Extended Kalman filter(EKF)