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Combined effects of oncolytic vaccinia virus and dendritic cells on the progression of melanoma B16-F10 in mice

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Journal of Cancer Metastasis and Treatment 2022年第1期8卷 67-80页

作者： Elena P.Goncharova Tatiana A.Gamburg Oleg V.Markov Marina A.Zenkova Laboratory of Biochemistry of Nucleic Acid Institute of Chemical Biology and Fundamental Medicine SB RASNovosibirsk 630090Russia Faculty of natural science Novosibirsk State UniversityNovosibirsk 630090Russia

Aim:We aimed to test the hypothesis that loading of dendritic cells(DCs)with both viral and tumor-specific antigens would enhance the efficacy antitumor DC-based therapy applied simultaneously with oncolytic ***:Vaccinia virus LIVP/GFP and melanoma B16-F10 were used in this *** were pulsed with various combinations of viral and tumor-associated *** maturation status of DCs was verified by expression of the markers CD80,CD86,and CCR7 and assessment of IL-6,TNF-α,and IL-12 *** most efficient combination of antigens for DC loading was selected based on the analysis of the cytotoxic activity of T *** therapy using vaccinia virus LIVP/GFP and DCs pulsed with viral and tumor-specific antigens was administered to the B16-F10 melanoma/mouse C57Bl tumor ***:We found that loading of DCs with viral antigens,or with a combination of viral and tumor antigens,resulted in similar levels of expression of DC maturation *** maximal in vitro cytotoxicity against virus-infected and non-infected B16 melanoma cells exhibited T lymphocytes activated by DCs loaded with the heat inactivated lysate of vaccinia virus LIVP/GFP infected tumor *** results show that the combination of vaccinia virus LIVP/GFP and DCs loaded with both tumor and viral antigens inhibit tumor growth of B16-F10 murine melanoma by more than ***:Combination therapy with oncolytic vaccinia virus LIVP/GFP and tumor/virus antigen-loaded DCs limited the growth of established melanoma B16-F10,but no synergistic antitumor effects were *** propose that optimization of the therapy regimen could enhance the efficiency of combination therapy.

关键词： Oncolytic virus vaccinia virus melanoma B16 dendritic cells cytotoxic T lymphocytes cancer immunotherapy

Direct modulation characteristics of microdisk lasers with InGaAs/GaAs quantum well-dots

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Photonics Research 2019年第6期7卷 664-668页

作者： N.V.KRYZHANOVSKAYA E.I.MOISEEV F.I.ZUBOV A.M.MOZHAROV M.V.MAXIMOV N.A.KALYUZHNYY S.A.MINTAIROV M.M.KULAGINA S.A.BLOKHIN K.E.KUDRYAVTSEV A.N.YABLONSKIY S.V.MOROZOV YU.BERDNIKOV S.ROUVIMOV A.E.ZHUKOV St.Petersburg Academic University Khlopina 8/3 S t Petersburg 194021 Russia Ioffe Institute of RAS Politehnicheskaya 26 St. Petersburg 194021 Russia Institute for Physics of Microstuctures of RAS Nizhny Novgorod 603950 Russia ITMO University Kronverkskiy prospekt 49 St. Petersburg 197101 Russia University of Notre Dame Notre Dame Indiana 46556 USA

GaAs-based microdisk lasers with an active region representing a dense array of indium-rich islands(InGaAs quantum well-dots) were studied using direct small-signal modulation. We demonstrate that using dense arrays of InGaAs quantum well-dots enables uncooled high-frequency applications with a GHz-range bandwidth for microdisk lasers. A maximum 3 dB modulation frequency of 5.9 GHz was found in the microdisk with a radius of 13.5 μm operating without a heatsink for cooling. A modulation current efficiency factor of 1.5 GHz∕mA1∕2 was estimated.

关键词： Direct modulation characteristics quantum well-dots

Texture,composition and properties of plugs formed by carbon dioxide hydrate and wax

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Petroleum Exploration and Development 2021年第6期48卷 1462-1470页

作者： SKIBA Sergey SAGIDULLIN Aleksey SHAPOVALOVA Alexandra STRELETS Larisa MANAKOV Andrey Nikolaev Institute of Inorganic Chemistry SB RASAc.Lavrentiev Ave.3Novosibirsk 630090Russia Novosibirsk State University Pirogova Str.2Novosibirsk 630090Russia Institute of Petroleum Chemistry SB RAS Akademichesky ave.4Tomsk 634021Russia

Gas hydrates and wax are the major flow assurance problems for the transportation of produced hydrocarbons through ***,in most research works both these two problems are studied *** simultaneous precipitation or deposition of these compounds in pipelines can lead to different mitigation/prevention strategies,the investi-gations in which both these problems are considered simultaneously appeared only *** is no information in the literature on the texture/composition and features of decomposition process of mixed wax/hydrate *** the same time,this information could be useful to understand how to treat the problem of formation of these *** this work,three wax/gas hydrate plugs were collected at quasi-static conditions from a water-in-oil emulsion to study their texture,composition and the features of decomposition *** X-ray diffraction and IR(infrared spectroscopy)analyses showed that the plugs consisted of wax and gas *** and DSC(Differential Scanning Calorimetry)experiments showed that the main part of gas hydrate in the plugs at the ambient pressure started to decompose at about 268 *** temperature was higher than the equilibrium temperature of carbon dioxide hydrate at this pressure,indicating that the gas hydrate in the plugs could be effectively preserved at temperatures below the ice melting point(273.2 K).It was found through observation of the hydrate decomposition process in the plugs under the microscope that the gas in the samples released in small bubbles,while the hydrate particles were not visible at this magnification,indicating that the hydrate was indeed highly dispersed in the samples.A residual wax was jelly-like after decomposition of hydrate in all the *** experiments showed that the plugs residues after decomposition of the hydrates had higher yield points and viscosities than the initial waxy crude oil origi-nally used for the experiments.

关键词： carbon dioxide hydrate hydrate/wax plug plug texture hydrate decomposition

Moving of a submarine under an ice cover in fluid of finite depth

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Journal of Hydrodynamics 2019年第3期31卷 562-569页

作者： Alexandra V. Pogorelova Vitali L. Zemlyak Victor M. Kozin Sholom-A leichem Priamursky State University Birobidzhan Russia Institute of Machining and Metallurgy FEB RAS Komsomolsk-na-Amure Russia

The influence of a basin depth on ice cover deflections, when a submarine moves under it in fluid, is experimentally and theoretically analyzed. For a theoretical research the ice cover is modelled by an elastic floating plate, and the submarine is modelled by a source-sink system in a fluid flow. The problem is solved by means of asymptotic analysis and integral transformations. The experimental study is conducted with submarine models in the pool with the sizes L*B*H= 10m*3m*lm . The ice cover for experiments is modelled in two ways. The first way is the thin ice plate received by freezing of the surface layer of water at low temperatures. In the second case the rubber sheet floating on a reservoir surface is used. The special velocity (the velocity at which maximum values of the wave height are reached) is analyzed. It is obtained that the decrease of the basin depth leads to decrease of the special speed. For small speeds (less than the special speed) there is the fact that the basin depth decrease leads to the increase of the height of the flexural-gravity wave.

关键词： Ice cover submarine flexural gravity wave source-sink system

Revealing the nature of optical activity in carbon dots produced from different chiral precursor molecules

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Light(science & Applications) 2022年第5期11卷 855-867页

作者： Ananya Das Evgeny V.Kundelev Anna A.Vedernikova Sergei A.Cherevkov Denis V.Danilov Aleksandra V.Koroleva Evgeniy V.Zhizhin Anton N.Tsypkin Aleksandr P.Litvin Alexander V.Baranov Anatoly V.Fedorov Elena V.Ushakova Andrey L.Rogach Center of Information Optical Technologies ITMO UniversitySaint Petersburg 197101Russia Research Park Saint Petersburg State UniversitySaint Petersburg 199034Russia Laboratory of Femtosecond Optics and Femtotechnology ITMO UniversitySaint Petersburg 197101Russia Laboratory of Quantum Processes and Measurements ITMO UniversitySaint Petersburg 197101Russia Department of Materials science and Engineering and Centre for Functional Photonics(CFP)City University of Hong KongKowloonHong Kong SAR 999077China Shenzhen Research Institute City University of Hong KongShenzhen 518057China

Carbon dots(CDs)are light-emitting nanoparticles that show great promise for applications in biology and medicine due to the ease of fabrication,biocompatibility,and attractive optical *** chirality,on the other hand,is an intrinsic feature inherent in many objects in nature,and it can play an important role in the formation of artificial complexes based on CDs that are implemented for enantiomer recognition,site-specific bonding,*** employed a one-step hydrothermal synthesis to produce chiral CDs from the commonly used precursors citric acid and ethylenediamine together with a set of different chiral precursors,namely,L-isomers of cysteine,glutathione,phenylglycine,and *** resulting CDs consisted of O,N-doped(and also S-doped,in some cases)carbonized cores with surfaces rich in amide and hydroxyl groups;they exhibited high photoluminescence quantum yields reaching 57%,chiral optical signals in the UV and visible spectral regions,and two-photon *** signals of CDs were rather complex and originated from a combination of the chiral precursors attached to the CD surface,hybridization of lower-energy levels of chiral chromophores formed within CDs,and intrinsic chirality of the CD *** DFT analysis,we showed how incorporation of the chiral precursors at the optical centers induced a strong response in their circular dichroism *** optical characteristics of these CDs,which can easily be dispersed in solvents of different polarities,remained stable during pH changes in the environment and after UV exposure for more than 400 min,which opens a wide range of bio-applications.

关键词： properties chiral carbon

Ultrafast Optomechanical Terahertz Modulators Based on Stretchable Carbon Nanotube Thin Films

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Ultrafast science 2023年第6期3卷 1-9页

作者： Maksim I.Paukov Vladimir V.Starchenko Dmitry V.Krasnikov Gennady A.Komandin Yuriy G.Gladush Sergey S.Zhukov Boris P.Gorshunov Albert G.Nasibulin Aleksey V.Arsenin Valentyn S.Volkov Maria G.Burdanova Center for Photonics and 2D Materials Moscow Institute of Physics and TechnologyDolgoprudny.Russia Skolkovo Institute of science and Technology MoscowRussia Prokhorov General Physics Institute of the russian Academy of sciences MoscowRussia Laboratory of Advanced Functional Materials Yerevan State UniversityYerevanArmenia Institute of Solid State Physics of the russian Academy of sciences ChernogolovkaRussia.

For terahertz wave applications,tunable and rapid modulation is highly *** studied by means of optical pump-terahertz probe spectroscopy,single-walled carbon nanotube(SWCNT)thin films demonstrated ultrafast carrier recombination lifetimes with a high relative change in the signal under optical excitation,making them promising candidates for high-speed ***,combination of SWCNT thin films and stretchable substrates facilitated studies of the SWCNT mechanical properties under strain and enabled the development of a new type of an optomechanical *** applying a certain strain to the SWCNT films,the effective sheet conductance and therefore modulation depth can be fine-tuned to optimize the designed *** exhibited a photoconductivity change of approximately 2 times of magnitude under the strain because of the structural modification in the SWCNT *** was used to control the terahertz signal with a modulation depth of around 100%without strain and 65%at a high strain operation of 40%.The sensitivity of modulators to beam polarization is also shown,which might also come in handy for the design of a stretchable *** results give a fundamental grounding for the design of high-sensitivity stretchable devices based on SWCNT films.

关键词： strain excitation films

Stabilization versus decomposition in alpine ecosystems of the Northwestern Caucasus:The results of a tea bag burial experiment

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Journal of Mountain science 2018年第8期15卷 1633-1641页

作者： Tatiana G.ELUMEEVA Vladimir G.ONIPCHENKO Asem A.AKHMETZHANOVA Mikhail I.MAKAROV Joost A.KEUSKAMP Department of Geobotany Biological FacultyLomonosov Moscow State University119234 Leninskie Gory 1/12MoscowRussia Department of General Soil science Faculty of Soil ScienceLomonosov Moscow State University119234 Leninskqe Gory 1/12MoscowRussia Ecology 8:Biodiversity Group Utrecht UniversityP.O.Box 80.0563508 TB UtrechtThe Netherlands Netherlands Institute of Ecology(NIOO-KNA W) P.O.Box 596700 AB WageningenThe Netherlands

Mountainous areas exhibit highly variable decomposition rates as a result of strong local differences in climate and vegetation type. This paper describes the effect of these factors on two major determinants of the local carbon cycle: litter decomposition and carbon stabilization. In order to adequately reflect local heterogeneity, we have sampled 12 typical plant communities of the russian Caucasus. In order to minimize confounding effects and encourage comparative studies, we have adapted the widely used tea bag index(TBI) that is typically used in areas with low decomposition. By incubating standardized tea litter for a year, we investigated whether(1) initial litter decomposition rate(k) is negatively correlated with litter stabilization(S) and(2) whether k or S exhibit correlations with altitude and other environmental conditions. Our results show that S and k are not correlated. Altitude, p H, and water content significantly influenced the stabilization factor S, while soil-freezing had no influence. In contrast, none of these factors predicted the decomposition rate k. Based on our data, we argue that collection of decomposition rates alone, as is now common practice, is not sufficient to understand carbon input to soils and can potentially lead to misleading results. Our data on community-specific decomposition and stabilization rates further constrain estimates of litter accumulation in subalpine communities and the potential effects of climate change.

关键词： Litter decomposition Alpine communities Tea bag index Carbon cycle

Solving the Faddeev-Merkuriev Equations in Total Orbital Momentum Representation via Spline Collocation and Tensor Product Preconditioning

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Communications in Computational Physics 2021年第6期30卷 255-287页

作者： Vitaly A.Gradusov Vladimir A.Roudnev Evgeny A.Yarevsky Sergey L.Yakovlev Department of Computational Physics St Petersburg State UniversitySt Petersburg 199034Russia

The computational approach for solving the Faddeev-Merkuriev equations in total orbitalmomentum representation is *** equations describe a systemof three quantumcharged particles and arewidely used in bound state and scattering *** approach is based on the spline collocation method and exploits intensively the tensor product formof discretized operators and preconditioner,which leads to a drastic economy in both computer resources and time.

关键词： Faddeev-Merkuriev equations total orbital momentum representation spline collocation tensor product preconditioner

Composition of Hydrocarbons in Diamonds, Garnet, and Olivine from Diamondiferous Peridotites from the Udachnaya Pipe in Yakutia, Russia

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Engineering 2019年第3期5卷 471-478页

作者： Nikolay V. Sobolev Anatoly A. Tomilenko Taras A. Bul’bak Alla M. Logvinova V.S. Sobolev Institute of Geology and Mineralogy Siberian Branch of the Russian Academy of Sciences Novosibirsk 630090 Russia Department of Geology and Geophysics Novosibirsk State University Novosibirsk 630090 Russia

Volatile components in diamonds, associated garnet (pyrope), and olivine from two extremely rare xenoliths of diamondiferous peridotites recovered from the Udachnaya kimberlite pipe in Yakutia, Russia, were analyzed by gas chromatography–mass spectrometry (GC–MS) using a Focus DSQ II Series Single Quadrupole GC–MS (Thermo Scientific, USA). These xenoliths are pyrope lherzolite and pyrope dunite based upon compositions of coexisting minerals. Unlike the pyrope lherzolite, which contained pyrope with moderate calcium (Ca)-component content (about 15 mol%), the dunite contained subcalcic chromium (Cr)-pyrope with low Ca-component content (less than 10 mol%). All investigated minerals contained dominating hydrocarbons and their derivatives represented by aliphatic (paraffins, olefins), cyclic (naphthenes, arenes), oxygenated (alcohols, ethers), and heterocyclic (dioxanes, furans) hydrocarbons;nitrogenated, chlorinated, and sulfonated compounds;carbon dioxide (CO2);and water (H2O). The relative concentration (rel%) of total hydrocarbon was 79.7 rel% for diamonds, 69.1 rel% for garnet, and 92.6 rel% for olivine, with a general amount of components ranging from 161 to 206. New data on volatiles in diamonds, associated garnet, and olivine suggest the presence of a wide spectrum of hydrocarbons along with nitrogen (N2), CO2, and H2O in some upper mantle areas.

关键词： Diamond Volatiles Hydrocarbons Pyrope Olivine Inclusions