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Bioinspired nanotransducers for neuromodulation

Nano Research 2024年第2期17卷 618-632页

作者： Fan Yang Xiang Wu Sa Cai Guosong Hong Department of Materials Science and Engineering Stanford UniversityStanfordCA 94305USA Wu Tsai Neurosciences Institute Stanford UniversityStanfordCA 94305USA School of Science Shenzhen Campus of Sun Yat-sen UniversityShenzhen 518107China

The field of neuromodulation has experienced significant advancements in the past decade,owing to breakthroughs in disciplines such as materials science,genetics,bioengineering,photonics,and *** convergence of these fields has resulted in the development of nanotransducers,devices that harness the synergies of these diverse *** nanotransducers,essential for neuromodulation,often draw inspiration from energy conversion processes found in nature for their unique *** this review,we will delve into the latest advancements in wireless neuromodulation facilitated by optical,magnetic,and mechanical *** will examine their working principles,properties,advantages,and limitations in comparison to current methods for deep brain neuromodulation,highlighting the impact of natural systems on their design and ***,we will underscore potential future directions,emphasizing how continued progress in materials science,neuroscience,and bioengineering might expand the horizons of what is achievable with nanotransducer-enabled neuromodulation.

关键词： bioinspired synthesis neuromodulation mechanoluminescence focused ultrasound nanotransducers sono-optogenetics

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Integrative single-cell analysis of cardiogenesis identifies developmental trajectories and non-coding mutations in congenital heart disease

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四川生理科学杂志 2022年第12期44卷 2229-2229页

作者： Mohamed Ameen Department of Cancer Biology Stanford University Stanford CA USA Department of Computer Science Stanford University Stanford CA USA Illumina Artificial Intelligence Laboratory Illumina Inc Foster City CA USA Cardiovascular Institute Stanford University Stanford CA USA Department of Physics Stanford University Stanford CA USA Department of Biomedical Informatics Stanford University Stanford CA USA Center for Stem Cell and Organoid Medicine CuSTOM Division of Developmental Biology Cincinnati Children’s Hospital Medical Center Cincinnati OH USA Department of Computer Science California Institute of Technology Pasadena CA USA Department of Cardiothoracic Surgery Stanford University Stanford CA USA Department of Genetics Stanford University Stanford CA USA Department of Dermatology Stanford University School of Medicine Stanford CA USA Veterans Affairs Palo Alto Healthcare System Palo Alto CA USA Division of Cardiovascular Medicine Stanford University School of Medicine Stanford CA USA Department of Applied Physics Stanford University Stanford CA USA

To define the multi-cellular epigenomic and transcriptional landscape of cardiac cellular development,we generated single-cell chromatin accessibility maps of human fetal heart *** identified eight major differentiation trajectories involving primary cardiac cell types,each associated with dynamic transcription factor(TF)activity signatures.

关键词： cardiac congenital fetal

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