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Acta Pharmaceutica Sinica B 2024年第8期14卷 3624-3642页

作者： Kai Tang Shu Wang Siqi Feng Xinyu Yang Yueyang Guo Xiangli Ren Linyue Bai Bin Yu Hong-Min Liu Yihui Song School of Pharmaceutical Sciences&Key Laboratory of Advanced Drug Preparation Technologies Ministry of EducationZhengzhou UniversityZhengzhou 450001China College of Chemistry Pingyuan LaboratoryState Key Laboratory of Antiviral DrugsZhengzhou UniversityZhengzhou 450001China Tianjian Laboratory of Advanced Biomedical Sciences Institute of Advanced Biomedical SciencesZhengzhou UniversityZhengzhou 450000China State Key Laboratory of Pharmaceutical biotechnology Nanjing UniversityNanjing 210023China

Src homology-2-containing protein tyrosine phosphatase 2(SHP2)is a promising therapeutic target for cancer *** this work,we presented the structure-guided design of 5,6-fused bicyclic allosteric SHP2 inhibitors,leading to the identification of pyrazolopyrazine-based TK-642 as a highly potent,selective,orally bioavailable allosteric SHP2 inhibitor(SHP2WT IC_(50)=2.7 nmol/L)with favorable pharmacokinetic profiles(F=42.5%;t_(1/2)=2.47 h).Both dual inhibition biochemical assay and docking analysis indicated that TK-642 likely bound to the“tunnel”allosteric site of ***-642 could effectively suppress cell proliferation(KYSE-520 cells IC_(50)=5.73μmol/L)and induce apoptosis in esophageal cancer cells by targeting the SHP2-mediated AKT and ERK signaling ***,oral administration of TK-642 also demonstrated effective anti-tumor effects in the KYSE-520 xenograft mouse model,with a T/C value of 83.69%.Collectively,TK-642 may warrant further investigation as a promising lead compound for the treatment of esophageal cancer.

关键词： Protein tyrosine phosphatase Pyrazolopyrazine SHP2 inhibitor Esophageal cancer

Cloud-Model-Based Feature Engineering to Analyze the Energy-Water Nexus of a Full-Scale Wastewater Treatment Plant

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Engineering 2024年第5期36卷 63-75页

作者： Shan-Shan Yang Xin-Lei Yu Chen-Hao Cui Jie Ding Lei He Wei Dai Han-Jun Sun Shun-Wen Bai Yu Tao Ji-Wei Pang Nan-Qi Ren State Key Laboratory of Urban Water Resource and Environment Harbin Institute of TechnologyHarbin 150000China Key Laboratory of Environmental biotechnology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China School of Civil and Environmental Engineering Harbin Institute of Technology(Shenzhen)Shenzhen 518055China China Energy Conservation and Environmental Protection Group Beijing 100089China

Wastewater treatment plants(WWTPs)are important and energy-intensive municipal *** energy consumption and relatively low operating performance are major challenges from the perspective of carbon ***,water-energy nexus analysis and models for WWTPs have rarely been reported to *** this study,a cloud-model-based energy consumption analysis(CMECA)of a WWTP was conducted to explore the relationship between influent and energy consumption by clustering its influent’s *** principal component analysis(PCA)and K-means clustering were applied to classify the influent condition using water quality and volume *** energy consumption of the WWTP is divided into five standard evaluation levels,and its cloud digital characteristics(CDCs)were extracted according to bilateral constraints and golden ratio *** results showed that the energy consumption distribution gradually dispersed and deviated from the Gaussian distribution with decreased water concentration and *** days with high energy efficiency were extracted via the clustering method from the influent category of excessive energy consumption,represented by a compact-type energy consumption distribution curve to identify the influent conditions that affect the steady distribution of energy *** local WWTP has high energy consumption with 0.3613 kW·h·m^(-3)despite low influent concentration and volumes,across four consumption levels from low(I)to relatively high(IV),showing an unsatisfactory operation and management *** average oxygenation capacity,internal reflux ratio,and external reflux ratio during high energy efficiency days recognized by further clustering were obtained(0.2924-0.3703 kg O_(2)·m^(-3),1.9576-2.4787,and 0.6603-0.8361,respectively),which could be used as a guide for the days with low energy ***,this study offers a water-energy nexus analysis method to identify influent conditions with operational manageme

关键词： Wastewater treatment plants Cloud-model theory Data mining Principal component analysis K-means clustering Cloud-model-based energy consumption analysis

A novel process for sorting fine-sized sulphide minerals by biocoagulation

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中国有色金属学会会刊：英文版 2008年第6期18卷 1473-1479页

作者： H. Z. KUYUMCU J. PINKA T. BIELIG Department of Mechanical Process Engineering and Solids Processing Technical University of Berlin Sekr. BH 11 Strasse des 17. Juni 135 10623 Berlin Germany

基于一个过程设计想法，在柏林的技术大学的调查证实微生物的 biocoagulation 和稳固的粒子将是一个新方法产生对排序合适的更粗糙的粒子。微生物的选择 biocoagulation 的过程，分别地例如酵母喜欢 Saccharomyces cerevisiae 和 Yarrow... 详细信息

基于一个过程设计想法，在柏林的技术大学的调查证实微生物的 biocoagulation 和稳固的粒子将是一个新方法产生对排序合适的更粗糙的粒子。微生物的选择 biocoagulation 的过程，分别地例如酵母喜欢 Saccharomyces cerevisiae 和 Yarrowia lipolytica，并且例如象方铅矿和闪锌矿一样的矿物质，微分散固体作为一个新奇排序过程的一个基础被分析了。因此，特别微生物的房间表面的特征例如静电的费用和细胞外的聚合物质的作文，以及他们对选择 biocoagulation 的影响被学习。在 10 m 下面的微生物和硫醚粒子有效地凝结的试验性的调查表演。而且，筹款对有选择地形成的 biocoagulates 的分离合适。与设计的列筹款，令人满意的恢复率被到达。

关键词：硫矿拣选生物凝固微生物

Piglet growth performance improved by dietary supplementation of porous or nano particles of zinc oxide may be related to the gut microbiota

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Animal Nutrition 2023年第4期15卷 159-172页

作者： Lina Long Xichen Zhao Jie Chen Zixi Wang Yanfang Tang Jian Huang Yulong Yin School of Life Science and Engineering Foshan UniversityFoshan 528231China Key Laboratory for Agro-Ecological Processes in Subtropical Region Hunan Research Center of Livestock and Poultry SciencesSouth Central Experimental Station of Animal Nutrition and Feed Science in the Ministry of AgricultureInstitute of Subtropical Agriculturethe Chinese Academy of SciencesChangsha 410125China Guangdong Laboratory of Lingnan Modern Agriculture College of Animal ScienceSouth China Agricultural UniversityGuangzhou 510642China Foshan Guangmuxing Feed Co. LtdFoshan 528000China

Previous studies on porous or nano particles zinc oxide(ZnO)in the piglets have mainly focused on growth performance and intestinal inflammation,but have scarcely explored the efficacy on gut *** addition,the efficacy of nano particles ZnO,which is related to its product quality,remains *** study aimed to determine the efficacy of dietary 500 mg/kg porous or nano particles ZnO on the growth performance and gut microbiota of the weaned piglets.A total of 128 weaned piglets were randomly assigned to the dietary groups:NC(basal diet),PC(basal diet+3,000 mg/kg conventional ZnO),500HiZ(basal diet+500 mg/kg porous particles ZnO),and 500ZNP(basal diet+500 mg/kg nano particles ZnO).Compared with the NC diet group,both 500HiZ and 500ZNP increased(P<0.05)average daily feed intake(1 to 28 d)and average daily gain(1 to 28 d),and the 500ZNP tended to decrease feed to gain ratio(F:G ratio,1 to 28 d)(P=0.09).Both 500HiZ and 500ZNP decreased crypt depth of the ileum and increased claudin-2 in the duodenum and zonula occludens-1 in the ileum(P<0.05).Moreover,both 500HiZ and 500ZNP decreased IL-1βand tumor necrosis factor-a(TNF-a)in the jejunum and decreased TNF-a and IL-6 in the ileum(P<0.05).Both 500HiZ and 500ZNP increased microbialβ-diversity index in the ileum and microbial a-diversity indices in the colon of piglets(P<0.05).The probiotic genera Coprococcus(500ZNP)and Blautia(500HiZ)were positively correlated with the F:G ratio(1to 28 d)in colon of piglets(P<0.05).In addition,500HiZ promoted mitochondrial fusion protein 1(MFN1)and zinc transporter-1(ZnT-1)in the jejunum(P<0.05),whilst 500ZNP decreased MFN1 in the jejunum and ZnT-1 in the ileum(P<0.05).In summary,both 500HiZ and 500ZNP improved the growth performance of piglets,which is likely via the genera Blautia and Coprococcus,*** 500HiZ and 500ZNP improved barrier function and inflammation of the intestine,and 500HiZ achieved better efficacy than 500ZNP on intestine mitochondrial functions

关键词： Growth performance Inflammation Intestine morphology Microbiota Piglet Zinc oxide

Comparison of Apigenin,Quercetin and Kaempferol Accumulation and Total Flavonoid Content in Leaves,Embryogenic Cultures and Cell Suspension Cultures of Parsley(Petroselinum crispum)

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国际实验植物学杂志(英文) 2023年第10期92卷 2807-2823页

作者： Laura Isabel Arias-Rodríguez Martha Alicia Rodríguez-Mendiola Carlos Arias-Castro Federico Antonio Gutiérrez Miceli Diana Reséndez Pérez María Celina Luján Hidalgo Juan JoséVillalobos Maldonado Norma Alejandra Mancilla Margalli Analytical Laboratory National Technological Institute of MexicoTuxtla Gutierrez CampusTuxtla GutierrezMexico Plant biotechnology Laboratory Instrumental Analysis LaboratoryPlant Biochemistry LaboratoryNational Technological Institute of MexicoTlajomulco de ZunigaMexico Department of Cellular Biology and Genetics Faculty of Biological SciencesAutonomous University of Nuevo LeonSan Nicolas delos GarzaMexico

In recent years,there has been a growing interest in exploring alternative treatments for bone *** tissue engineering has turned its attention to plant extracts containing osteogenic flavonoids as potential promoters of bone *** our study,we specifically investigated the extract of Petroselinum crispum,a plant known for its abundance of osteogenic flavonoids such as apigenin,quercetin,and *** objective was to compare the total flavonoid content(TFC)and their accumulation in different *** obtained hydrolyzed aqueous extracts from the leaves of parsley plants(grown for 12 weeks in the field),weekly embryogenic cultures,and suspension cell *** TFC,measured in mg quercetin equivalent per gram of dry weight(QE mg/g dw),was found to be 53.81±0.97 for 52 g dw of leaves(1 kg plant fw),31.10±1.52 for 420 g dw of embryogenic cultures,and 11.80±0.76 for 210 g dw of cell ***,only the leaves and embryogenic cultures showed significant accumulation of osteogenic flavonoids,with apigenin levels of 1.8±0.3 and 0.32±0.02 mg/g dw,and kaempferol levels of 1.0±0.18 and 0.2±0.01 mg/g dw,*** findings indicate that embryogenic cultures have the potential to produce up to 40%more apigenin in 12 weeks compared to 1 kg of parsley plant,thanks to their superior biomass reproductive *** results present a promising biotechnological approach for generating extracts enriched with bioactive compounds,which can be further utilized in in vitro osteogenic testing.

关键词： Parsley(Petroselinum crispum)cultures osteogenic flavonoids bone regeneration aqueous extracts

Evolutionary divergence in Chenopodium and validation of SNPs in chloroplast rbcL and matK genes by allele-specific PCR for development of Chenopodium quinoa-specific markers

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The Crop Journal 2017年第1期5卷 32-42页

作者： Rajkumari Jashmi Devi Nikhil K.Chrungoo Centre for Advanced Studies in Botany North Eastern Hill UniversityShillongIndia

The genus Chenopodium comprises about 150 species, of which Chenopodium quinoa and C. album are important for their nutritional value. Evaluation of variation in qualitative morphological traits of plants and SNPs in chloroplast rbc L and mat K gene sequences in 19 accessions representing C. quinoa and C. album indicated that the accessions IC-411824 and IC-411825,which have white seeds, belong to C. quinoa rather than C. album. This observation was also supported by a time tree that indicated IC-411824 and IC-411825 to be a sister clade to accessions of C. quinoa with an estimated age of 1.2 Mya. Whereas multiple alignments of rbc L gene sequences from the 19 accessions revealed 1.26% parsimony-informative sites with 0.68%interspecific sequence diversity, alignment of nucleotide sequences of amplicons representing the mat K gene revealed 4.97% parsimony-informative sites and 2.81% interspecific sequence diversity. Validation of SNPs in the cp rbc L and mat K regions of 36 accessions belonging to C. quinoa and C. album was performed by allele-specific PCR with primers carrying a single base change at the 3′ end. We report the first C. quinoa-specific SNP-based primer, R1RQ-AFR,designed from rbc L sequences, that could differentiate quinoa from 64 genera including13 species of the genus Chenopodium. With an estimated age of 10.5–4.1 million years(Myr), the Himalayan chenopods are evolutionarily younger than the Andean chenopods. The results establish the paraphyletic origin of the genus Chenopodium.

关键词： Chenopodium quinoa Chenopodium album Million years ago(Mya) Single-nucleotide polymorphism(SNP) Allele-specific primer extension

Hetero-trans-β-Glucanase Produces Cellulose-Xyloglucan Covalent Bonds in the Cell Walls of Structural Plant Tissues and Is Stimulated by Expansin

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Molecular Plant 2020年第7期13卷 1047-1062页

作者： Klaus Herburger Lenka Frankova Martina Picmanova Jia Wooi Loh Marcos Valenzuela-Ortega Frank Meulewaeter Andrew D.Hudson Christopher E.French Stephen C.Fry The Edinburgh Cell Wall Group Institute of Molecular Plant SciencesSchool of Biological SciencesThe University of EdinburghEdinburgh EH93BFUnited Kingdom Institute of Quantitative Biology Biochemistry and BiotechnologySchool of Biological SciencesThe University of EdinburghEdinburgh EH93BFUnited Kingdom BASF BBCC Innovation Center Gent-Trait Research9052 Gent(Zwijnaarde)Belgium Zhejiang University-University of Edinburgh Joint research Centre for Engineering Biology Zhejiang UniversityHainingZhejiang 314400China Present address:Section for Plant Glycobiology Department of Plant and Environmental SciencesUniversity of CopenhagenFrederiksberg 1871Denmark

Current cell-wall models assume no covalent bonding between cellulose and hemicelluloses such as xyloglu-can or mixed-linkageβ-D-glucan(MLG).However,Equisetum hetero-trans-β-glucanase(HTG)grafts cellu-lose onto xyloglucan oligosaccharides(XGOs)-and,we now show,xyloglucan polysaccharide-in vitro,thus exhibiting CXE(cellulose:xyloglucan endotransglucosylase)*** addition,HTG also catalyzes MLG-to-XGO bonding(MXE activity).In this study,we explored the CXE action of HTG in native plant cell walls and tested whether expansin exposes cellulose to HTG by disrupting hydrogen *** quantify and visu-alize CXE and MXE action,we assayed the sequential release of HTG products from cell walls pre-labeled with substrate *** demonstrated covalent cellulose--xyloglucan bonding in plant cell walls and showed that CXE and MXE action was up to 15%and 60%of total transglucanase action,respectively,and peaked in aging,strengthening tissues:CXE in xylem and cells bordering intercellular canals and MXE in *** bacterial expansin(EXLX1)strongly augmented CXE activity in *** and MXE ac-tion in living Equisetum structural tissues potentially strengthens stems,while expansin might augment the HTG-catalyzed CXE reaction,thereby allowing efficient CXE action in *** methods will enable surveys for comparable reactions throughout the plant ***,engineering similar hetero-polymer formation into angiosperm crop plants may improve certain agronomic traits such as lodging tolerance.

关键词： cell wall cellulose hemicelluloses hetero-trans-p-glucanase hetero-transglycosylation xyloglucan

Molecular Mapping of QTLs for Yield and Yield-Related Traits in Oryza sativa cv Swarna × O. nivara (IRGC81848) Backcross Population

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Rice science 2011年第3期18卷 178-186页

作者： B. P. MALLIKARJUNA SWAMY K. KALADHAR M. S. RAMESHA B. C. VIRAKTAMATH N. SARLA Directorate of Rice research Rajendranagar Hyderabad India - 500030 Plant Breeding Genetics and Biotechnology Division International Rice Research Institute DAPO Box 7777 Metro Manila Philippines

Advanced backcross QTL analysis was used to identify QTLs for seven yield and yield-related traits in a BC2F2 population from the cross between a popular Oryza sativa cv Swarna and O. nivara IRGC81848. Transgressive segregants with more than 15% increased effect over Swarna were observed for all the traits except days to heading and days to 50% flowering. Thirty QTLs were detected for seven yield and yield-related traits using interval and composite interval mapping. Enhancing alleles at 13 (45%) of these QTLs were derived from O. nivara, and enhancing alleles at all the QTLs for stem diameter and rachis diameter were derived from O. nivara. Three stem diameter QTLs, two rachis diameter QTLs and one number of secondary branches QTL identified by both Interval and composite interval mapping contributed more than 15% of the total phenotypic variance. The QTL epistasis was significant for stem diameter and plot yield. The most significant QTLs qSD7.2, qSD8.1 and qSD9.1 for stem diameter, qRD9.1 for rachis diameter and qNSB1.1 for number of secondary branches are good targets to evaluate their use in marker-assisted selection. O. nivara is a good source of novel alleles for yield related traits and reveals major effect QTLs suitable for marker-assisted selection.

关键词： Oryza sativa Oryza nivara stem diameter rachis diameter yield yield components quantitative trait locus

Denatured proteins as a novel template for the synthesis of well-defined,ultra-stable and water-soluble metal nanostructures for catalytic applications

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Journal of Leather Science and Engineering 2020年第1期2卷 66-76页

作者： Chaojian Chen David Yuen Wah Ng Tanja Weil Max Planck Institute for Polymer research Ackermannweg 1055128 MainzGermany Ulm University Albert-Einstein-Allee 1189081 UlmGermany

The templated synthesis of noble metal nanoparticles using biomass,such as proteins and polysaccharides,has generated great interest in recent *** this work,we report on denatured proteins as a novel template for the preparation of water-soluble metal nanoparticles with excellent stability even after high speed centrifugation or storage at room temperature for one *** noble metal nanoparticles including spherical gold and platinum nanoparticles as well as gold nanoflowers are obtained using sodium borohydride or ascorbic acid as the reducing *** particle size can be controlled by the concentration of the *** metal nanoparticles are further used as catalysts for the hydrogenation reaction of p-nitrophenol to ***,spherical gold nanoparticles with an average size of 2 nm show remarkable catalytic performance with a rate constant of 1.026×10^(-2) L s^(-1) mg^(-1).These metal nanoparticles with tunable size and shape have great potential for various applications such as catalysis,energy,sensing,and biomedicine.

关键词： Unfolded proteins Gold nanoparticles Gold nanoflowers Platinum nanoparticles Biotemplated synthesis Catalysis

Electrospinning of a sandwich-structured membrane with sustained release capability and long-term anti-inflammatory effects for dental pulp regeneration

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Bio-Design and Manufacturing 2022年第2期5卷 305-317页

作者： Fenghe Yang Jiangxue Wang Xiaoyu Li Zhenzhen Jia Qiang Wang Dazhi Yu Jinyu Li Xufeng Niu Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijing 100083China Department of Burn Plastic Surgery 80th Army Hospital of PLAWeifang 261021China Department of Hand Surgery 971st Army Hospital of PLAQingdao 266000China Department of Orthopaedics Dongzhimen HospitalBeijing University of Chinese MedicineBeijing 100700China

Current electro spun membranes used for pulp capping still lack the sustained-release capability and long-term anti-inflammatory effects that are favorable for dental pulp *** this work,a single-layered poly(lac tic acid)(PLA)electro spun membrane loaded with amorphous calcium phosphate(ACP)and aspirin(PLA/ACP/Aspirin membrane,i.e.,PA A membrane)is sandwiched between two poly(lactic-co-glycolic acid)(PLGA)electro spun membranes as a novel sandwich-structured PLGA and PA A composite electro spun membrane(PLGA-PAA membrane)to resolve the need for sustained-release design and anti-inflammatory *** angle measurements indicate that the PLGA-PAA membrane is more hydrophilic than the PAA *** in vitro release study reveals that PLGA membranes coated on PAA membrane could slightly slow down ion release,while signiificantly prolonging aspirin *** also co-cultured membranes with dental pulp stem cells(DPSCs)and human monocytic THP-1 cells to evaluate their osteogenic ability and anti-inflammatory effects,*** with the PAA membrane,the PLGA-PAA membrane promotes cell adhesion,proliferation,and osteogenic differentiation.A prolonged anti-inflammatory effect of up to 18 days is also observed in the PLGA-PAA *** results suggest a promising strategy for fabricating an electro spun membrane system with controlled release capabilities and long-term anti-inflammatory effects for use as pulp-capping material for regeneration of the dentin-pulp complex.

关键词： Electrospinning Sandwich-structured Pulp capping Controlled release Anti-inflammatory effects