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Dysregulation and implications of N6-methyladenosine modification in renal cell carcinoma

Current Urology 2023年第1期17卷 45-51页

作者： Yaohai Wu Shiqiang Zhang Chujie Chen Jun Pang Department of Urology Kidney and Urology CenterPelvic Floor Disorders CenterThe Seventh Affiliated HospitalSun Yat-sen UniversityShenzhen518107China

Increasing evidence indicates that N6-methyladenosine(m6A)methylation modification serves important functions in biological *** of m6A regulators is related to the progression of different malignancies,including renal cell carcinoma(RCC).Recent studies have reported preliminary findings on the influence of m6A regulator dysregulation on RCC tumorigenesis and ***,no comprehensive review that integrates and analyzes the roles of m6A modification in RCC has been published to *** this review,we focus on the dysregulation of m6A regulators as it relates to RCC tumorigenesis and development,as well as possible applications of m6A modification in RCC diagnosis and therapeutics.

关键词： Dysregulation m6A modification Renal cell carcinoma

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Smart nanocarriers as therapeutic platforms for bladder cancer

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Nano research 2022年第3期15卷 2157-2176页

作者： Tongyu Tong Yupeng Guan Yuanji Gao Chengyuan Xing Shiqiang Zhang Donggen Jiang Xiangwei Yang Yang Kang Jun Pang Department of Urology Kidney and Urology Centerthe Seventh Affiliated HospitalSun Yat-sen UniversityShenzhen 518107China Scientific research Center the Seventh Affiliated HospitalSun Yat-sen UniversityShenzhen 518107China College of Chemistry and Materials Science Sichuan Normal UniversityChengdu 610068China

Although patients benefit from surgical transurethral resection of bladder cancers,some niduses are missed or incompletely resected,and small malignant lesions may *** chemotherapy and immunotherapy are universally accepted as adjuvant treatments after surgery to avoid recurrence and ***,these treatments still have limitations,including an insufficient retention period,inefficient permeability of chemotherapeutic agents,and dilution of the agents by ***-based smart therapeutic platforms can be tailored to be responsive to internal or external stimuli to ameliorate this *** unparalleled capability empowers the precise aggregation of stimulus–responsive nanocarriers in the target regions,namely,the tumors,and subsequent release of the anticancer *** review summarizes the current nanostructure-based therapeutic platforms,especially stimulus–responsive nanocarriers,and highlights their benefits and limitations in bladder cancer *** innovations in nanotechnology have undoubtedly arrived at a new height and have become useful for practical *** will positively promote the development of anticancer agents not only for bladder cancer but also for other solid tumors.

关键词： nanocarriers stimulus-responsive therapeutic platform drug delivery bladder cancer

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