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The energetics of cellular life transitions

Life Metabolism 2024年第3期3卷 12-20页

作者： Anna S.Monzel Michael Levin Martin Picard Department of Psychiatry Division of Behavioral MedicineCollege of Physicians and SurgeonsColumbia University Irving Medical CenterNew YorkNY 10032United States Department of Biology Tufts UniversityMedfordMA 02155United States Allen Discovery Center at Tufts University MedfordMA 02155United States Wyss Institute for Biologically Inspired Engineering Harvard UniversityBostonMA 02115United States Department of Neurology H.Houston Merritt CenterColumbia Translational Neuroscience InitiativeCollege of Physicians and SurgeonsColumbia University Irving Medical CenterNew YorkNY 10032United States New York State Psychiatric Institute New YorkNY 10032United States robert N Butler Columbia Aging Center Columbia University Mailman School of Public HealthNew YorkNY 10032United States

Major life transitions are always difficult because change costs *** findings have demonstrated how mitochondrial oxidative phosphorylation(OxPhos)defects increase the energetic cost of living and that excessive integrated stress response(ISr)signaling may prevent cellular identity transitions during *** this perspective,we discuss general bioenergetic principles of life transitions and the costly molecular processes involved in reprograming the cellular hardware/software as cells shift *** energetic cost of cellular differentiation has not been directly quantified,representing a gap in *** propose that the ISr is an energetic checkpoint evolved to(i)prevent OxPhos-deficient cells from engaging in excessively costly transitions and(ii)allow ISr-positive cells to recruit systemic energetic resources by signaling via GDF15 and the brain.

关键词： energy mitochondria signaling pathway growth differentiation factor 15 energy balance development

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Why Do We Care More About Disease than Health?

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Phenomics 2022年第3期2卷 145-155页

作者： Martin Picard Department of Psychiatry Division of Behavioral MedicineColumbia University Irving Medical CenterNew YorkNY 10032USA Department of Neurology Merritt CenterColumbia Translational Neuroscience InitiativeColumbia University Irving Medical CenterNew YorkNY 10032USA New York State Psychiatric Institute New YorkNY 10032USA

Modern Western biomedical research and clinical practice are primarily focused on *** disease-centric approach has yielded an impressive amount of knowledge around what goes wrong in ***,in comparison,researchers and physicians know little about *** is health?How do we quantify it?And how do we improve it?We currently do not have good answers to these *** lack of fundamental knowledge about health is partly driven by three main factors:(i)a lack of understanding of the dynamic processes that cause variations in health/disease states over time,(ii)an excessive focus on genes,and(iii)a pervasive psychological bias towards additive *** I briefly discuss potential reasons why scientists and funders have generally adopted a gene-and disease-centric framework,how medicine has ended up practicing“diseasecare”rather than healthcare,and present cursory evidence that points towards an alternative energetic view of *** the basis of human health with a similar degree of precision that has been deployed towards mapping disease processes could bring us to a point where we can actively support and promote human health across the lifespan,before disease shows up on a scan or in bloodwork.

关键词： Health Medical care Genomics Personalized medicine Energetics Preventative medicine

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