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Mineralogy of Chang'e-4 landing site:preliminary results of visible and near-infrared imaging spectrometer

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Science China(Information Sciences) 2020年第4期63卷 195-206页

作者： Jian CHEN Zongcheng LING Le QIAO Zhiping HE Rui XU Lingzhi SUN Jiang ZHANG Bo LI Xiaohui FU Changqing LIU Xiaobin QI shandong Key Laboratory of Optical Astronomy and Solar-Terrestrial Environment School of Space Science and PhysicsInstitute of Space Sciences Shandong University Key Laboratory of Space Active Opto-Electronics Technology Shanghai Institute of Technical PhysicsChinese Academy of Sciences Hawai'i Institute of Geophysics and Planetology Department of Earth Sciences University of Hawai'i at Manoa

The exploration of mafic anomaly in South Pole-Aitken(SPA, the largest confirmed) basin on the Moon provides important insights into lunar interior. The landing of Chang’e-4(CE-4) and deployment of Yutu-2 rover on the discontinuous ejecta from Finsen crater enabled in-situ measurements of the unusual mineralogy in the central portion of SPA basin with visible and near-infrared imaging spectrometer(VNIS).Here we present detailed processing procedures based on the level 2B data of CE-4 VNIS and preliminary mineralogical results at the exploration area of Yutu-2 rover. A systematic processing pipeline is developed to derive credible reflectance spectra, based on which several spectral and mineral indices are calculated to constrain the mafic mineralogy. The mafic components in the soils and boulder around CE-4 landing site are concluded as clinopyroxene-bearing with intermediate composition and probably dominated by pigeonite although the possibility of mixing orthopyroxen(OPX) and calcic clinopyroxene(CPX) also exists. These mineralogical results are more consistent with a petrogenesis that the CE-4 regolith and rock fragment are derived from rapid-cooling magmatic systems and we interpret that the materials at the CE-4 landing site ejected from Finsen crater are probably recrystallized from impact melt settings.

关键词： Chang’e-4 visible and near-infrared spectroscopy mineralogy impact melt the Moon

Gut-on-a-chip for exploring the transport mechanism of Hg(II)

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Microsystems & Nanoengineering 2023年第1期9卷 215-227页

作者： Li Wang Junlei Han Weiguang Su Anqing Li Wenxian Zhang Huimin Li Huili Hu Wei Song Chonghai Xu Jun Chen School of Mechanical Engineering Qilu University of Technology(Shandong Academy of Sciences)Jinan250353China shandong Institute of Mechanical Design and Research Jinan250353China The Key Laboratory of Experimental Teratology Ministry of Education and Department of GeneticsSchool of Basic Medical SciencesShandong University250012JinanChina The Research Center of Stem Cell and Regenerative Medicine School of Basic Medical SciencesCheeloo Medical CollegeShandong University250012JinanChina Department of Oncology Shandong Provincial Hospital Affiliated to Shandong UniversityJinanShandong250021China

Animal models and static cultures of intestinal epithelial cells are commonly used platforms for exploring mercury ion(Hg(II))***,they cannot reliably simulate the human intestinal microenvironment and monitor cellular physiology in situ;thus,the mechanism of Hg(II)transport in the human intestine is still ***,a gut-on-a-chip integrated with transepithelial electrical resistance(TEER)sensors and electrochemical sensors is proposed for dynamically simulating the formation of the physical intestinal barrier and monitoring the transport and absorption of Hg(II)in *** cellular microenvironment was recreated by applying fluid shear stress(0.02 dyne/cm^(2))and cyclic mechanical strain(1%,0.15 Hz).Hg(II)absorption and physical damage to cells were simultaneously monitored by electrochemical and TEER sensors when intestinal epithelial cells were exposed to different concentrations of Hg(II)mixed in culture ***(II)absorption increased by 23.59%when tensile strain increased from 1%to 5%,and the corresponding expression of Piezo1 and DMT1 on the cell surface was upregulated.

关键词： intestine transport mechanism

Heterologous expression facilitates the discovery and characterization of marine microbial natural products

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Engineering Microbiology 2024年第2期4卷 77-90页

作者： Shuang Zhao Ruiying Feng Yuan Gu Liyuan Han Xiaomei Cong Yang Liu Shuo Liu Qiyao Shen Liujie Huo Fu Yan State Key Laboratory of Microbial Technology Shandong UniversityQingdao 266237China Helmholtz-Institute for Pharmaceutical Research Saarland Saarland University Campus66123SaarbrückenGermany

Microbial natural products and their derivatives have been developed as a considerable part of clinical drugs and agricultural *** microbial natural products exhibit diverse chemical structures and bioactivities with substantial potential for the development of novel ***,discovering compounds with new skeletons from marine microbes remains *** recent decades,multiple approaches have been de-veloped to discover novel marine microbial natural products,among which heterologous expression has proven to be an effective *** by large DNA cloning and comparative metabolomic technologies,a few novel bioactive natural products from marine microorganisms have been identified by the expression of their biosynthetic gene clusters(BGCs)in heterologous *** expression is advantageous for character-izing gene functions and elucidating the biosynthetic mechanisms of natural *** review provides an overview of recent progress in heterologous expression-guided discovery,biosynthetic mechanism elucidation,and yield optimization of natural products from marine microorganisms and discusses the future directions of the heterologous expression strategy in facilitating novel natural product exploitation.

关键词： Marine natural products Heterologous expression Biosynthetic gene clusters Biosynthetic mechanism

Progress in densification and toughening of high entropy carbide ceramics

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Journal of Materials Science & Technology 2023年第30期161卷 10-43页

作者： Zhennan Cao Jialin Sun Lingtao Meng Keguo Zhang Jun Zhao Zhifu Huang Xialun Yun School of Mechanical Electrical&Information EngineeringShandong University(Weihai)Weihai 264209China State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China Shenzhen Research Institute of shandong university Shenzhen 518057China Key Laboratory of High Efficiency and Clean Mechanical Manufacture of MOE School of Mechanical EngineeringShandong UniversityJinan 250061China State Key Laboratory for Mechanical Behavior of Materials School of Materials Science and EngineeringXi’an Jiaotong UniversityXi’an 710049China State Key Laboratory for Manufacturing System Engineering School of Mechanical EngineeringXi’an Jiaotong UniversityXi’an 710049China

High entropy carbide ceramics(HECC)are solid solution of inorganic compounds with five or more prin-cipal metal *** interests in HECC are dramatically sparked by the enormous possibilities in composition-microstructure-property *** widely acknowledged,HECCs enjoy higher hardness and oxidation/corrosion/wear resistance,as well as lower thermal conductivity than conventional engi-neering carbide ceramics,making them the most potential candidates for state-of-the-art structural and functional applications in extreme service *** the advantages,however,the poor den-sification coupled with low fracture toughness significantly limited the practical applications of *** to the difficulty,the literature available for toughening HECC is woefully *** considera-tion of this insufficiency,we apply towards offer a comprehensive,critical review of the mechanical be-havior of HECC,highlighting the densification enhancing strategies(carbon content,sintering techniques,grain size,sintering aids,etc.)as well as toughening methods including particle toughening,whisker/fiber toughening,synergistic toughening,graphene-carbon nanotube toughening,to further the service reliabil-ity of HECC in practical industrial ***,despite some significant successes,important directions for further development of HECC are given as multi-dimensional gradient HECC,additive man-ufacturing of HECC,processing-composition-microstructure-property relationship prediction and genomes of HECC based on machine learning,and high-throughput computing,etc.

关键词： High entropy carbide ceramic Densification Toughening Mechanical properties

Palmitoleic acid on top of HFD ameliorates insulin resistance independent of diacylglycerols and alters gut microbiota in C57BL/6J mice

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Food Science and Human Wellness 2024年第2期13卷 856-868页

作者： Qijian Liang Yan Zheng Fanli Meng Xiaofan Jiang Qingcai Zhen Zhongting Lu Shixiu Zhang Lei Du Hao Wu Xin Guo Department of Nutrition and Food Hygiene School of Public HealthCheeloo College of MedicineShandong UniversityJinan 250012China Research Center of Translational Medicine Jinan Central Hospital Affiliated to Shandong First Medical UniversityJinan 250013China Department of Hepatology Qilu Hospital of Shandong UniversityJinan 250012China Institute of Hepatology Shandong UniversityJinan 250012China

With the prevalence of obesity and obesity-related metabolic syndrome,such as insulin resistance in recent years,it is urgent to explore effective interventions to prevent the progression of obesity-related metabolic *** acid is a monounsaturated fatty acid that is available from dietary sources,mainly derived from marine products.P almitoleic acid plays a positive role in maintaining glucose homeostasis and reducing ***,it is still unknow the mechanism of palmitoleic acid in ameliorating insulin ***,we investigated the effects of palmitoleic acid on chow diet(CD)-fed and high-fat diet(HFD)-fed mice,which were fed CD or HFD for 12 weeks before *** administrated mice with BSA(control),oleic acid,or palmitoleic acid for 6 weeks on top of CD or HFD *** found that palmitoleic acid only improved glucose homeostasis in HFD-fed obese mice by increasing glucose clearance and reducing *** study explored that palmitoleic acid changed the composition of gut microbiota by decreasing Firmicutes population and increasing Bacteroidetes *** colon,palmitoleic acid increased intestinal tight junction integrity and reduced ***,palmitoleic acid decreased macrophage infiltration in liver and adipose tissue and increase glucose uptake in adipose ***(DAG)in tissue(for example,liver)is found to positively correlated with *** enhanced the levels of DAGs in liver but not in adipose tissue in this *** acid did not reverse the high DAG levels induced by HFD in ***,in HFD-fed mice,palmitoleic acid reduced insulin resistance by an independent-manner of *** might be associated with the beneficial effects of palmitoleic acid on altering the gut microbiota composition,improving of intestinal barrier function,and downregulating the inflammation in colon,liver,and adipose tissue.

关键词： Palmitoleic acid High fat diet Insulin resistance Gut microbiota

NAC1 regulates root ground tissue maturation by coordinating with the SCR/SHR-CYCD6;1 module in Arabidopsis

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Molecular Plant 2023年第4期16卷 709-725页

作者： Chuantian Xie Cuiling Li Fengxia Wang Feng Zhang Jiajia Liu Junxia Wang Xiansheng Zhang Xiangpei Kong Zhaojun Ding The Key Laboratory of Plant Development and Environmental Adaptation Biology Ministry of EducationCollege of Life SciencesShandong UniversityQingdao Shandong266237China National Key Laboratory of Crop Biology College of Life SciencesShandong Agricultural UniversityTaianShandong 271018China

Precise spatiotemporal control of the timing and extent of asymmetric cell divisions(AcDs)is essential for plant *** the Arabidopsis root,ground tissue maturation involves an additional AcD of the endo-dermis that maintains the inner cell layer as the endodermis and generates the middle cortex to the *** regulation of the cell cycle regulator CYCLIND6;1(CYCD6;1),the transcription factors SCARECROW(SCR)and SHORT-ROOT(SHR)play critical roles in this *** the present study,we found that loss of function of NAC1,a NAC transcription factor family gene,causes markedly increased periclinal cell divisions in the root ***,NAC1 directly represses the transcription of CYCD6;1 by recruiting the co-repressor TOPLESS(TPL),creating a fine-tuned mechanism to maintain proper root ground tissue patterning by limiting production of middle cortex *** and genetic analyses further showed that NAC1 physically interacts with SCR and SHR to restrict excessive periclinal cell divisions in the endo-dermis during root middle cortex *** NAC1-TPL is recruited to the CYCD6;1 promoter and represses its transcription in an SCR-dependent manner,NAC1 and SHR antagonize each other to regu-late the expression of CYCD6;***,our study provides mechanistic insights into how the NAC1-TPL module integrates with the master transcriptional regulators SCR and SHR to control root ground tissue patterning by fine-tuning spatiotemporal expression of CYCD6;1 in Arabidopsis.

关键词： root,NAC1,SCR,SHR,TOPLESS,CYCD6 1

Optimized operation scheme of flash-memory-based neural network online training with ultra-high endurance

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Journal of Semiconductors 2024年第1期45卷 33-37页

作者： Yang Feng Zhaohui Sun Yueran Qi Xuepeng Zhan Junyu Zhang Jing Liu Masaharu Kobayashi Jixuan Wu Jiezhi Chen School of Information Science and Engineering(ISE) Shandong UniversityQingdao 266200China Neumem Co. LtdHefei 230093China Key Laboratory of Microelectronic Devices and Integrated Technology Institute of Microelectronics of Chinese Academy of SciencesBeijing 100084China Institute of Industrial Science The University of TokyoTokyoJapan

With the rapid development of machine learning,the demand for high-efficient computing becomes more and more *** break the bottleneck of the traditional Von Neumann architecture,computing-in-memory(CIM)has attracted increasing attention in recent *** this work,to provide a feasible CIM solution for the large-scale neural networks(NN)requiring continuous weight updating in online training,a flash-based computing-in-memory with high endurance(10^(9) cycles)and ultrafast programming speed is *** the one hand,the proposed programming scheme of channel hot electron injection(CHEI)and hot hole injection(HHI)demonstrate high linearity,symmetric potentiation,and a depression process,which help to improve the training speed and *** the other hand,the low-damage programming scheme and memory window(MW)optimizations can suppress cell degradation effectively with improved computing *** after 109 cycles,the leakage current(I_(off))of cells remains sub-10pA,ensuring the large-scale computing ability of *** characterizations are done on read disturb to demonstrate its robust *** processing CIFAR-10 tasks,it is evident that~90%accuracy can be achieved after 109 cycles in both ResNet50 and VGG16 *** results suggest that flash-based CIM has great potential to overcome the limitations of traditional Von Neumann architectures and enable high-performance NN online training,which pave the way for further development of artificial intelligence(AI)accelerators.

关键词： NOR flash memory computing-in-memory endurance neural network online training

Simultaneous degradation of RhB and reduction of Cr(Ⅵ) by MIL-53(Fe)/Polyaniline(PANI) with the mediation of organic acid

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Chinese Journal of Chemical Engineering 2022年第2期35卷 55-63页

作者： Wanyuan Wang Chengxin Wen Daoyuan Zheng Chunhu Li Junjie Bian Xinbo Wang Key Laboratory of Marine Chemistry Theory and Technology of Ministry of Education Ocean University of ChinaQingdao 266100China School of Environmental Science and Engineering Shandong UniversityQingdao 266237China

MIL-53(Fe)/polyaniline(PANI) composite was prepared by in situ depositing PANI on the surface of MIL-53(Fe) and their catalytic performances on the simultaneous removal of Rh B and Cr(Ⅵ) were investigated. The elimination efficiency of both RhB and Cr(Ⅵ) reached more than 98% under pH = 2 where hydrochloric acid and citric acid were used to adjust the pH. The results indicated that MIL-53(Fe)/PANI revealed an obvious pH response to the degradation of RhB, while citric acid promoted the Cr(Ⅵ)photoreduction. UV–Vis spectra, EIS, and photocurrent response experiments showed that MIL-53(Fe)/PANI had a better light response and carrier migration ability than MIL-53(Fe). The transient absorption spectra also exhibited that the lifetimes of photo-generated carriers were prolonged after the conductive polymer deposition on the MIL-53(Fe) surface. Scavenger experiments demonstrated that the main active species were·O;-and·OH. Combined with activity evaluation results, and the possible photocatalytic mechanism of MIL-53(Fe)/PANI on RhB oxidation and Cr(Ⅵ) reduction was proposed. The addition of conductive polymer can effectively improve the light response of the catalyst under acidic conditions, and meanwhile citric acid also provided a new mediation for the synergistic degradation of multiple pollutants. Good activity and stability of the catalysts made the scale-up purification of acid water feasible under UV–Vis light.

关键词： Photocatalyst MIL-53(Fe) Polyaniline Synergistic effects Cr(Ⅵ)-RhB coexistence system

Flash-based in-memory computing for stochastic computing in image edge detection

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Journal of Semiconductors 2023年第5期44卷 145-149页

作者： Zhaohui Sun Yang Feng Peng Guo Zheng Dong Junyu Zhang Jing Liu Xuepeng Zhan Jixuan Wu Jiezhi Chen School of Information Science and Engineering(ISE) Shandong UniversityQingdao 266000China shandong Sinochip Semiconductors Co.Ltd Jinan 250101China Neumem Co. LtdHefei 230088China Key Laboratory of Microelectronic Devices and Integrated Technology Institute of Microelectronics of Chinese Academy of SciencesBeijing 100029China

The“memory wall”of traditional von Neumann computing systems severely restricts the efficiency of data-intensive task execution,while in-memory computing(IMC)architecture is a promising approach to breaking the *** variations and instability in ultra-scaled memory cells seriously degrade the calculation accuracy in IMC architectures,stochastic computing(SC)can compensate for these shortcomings due to its low sensitivity to cell ***,massive parallel computing can be processed to improve the speed and efficiency of the *** this paper,by designing logic functions in NOR flash arrays,SC in IMC for the image edge detection is realized,demonstrating ultra-low computational complexity and power consumption(25.5 fJ/pixel at 2-bit sequence length).More impressively,the noise immunity is 6 times higher than that of the traditional binary method,showing good tolerances to cell variation and reliability degradation when implementing massive parallel computation in the array.

关键词： in-memory computing stochastic computing NOR flash memory image edge detection