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Cascade degradation and electrocatalytic upcycling of waste poly(ethylene terephthalate)to valued products

Nano research 2025年第1期18卷 76-93页

作者： Xin Li Zirui Jiang Zongkui Kou John Wang Shiyou Zheng School of Materials and Chemistry University of Shanghai for Science and TechnologyShanghai 200093China School of Materials Science and Engineering Wuhan University of TechnologyWuhan 430070China Department of Materials Science and Engineering National University of SingaporeSingapore 117574Singapore

The global annual production of poly(ethylene terephthalate)(PET)has reached 82 million tons,yet only a small fraction(less than 20%)is *** ultra-slow degradation rate of PET results in the accumulation of PET waste in the environment,causing serious plastic pollution and posing severe challenges to *** response,great efforts have been directed toward developing a cascade degradation and electrocatalytic upcycling strategy,which serves as a“waste-towealth”*** strategy involves electro-reforming PEThydrolyzed intermediates or using PET pyrolyzed products as electrocatalysts to generate high-value *** review provides an overview of the state-of-the-art strategies for the“degradation-electrocatalytic upcycling(De-eUp)”of PET ***,an introduction to the strategy is provided,categorizing it into two main frameworks:“pyrolysis-electrocatalytic upcycling”and“hydrolysis-electrocatalytic upcycling”.The section on“pyrolysis-electrocatalytic upcycling”delves into the degradation methods for designing derived carbon nanomaterials and their utilization as high-performance ***“hydrolysis-electrocatalytic upcycling”section discusses recent advancements in electro-reforming of PET hydrolyzed intermediates for the production of C_(1) and C_(2) *** review concludes by examining the challenges and future prospects in developing an efficient and economical PET upcycling *** is anticipated that this review will stimulate further progress in plastic waste valorization.

关键词： poly(ethylene terephthalate)waste electrocatalytic upcycling pyrolysis hydrolysis ethylene glycol oxidation reaction

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Intravenous route to choroidal neovascularization by macrophage-disguised nanocarriers for mTOR modulation

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Acta Pharmaceutica Sinica B 2022年第5期12卷 2506-2521页

作者： Weiyi Xia Chao Li Qinjun Chen Jiancheng Huang Zhenhao Zhao Peixin Liu Kai Xu Lei Li Fangyuan Hu Shujie Zhang Tao Sun Chen Jiang Chen Zhao Department of Ophthalmology and Vision Science Eye&ENT HospitalShanghai Medical SchoolFudan UniversityShanghai 200031China Key Laboratory of Smart Drug Delivery Ministry of EducationDepartment of PharmaceuticsSchool of PharmacyFudan UniversityShanghai 201203China

Retinal pigment epithelial(RPE) is primarily impaired in age-related macular degeneration(AMD), leading to progressive loss of photoreceptors and sometimes choroidal neovascularization(CNV). mTOR has been proposed as a promising therapeutic target, while the usage of its specific inhibitor,rapamycin, was greatly limited. To mediate the mTOR pathway in the retina by a noninvasive approach, we developed novel biomimetic nanocomplexes where rapamycin-loaded nanoparticles were coated with cell membrane derived from macrophages(termed as MRaNPs). Taking advantage of the macrophage-inherited property, intravenous injection of MRaNPs exhibited significantly enhanced accumulation in the CNV lesions, thereby increasing the local concentration of rapamycin. Consequently, MRaNPs effectively downregulated the mTOR pathway and attenuate angiogenesis in the eye. Particularly, MRaNPs also efficiently activated autophagy in the RPE, which was acknowledged to rescue RPE in response to deleterious stimuli. Overall, we design and prepare macrophage-disguised rapamycin nanocarriers and demonstrate the therapeutic advantages of employing biomimetic cell membrane materials for treatment of AMD.

关键词： Choroidal neovascularization Age-related macular degeneration Biomimetic nanoparticles Targeted drug delivery mTOR signaling Rapamycin Macrophage membrane Inflammation

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Synthesis,characterization of a DOPO-based polymeric flame retardant and its application in polyethylene terephthalate

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Progress in Natural Science:Materials International 2020年第2期30卷 200-207页

作者： Xiang Ao Ya Du Dan Yu Wei Wang Weizhong Yang Bin Sun Meifang Zhu State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringDonghua University Key Laboratory of Science & Technology of Eco-Textile Ministry of EducationCollege of ChemistryChemical Engineering and BiotechnologyDonghua University shanghai Different Chemical Fiber Co. Ltd

A high molecular weight DOPO-based flame retardant(DP-DE) containing phosphorus linked pendent groups was synthesized by a two-step esterification and polycondensation reaction,and characterized by Fourier transform infrared spectroscopy(FTIR),13C nuclear magnetic resonance(13C NMR) and gel permeation chromatography(GPC).After added into polyethylene terephthalate(PET) via melt-blending method,the flame retardancy of DP-DE were monitored by thermo-gravimetric analysis(TGA),limiting oxygen index(LOI) and underwriter laboratories(UL-94) *** results showed that DP-DE display good flame retardancy in *** the thermal stability,char residue yield and LOI values of the composites increased with the increase of DP-DE *** flame retarded mechanism of DP-DE was investigated by pyrolysis-gas chromatogram-mass(PY-GCMS),in situ FTIR,scanning electron microscope(SEM) and laser Raman spectroscopy(LRS).DP-DE was evidenced to release phosphorus acid and its derivatives,which catalyze carbonization and produce compact carbonaceous *** protecting the polymeric materials substrate from further degradation and inhibiting the pyrolysis degree,both the amount and thermal stability of carbonaceous layers of DP-DE were improved,and hence enhancing the flame retarded performance of PET/DP-DE composites.

关键词： High molecular weight DOPO-Based Flame retardant PET Mechanism

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Estrogen enhances the functions of CD4^(+)CD25^(+)Foxp3^(+) regulatory T cells that suppress osteoclast differentiation and bone resorption in vitro

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Cellular & Molecular Immunology 2011年第1期8卷 50-58页

作者： CY Luo L Wang C Sun DJ Li Laboratory for Reproductive Immunology Hospital and Institute of Obstetrics and GynecologyFudan University Shanghai Medical CollegeShanghaiChina Jiangsu Province Hospital the First Affiliated Hospital with Nanjing Medical UniversityNanjingChina Department of Obstetrics and Gynecology Affiliated HospitalHainan Medical CollegeHaikouChina

Cross-talk has been shown to occur between the immune system and bone metabolism *** the present study,we investigated the impact of CD4^(+)CD25^(+)Foxp3^(+) regulatory T(Treg)cells on osteoclastogenesis and bone *** cells that were isolated and purified from peripheral blood mononuclear cells(PBMCs)of healthy adults inhibited both the differentiation of osteoclasts(OCs)from human embryo bone marrow cells(BMCs)and the pit formation in a dose-dependent *** cell cocultures,the production levels of both interleukin-10(IL-10)and transforming growth factor-beta 1(TGF-β1)were proportionally upregulated as the ratio of Treg cells to BMCs was increased,and the inhibition of OC differentiation and bone resorption by Treg cells was completely reversed by anti-IL-10 and anti-TGF-β1 *** of BMC and Treg cell cocultures with 17β-estradiol(E2)at concentrations between 10^(-7) and 10^(-9) mol/l suppressed OC differentiation and bone resorption more efficiently than it did in cultures of BMCs alone;this enhanced suppression occurred via the stimulation of Treg cell IL-10 and TGF-b1 *** data suggest that Treg cells suppress OC differentiation and bone resorption by secreting IL-10 and TGF-β1.E2 enhances the suppressive effects of Treg cells on OC differentiation and bone resorption by stimulating IL-10 and TGF-β1 secretion from these ***,Treg cell-derived IL-10 and TGF-b1 are likely involved in the regulation of E2 on bone metabolism and represent potential therapeutic targets for the treatment of postmenopausal osteoporosis(PMO).

关键词： bone resorption osteoclast PMO regulatory T cells

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Effects and Clinical Significance of Pentoxifylline on the Oxidative Stress of Rats with Diabetic Nephropathy

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2015年第3期35卷 356-361页

作者：安增梅董兴刚过源周佳亮秦涛 Department of Endocrinology Shanghai Second People’s Hospital Laboratory Animal Science Center Fudan University

Diabetic nephropathy（DN） is a common and serious clinical complication of diabetes and presently there are no effective ways to prevent its occurrence and progression. Recent studies show that pentoxifylline（PTX） can improve renal hemodynamics, reduce urinary protein excretion, and alleviate or delay renal failure in DN patients. In this study, we focused on the anti-oxidative stress effect of PTX on alleviating renal damages of DN using rat models. DN rats were established with injection of streptozotocin. Blood glucose, urinary protein excretion, serum cystatin C, renal biopsy, superoxide dismutase（SOD） and malondialdehyde（MDA） in serum and renal homogenate and renal nitrotyrosine levels were analyzed before and 12 weeks after the treatment of PTX. Before treatment, all the DN rats had elevated blood glucose, increased urinary protein excretion and elevated serum cystatin C. Morphologically, DN rats exhibited renal tissue damages, including swelling and fusions of foot processes of podocytes under electron microscope. Masson staining revealed blue collagen deposition in glomeruli and renal interstitium. With treatment of PTX, symptoms and renal pathological changes of DN rats were alleviated. Furthermore, the MDA levels were increased and the SOD levels were decreased in the serum and kidneys of DN rats, and these changes were reversed by PTX. The expression of nitrotyrosine was up-regulated in DN rat model and down-regulated by PTX, indicating that PTX was able to inhibit oxidative reactions in DN rats. PTX could alleviate renal damage in DN, which may be attributable to its anti-oxidative stress activity.

关键词： diabetic nephropathy pentoxifylline oxidative stress nitrotyrosine superoxide dismutase

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Global profiling of O-GlcNAcylated and/or phosphorylated proteins in hepatoblastoma

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Signal Transduction and Targeted Therapy 2019年第1期4卷 311-319页

作者： Hang Song Ji Ma Zhixuan Bian Shuhua Chen Jiabei Zhu Jing Wang Nan Huang Minzhi Yin Fenyong Sun Min Xu Qiuhui Pan Department of Laboratory Medicine Shanghai Children’s Medical CenterSchool of MedicineShanghai Jiaotong University200127 ShanghaiChina Department of Laboratory Medicine Yunfu People’s Hospital527300 GuangdongChina Department of Surgery Shanghai Children’s Medical CenterSchool of MedicineShanghai Jiaotong University200127 ShanghaiChina Department of Laboratory Medicine Shanghai Tenth People’s Hospital of Tongji University200072 ShanghaiChina Department of Pathology Shanghai Children’s Medical CenterSchool of MedicineShanghai Jiaotong University200127 ShanghaiChina

O-linked-β-N-acetylglucosamine(O-GlcNAc)glycosylation(O-GlcNAcylation)and phosphorylation are critical posttranslational modifications that are involved in regulating the functions of proteins involved in tumorigenesis and the development of various solid ***,a detailed characterization of the patterns of these modifications at the peptide or protein level in hepatoblastoma(HB),a highly malignant primary hepatic tumor with an extremely low incidence in children,has not been ***,we examined O-GlcNAc-modified or phospho-modified peptides and proteins in HB through quantitative proteomic analysis of HB tissues and paired normal liver *** results identified 114 O-GlcNAcylated peptides belonging to 78 proteins and 3494 phosphorylated peptides in 2088 ***,41 proteins were modified by both O-GlcNAcylation and *** proteins are involved in multiple molecular and cellular processes,including chromatin remodeling,transcription,translation,transportation,and organelle *** addition,we verified the accuracy of the proteomics results and found a competitive inhibitory effect between O-GlcNAcylation and phosphorylation of ***,O-GlcNAcylation modification of HSPB1 promoted proliferation and enhanced the chemotherapeutic resistance of HB cell lines in ***,our research suggests that O-GlcNAc-modified and/or phospho-modified proteins may play a crucial role in the pathogenesis of HB.

关键词： hepato competitive modification

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Dysfunction of two lysosome degradation pathways of α-synuclein in Parkinson's disease: potential therapeutic targets?

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Neuroscience Bulletin 2012年第5期28卷 649-657页

作者： Tian-Fang Jiang Sheng-Di Chen Department of Neurology & Institute of Neurology Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine Shanghai 200025 China

Parkinson＇s disease （PD） is pathologically characterized by the presence of α-synuclein （α-syn）-positive intra-cytoplasmic inclusions named Lewy bodies in the dopaminergic neurons of the substantia nigra. A series of morbid consequences are caused by pathologically high amounts or mutant forms of α-syn, such as defects of membrane trafficking and lipid metabolism. In this review, we consider evidence that both point mutation and overexpression of α-syn result in aberrant degradation in neurons and microglia, and this is associated with the autophagy-lysosome pathway and endosome-lysosome system, leading directly to pathological intracellular aggregation, abnormal externalization and re-internalization cycling （and, in turn, internalization and re-externalization）, and exocytosis. Based on these pathological changes, an increasing number of researchers have focused on these new therapeutic targets, aiming at alleviating the pathological accumulation of α-syn and re-establishing normal degradation.

关键词： Parkinson’s disease α-synuclein neurodegenerative disease

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Electrolyte/Electrode Interfaces in All‑Solid‑State Lithium Batteries:A Review

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Electrochemical Energy Reviews 2021年第2期4卷 169-193页

作者： Yuepeng Pang Jinyu Pan Junhe Yang Shiyou Zheng Chunsheng Wang School of Materials Science and Engineering University of Shanghai for Science and TechnologyShanghai 200093China Department of Chemical and Biomolecular Engineering University of MarylandCollege ParkMD 20742USA

All-solid-state lithium batteries are promising next-generation energy storage devices that have gained increasing attention in the past decades due to their huge potential towards higher energy density and *** a key component,solid electrolytes have also attracted significant attention and have experienced major breakthroughs,especially in terms of Li-ion ***,the poor electrode compatibility of solid electrolytes can lead to the degradation of electrolyte/electrode interfaces,which is the major cause for failure in all-solid-state lithium *** address this,this review will summarize the indepth understanding of physical and chemical interactions between electrolytes and electrodes with a focus on the contact,charge transfer and Li dendrite formation occurring at electrolyte/electrode *** on mechanistic analyses,this review will also briefly present corresponding strategies to enhance electrolyte/electrode interfaces through compositional modifications and structural ***,the comprehensive insights into electrolyte/electrode interfaces provided by this review can guide the future investigation of all-solid-state lithium batteries.

关键词： electrolyte electrode lithium

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Advances in solid Mg-ion electrolytes for solid-state Mg batteries

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Journal of Materials Science & Technology 2023年第30期161卷 136-149页

作者： Yuepeng Pang Yu Zhu Fang Fang Dalin Sun Shiyou Zheng School of Materials and Chemistry University of Shanghai for Science and TechnologyShanghai 200093China Department of Materials Science Fudan UniversityShanghai 200433China

Rechargeable Mg batteries have attracted much attention in the past decade due to their high theoretical energy density and low production cost,in which the electrolyte is the key component that determines the overall *** solid Mg-ion electrolytes brings many benefits to rechargeable Mg bat-teries,which can improve safety under aggressive conditions and open opportunities for new electrode *** extensive investigations,researchers make major breakthroughs in the solid Mg-ion electrolyte field,especially in terms of Mg-ion ***,the development of solid-state Mg batteries is still at the early stage since their stable cycling has not been achieved *** this review,we introduce the Mg-ion conducting properties of current solid Mg-ion electrolytes,and then summarize the performances of corresponding solid-state Mg *** addition,we provide a discussion on the application potentials and future directions of each type of solid Mg-ion electrolytes that are applied in solid-state Mg batteries.

关键词： Solid Mg-ion electrolytes Solid-state Mg batteries Phosphates Borohydrides Chalcogenides Metal-organic frameworks Polymers

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Theoretical study on isotope separation of an ytterbium atomic beam by laser deflection

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Chinese Physics B 2014年第1期23卷 192-196页

作者：徐闰徐海涛汤敏燕王林军 School of Materials Science and Engineering Shanghai University State Key Laboratory of Surface Physics and Department of Physics Fudan University

Isotope separation by laser deflecting an atomic beam is analyzed theoretically. Interacting with a tilted one- dimensional optical molasses, an ytterbium atomic beam is split into multi-beams with different isotopes like 172yb, Jv3yb, and J74yb. By using the numerical calculation, the dependences of the splitting angle on the molasses laser intensity and detuning are studied, and the optimal parameters for the isotope separation are also investigated. Furthermore, the isotope separation efficiency and purity are estimated. Finally a new scheme for the efficient isotope separation is proposed. These findings will give a guideline for simply obtaining pure isotopes of various elements.

关键词： isotope separation ytterbium optical molasses laser cooling

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