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Journal of zhejiang University-science A(Applied Physics & Engineering) 2024年第5期25卷 395-410页

作者： Yichuan HONG Haojie YU Li WANG Xiang CHEN Di SHEN Yu WANG Shuning REN Yudi HUANG Jian YANG State Key Laboratory of Chemical Engineering College of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310058China zhejiang-Russia Joint Laboratory of Photo-Electro-Magnetic Functional Materials College of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310058China

To overcome the pain and risk of hypoglycemia in insulin administration,glucose-responsive microneedles have been developed by researchers,which could release insulin according to the blood glucose *** designed a kind of particles by a reversible addition-fragmentation chain transfer(RAFT)method containing a phenylboronic acid group as the sensor of glucose and carrier of ***(ethylene glycol)(PEG)-2-(dodecylthio(thiocarbonyl)thio)-2-methylpropionic acid(DDMAT)was synthesized as a macromolecular RAFT agent,which was then reacted with 3-acrylamidophenylboronic acid(AAPBA)to synthesize the block copolymer ***-responsive particles loaded with insulin were prepared by self-assembly based on hydrophilic-hydrophobic *** patches loaded with glucose-responsive particles were prepared using hyaluronic acid as the *** insulin release behavior of the particles in glucose solutions of 0,100,and 400 mg/dL showed significant glucose responsiveness and good *** results of blood glucose control experiments in rats indicate that a single microneedle patch can effectively maintain normal blood glucose for over 7 h.

关键词： Diabetes Hyaluronic acid Phenylboronic acid(PBA) Glucose responsive hydrogel Microneedles

The interaction mechanism between zein and folic acid in alkaline aqueous solutions:an experimental and molecular simulation study

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Food Quality and Safety 2024年第1期8卷 166-178页

作者： Jun Zhu Yiling Yao Yuying Liao Lala Cai Wenqi Zhang Nuo Hong Wenlin Sun Chunhua Xiong Lanying Yao School of Food science and Biotechnology Zhejiang Gongshang UniversityHangzhouChina

Objectives:Folic acid is a vitamin that is not highly soluble in water and is sensitive to the ***,it is important to find suitable *** study aimed to exemplify the interaction of folic acid with zein in alkaline aqueous solutions and shed light on how zein can be used as a carrier for folic *** and Methods:Zein and folic acid were separately dissolved in NaOH solutions with a PH of *** solution and folic acid solution were combined in specific *** methods including multi-spectroscopy,dynamic light scattering,and electron microscopy combining with molecular dynamics simulations were used to study the interaction mechanism between zein and folic acid in alkaline aqueous ***:Fluorescence spectroscopy showed that the quenching of zein by folic acid was mainly static,and the main driving force behind this interaction was van der Waals forces and hydrogen *** formation of zein–folic acid complexes was confirmed by ultraviolet–visible spectroscopy,Fourier transform infrared spectroscopy,and circular dichroism *** results also showed that the structure of zein changed when it interacted with folic *** light scattering analysis revealed that the addition of folic acid caused proteins to *** aggregates of the complexes had an irregular shape and were large,as observed by scanning electron microscopy and transmission electron *** simulation was used to further investigate the interaction *** to these findings,the folic acid molecule interacted with zein in a shallow recess near the protein *** dominant forces at play in the zein–folic acid interaction were van der Waals forces and electrostatic forces,including hydrogen ***:The zein alkali-soluble system is very suitable for folic acid delivery.

关键词： Zein folic acid alkaline aqueous solutions molecular simulation interaction mechanism.

Urban Traffic Control Meets Decision Recommendation System:A Survey and Perspective

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IEEE/CAA Journal of Automatica Sinica 2024年第10期11卷 2043-2058页

作者： Qingyuan Ji Xiaoyue Wen Junchen Jin Yongdong Zhu Yisheng Lv zhejiang Lab Hangzhou 311121China College of Engineering and Architecture Zhejiang UniversityHangzhou 310013China College of Electrical Engineering Zhejiang UniversityHangzhou 310013China the State Key Laboratory for Management and Control of Complex Systems Institute of AutomationChinese Academy of SciencesBeijing 100190China IEEE

Urban traffic control is a multifaceted and demanding task that necessitates extensive decision-making to ensure the safety and efficiency of urban transportation *** approaches require traffic signal professionals to manually intervene on traffic control devices at the intersection level,utilizing their knowledge and ***,this process is cumbersome,labor-intensive,and cannot be applied on a large network *** studies have begun to explore the applicability of recommendation system for urban traffic control,which offer increased control efficiency and *** a decision recommendation system is complex,with various interdependent components,but a systematic literature review has not yet been *** this work,we present an up-to-date survey that elucidates all the detailed components of a recommendation system for urban traffic control,demonstrates the utility and efficacy of such a system in the real world using data and knowledgedriven approaches,and discusses the current challenges and potential future directions of this field.

关键词： Recommendation system traffic control traffic perception traffic prediction

An Improved Chromosome-Level Genome Assembly and Annotation of Belted Beard Grunt(Hapalogenys analis)

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Journal of Ocean University of China 2024年第4期23卷 1026-1034页

作者： GAO Tianxiang WANG Yiting SHI Huilai PING Hongling LIU Qi ZHANG Yang Fishery College Zhejiang Ocean UniversityZhoushan 316022China zhejiang province Key Laboratory of Mariculture and Enhancement Zhejiang Marine Fisheries Research InstituteZhoushan 316021China Wuhan Onemore-Tech Co. Ltd.Wuhan 430076China Shenzhen Institute of Quality&Safety Inspection and Research Shenzhen 518000China

Hapalogenys analis(order Lobotiformes)is an economically and ecologically significant fish *** is a typical sedentary rocky reef fish and is primarily found in the northern Pacific ***,we used Hi-C and PacBio sequencing technique to assemble a high-quality,chromosome-level genome for this *** 539 Mb genome had a contig N50 with a size of 3.43 Mb,while 755 contigs clustered into 24 chromosomal groups with an anchoring rate of 99.02%.Of the total genomic sequence,132.74Mb(24.39%)were annotated as repeat elements.A total of 21360 protein-coding genes were identified,of which 20787 genes(97.32%)were successfully annotated to public *** BUSCO evaluation indicated that 96.90%of the total orthologous genes were *** phylogenetic tree representing *** and 14 other bony fish species indicated that the *** genome contained 364 expanded gene families related to olfactory receptor activity,compared with the common ancestor of *** and *** genomic analysis further identified 3584 contracted gene ***-site modeling identified 277 genes experiencing positive selection,which may facilitate the adaptation to rocky reef *** genome reported here is helpful for ecological and evolutionary studies of ***.

关键词： Hapalogenys analis de novo assembly PacBio comparative genomics

Deformation and stability of the seawall,considering the strength uncertainty of cement mixing piles

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Journal of zhejiang University-science A(Applied Physics & Engineering) 2024年第6期25卷 483-501页

作者： Yuansheng YU Lingling LI Xiangmiao KONG Chengyuan LI Zhen GUO Key Laboratory of Offshore Geotechnics and Material of zhejiang province College of Civil Engineering and ArchitectureZhejiang UniversityHangzhou310058China Hainan Institute Zhejiang UniversitySanya572000China Ninghai Highway and Transportation Management Center Ningbo315600China Ninghai Traffic Engineering Construction Management Institute Ningbo315600China

The cement mixing (CM) pile is a common method of improving soft offshore ground. The strength growth of CM piles under complex conditions is affected by many factors, especially the cement and moisture contents, and shows significant uncertainty. To investigate the stochasticity of the early strength of CM piles and its impact on the displacement and stability of a seawall, a series of laboratory tests and numerical analyses were carried out in this study. Vane shear tests were conducted on the cement-solidified soil to determine the relationships between the undrained shear strength s_(u) of the cement soil curing in the seawater and the cement content a_(c), as well as the in situ soil moisture content w. It can be inferred that the 24 h undrained shear strength follows a normal distribution. A numerical model considering the random CM pile strength was established to investigate the deformation of the seawall. Due to the uncertainty of CM pile strength, the displacement of the seawall demonstrates a certain discreteness. The decrease of the mean undrained shear strength of CM piles causes a corresponding increase in the average displacement of the seawall. When the mean strength of CM piles is lower than a certain threshold, there is a risk of instability. Furthermore, the heterogeneity of the strength within an individual CM pile also has an impact on seawall displacement. Attention should be paid to the uncertainty of CM pile strength to control displacement and stability.

关键词： Construction uncertainty Cement mixing(CM)pile Strength of cement soil Seawall stability Random finite element method(RFEM) Monte Carlo simulation(MCS)

Ru-Ni alloy nanosheets as tandem catalysts for electrochemical reduction of nitrate to ammonia

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Nano Research 2024年第6期17卷 4815-4824页

作者： Xingchao You Jiawei Xu Zechao Zhuang Junkai Xia Suwen Wang Haiyan Wei Yongfu Li Yanjiang Cai Hai Xiang Bing Yu State Key Laboratory of Subtropical Silviculture Zhejiang A&F UniversityHangzhou 311300China Ecological-Environment&Health College(EEHC) Zhejiang A&F UniversityHangzhou 311300China Jiangsu Key Laboratory of Numerical Simulation of Large Scale Complex Systems and School of Chemistry and Materials science Nanjing Normal UniversityNanjing 210023China department of Chemistry Tsinghua UniversityBeijing 100084China department of Chemical Engineering Columbia UniversityNew YorkNY 10027USA

Developing electrocatalysts that exhibit both high activity and ammonia selectivity for nitrate reduction is a significant and demanding challenge,primarily due to the complex nature of the multiple-electron reduction process *** encouraging approach involves coupling highly active precious metals with transition metals to enhance catalytic performance through ***,we report a ruthenium-nickel alloy catalyst with nanosheets(Ru-Ni NSs)structure that achieves a remarkable ammonia Faradaic efficiency of approximately 95.93%,alongside a yield rate of up to 6.11 g·h^(−1)·cm^(−2).Moreover,the prepared Ru-Ni NSs exhibit exceptional stability during continuous nitrate reduction in a flow reactor for 100 h,maintaining a Faradaic efficiency of approximately 90%and an ammonia yield of 37.4 mg·L^(−1)·h^(−1)using 0.05 M nitrate alkaline *** studies reveal that the catalytic process follows a two-step pathway,in which HONO serves as a migration *** presence of a partially oxidized Ru(002)surface enhances the adsorption of nitrate and facilitates the release of the migration intermediate by adjusting the strength of the electrostatic and covalent interactions between the adsorbate and the surface,*** the other hand,the Ni(111)surface promotes the utilization of the migration intermediate and requires less energy for NH_(3)*** tandem process contributes to a high catalytic activity of Ru-Ni NSs towards nitrate reduction.

关键词： alloy catalyst nitrate reduction ammonia synthesis Faradaic efficiency

Laboratory Evaluation of Performance Recovery of Aged SBS-modified Asphalt Using Regenerants with Different Base Oil Components

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China Petroleum Processing & Petrochemical technology 2024年第2期26卷 98-107页

作者： Li Hongzhen Li Shengbin Feng Zhuangzhuang Jiang Mengmeng Li Ning Dong Fuqiang Shandong Yimeng Traffic Development Group Co. Ltd.Zibo 276004China College of Civil and Transportation Engineering Hohai UniversityNanjing 210098China

In this study,the regenerative effects of different regenerants on aged SBS-modified asphalt from different perspectives were investigated,including their conventional properties,viscoelastic behavior,creep-related properties,and *** oils composed of different proportions of aromatic and saturated hydrocarbons as well as the styrene-butadiene-styrene(SBS)restorer were used to prepare the *** results showed that the components of the base oil of the regenerant played a crucial role in determining the characteristics and performance of the recycled SBSmodified *** containing a high proportion of aromatics dissolved the hard segment in the SBS restorer,thereby delaying the effect of a reduction in the regenerants on the performance of the aged asphalts at a high *** containing a high proportion of saturates dissolved the soft segment in the SBS restorer to enhance the lowtemperature performance of the recycled *** addition,the stress sensitivity of the recycled asphalts increased with the fraction of aromatics in the *** the aromatic content of the base oil components of the regenerants increased and their saturate content decreased,the state of dispersion of the SBS phase in the recycled SBS-modified asphalts *** optimal content of aromatics in the base oil of the regenerants should be set in the range of 33%to 47%to ensure the adequate performance of the recycled asphalts and a high efficiency of the SBS restorer.

关键词： aged SBS-modified asphalt regeneration mechanisms base oil rheological properties morphology

Exploring the Applications of Digital Twin technology in Enhancing Sustainability in Civil Engineering:A Review

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Structural Durability & Health Monitoring 2024年第5期18卷 577-598页

作者： Jiamin Huang Ping Wu Wangxin Li Jun Zhang Yidong Xu School of Civil Engineering Chongqing Jiaotong UniversityChongqing400074China School of Civil Engineering and Architecture NingboTech UniversityNingbo315100China School of Civil Engineering Lanzhou University of TechnologyLanzhou730050China

With the advent of the big data era and the rise of Industrial Revolution 4.0,digital twins(DTs)have gained sig-niﬁcant attention in various *** offer the opportunity to combine the physical and digital worlds and aid the digital transformation of the civil engineering *** this paper,605 documents obtained from the search wereﬁrst analysed using CiteSpace for literature visualisation,and an author co-occurrence network,a keyword co-occurrence network,and a keyword clustering set were ***,through a literature review of 86 papers,this paper summarises the current status of DT application in civil engineering based on a review of the origins,concepts,and implementation techniques of DTs,and it introduces the application of DTs in the full project *** study shows that DTs have great potential to address many of the challenges faced by civil *** this regard,the paper also presents some thoughts on the future directions of DT research.

关键词： Digital twins civil engineering full lifecycle literature visualisation analysis

Combined effect of cortical superficial siderosis and cerebral microbleed on short-term and long-term outcomes after intracerebral haemorrhage

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Stroke & Vascular Neurology 2024年第4期9卷 429-438,I0131-I0146页

作者： Yujia Jin Yu-hui Huang Yu-ping Chen Yao-dan Zhang Jiawen Li Kai-cheng Yang Xianghua Ye Lu-hang Jin Jian Wu Chang-zheng Yuan Feng Gao Lu-sha Tong Neurology department The Second Affiliated Hospital of Zhejiang UniversitySchool of MedicineHangzhouChina School of Public Health Zhejiang UniversityHangzhouChina department of Neurology Tiantai People's Hospital of Zhejiang ProvinceTaizhouChina

Background and purpose Cortical superficial siderosis(cSS)and cerebral microbleed(CMB)have distinct effects on intracerebral haemorrhage(ICH).We aim to investigate the combined effect of cSS and CMB on outcomes after *** Based on a single-centre stroke registry database,patients with spontaneous ICH who had CT scan within 48 hours after ictus and MRI subsequently were *** patients were divided into four groups(cSS-CMB−,cSS-CMB+,cSS+CMB−,cSS+CMB+)according to cSS and CMB on susceptibility-weighted image of *** outcomes were haematoma volume on admission and unfavourable outcome defined as modified Rankin Scale scores≥3 at 3 *** outcomes were all-cause death,recurrence of stroke and ICH during follow-up(median follow-up 2.0 years,IQR 1.0-3.0 years).Results A total of 673 patients were identified from 1044 patients with spontaneous ICH.131(19.5%)had cSS and 468(69.5%)had *** with cSS+CMB+had the highest rate of poor outcome at 3 months,as well as all-cause death,recurrent stroke and ICH during *** cSS−patients,CMB was associated with smaller haematoma(β−0.13;95%CI−0.22 to−0.03;p=0.009),but it still increased risks of recurrent ICH(OR 4.6;95%CI 1.3 to 15.6;p=0.015)and stroke(OR 2.0;95%CI 1.0 to 4.0;p=0.049).These effects of CMB became unremarkable in the context of cSS+.Conclusions Patients with different combinations of cSS and CMB have distinct patterns of short-term and long-term *** CMB is related to restrained haematoma,it does not improve long-term outcomes.

关键词： superficial cerebral effect

A deep learning model based on contrast-enhanced computed tomography for differential diagnosis of gallbladder carcinoma

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Hepatobiliary & Pancreatic Diseases International 2024年第4期23卷 376-384页

作者： Fei Xiang Qing-Tao Meng Jing-Jing Deng Jie Wang Xiao-Yuan Liang Xing-Yu Liu Sheng Yan department of Hepatobiliary Pancreatic Surgery Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China department of Radiology Affiliated Chuzhou First People’s HospitalAnhui Medical UniversityChuzhou 239000China

Background:Gallbladder carcinoma(GBC)is highly malignant,and its early diagnosis remains *** study aimed to develop a deep learning model based on contrast-enhanced computed tomography(CT)images to assist radiologists in identifying ***:We retrospectively enrolled 278 patients with gallbladder lesions(>10 mm)who underwent contrast-enhanced CT and cholecystectomy and divided them into the training(n=194)and validation(n=84)*** deep learning model was developed based on ResNet50 *** and clinical models were built based on support vector machine(SVM)*** comprehensively compared the performance of deep learning,radiomics,clinical models,and three ***:Three radiomics features including LoG_3.0 gray-level size zone matrix zone variance,HHL firstorder kurtosis,and LHL gray-level co-occurrence matrix dependence variance were significantly different between benign gallbladder lesions and GBC,and were selected for developing radiomics *** regression analysis revealed that age≥65 years[odds ratios(OR)=4.4,95%confidence interval(CI):2.1-9.1,P37 U/mL(OR=4.0,95%CI:1.6-10.0,P=0.003)were significant clinical risk factors of *** deep learning model achieved the area under the receiver operating characteristic curve(AUC)values of 0.864(95%CI:0.814-0.915)and 0.857(95%CI:0.773-0.942)in the training and validation datasets,which were comparable with radiomics,clinical models and three *** sensitivity of deep learning model was the highest both in the training[90%(95%CI:82%-96%)]and validation[85%(95%CI:68%-95%)]***:The deep learning model may be a useful tool for radiologists to distinguish between GBC and benign gallbladder lesions.

关键词： Gallbladder carcinoma Computed tomography Deep learning Radiomics