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Identification of a natural PLA2 inhibitor from the marine fungus Aspergillus sp.c1 for MAFLD treatment that suppressed lipotoxicity by inhibiting the IRE-1a/XBP-1s axis and JNK signaling

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Acta Pharmaceutica Sinica B 2024年第1期14卷 304-318页

作者： Yong Rao Rui Su Chenyan Wu Xingxing Chai Jinjian Li Guanyu Yang Junjie Wu Tingting Fu Zhongping Jiang Zhikai Guo Congjun Xu Ling Huang Key Laboratory of Tropical Biological Resources of Ministry of Education School of Pharmaceutical SciencesHainan UniversityHaikou 570200China hainan Key Laboratory of Tropical Microbe Resources Institute of Tropical Bioscience and BiotechnologyChinese Academy of Tropical Agricultural Sciences&Key Laboratory for Biology and Genetic Resources of Tropical Crops of Hainan ProvinceHainan Institute for Tropical Agricultural ResourcesHaikou 571101China School of Pharmaceutical Sciences Guangdong Provincial Key Laboratory of New Drug Design and EvaluationSun Yat-sen UniversityGuangzhou 510275China Laboratory Animal Center of Guangdong Medical university Dongguan 523808China

Lipotoxicity is a pivotal factor that initiates and exacerbates liver injury and is involved in the development of metabolic-associated fatty liver disease(MAFLD).However,there are few reported lipotoxicity ***,we identified a natural anti-lipotoxicity candidate,HN-001,from the marine fungus Aspergillus ***-001 dose-and time-dependently reversed palmitic acid(PA)-induced hepatocyte *** protection was associated with IRE-1a-mediated XBP-1 splicing inhibition,which resulted in suppression of XBP-1s nuclear translocation and transcriptional *** of XBP-1s attenuated lipotoxicity,but no additional ameliorative effect of HN-001 on lipotoxicity was observed in XBP-1s knockdown ***,the ER stress and lipotoxicity amelioration was associated with *** HN-001 and the PLA2 inhibitor MAFP inhibited PLA2 activity,reduced lysophosphatidylcholine(LPC)level,subsequently ameliorated *** contrast,overexpression of PLA2 caused exacerbation of lipotoxicity and weakened the anti-lipotoxic effects of ***,HN-001 treatment suppressed the downstream pro-apoptotic JNK *** vivo,chronic administration of HN-001(i.p.)in mice alleviated all manifestations of MAFLD,including hepatic steatosis,liver injury,inflammation,and *** effects were correlated with PLA2/IRE-1a/XBP-1s axis and JNK signaling *** data indicate that HN-001 has therapeutic potential for MAFLD because it suppresses lipotoxicity,and provide a natural structural basis for developing anti-MAFLD candidates.

关键词： Lipotoxicity MAFLD ER stress IRE-1a XBP-1s JNK PLA2

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Controlling electrodeposited Ni layers by different-sized graphene oxides enables conductive e-textiles for the highly sensitive electrochemical detection of glucose

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Nano research 2024年第7期17卷 6258-6264页

作者： Zhen Li Zibo Chen Xiaodong Ji Huihui Jin Yunfa Si Jingwei Zhang Cheng Chen Daping He Sanya Science and Education Innovation Park of Wuhan university of Technology Sanya 572000China School of Science Wuhan University of TechnologyWuhan 430070China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China Hubei Engineering research Center of RF-Microwave Technology and Application Wuhan University of TechnologyWuhan 430070China

With the increasing popularity of wearable electronic devices,there is an urgent demand to develop electronic textiles(e-textiles)for device ***,the difficulty in reconciliation between conductivity and manufacturing costs hinders their large-scale practical ***,we reported a facile and economic method for preparing conductive ***,nonconductive polypropylene(PP)was wrapped by reduced graphene oxide(rGO),followed by the electrodeposition of Ni nanoparticles(NPs).Notably,modulating the sheet size of graphene oxide(GO)resulted in controllable deposition of Ni NPs with adjustable size,allowing for controlled manipulations over the structures,morphologies,and conductivity of the obtained e-textiles,which influenced their performance in electrochemical glucose detection *** optimal material,denoted as Ni/rGO+(0.2)/PP,exhibited an impressive conductivity of 7.94×10^(4)S·m^(−1).With regard to the excellent conductivity of the as-prepared e-textiles and the high electrocatalytic activity of Ni for glucose oxidation,the asprepared e-textiles were subjected to glucose *** was worth emphasizing that the Ni/rGO_(0.2)/PP-based electrode demonstrated promising performance for nonenzymatic/label-free glucose detection,with a detection limit of 0.36μM and a linear response range of 0.5μM to 1 *** study paves the way for further development and application prospects of conductive etextiles.

关键词： conductive e-textiles nonenzymatic/label-free glucose detection controllable Ni deposition graphene oxides sizedependent effect

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Joint Transmit and Reflective Beamforming Design for Active IRS-Aided SWIPT Systems

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Chinese Journal of Electronics 2024年第2期33卷 536-548页

作者： Weiping SHI Qingqing WU Di WU Feng SHU Jiangzhou WANG School of Electronic and Optical Engineering Nanjing University of Science and Technology Department of Electronic Engineering Shanghai Jiao Tong University School of Information and Communication Engineering Hainan University Department of Automation Shanghai Jiao Tong University School of Engineering University of Kent

To further improve the performance of passive intelligent reflecting surface(IRS)-assisted communication systems and mitigate the serious path loss due to “double-fading ” of IRS-assisted links, an active IRS-aided simultaneous wireless information and power transfer(SWIPT) system is investigated. This paper jointly optimizes the transmit beamforming at the base station(BS) and the phase shifts at the active IRS in order to maximize the power collected by the energy harvesting receiver under both perfect and imperfect channel state information(CSI)states, subject to the signal-to-interference-noise ratio constraint of the information decoding receiver, and the power constraints of the BS/IRS. Under perfect CSI, the alternating optimization algorithm is utilized for obtaining the transmit beamforming at the BS and the phase shifts at the active IRS. For each subproblem, we first transform nonconvex objective function and constraints into convex ones by performing a first-order Taylor expansion. Then, each subproblem is solved by using the interior point method. Given that obtaining perfect CSI is impractical, two robust beamforming designs are proposed for imperfect CSI case. Under the bounded CSI error model, we first transform the non-convex optimization problem into two semidefinite programming subproblems, and then solve each subproblem based on S-procedure and sequential rank-one constraint relaxation(SROCR) techniques. Under the stochastic CSI error model, the alternating optimization method is applied in an iterative manner based on Bernstein-type inequality and SROCR technique. Simulation results show that both robust and non-robust schemes for active IRS-assisted SWIPT systems can achieve extremely superior performance over conventional passive IRS-assisted systems under the same overall power budget.

关键词： Wireless communication Semidefinite programming Array signal processing Simulation Stochastic processes Transforms Receivers

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Andrographolide Attenuates Noise-Induced Hearing Loss by Ameliorating Cochlear Inflammation

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World Journal of Traditional Chinese Medicine 2024年第2期10卷 204-212页

作者： Meng-Hua Li Wan-Qi Wang Li-Ting Zheng Meng Bing Chen Yang Chu Miao Qiao Zuo-Li Zhang Konduru Naveena Yong Pan Yun-Shi Zhang He Sun Xiao-Hui Ma Xi Shi Artificial Auditory Laboratory of Jiangsu Province Xuzhou Medical UniversityXuzhouChina Key Laboratory of Tropical Biological Resources of Ministry of Education School of Pharmaceutical SciencesHainan UniversityHaikouChina Department of ENT Beijing Friendship HospitalCapital Medical UniversityBeijingChina National Key Laboratory of Chinese Medicine Modernization Tasly AcademyTasly Pharmaceutical Group Co.Ltd.TianjinChina Endoscopy Center Ankang People's HospitalAnkangChina Department of Respiratory Medicine Xuzhou Infectious Diseases HospitalAffiliated Hospital of Xuzhou Medical UniversityXuzhouChina Department of ENT The People's Hospital of Rongchang DistrictChongqingChina

Objective:This study aimed to explore andrographolide's mechanism of action and its protective effect on noise-induced hearing loss(NIHL).Materials and Methods:A mice animal model for NIHL was established through exposure to broadband noise at 120 d B sound pressure level for 4 *** analysis and pharmacodynamic experiments were carried ***:Andrographolide enters the inner ear and effectively prevents hearing damage following noise exposure in the mice model for permanent hearing ***,treatment with andrographolide inhibited the excessive activation of inflammatory factors in the cochleae of noise-exposed ***:Andrographolide might be a promising candidate for auditory protective drug investigation.

关键词： Andrographolide anti-inflammatory auditory protection noise-induced hearing loss traditional Chinese medicine compound

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Beamforming Design for IRS-and-UAV-Aided Two-Way Amplify-and-Forward Relay Networks in Maritime IoT

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China Communications 2024年第8期21卷 45-61页

作者： Wang Xuehui Shu Feng Wu Yuanyuan Shi Weiping Yan Shihao Zhao Yifan Cheng Qiankun Sun Zhongwen Wang Jiangzhou School of Information and Communication Engineering Hainan UniversityHaikou 570228China Collaborative Innovation Center of Information Technology Hainan UniversityHaikou 570228China School of Electronic and Optical Engineering Nanjing University of Science and TechnologyNanjing 210094China School of Network and Communication Nanjing Vocational College of Information TechnologyNanjing 210023China School of Science and Security research Institute Edith Cowan UniversityPerthWA 6027Australia School of Engineering University of KentCanterbury CT27NTU.K

In this paper,an intelligent reflecting surface(IRS)-and-unmanned aerial vehicle(UAV)-assisted two-way amplify-and-forward(AF)relay network in maritime Internet of Things(IoT)is proposed,where ship1(S1)and ship2(S2)can be viewed as data collecting *** enhance the message exchange rate between S1 and S2,a problem of maximizing minimum rate is cast,where the variables,namely AF relay beamforming matrix and IRS phase shifts of two time slots,need to be *** achieve a maximum rate,a low-complexity alternately iterative(AI)scheme based on zero forcing and successive convex approximation(LC-ZF-SCA)algorithm is *** obtain a significant rate enhancement,a high-performance AI method based on one step,semidefinite programming and penalty SCA(ONSSDP-PSCA)is *** results show that by the proposed LC-ZF-SCA and ONS-SDP-PSCA methods,the rate of the IRS-and-UAV-assisted AF relay network surpass those of with random phase and only AF relay ***,ONS-SDP-PSCA perform better than LC-ZF-SCA in aspect of rate.

关键词： beamforming maritime Internet of Things phase shift rate performance two-way amplify-and-forward relay unmanned aerial vehicle

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Metallosalen covalent organic frameworks for heterogeneous catalysis

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Interdisciplinary Materials 2024年第1期3卷 87-112页

作者： Wei Zhou Wei‐Qiao Deng Xing Lu School of Chemistry and Chemical Engineering Hainan UniversityHaikouHainanChina Institute of Molecular Sciences and Engineering Shandong UniversityQingdaoShandongChina

Metallosalen covalent organic frameworks(M(salen)-COFs)have garnered significant attention as promising candidates for advanced heterogeneous catalysis,including organocatalysis,electrocatalysis,and photocatalysis,due to their unique structural advantages(combining molecules catalysts and crystalline porous materials)and tunable topological *** is essential to provide a comprehensive overview of emerging designs of M(salen)-COFs and corresponding advances in this ***,this review first summarizes the reported metallolinkers and the synthesis methods of M(salen)-*** addition,the review enumerates the excellent M(salen)-COF based heterogeneous catalysts and discusses the fundamental mechanisms behind the outstanding heterogeneous catalytic performance of M(salen)-*** mechanisms include the pore enrichment effect(enhancing local concentration within porous materials to promote catalytic reactions),the three-in-one strategy(integrating enrichment,reduction,and oxidation sites in one system),and the incorporation of a built-in electric field(implanting a built-in electric field in heterometallic phthalocyanine covalent organic frameworks).Furthermore,this review discusses the challenges and prospects related to M(salen)-COFs in heterogeneous catalysis.

关键词： covalent organic frameworks heterogeneous catalysis metallosalen

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氧掺杂和中空结构介导效应在高效光催化过氧化氢生产中实现快速电子转移

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Science China Materials 2024年第1期67卷 153-161页

作者：徐燕东台婉玉王沚睿张琳琳王德欣廖建军 Key Laboratory of Agro-Forestry Environmental Processes and Ecological Regulation of hainan Province School of Ecology and EnvironmentHainan UniversityHaikou 570228China

因其安全、绿色、低成本的特点,利用太阳能光催化生产过氧化氢是解决能源危机的环境友好型方案,但其效率低下,严重阻碍了其规模化可行性.在这项工作中,通过使用简单的两步水热法在O掺杂的空心g-C_(3)N_(4)纳米球表面生长In_(2)S_(3)超... 详细信息

因其安全、绿色、低成本的特点,利用太阳能光催化生产过氧化氢是解决能源危机的环境友好型方案,但其效率低下,严重阻碍了其规模化可行性.在这项工作中,通过使用简单的两步水热法在O掺杂的空心g-C_(3)N_(4)纳米球表面生长In_(2)S_(3)超薄纳米片,成功构建了空心核壳结构OCN@In_(2)S_(3)复合光催化剂.独特的中空结构提供了更大的比表面积,增强了光吸收.O掺杂增加了活性位点的数量,异质结的存在促进了光生载流子的快速分离和转移.在可见光照射下,OCN@In_(2)S_(3)的H_(2)O_(2)产率达到632.5μmol h^(-1)g^(-1),是普通g-C_(3)N_(4)的5.7倍,是In_(2)S_(3)的12.3倍,高于大多数g-C_(3)N_(4)基光催化剂.淬灭实验和电子顺磁共振光谱表明,·O_(2)^(-)是光催化产生H_(2)O_(2)的中间产物,并且反应过程主要遵循两步单电子反应路径.Koutecky-Levich图证实了合成的OCN@In_(2)S_(3)在催化反应中保持了较高的两电子ORR选择性(n=1.67).通过光致发光、电化学阻抗谱和紫外光电子能谱等表征手段阐明了可能的光催化机理,证实了OCN@In_(2)S_(3)有效抑制光生载流子的复合.这项工作为开发高活性的能量转换光催化剂提供了一种简单而有吸引力的策略.

关键词：光生载流子电子转移紫外光电子能谱中空结构单电子过氧化氢光催化光致发光

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MMAE-loaded PLGA nanomedicine with improved biosafety to achieve efficient antitumor treatment

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Journal of Innovative Optical Health Sciences 2024年第2期17卷 79-93页

作者： Changqiang Xie Yan Wang Zhenzhen Cai Jianghai Du Zhengyu Chen Junjie Wang Xingzhou Peng State Key Laboratory of Digital Medical Engineering School of Biomedical Engineering hainan university Haikou 570228P.R.China Key Laboratory of Biomedical Engineering of hainan Province One Health Institute Hainan University Haikou 570228P.R.China Key Laboratory of hainan Trauma and Disaster Rescue The First Affiliated Hospital of hainan Medical university hainan Medical university Haikou 571199P.R.China Engineering research Center for hainan Bio.Smart Materials and Bio-Medical Devices Key Laboratory of Emergency and Trauma Ministry of EducationKey Laboratory of Hainan Functional Materials and Molecular ImagingCollege of Emergency and Trauma Hainan Medical UniversityHaikou 571199P.R.China

Monomethyl auristatin E(MMAE)is a derivative of the marine peptide Dolastatin 10,which has therapeutic effects against various cancers according to its antimitotic activity in multiple clinical *** antibody drug conjugate(ADC)of MMAE is currently used in clinical ***,the safety issues of MMAE-based ADC,such as high drug toxicity and poor bioavailability,still exist when using it for anticancer therapy.A sustained release of drug delivery approach should be used to reduce toxicity and achieve sufficient anticancer ***,PLGA-b-PEG 2000 with excellent biocompatibility and slow degradation ability was adopted to construct MMAE-loaded nanoparticles for safe and effective *** sustained release effect and the immunogenic cell death(ICD)effect of PLGA-MMAE nanoparticles were assessed by in vitro *** PLGA-MMAE nanoparticles effectively accumulated in the tumor through the enhanced permeability and retention(EPR)effect,inducing cell apoptosis and causing a certain degree of immune *** sustained drug release of PLGA-MMAE improved the bioavailability and effectively reduced the toxicity and development of the tumor compared to the effect of free MMAE or ***,this study provides a safe and effective chemotherapeutic approach,as well as a simple and effective synthetic process for MMAE-based nanoparticles,improving their therapeutic efficacy and safety.

关键词： Monomethyl auristatin E poly(lactic-co-glycolic acid)nanoparticles sustained release chemotherapy immunogenic cell death

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Gradient sparsification for efficient wireless federated learning with differential privacy

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Science China(Information Sciences) 2024年第4期67卷 272-288页

作者： Kang WEI Jun LI Chuan MA Ming DING Feng SHU Haitao ZHAO Wen CHEN Hongbo ZHU School of Electronic and Optical Engineering Nanjing University of Science and Technology Zhejiang Lab Key Laboratory of Computer Network and Information Integration(Southeast university) Ministry of Education Data61 Commonwealth Scientific and Industrial Research Organisation School of Information and Communication Engineering Hainan University School of Communications and Information Engineering Nanjing University of Posts and Telecommunications School of Electronic Information and Electrical Engineering Shanghai Jiao Tong University

Federated learning(FL) enables distributed clients to collaboratively train a machine learning model without sharing raw data with each other. However, it suffers from the leakage of private information from uploading models. In addition, as the model size grows, the training latency increases due to the limited transmission bandwidth and model performance degradation while using differential privacy(DP)protection. In this paper, we propose a gradient sparsification empowered FL framework with DP over wireless channels, to improve training efficiency without sacrificing convergence performance. Specifically, we first design a random sparsification algorithm to retain a fraction of the gradient elements in each client’s local model, thereby mitigating the performance degradation induced by DP and reducing the number of transmission parameters over wireless channels. Then, we analyze the convergence bound of the proposed algorithm, by modeling a non-convex FL problem. Next, we formulate a time-sequential stochastic optimization problem for minimizing the developed convergence bound, under the constraints of transmit power, the average transmitting delay, as well as the client’s DP requirement. Utilizing the Lyapunov drift-plus-penalty framework, we develop an analytical solution to the optimization problem. Extensive experiments have been implemented on three real-life datasets to demonstrate the effectiveness of our proposed algorithm. We show that our proposed algorithms can fully exploit the interworking between communication and computation to outperform the baselines, i.e., random scheduling, round robin, and delay-minimization algorithms.

关键词： federated learning differential privacy gradient sparsification Lyapunov drift convergence analysis

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Journal of Integrative Agriculture 2024年第11期23卷 3788-3800页

作者： Chengdong Yang Manfei Luo Xue Zhang Linlin Ye Ge Yu Yi Lü Yi Chen Taixu Chen Xuejian Wang Wanzhen Feng Qinghe Chen School of Breeding and Multiplication (Sanya Institute of Breeding and Multiplication) Hainan University Key Laboratory of Green Prevention and Control of Tropical Plant Diseases and Pests of Ministry of Education School of Tropical Agriculture and Forestry Hainan University Fujian Key Laboratory for Monitoring and Integrated Management of Crop Pests

Litchi downy blight, caused by the plant pathogenic oomycete Peronophythora litchii, is one of the most devastating diseases on litchi and resulted in huge economic losses. Autophagy plays an essential role in the development and pathogenicity of the filamentous fungi. However, the function of autophagy in oomycetes remain elusive. Here, an autophagy-related protein Atg3 homolog PlAtg3 was identified and characterized in P. litchii. The absence of PlATG3 through the CRISPR/Cas9 gene replacement strategy compromised vegetative growth and sexual/asexual development. Cytological analyses revealed that the deletion of PlATG3 impaired autophagosome formation with monodansylcadaverine(MDC) staining and significantly disrupted zoospore release due to defects of sporangial cleavage with FM4-64 staining. Atg8 is considered to be an autophagy marker protein in various species. Western blot analysis indicated that PlAtg3 is involved in degradation of PlAtg8-PE. Interestingly, PlAtg3 was unable to interact with PlAtg8 in yeast two hybrid(Y2H) assays, possibly due to the absence of the Atg8 family interacting motif(AIM) in PlAtg3. Furthermore, pathogenicity assays revealed that the deletion of PlATG3 considerably reduced the virulence of P. litchii. Taken together, our data reveal that PlAtg3 plays an important role in radial growth, asexual/sexual development, sporangial cleavage and zoospore release, autophagosome formation, and pathogenicity in P. litchii. This study contributes to a better understanding of the pathogenicity mechanisms of P. litchii and provides insights for the development of more effective strategies to control oomycete diseases.

关键词： PlAtg3 sporangial cleavage autophagy pathogenicity Peronophythora litchii

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