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The microscopic mechanical performance for nonuniform welded joint of nickel-based alloy with nanoindentation

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China Welding 2019年第2期28卷 29-34页

作者： Li Xiaoquan Hao Benxing Chen Yixin Yun Yeling Yang Zonghui School of Materials Science and Engineering Nanjing Institute of TechnologyNanjing 211167China Jiangsu Key Laboratory of Advanced Structural Materials and Application Technology Nanjing 211167China

To quantify the nonuniform micromechanical performance of welded joint,the load-displacement curves by nanoindentation test were introduced to examine different zones including base metal,coarse grained heat affected zone,partially melted zone,weld metal near the fusion boundary and weld metal *** results showed that the strengthening effect of weld metal was more obvious than that of heat affected zone for nickel based welded joint and especially in coarse grained heat affected zone,the hardening resulted from overheating was not *** based weld metal with high content of alloying elements which were often segregated at interdendritic regions or precipitated in grain interior under nonequilibrium solidification contributed to the characteristics that differ from conventional low alloy steel welded joint.

关键词： microscopic mechanical performance nanoindentation nickel based alloy welded joint

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The functions and applications of A7R in anti-angiogenic therapy, imaging and drug delivery systems

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Asian Journal of Pharmaceutical Sciences 2019年第6期14卷 595-608页

作者： Lu Lu Hongyuan Chen Dake Hao Xinke Zhang Fengshan Wang Key Laboratory of Chemical Biology(Ministry of Education) Institute of Biochemical and Biotechnological DrugSchool of Pharmaceutical SciencesShandong UniversityJinan 250012China Department of General Surgery Shandong University Affiliated Shandong Provincial HospitalJinan 250021China Department of Surgery UC Davis Health Medical CenterSacramento 95817USA Key Laboratory of Chemical Biology(Ministry of Education) Department of PharmacologySchool of Pharmaceutical SciencesShandong UniversityJinan 250012China

Vascular endothelial growth factor receptor 2(VEGFR-2)and neuropilin-1(NRP-1)are two prominent antiangiogenic *** are highly expressed on vascular endothelial cells and some tumor ***,targeting VEGFR-2 and NRP-1 may be a potential antiangiogenic and antitumor strategy.A7R,a peptide with sequence of Ala-Thr-Trp-Leu-Pro-Pro-Arg that was found by phage display of peptide libraries,can preferentially target VEGFR-2 and NRP-1 and destroy the binding between vascular endothelial growth factor 165(VEGF165)and VEGFR-2 or *** peptide is a new potent inhibitor of tumor angiogenesis and a targeting ligand for cancer *** review describes the discovery,function and mechanism of the action of A7R,and further introduces the applications of A7R in antitumor angiogenic treatments,tumor angiogenesis imaging and targeted drug delivery *** this review,strategies to deliver different drugs by A7R-modified liposomes and nanoparticles are highlighted.A7R,a new dual targeting ligand of VEGFR-2 and NRP-1,is expected to have efficient therapeutic or targeting roles in tumor drug delivery.

关键词： A7R Vascular endothelial growth factor receptor 2 Neuropilin-1 Antiangiogenesis Tumor angiogenesis imaging Drug delivery

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Flexible strain sensors fabricated using aligned carbon nanofiber membranes with cross-stacked structure for extensive applications

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International Journal of Smart and Nano Materials 2022年第3期13卷 432-446页

作者： Tao Yan Yuting Wu Jian Tang Zhijuan Pan College of Textile and Clothing Engineering Soochow UniversitySuzhouP.R.China National Engineering Laboratory for Modern Silk SuzhouP.R.China

Carbon nanofibers(CNFs)with excellent conductivity and stability have become a promising material to design the strain sensing *** date,however,the effect of the stacked structure of CNF membrane on the sensing performance has rarely been *** this work,we reported a high-performance sensor based on the cross-stacked aligned CNF *** effects of crossstacked structures on the sensing characteristics were systemati-cally *** flexible strain sensor could capture low detection limit(0.998),excellent durability and quick response time(<200 ms)were *** excellent com-prehensive performances were simultaneously *** sen-sor could be used in extensive applications,such as monitoring body movements and distinguishing the track of writing.

关键词： Electrospinning carbon nanofiber membrane crossstacked structure strain sensor extensive applications

Multi-label Image Classification via Coarse-to-Fine Attention

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Chinese Journal of Electronics 2019年第6期28卷 1118-1126页

作者： LYU Fan LI Linyan Victor S.Sheng FU Qiming HU Fuyuan School of Electronic and Information Engineering Suzhou University of Science and Technology College of Intelligence and Computing Tianjin University Suzhou Institute of Trade and Commerce Department of Computer Science Texas Tech University

Great efforts have been made by using deep neural networks to recognize multi-label *** multi-label image classification is very complicated,many studies seek to use the attention mechanism as a kind of guidance. Conventional attention-based methods always analyzed images directly and aggressively, which is difficult to well understand complicated scenes. We propose a global/local attention method that can recognize a multi-label image from coarse to fine by mimicking how human-beings observe images. Our global/local attention method first concentrates on the whole image, and then focuses on its local specific objects. We also propose a joint max-margin objective function, which enforces that the minimum score of positive labels should be larger than the maximum score of negative labels horizontally and vertically. This function further improve our multi-label image classification method. We evaluate the effectiveness of our method on two popular multi-label image datasets(i.e., Pascal VOC and MS-COCO). Our experimental results show that our method outperforms state-of-the-art methods.

关键词： Multi-label classification Convolutional neural network Recurrent neural network Attention

Molecular characterization and expression analysis of Lily- type lectin (SmLTL) in turbot Scophthalmus maximus, and its response to Vibrio anguillarum

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Journal of Oceanology and Limnology 2018年第2期36卷 508-518页

作者： XIA Dandan MA Aijun HUANG Zhihui SHANG Xiaomei CUI Wenxiao YANG Zhi QU Jiangbo Key Laboratory of Sustainable Development of Marine Fisheries Ministry of Agriculture Qingdao Key Laboratory for Marine Fish Breeding and Biotechnology Yellow Sea Fisheries Research Institute Chinese Academy of Fishery Sciences Qingdao 266071 China Ocean University of Shanghai Shanghai 201306 China Laboratory for Marine Biology and Biotechnology Qingdao National Laboratory for Marine Science and Technology Qingdao 266071 China Yantai Tianyuan Aquatic Limited Corporation Yantai 264006 China

A full-length lily-type lectin （SmLTL） was identified from turbot （Scophthalmus maximus） in this study. By searching database for protein identification and fimction prediction, SmLTL were confirmed. The full-length cDNA of SmLTL is composed of 569 bp and contains a 339 bp ORF that encodes 112 amino acid residues. The SmLTL peptide is characterized by a specific J3-prism architecture and contains three mannose binding sites in a three-fold internal repeat between amino acids 30-99; two of the repeats share the classical mannose binding domain （QxDxNxVxY） while the third binding site was similar to other fish-specific binding motifs （TxTxGxRxV）. The primary, secondary, and tertiary structures of SmLTL were predicted and analyzed, indicating that the SmLTL protein was hydrophilic, contained 5.36% a-helices, 39.29% extended strands, 16.07% [3-folds, and 39.29% random coils, and three [3-folds. Quantitative real- time polymerase chain reaction （qPCR） analysis revealed that the SmLTL mRNA was abundantly expressed in skin, gill, and intestine. Low levels of SmLTL expression were observed in other tissues. The expression of SmLTL in gill, skin and intestine increased at mRNA level after stimulation of Hbrio anguillarum, our results suggest that SmLTL serve as the first line of defence against microbial infections and play a pivotal role in the innate mucosal immune system. The current study indicates that SmLTL is a member of the lily- type lectin family and the information reported here will provide an important foundation for future research on the role of this protein.

关键词： lily-type lectin full-length of cDNA quantitative real-time polymerase chain reaction protein structure Vibrio anguillarum

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