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Rituximab or irradiation promotes IL-17 secretion and thereby induces resistance to rituximab or irradiation

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Cellular & Molecular Immunology 2017年第12期14卷 1020-1022页

作者： Weijie Zhong Qingshan Li Department of Geriatrics Hematology&Oncology WardGuangzhou First People’s HospitalGuangzhou Medical UniversityGuangzhou 510180China Department of Hematology Guangzhou First People’s HospitalGuangzhou Medical UniversityGuangzhou 510180China

Lymphoma is a hematological malignancy that involves T or B *** large B-cell lymphoma(DLBCL)accounts for~40%of cases of non-Hodgkin’s lymphoma(NHL)and is a highly aggressive and heterogeneous subtype of NHL.1 The pathogenesis of DLBCL remains *** is also closely related to inflammatory factors and immune cells in the tumor microenvironment(TME),and alterations of the cytokine network in the TME may activate oncogenes or inactivate tumor suppressor genes.2–4 In the TME,a variety of immune cells and cytokines have crucial roles in the pathogenesis of tumors.

关键词： alterations pathogenesis NHL

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World Journal of Gastroenterology 2023年第20期29卷 3168-3184页

作者： Jia-Lin Wu Jun-Yang Luo Zai-Bo Jiang Si-Bo Huang Ge-Run Chen Hui-Ying Ran Qi-Yue Liang Ming-Sheng Huang Li-Sha Lai Jun-Wei Chen Department of Interventional Radiology The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630Guangdong ProvinceChina The First Clinical Medical College Guangdong Medical UniversityZhanjiang 524000Guangdong ProvinceChina Zhongshan School of Medicine Sun Yat-sen UniversityGuangzhou 510080Guangdong ProvinceChina Department of Radiology Guangzhou First People's HospitalSchool of MedicineSouth China University of TechnologyGuangzhou 510010Guangdong ProvinceChina

BACKGROUND The efficacy of conversion therapy for patients with unresectable hepatocellular carcinoma(HCC)is a common clinical *** To analyse the prognostic factors of overall survival(OS)in patients with unresectable HCC who received conversion *** One hundred and fifty patients who met the inclusion criteria were enrolled and divided into a training cohort(n=120)and a validation cohort(n=30).Using the independent risk factors in the training cohort,a nomogram model was constructed to predict OS for patients treated with transarterial chemoembolization following hepatic *** nomogram was internally validated with the bootstrapping *** predictive performance of nomogram was assessed by Harrell’s concordance index(C-index),calibration plot and timedependent receiver operating characteristic curves and compared with six other conventional HCC staging *** Multivariate Cox analysis identified that albumin,blood urea nitrogen,gamma-glutamyl transpeptidase to platelet ratio,platelet to lymphocyte ratio,macrovascular invasion and tumour number were the six independent prognostic factors correlated with OS in nomogram *** C-index in the training cohort and validation cohort were 0.752 and 0.807 for predicting OS,which were higher than those of the six conventional HCC staging systems(0.563 to 0.715 for the training cohort and 0.458 to 0.571 for the validation cohort).The calibration plots showed good consistency between the nomogram prediction of OS and the actual observations of *** curve analyses indicated satisfactory clinical *** a total nomogram score of 196,patients were accurately classified into low-risk and high-risk ***,we have deployed the model into online calculators that can be accessed for free at https://***/DynNomapp/.CONCLUSION The nomogram achieved optimal individualized prognostication of OS in HCC patients who received conversion ther

关键词： Hepatocellular carcinoma Conversion therapy Nomogram Inflammation Transarterial chemoembolization

Significant value of 18F-FDG-PET/CT in diagnosing small cervical lymph node metastases in patients with nasopharyngeal carcinoma treated with intensity-modulated radiotherapy

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Chinese Journal of Cancer 2017年第12期36卷 757-766页

作者： Hao Peng Lei Chen Ling-Long Tang Wen-Fei Li Yan-Ping Mao Rui Guo Yuan Zhang Li-Zhi Liu Li Tian Xu Zhang Xiao-Ping Lin Ying Guo Ying Sun Jun Ma Department of Radiation Oncology State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China Imaging Diagnosis and Interventional Center State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China Department of Nuclear Medicine State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China Department of Clinical Trials Center State Key Laboratory of Oncology in Southern ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China

Background: Little is known about the nature of metaistasis to small cervical lymph nodes(SCLNS) in the patients with nasopharyngeal carcinoma(NPC)examined by using 18-fluoro-2-deoxy-glucose(^(18)F-FDG) positron emission tomography/computed tomography(PET/CT).The present study aimed to evaluate the diagnostic values of PET/CT in identifying metastasis in SCLNs in NPC ***: Magnetic resonance images(MRI) and PET/CT scans for 470 patients with newly diagnosed, non-distant metastatic NPC were analyzed. Metastatic rates of SCLNs were defined by the positive number of SCLNs on PET/CT scans and total number of SCLNs on MRI scans. Receiver operating characteristic curve was applied to compare PET/CT-determined stage with MRI-determined ***: In total, 2082 SCLNs were identified, with 808(38.8%) ≥ 5 and < 6 mm in diameter(group A), 526(25.3%)≥ 6 and < 7 mm in diameter(group B),374(18.0%)≥ 7 and < 8 mm in diameter(group C), 237(11.4%) ≥8 and<9 mm in diameter(group D),and 137(6.5%) ≥ 9 and <10 mm in diameter(group E).The overall metastatic rates examined by using PET/CT for groups A, B,C,D, and E were 3.5%, 8.0%, 31.3%, 60.0%, and 83.9%, respectively(P< 0.001). In level IV/Vb, the metastatic rate for nodes ≥ 8 mm was 84.6%. PET/CT examination resulted in modification of N category and overall stage for 135(28.7%) and 46(9.8%) patients, respectively. The areas under curve of MRIdetermined and PET/CT-determined overall stage were 0.659 and 0.704 for predicting overall survival, 0.661 and 0.711 for predicting distant metastasis-free survival, and 0.636 and 0.663 for predicting disease-free ***: PET/CT was more effective than MRI in identifying metastatic SCLNs, and the radiologic diagnostic criteria for metastatic lymph nodes in level IV/Vb should be re-defined.

关键词： Nasopharyngeal carcinoma 18-fluoro-2-deoxy-glucose positron emission tomography with computed tomography (18F-PET/CT) Magnetic resonance image Intensity-modulated radiotherapy Small cervical lymph nodes

Gut microbiome and metabolic-associated fatty liver disease:Current status and potential applications

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World Journal of Hepatology 2023年第7期15卷 867-882页

作者： Gong-Jing Guo Fei Yao Wei-Peng Lu Hao-Ming Xu Gastroenterology Department of The Second Affiliated Hospital School of MedicineThe Chinese University of Hong KongShenzhen&Longgang District People’s Hospital of ShenzhenShenzhen 518172Guangdong ProvinceChina Department of science and Education The Affiliated Brain Hospital of Guangzhou Medical UniversityGuangzhou 510370Guangdong ProvinceChina The First Clinical School Guangzhou Medical UniversityGuangzhou 510120Guangdong ProvinceChina Department of Gastroenterology and Hepatology Guangzhou First People's HospitalSchool of MedicineSouth China University of TechnologyGuangzhou 510180Guangdong ProvinceChina

Metabolic-associated fatty liver disease(MAFLD)is one of the most common chronic liver diseases *** recent years,the occurrence rate of MAFLD has been on the rise,mainly due to lifestyle changes,high-calorie diets,and imbalanced dietary structures,thereby posing a threat to human health and creating heavy social and economic *** the development of 16S sequencing and integrated multi-omics analysis,the role of the gut microbiota(GM)and its metabolites in MAFLD has been further *** GM plays a role in digestion,energy metabolism,vitamin synthesis,the prevention of pathogenic bacteria colonisation,and *** gut-liver axis is one of the vital links between the GM and the *** substances in the intestine can enter the liver through the portal vascular system when the intestinal barrier is severely *** liver also influences the GM in various ways,such as bile acid *** gut-liver axis is essential in maintaining the body’s normal physiological state and plays a role in the onset and prognosis of many diseases,including *** article reviews the status of the GM and MAFLD and summarizes the GM characteristics in *** relationship between the GM and MAFLD is discussed in terms of bile acid circulation,energy metabolism,micronutrients,and signalling *** MAFLD treat ments targeting the GM are also listed.

关键词： Metabolic-associated fatty liver disease Gut microbiota Current status Application

Clinical treatment considerationsin the intensity-modulated radiotherapy era for patients with NO-category nasopharyngeal carcinoma and enlarged neck lymph nodes

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Chinese Journal of Cancer 2017年第7期36卷 306-314页

作者： Hao Peng Lei Chen Rui Guo Yuan Zhang Wen.Fei Li Yan.Ping Mao Ying Sun Fan Zhang Li.Zhi Liu Li Tian Jun Ma State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Sun Yat-sen University Cancer Center Guangzhou 510060 Guangdong P. R. China Department of Radiation Oncology Sun Yat-sen University Cancer Center Guangzhou 510060 Guangdong P. R. China Imaging Diagnosis and Interventional Center Sun Yat-sen University Cancer Center Guangzhou 510060 Guangdong P. R. China State Key Laboratory of Oncology in South China Department of Radiation OncologySun Yat-sen University Cancer Center 651 Dongfeng Road East Guangzhou 510060 P. R. China

Background:Nasopharyngeal carcinoma(NPC) shows a high proportion of lymph node metastasis,and treatment guidelines have been developed for positive ***,no irradiation guidelines have been proposed for patients with enlarged neck lymph nodes(ENLNs) that do not meet the radiological criteria of 10 mm in diameter for positive lymph *** study aimed to determine the prognostic value and radiation dose for ENLNs in NO-category NPC patients treated with intensity-modulated radiotherapy(IMRT).Methods:We reviewed the medical data of 251 patients with non-metastatic,NO-category NPC treated with *** operating characteristic curves were used to calculate the cut-off value of the ENLN diameter for the prediction of disease *** biological equivalent dose(BED) for ENLNs was *** survival was compared between the small and large ENLN *** prognostic factors were identified using the Cox proportional hazards ***:The estimated 4-year regional relapse-free survival rate was higher in patients with ENLNs ≥5.5 mm than in those with ENLNs 0.05 for all survival rates).In the subgroup analysis,patients receiving BED ≥72 Gy had a similar prognosis as patients receiving BED <72 Gy in both the small and large ENLN *** multivariate analysis also confirmed that BED≥72 Gy was not associated with significantly improved prognosis in patients with NO-category ***:A BED of 72 Gy to ENLNs is considerably sufficient to provide a clinical benefit to patients with NO-category *** studies are warranted to validate the findings in the present study.

关键词： Nasopharyngeal carcinoma N0-category Enlarged neck lymph node Biological equivalent dose Intensity-modulated radiotherapy Prognosis

Abnormal Effective Connectivity of the Anterior Forebrain Regions in Disorders of Consciousness

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Neuroscience Bulletin 2018年第4期34卷 647-658页

作者： Ping Chen Qiuyou Xie Xiaoyan Wu Huiyuan Huang Wei Lv Lixiang Chen Yequn Guo Shufei Zhang Huiqing Hu You Wang Yangang Nie Ronghao Yu Ruiwang Huang Center for the Study of Applied Psychology Guangdong Key Laboratory of Mental Health and Cognitive Science School of Psychology Institute for Brain Research and Rehabilitation South China Normal University Centre for Hyperbaric Oxygen and Neurorehabilitation Guangzhou General Hospital of Guangzhou Military Command Department of Psychology School of Public Health Southern Medical University School of Education Guangzhou University

A number of studies have indicated that disor- ders of consciousness result from multifocal injuries as well as from the impaired functional and anatomical connectivity between various anterior forebrain regions. However, the specific causal mechanism linking these regions remains unclear. In this study, we used spectral dynamic causal modeling to assess how the effective connections （ECs） between various regions differ between individuals. Next, we used connectome-based predictive modeling to evaluate the performance of the ECs in predicting the clinical scores of DOC patients. We found increased ECs from the striatum to the globus pallidus as well as from the globus pallidus to the posterior cingulate cortex, and decreased ECs from the globus pallidus to the thalamus and from the medial prefrontal cortex to the striatum in DOC patients as compared to healthy controls. Prediction of the patients＇ outcome was effective using the negative ECs as features. In summary, the present study highlights a key role of the thalamo-basal ganglia-cortical loop in DOCs and supports the anterior forebrain mesocircuit hypothesis. Furthermore, EC could be potentially used to assess the consciousness level.

关键词： Mesocircuit Basal ganglia Posterior cingu-late cortex Spectral dynamic causal modeling Connec-tome-based predictive modeling

Prognostic factors and failure patterns in non-metastatic nasopharyngeal carcinoma after intensity-modulated radiotherapy

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Chinese Journal of Cancer 2016年第12期35卷 673-682页

作者： Yan-Ping Mao Ling-Long Tang Lei Chen Ying Sun Zhen-Yu Qi Guan-Qun Zhou Li-Zhi Liu Li Li Ai-Hua Lin Jun Ma State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer Center Department of Radiation Oncology Sun Yat-sen University Cancer Center Imaging Diagnosis and Interventional Center Sun Yat-sen University Cancer Center Department of Medical Statistics and Epidemiology School of Public HealthSun Yat-sen University

Background: The prognostic values of staging parameters require continual re?assessment amid changes in diag?nostic and therapeutic methods. This study aimed to identify the prognostic factors and failure patterns of non?meta?static nasopharyngeal carcinoma(NPC) in the intensity?modulated radiotherapy(IMRT) ***: We reviewed the data from 749 patients with newly diagnosed, biopsy?proven, non?metastatic NPC in our cancer center(South China, an NPC endemic area) between January 2003 and December 2007. All patients under?went magnetic resonance imaging(MRI) before receiving IMRT. The actuarial survival rates were estimated using the Kaplan–Meier method, and survival curves were compared using the log?rank test. Multivariate analyses with the Cox proportional hazards model were used to test for the independent prognostic factors by backward eliminating insigniicant explanatory ***: The 5?year occurrence rates of local failure, regional failure, locoregional failure, and distant failure were 5.4, 3.0, 7.4, and 17.4%, respectively. The 5?year survival rates were as follows: local relapse?free survival, 94.6%; nodal relapse?free survival, 97.0%; distant metastasis?free survival, 82.6%; disease?free survival, 75.1%; and overall survival, 82.0%. Multivariate Cox regression analysis revealed that orbit involvement was the only signiicant prognostic fac?tor for local failure(P = 0.011). Parapharyngeal tumor extension, retropharyngeal lymph node involvement, and the laterality, longest diameter, and Ho's location of the cervical lymph nodes were signiicant prognostic factors for both distant failure and disease failure(all P < 0.05). Intracranial extension had signiicant prognostic value for distant failure(P = 0.040).Conclusions: The key failure pattern for NPC was distant metastasis in the IMRT era. With changes in diagnostic and therapeutic technologies as well as treatment modalities, the signiicant prognostic parameters for local control have also been

关键词： Nasopharyngeal carcinoma Intensity-modulated radiotherapy Prognosis Failure pattern Tumor staging

Plasma microRNA-15a/16-1-based machine learning for early detection of hepatitis B virus-related hepatocellular carcinoma

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Liver Research 2024年第2期8卷 105-117页

作者： Huan Wei Songhao Luo Yanhua Bi Chunhong Liao Yifan Lian Jiajun Zhang Yuehua Huang Guangdong Provincial Key Laboratory of Liver Disease Research The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina School of Mathematics Sun Yat-sen UniversityGuangzhouChina School of Public Health Sun Yat-sen UniversityGuangzhouChina Guangdong Province Key Laboratory of Computational science Sun Yat-sen UniversityGuangzhouChina Department of Infectious Diseases The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina

Background and aims:Hepatocellular carcinoma(HCC),which is prevalent worldwide and has a high mortality rate,needs to be effectively *** aimed to evaluate the significance of plasma microRNA-15a/16-1(miR-15a/16)as a biomarker of hepatitis B virus-related HCC(HBV-HCC)using the machine learning *** study was the first large-scale investigation of these two miRNAs in HCC plasma ***:Using quantitative polymerase chain reaction,we measured the plasma miR-15a/16 levels in a total of 766 participants,including 74 healthy controls,335 with chronic hepatitis B(CHB),47 with compensated liver cirrhosis,and 310 with *** diagnostic performance of miR-15a/16 was examined using a machine learning model and compared with that of alpha-fetoprotein(AFP).Lastly,to validate the diagnostic efficiency of miR-15a/16,we performed pseudotemporal sorting of the samples to simulate progression from CHB to ***:Plasma miR-15a/16 was significantly decreased in HCC than in all control groups(P<0.05 for all).In the training cohort,the area under the receiver operating characteristic curve(AUC),sensitivity,and average precision(AP)for the detection of HCC were higher for miR-15a(AUC=0.80,67.3%,AP=0.80)and miR-16(AUC=0.83,79.0%,AP=0.83)than for AFP(AUC=0.74,61.7%,AP=0.72).Combining miR-15a/16 with AFP increased the AUC to 0.86(sensitivity 85.9%)and the AP to 0.85 and was significantly superior to the other markers in this study(P<0.05 for all),as further demonstrated by the detection error tradeoff ***,miR-15a/16 impressively showed potent diagnostic power in early-stage,small-tumor,and AFP-negative HCC.A validation cohort confirmed these ***,the simulated follow-up of patients further validated the diagnostic efficiency of miR-15a/***:We developed and validated a plasma miR-15a/16-based machine learning model,which exhibited better diagnostic performance for the early diagnosis of HCC compared to that of AFP.

关键词： Hepatitis B virus-related hepatocellular carcinoma(HBV-HCC) microRNA-15a microRNA-16-1 Biomarker Machine learning Pseudotemporal ordering

Dosimetric benefit to organs at risk following margin reductions in nasopharyngeal carcinoma treated with intensity-modulated radiation therapy

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Chinese Journal of Cancer 2015年第5期34卷 189-197页

作者： Yan-Ping Mao Wen-Jing Yin Rui Guo Guang-Shun Zhang Jian-Lan Fang Feng Chi Zhen-Yu Qi Meng-Zhong Liu Jun Ma Ying Sun Department of Radiation Oncology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Department of Radiation Oncology Cancer Center of Guangzhou Medical University

Introduction:It is important to decrease the radiation exposure of normal tissue in intensity-modulated radiation therapy(IMRT).Minimizing planning target volume(PTV) margins with more precise target localization techniques can achieve this *** study aimed to quantify the extent to which organs at risk(OARs) are spared when using reduced margins in the treatment of nasopharyngeal carcinoma(NPC).Methods:Two IMRT plans were regenerated for 40 patients with NPC based on two PTV margins,which were reduced or unchanged following cone beam computed tomography online *** reduced-margin plan was optimized based on maximal dose reduction to OARs without compromising target *** comparisons were evaluated in terms of target coverage and OAR ***:Improvements in target coverage occurred with margin reduction,and significant improvements in dosimetric parameters were observed for all OARs(P<0.05) except for the right optic nerve,chiasm,and *** to OARs decreased at a rate of 1.5%to 7.7%.Sparing of the left parotid and right parotid,where the mean dose(D_(mean)) decreased at a rate of 7.1%and 7.7%,respectively,was greater than the sparing of other ***:Significant improvements in OAR sparing were observed with margin reduction,in addition to improvement in target *** parotids benefited most from the online imaging-guided approach.

关键词：放射治疗大剂量保证金鼻咽癌风险放疗机关效益