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Variant selection in laser powder bed fusion of non-spherical Ti-6Al-4V powder

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Journal of Materials Science & technology 2023年第16期147卷 56-67页

作者： Mohammadreza Asherloo Ziheng Wu Julian E.C.Sabisch Iman Ghamarian Anthony D.Rollett Amir Mostafaei Department of Mechanical Materials and Aerospace EngineeringIllinois Institute of Technology10 W 32nd StreetChicagoIL 60616United States Materials Engineering Division Lawrence Livermore National Laboratory7000 East AveLivermoreCA 94550United States Samuel Roberts Noble Microscopy Laboratory University of OklahomaNormanOK 73019United States School of Aerospace and Mechanical Engineering University of OklahomaNormanOK 73019United States Department of Materials Science and Engineering Carnegie Mellon UniversityPittsburghPA 15213United States

The presence ofα/αon priorβ/βgrain boundaries directly impacts the final mechanical properties of the titanium ***β/βgrain boundary variant selection of titanium alloys has been assumed to be unlikely owing to the high cooling rates in laser powder bed fusion(L-PBF).However,we hypothesize that powder characteristics such as morphology(non-spherical)and particle size(50–120μm)could affect the initial variant selection in L-PBF processed Ti-6Al-4V alloy by locally altering the cooling *** the high cooling rate found in L-PBF,results showed the presence ofβ/βgrain boundaryαlath growth inside two adjacent priorβ*** backscatter diffraction micrographs confirmed the presence ofβ/βgrain boundary variant selection,and synchrotron X-ray high-speed imaging observation revealed the role of the“shadowing effect”on the locally decreased cooling rate because of keyhole depth reduction and the consequentβ/βgrain boundaryαlath *** self-accommodation mechanism was the main variant selection driving force,and the most abundantα/αboundary variant was type 4(63.26°//[10553¯]).The dominance of Category IIαlath clusters associated with the type 4α/αboundary variant was validated using the phenomenological theory of martensite transformations and analytical calculations,from which the stress needed for theβ→αtransformation was calculated.

关键词： Variant selection Phase formation Additive Manufacturing Hydride-dehydride powder Texture analysis Electron backscattered diffraction

Identification of Risk Pathways and Functional Modules for Coronary Artery Disease Based on Genome-wide SNP Data

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Genomics, Proteomics & Bioinformatics 2016年第6期14卷 349-356页

作者： Xiang Zhao Yi-Zhao Luan Xiaoyu Zuo Ye-Da Chen Jiheng Qin Lv Jin Yiqing Tan Meihua Lin Naizun Zhang Yan Liang Shao-Qi Rao Institute for Medical Systems Biology and Department of Medical Statistics and Epidemiology School of Public HealthGuangdong Medical CollegeDongguan 523808China School of Life Sciences Sun Yat-sen UniversityGuangzhou 510080China Department of Medical Statistics and Epidemiology School of Public HealthSun Yat-sen UniversityGuangzhou 510080China Maoming People's Hospital Maoming 525000China

Coronary artery disease （CAD） is a complex human disease, involving multiple genes and their nonlinear interactions, which often act in a modular fashion. Genome-wide single nucleotide polymorphism （SNP） profiling provides an effective technique to unravel these underlying genetic interplays or their functional involvements for CAD. This study aimed to identify the susceptible pathways and modules for CAD based on SNP omics. First, the Wellcome Trust Case Control Consortium （WTCCC） SNP datasets of CAD and control samples were used to assess the joint effect of multiple genetic variants at the pathway level, using logistic kernel machine regression model. Then, an expanded genetic network was constructed by integrating statistical gene-gene interactions involved in these susceptible pathways with their protein protein interaction （PPI） knowledge. Finally, risk functional modules were identified by decomposition of the network. Of 276 KEGG pathways analyzed, 6 pathways were found to have a significant effect on CAD. Other than glycerolipid metabolism, glycosaminoglycan biosynthesis, and cardiac muscle contraction pathways, three pathways related to other diseases were also revealed, including Alzheimer＇s disease, non-alcoholic fatty liver disease, and Huntington＇s disease. A genetic epistatic network of 95 genes was further constructed using the abovementioned integrative approach. Of 10 functional modules derived from the network, 6 have been annotated to phospholipase C activity and cell adhesion molecule binding, which also have known functional involvement in Alzheimer＇s disease. These findings indicate an overlap of the underlying molecular mechanisms between CAD and Alzheimer＇s disease, thus providing new insights into the molecular basis for CAD and its molecular relationships with other diseases.

关键词： Coronary artery disease Genome-wide SNP profiling Risk pathway Functional module Genetic network

Pathway-based Analysis of the Hidden Genetic Heterogeneities in Cancers

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Genomics, Proteomics & Bioinformatics 2014年第1期12卷 31-38页

作者： Xiaolei Zhao Shouqiang Zhong Xiaoyu Zuo Meihua Lin Jiheng Qin Yizhao Luan Naizun Zhang Yan Liang Shaoqi Rao Institute for Medical Systems Biology and Department of Medical Statistics and Epidemiology School of Public HealthGuangdong Medical College Maoming People’s Hospital Department of Medical Statistics and Epidemiology School of Public HealthSun Yat-Sen University

Many cancers apparently showing similar phenotypes are actually distinct at the molecular level,leading to very different responses to the same *** has been recently demonstrated that pathway-based approaches are robust and reliable for genetic analysis of ***,it remains unclear whether such function-based approaches are useful in deciphering molecular heterogeneities in ***,we aimed to test this possibility in the present ***,we used a NCI60 dataset to validate the ability of pathways to correctly partition ***,we applied the proposed method to identify the hidden subtypes in diffuse large B-cell lymphoma （DLBCL）.Finally,the clinical significance of the identified subtypes was verified using survival *** the NCI60 dataset,we achieved highly accurate partitions that best fit the clinical cancer ***,for a DLBCL dataset,we identified three hidden subtypes that showed very different 10-year overall survival rates （90％,46％ and 20％） and were highly significantly （P =0.008） correlated with the clinical survival *** study demonstrated that the pathwaybased approach is promising for unveiling genetic heterogeneities in complex human diseases.

关键词： Genetic heterogeneity Pathway-based approach Sample partitioning Enrichment analysis Survival analysis Cancer

Strain-Insensitive Hierarchically Structured Stretchable Microstrip Antennas for Robust Wireless Communication

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Nano-Micro Letters 2021年第8期13卷 1-12页

作者： Jia Zhu Senhao Zhang Ning Yi Chaoyun Song Donghai Qiu Zhihui Hu Bowen Li Chenghao Xing Hongbo Yang Qing Wang Huanyu Cheng Department of Engineering Science and Mechanics The Pennsylvania State UniversityUniversity ParkPA 16802USA Division of Life Sciences and Medicine School of Biomedical Engineering(Suzhou)University of Science and Technology of ChinaHefei 230022People’s Republic of China Institute of Biomedical Engineering and technology Chinese Academy of ScienceSuzhou 215011People’s Republic of China Department of Materials Science and Engineering The Pennsylvania State UniversityUniversity ParkPA 16802USA School of Engineering and Physical Sciences Heriot-Watt UniversityUniversity ParkEdinburgh EH144ASScotlandUK Department of Electrical Engineering The Pennsylvania State UniversityUniversity ParkPA 16802USA

As the key component of wireless data transmission and powering,stretchable antennas play an indispensable role in flexible/stretchable ***,they often suffer from frequency detuning upon mechanical deformations;thus,their applications are limited to wireless sensing with wireless transmission capabilities remaining ***,a hierarchically structured stretchable microstrip antenna with meshed patterns arranged in an arched shape showcases tunable resonance frequency upon deformations with improved overall *** almost unchanged resonance frequency during deformations enables robust on-body wireless communication and RF energy harvesting,whereas the rapid changing resonance frequency with deformations allows for wireless *** proposed stretchable microstrip antenna was demonstrated to communicate wirelessly with a transmitter(input power of−3 dBm)efficiently(i.e.,the receiving power higher than−100 dBm over a distance of 100 m)on human bodies even upon 25%*** flexibility in structural engineering combined with the coupled mechanical-electromagnetic simulations,provides a versatile engineering toolkit to design stretchable microstrip antennas and other potential wireless devices for stretchable electronics.

关键词： Stretchable microstrip antennas Strain-insensitive resonance frequency Wireless communication RF energy harvesting Wearable and bio-integrated electronics