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One chloro-furoeremophilanoid and two new natural dimers from Ligularia atroviolacea

Chinese Chemical Letters 2008年第11期19卷 1319-1322页

作者： Jun Zhao Hao Wu Ke Xin Huang Shu Yun Shi Hua Peng Xian Feng Sun Liu Rong Chen Qun Xiong Zheng Qi Jun zhang Xiao Jiang Hao Joachim Stockigt Xiao Kun Li Yu Zhao Jia Qu Department of Traditional Chinese Medicine and Natural Drug Research College of Pharmaceutical Sciences Zhejiang University Hangzhou 310058 China Key Laboratory of Southern Zhejiang TCM R＆D Pharmacy School of Wenzhou Medical College Wenzhou 325035 China School of Chemical Engineering Central South University Changsha 410083 China Kunming Institute of Botany Chinese Academy of Sciences Kunming 650204 China

Three new compounds, including one chloro-furoeremophilanoid （1）, one eremophiladiolide （2）, a rare dimer of nor- furoeremophilanoid, ligulatrovine A （3）, and a known furoeremophilanolide （4）, were isolated from Ligularia atroviolacea. The structures of compounds 1-4 were elucidated by spectroscopic methods including 1D and 2D NMR experiments as well as X- ray diffraction study.

关键词： Natural scsquilcrpene Eremophiladiolidc Dimcr Chloro-furanocrcmophilanc X-ray Ligularia atroviolacea

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Controllable and switchable capillary adhesion mechanism for bio-adhesive pads: Effect of micro patterns

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Chinese Science Bulletin 2009年第10期54卷 1648-1654页

作者： ZHANG XiangJun LIU Yuan LIU YongHe AHMED S.I.-U. State Key Laboratory of Tribology Tsinghua University Beijing 100084 China Institute of Physics and Center for Micro/Nano Technology Technical University of IImenau PF 100565 Germany

Some insects and animals, such as bugs, grasshoppers and tree frogs, realize their efficient adhesion mechanism to glass surface, wall and ceiling by injecting a wetting liquid thin film into the pad-substrate contact area. Their ability to control adhesion (attaching or detaching from a surface) is in many cases connected to the contact geometry and surface patterns of their attachment pads. This paper focuses on the dependence of the capillary adhesion (wet adhesion) on the micro patterns of the bio-adhesive pads. The objective is to reveal the possible mechanism for a bio-adhesive pad to control capillary force through adjusting its micro-scale surface pattern and topography. A capillary adhesion force model is built up taking account of the combined role of micro-dimple geometry as well as the wetting behavior of the confined liquid thin film. Calculated results of the apparent contact angle on the regularly micro-dimpled surfaces are compared with and in good agreement with the experimental measurements. Simulation of the capillary adhesion force reveals that it is controllable in a large mag- nitude by adjusting a dimensionless surface pattern parameter k defined as a/(a+b), where a is the dia- meter of micro dimple, and (a+b) is the side length of one pattern cell. When adjusting the parameter k more than 0.75, the capillary adhesion force could be switchable from attractive to repulsive. This effect of micro patterns on the interfacial capillary force is proved to be dominant when the pad-substrate clearance decreases to the nano/micrometer scale. These results indicate that a controllable and switchable capillary adhesive mechanism might be utilized by a living insect or animal to realize its stable adhesion and quick releasing movement through adjusting the micro-pattern topography of its bio-adhesive pad.

关键词：毛细管力可能机制粘合剂粘附生物开关可控玻璃表面

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DeepFilter: A Deep Learning Based Variant Filter for VarDict

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Tsinghua Science and Technology 2023年第4期28卷 665-672页

作者： Hao Zhang Zekun Yin Yanjie Wei Bertil Schmidt Weiguo Liu School of Software Shandong UniversityJinan 250100China Shenzhen Research Institute of Shandong University Shenzhen 518057China Shenzhen Institute of Advanced Technology Chinese Academy of SciencesShenzhen 518055China Institute for Computer Science Johannes Gutenberg UniversityMainz 55128Germany

With the development of sequencing technologies,somatic mutation analysis has become an important component in cancer research and *** is a commonly used somatic variant caller for this *** the heuristic-based VarDict algorithm exhibits high sensitivity and versatility,it may detect higher amounts of false positive variants than callers,limiting its clinical *** address this problem,we propose DeepFilter,a deep-learning based filter for VarDict,which can filter out the false positive variants detected by VarDict *** approach trains two models for insertion-deletion mutations(InDels)and single nucleotide variants(SNVs),*** show that DeepFilter can filter at least 98.5%of false positive variants and retain 93.5%of true positive variants for InDels and SNVs in the commonly used tumor-normal paired *** code and pre-trained models are available at https://***/LeiHaoa/DeepFilter.

关键词： variant filter deep learning somatic variant

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Appropriately adapted properties of hot-extruded Zn-0.5Cu-xFe alloys aimed for biodegradable guided bone regeneration membrane application

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Bioactive Materials 2021年第4期6卷 975-989页

作者： Wentai Zhang Ping Li Gang Shen Xiaoshan Mo Chao Zhou Dorothea Alexander Frank Rupp Jürgen Geis-Gerstorfer Haijun Zhang Guojiang Wan Key Laboratory of Advanced Technologies of Materials Ministry of EducationSchool of Materials Science and EngineeringSouthwest Jiaotong UniversityChengdu610031China Section Medical Materials Science and Technology University Hospital TübingenOsianderstrasse 2-8Tübingen72076Germany Beijing Advanced Innovation Center for Materials Genome Engineering School of Materials Science and EngineeringUniversity of Science and Technology BeijingBeijing100083China Department of Oral and Maxillofacial Surgery University Hospital TübingenOsianderstrasse 2-8Tübingen72076Germany Department of Interventional and Vascular Surgery The Tenth People’s Hospital of ShanghaiTongji UniversityShanghai200072China National United Engineering Laboratory for Biomedical Material Modification Branden Industrial ParkQihe Economic&Development ZoneDezhouShandong251100China

Appropriately adapted comprehensive mechanical properties,degradation behavior and biocompatibility are prerequisites for the application of Zn-based biodegradable *** this study,hot-extruded Zn-0.5Cu-xFe(x=0.1,0.2 and 0.4 wt%)alloys were fabricated as candidates for biodegradable materials for guided bone regeneration(GBR)*** hot-extrusion process and Cu alloying were expected mostly to enhance the mechanical properties,and the Fe alloying was added mainly for regulating the *** microstructure,mechanical properties and in vitro degradation behavior were systematically *** ZnCuFe alloys were composed of a Zn matrix and FeZn13 *** increasing Fe content,a higher FeZn13 phase precipitation with larger particles was *** elongation declined significantly until fracture with increasing Fe content up to 0.4 wt%,the ZnCuFe(0.2 wt%)alloy achieved a good balance between mechanical strength and ductility,with an ultimate tensile strength of 202.3 MPa and elongation at fracture of 41.2%.Moreover,the addition of Fe successfully accelerated the degradation of ZnCuFe *** ZnCuFe(0.2 wt%)alloy showed relatively uniform corrosion in the long-term degradation ***,extracts of the ZnCuFe(0.2 wt%)alloy showed no apparent cytotoxic effects against L929 fibroblasts,Saos-2 osteoblasts or TAg periosteal *** ZnCuFe(0.2 wt%)alloy exhibited the potential to inhibit bacterial adhesion of Streptococcus gordonii and mixed oral *** study provides evidence that the ZnCuFe(0.2 wt%)alloy can represent a promising material for the application as a suitable GBR membrane.

关键词： Zn-based biodegradable metal Mechanical properties Degradation behavior Biocompatibility Guided bone regeneration membrane

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