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Clinical benefit of COX-2 inhibitors in the adjuvant chemotherapy of advanced non-small cell lung cancer: A systematic review and metaanalysis

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World Journal of Clinical Cases 2021年第3期9卷 581-601页

作者： Yu-Qiong Xu Xiang Long Ming Han Ming-Qiang Huang Jia-Fa Lu Xue-Dong Sun Wei Han Department of Emergency Medicine Shenzhen University General HospitalShenzhen University Clinical Medical AcademyShenzhen 518000Guangdong ProvinceChina Department of Respiratory and Critical Care Medicine Peking University Shenzhen HospitalShenzhen 518000Guangdong ProvinceChina

BACKGROUND Lung cancer is a major cause of death among patients,and non-small cell lung cancer(NSCLC)accounts for more than 80%of all lung cancers in many *** To evaluate the clinical benefit(CB)of COX-2 inhibitors in patients with advanced NSCLC using systematic *** We searched the six electronic databases up until December 9,2019 for studies that examined the efficacy and safety of the addition of COX-2 inhibitors to chemotherapy for *** survival(OS),progression free survival(PFS),1-year survival rate(SR),overall response rate(ORR),CB,complete response(CR),partial response(PR),stable disease(SD),and toxicities were measured with more than one outcome as their *** and random effects models were used to calculate risk estimates in a *** publication bias was calculated using Egger’s linear regression *** analysis was performed using R *** The COX-2 inhibitors combined with chemotherapy were not found to be more effective than chemotherapy alone in OS,progression free survival,1-year SR,CB,CR,and ***,there was a difference in overall response rate for patients with advanced *** a subgroup analysis,significantly increased ORR results were found for celecoxib,rofecoxib,first-line treatment,and *** adverse events,the increase in COX-2 inhibitor was positively correlated with the increase in grade 3 and 4 toxicity of leukopenia,thrombocytopenia,and cardiovascular *** COX-2 inhibitor combined with chemotherapy increased the total effective rate of advanced NSCLC with the possible increased risk of blood toxicity and cardiovascular events and had no effect on survival index.

关键词： Non-small cell lung cancer COX-2 Survival Progression free survival Systematic review Randomized controlled trials

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Unmanned aerial vehicle based intelligent triage system in mass-casualty incidents using 5G and artificial intelligence

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World Journal of Emergency Medicine 2023年第4期14卷 273-279页

作者： Jiafa Lu Xin Wang Linghao Chen Xuedong Sun Rui Li Wanjing Zhong Yajing Fu Le Yang Weixiang Liu Wei Han Emergency Department of Shenzhen University General Hospital Shenzhen 518055China Shenzhen Institute of Advanced Technology Chinese Academy of SciencesShenzhen 518055China School of Biomedical Engineering Health Science CenterShenzhen UniversityShenzhen 518060China Tianjin University Tianjin 300072China

BACKGROUND:Rapid on-site triage is critical after mass-casualty incidents(MCIs)and other mass injury *** aerial vehicles(UAVs)have been used in MCIs to search and rescue wounded individuals,but they mainly depend on the UAV operator’s *** used UAVs and artificial intelligence(AI)to provide a new technique for the triage of MCIs and more efficient solutions for emergency ***:This was a preliminary experimental *** developed an intelligent triage system based on two AI algorithms,namely OpenPose and *** were recruited to simulate the MCI scene and triage,combined with UAV and Fifth Generation(5G)Mobile Communication Technology real-time transmission technique,to achieve triage in the simulated MCI ***:Seven postures were designed and recognized to achieve brief but meaningful triage in *** volunteers participated in the MCI simulation *** results of simulation scenarios showed that the proposed method was feasible in tasks of triage for ***:The proposed technique may provide an alternative technique for the triage of MCIs and is an innovative method in emergency rescue.

关键词： Mass-casualty incidents Emergency medical service Unmanned aerial vehicle Fifth Generation Mobile Communication Technology Artificial intelligence

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A case of coronavirus disease 2019 with twice negative nucleic acid testing within 8 days

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Chinese Medical Journal 2020年第12期133卷 1487-1488页

作者： Zhong-Rui Ruan Peng Gong Wei Han Min-Qiang Huang Ming Han Department of Emergency The Shenzhen University General HospitalShenzhen UniversityShenzhenGuangdong 518000China Department of General Surgery The Shenzhen University General HospitalShenzhen UniversityShenzhenGuangdong 518000China

To the Editor:To date,coronavirus disease 2019(COVID-19)has spread all over the *** the exact sources of the virus,the time of virus shedding after infection and viral propagation are still undefined,there are still great challenges in controlling the virus spreading and the treatment of *** diagnosis of infection cases and early isolation are extremely important for the overall prevention and control work.[1]Therefore,rapid diagnosis of infection cases and early isolation are extremely important for overall disease prevention and control.[2]

关键词： prevention diagnosis infection

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