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Successful management of delirium with dexmedetomidine in a patient with haloperidol-induced neuroleptic malignant syndrome:A case report

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World Journal of Clinical Cases 2022年第2期10卷 625-630页

作者： Chi-Ju Yang Ching-Tang Chiu Yu-Chang Yeh Anne Chao Department of Pharmacy National Taiwan University HospitalTaipei 100220Taiwan Department of Anesthesiology National Taiwan University HospitalTaipei 100220Taiwan

BACKGROUND We report a case of lorazepam-induced agitated delirium treated with haloperidol,which in turn triggered the onset of neuroleptic malignant syndrome(Nms).The latter condition,a medical emergency,was effectively treated with medical treatment and dexmedetomidine,a versatile and highly selective shortacting alpha-2 adrenergic agonist with sedative-hypnotic and anxiolytic *** SUMMARY A 65-year-old man with a history of bipolar disorder presented to the emergency department with severe abdominal discomfort after binge *** his hospital stay,he received intravenous lorazepam for *** the next day,he became delirious and was thus treated with seven doses(5 mg each)of haloperidol over a 48 h *** of Nms(hyperthermia,rigidity,myoclonus of upper limbs,impaired consciousness,tachypnea,and dark urine)became apparent and haloperidol was immediately suspended and brisk diuresis was *** intensive care unit admission,he was confused,disoriented,and markedly *** infusion was started with the goal of achieving a Richmond Agitation-Sedation Scale score of-1 or *** was resolved gradually and the patient stabilized,permitting discontinuation of dexmedetomidine after 3 *** Dexmedetomidine may be clinically helpful for the management of Nms,most likely because of its sympatholytic activity.

关键词： Haloperidol Dexmedetomidine Delirium Neuroleptic malignant syndrome Alpha-2 adrenergic agonists Case report

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