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Abundance of Enterobacteriaceae in the colon mucosa in diverticular disease

World Journal of Gastrointestinal Pathophysiology 2018年第1期9卷 18-27页

作者： Caroline Linninge Bodil Roth Charlotte Erlanson-Albertsson Goran Molin Ervin Toth Bodil Ohlsson Department of food Technology Engineering and NutritionLund UniversityLund S-223 63Sweden Department of Internal Medicine Skane University HospitalLund UniversityMalman-205 02Sweden Appetite Regulation Unit Department of Experimental Medical ScienceLund UniversityLund S-222 41Sweden Department of Gastroenterology Skane University HospitalLund UniversityMalmo-205 02Sweden

AIM To compare gut bacterial diversity and amount of Enterobacteriaceae in colonic mucosa between patients with and without diverticular disease(DD).METHODS Patients in a stable clinical condition with planned elective colonoscopy were included. Blood samples and colon mucosa biopsies were collected at the colonoscopy. Study questionnaires including questions about gastrointestinal symptoms were completed by the patients and physicians. DNA from mucosa samples was isolated and the amount of Enterobacteriaceae was estimated using PCR assay. Terminal restriction frag mentlength polymorphism was applied to assess microbial diversity. Diversity was estimated by calculations of richness(number of terminal restriction fragments) and Shannon-Wiener and Simpson's indices. RESULTS A total of 51 patients were included, 16 patients with DD [68(62-76) years] and 35 controls [62(40-74) years] without any diverticula. Patients with DD had significantly higher levels of Enterobacteriaceae than those without DD(P = 0.043), and there was an inverse relationship between the amount of Enterobacteriaceae and the Simpson's index(rs =-0.361, P = 0.033) and the Shannon-Wiener index(rs =-0.299, P = 0.081). The Simpson's index(P = 0.383), Shannon-Wiener index(P = 0.401) or number of restrictions fragments(P = 0.776) did not differ between DD and controls. The majority of patients experienced gastrointestinal symptoms, and 22 patients(43.1%) fulfilled the criteria for irritable bowel syndrome, with no difference between the groups(P = 0.212). Demography, socioeconomic status, lifestyle habits, inflammatory biomarkers, or symptoms were not related to the amount of Enterobacteriaceae or bacterial diversity. CONCLUSION Patients with DD had higher amount of Enterobacteriaceae in the colon mucosa compared to patients without diverticula.

关键词： Bacterial diversity Diverticular disease Enterobacteriaceae Gut microbiota Irritable bowel syndrome

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