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Glial cell line-derived neurotrophic factor and brain-derived neurotrophic factor regulate the interaction between astrocytes and Schwann cells at the trigeminal root entry zone

引用

Neural Regeneration Research 2023年第6期18卷 1364-1370页

作者： Madeha Ishag Adam Ling Lin Amir Mahmoud Makin Xiao-Fen Zhang Lu-Xi Zhou Xin-Yue Liao Li Zhao Feng Wang Dao-Shu Luo Key Laboratory of Brain Aging and Neurodegenerative Diseases of Fujian Province Laboratory of Clinical Applied AnatomySchool of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina Public Technology Service Center of Fujian Medical University FuzhouFujian ProvinceChina Center for Membrane and Water Science&Technology Institute of Oceanic and Environmental Chemical EngineeringZhejiang University of TechnologyHangzhouZhejiang ProvinceChina

The trigeminal root entry zone is the zone at which the myelination switches from peripheral Schwann cells to central *** special anatomical and physiological structure renders it susceptible to nerve *** etiology of most primary trigeminal neuralgia is closely related to microvascular compression of the trigeminal root entry *** study aimed to develop an efficient in vitro model mimicking the glial environment of trigeminal root entry zone as a tool to investigate the effects of glial cell line-derived neurotrophic factor and brain-derived neurotrophic factor on the structural and functional integrity of trigeminal root entry zone and modulation of cellular *** astrocytes and Schwann cells isolated from trigeminal root entry zone of postnatal rats were inoculated into a two-well silicon culture insert to mimic the trigeminal root entry zone microenvironment and treated with glial cell line-derived neurotrophic factor and brain-derived neurotrophic *** monoculture,glial cell line-derived neurotrophic factor promoted the migration of Schwann cells,but it did not have effects on the migration of *** the co-culture system,glial cell line-derived neurotrophic factor promoted the bidirectional migration of astrocytes and Schwann ***-derived neurotrophic factor markedly promoted the activation and migration of ***,in the co-culture system,brain-derived neurotrophic factor inhibited the migration of astrocytes and Schwann cells to a certain *** findings suggest that glial cell line-derived neurotrophic factor and brain-derived neurotrophic factor are involved in the regulation of the astrocyte-Schwann cell interaction in the co-culture system derived from the trigeminal root entry *** system can be used as a cell model to study the mechanism of glial dysregulation associated with trigeminal nerve injury and possible therapeutic interventions.

关键词： astrocytes brain-derived neurotrophic factor cell migration glial cell line-derived neurotrophic factor glial interaction Schwann cells trigeminal nerve

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