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Diabetes and susceptibility to COVID-19:Risk factors and preventive and therapeutic strategies

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World Journal of Diabetes 2024年第8期15卷 1663-1671页

作者： Jing-Wen Liu Xiao Huang Ming-Ke Wang Ji-Shun yang School of Pharmacy Bengbu Medical UniversityBengbu 233000Anhui ProvinceChina Naval Medical Center Naval Medical UniversityShanghai 200052China

Coronavirus disease 2019(COVID-19)is a highly infectious disease caused by a novel human coronavirus called severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).Diabetes is a well-known risk factor for infectious diseases with high prevalence and increased ***,we elucidated the possible factors for the increased vulnerability of diabetic patients to SARS-CoV-2 infection and the more severe COVID-19 *** worsened prognosis of patients with both COVID-19 and diabetes may be attributable to host receptor angiotensinconverting enzyme 2-assisted viral ***,insulin resistance is often associated with impaired mucosal and skin barrier integrity,resulting in microbiota dysbiosis,which increases susceptibility to viral *** may also be associated with higher levels of pro-inflammatory cytokines resulting from an impaired immune system in diabetics,inducing a cytokine storm and excessive *** review describes diabetes mellitus and its complications,explains the risk factors,such as disease characteristics and patient lifestyle,which may contribute to the high susceptibility of diabetic patients to COVID-19,and discusses preventive and therapeutic strategies for COVID-19-positive diabetic patients.

关键词： Diabetes mellitus SARS-CoV-2 COVID-19 Susceptibility Prevention Treatment

Clinical application value of long non-coding RNAs signatures of genomic instability in predicting prognosis of hepatocellular carcinoma

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2386-2392页

作者： Xiao-Wen Xing Xiao Huang Wei-Peng Li Ming-Ke Wang Ji-Shun yang Department of Disease Control and Prevention Naval Medical CenterNaval Medical UniversityShanghai 200052China Medical Care Center Naval Medical UniversityShanghai 200052China

Hepatocellular carcinoma(HCC)presents challenges due to its high recurrence and metastasis rates and poor *** current clinical diagnostic and prognostic indicators exist,their accuracy remains imperfect due to their biol-ogical ***,there is a quest to identify improved biomarkers for HCC diagnosis and *** combining long non-coding RNA(lncRNA)expression and somatic mutations,Duan et al identified five representative lncRNAs from 88 lncRNAs related to genomic instability(GI),forming a GI-derived lncRNA signature(LncSig).This signature outperforms previously re-ported LncSig and TP53 mutations in predicting HCC *** this editorial,we comprehensively evaluate the clinical application value of such prognostic evaluation model based on sequencing technology in terms of cost,time,and ***,we provide an overview of various prognostic models for HCC,aiding in a comprehensive understanding of research progress in pro-gnostic evaluation methods.

关键词： Hepatocellular carcinoma Prognosis Prognostic model Biomarkers Genomic instability long non-coding RNA Clinical application value

Combined prevention and treatment measures are essential to control nosocomial infections during the COVID-19 pandemic

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World Journal of Virology 2024年第2期13卷 11-18页

作者： Jing-Wen Liu yue-yue Li Ming-Ke Wang Ji-Shun yang Medical Care Center Naval Medical Center of PLANaval Medical UniversityShanghai 200052China School of Pharmacy Bengbu Medical CollegeBengbu 233000Anhui ProvinceChina Department of Disease Control and Prevention Naval Medical Center of PLANaval Medical UniversityShanghai 200052China

Severe acute respiratory syndrome coronavirus-2 is a highly contagious positive-sense,single-stranded RNA virus that has rapidly spread *** of December 17,2023,772838745 confirmed cases including 6988679 deaths have been reported *** virus primarily spreads through droplets,airborne transmission,and direct *** harbor a substantial number of confirmed coronavirus disease 2019(COVID-19)patients and asymptomatic carriers,accompanied by high population density and a larger susceptible *** factors serve as potential triggers for nosocomial infections,posing a threat during the COVID-19 *** infections occur to varying degrees across different countries worldwide,emphasizing the urgent need for a practical approach to prevent and control the intra-hospital spread of *** study primarily concentrated on a novel strategy combining preventive measures with treatment for combating COVID-19 nosocomial *** suggests preventive methods,such as vaccination,disinfection,and training of heathcare personnel to curb viral ***,it explored therapeutic strategies targeting cellular inflammatory factors and certain new medications for COVID-19 *** methods hold promise in rapidly and effectively preventing and controlling nosocomial infections during the COVID-19 pandemic and provide a reliable reference for adopting preventive measures in the future pandemic.

关键词： COVID-19 SARS-CoV-2 Nosocomial infection Prevention Treatment

Influencing factors and preventive measures of infectious complications after intestinal resection for Crohn’s disease

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World Journal of Gastrointestinal Surgery 2024年第10期16卷 3363-3370页

作者： Shi-Rong Lv Xiao Huang Li-yun Zhou Jie Shi Chu-Chu Gong Ming-Ke Wang Ji-Shun yang Naval Medical Center of PLA Naval Medical UniversityShanghai 200052China

The incidence of Crohn’s disease(CD)has increased in recent years,with most patients requiring intestinal *** after intestinal resection for CD can lead to poor prognosis and recurrence,among which infectious complic-ations are the most *** study aimed to investigate the common risk factors,including medications,preoperative nutritional status,surgery-related factors,microorganisms,lesion location and type,and so forth,causing infectious complications after intestinal resection for CD,and to propose corresponding preventive *** findings provided guidance for identifying suscept-ibility factors and the early intervention and prevention of infectious complic-ations after intestinal resection for CD in clinical practice.

关键词： Crohn’s disease Intestinal resection Postoperative infectious complications Influencing factors Preventive measures

Impact of COVID-19 pandemic on routine childhood vaccinations

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World Journal of Virology 2024年第2期13卷 1-4页

作者： Shi-Rong Lv Ming-Ke Wang Xue-Lu yu Xin-yue Li Ji-Shun yang Department of Disease Control and Prevention Naval Medical Center of PLANaval Medical UniversityShanghai 200052China Medical Care Center Naval Medical Center of PLANaval Medical UniversityShanghai 200052China

Routine pediatric vaccination is one of the most effective public health inter-ventions for the control of a number of fatal ***,during the coronavirus disease 2019 pandemic,routine pediatric vaccination rates were severely affected by disruptions of health services and vaccine confidence *** and the United Nations have taken measures to re-establish routine pediatric vaccination,while additional efforts are needed to catch up and develop plans to ensure routine vaccination services for the future pandemics.

关键词： Vaccines Childhood immunizations COVID-19 SARS-CoV-2 Pandemic