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PD-L1 targeted iron oxide SERS bioprobe for accurately detecting circulating tumor cells and delineating tumor boundary

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Chinese Chemical Letters 2025年第1期36卷 408-414页

作者： Ting Pan Dinghu Zhang Guomei You Xiaoxia Wu Chenguang Zhang Xinyu Miao Wenzhi Ren Yiwei He Lulu He Yuanchuan Gong Jie Lin Aiguo Wu Guoliang Shao Department of Interventional Radiology Zhejiang Cancer HospitalInstitute of Basic Medicine and Cancer(IBMC)Chinese Academy of SciencesHangzhou 310022China ningbo key Laboratory of Biomedical Imaging Probe Materials and Technology Cixi Institute of Biomedical EngineeringInternational Cooperation Base of Biomedical Materials Technology and ApplicationChinese Academy of Science(CAS)Key Laboratory of Magnetic Materials and Devices and Zhejiang Engineering Research Center for Biomedical MaterialsNingbo Institute of Materials Technology and EngineeringCASNingbo 315201China Advanced Energy Science and Technology Guangdong Laboratory Huizhou 516000China

Early diagnosis and accurate boundary delineation are the key steps of tumor precision *** tumor cells(CTCs)detection of liquid biopsy can provide abundant information for early diagnosis of *** detection specificity and good enrichment features are two key factors for CTCs accurate identification in peripheral blood *** this purpose,iron oxide(IO)-based surface-enhanced Raman scattering(SERS)bioprobes with good biocompatibility,high detection sensitivity,remarkable detection specificity,and good enrichment efficiency,were developed for detecting different types of *** SERS bioprobes combined with programmed death ligand-1(PD-L1)antibody are regarded as an effective way to boost the targeting ability and detection specificity,benefiting for accurately capturing and identifying rare *** types of CTCs with different PD-L1 expression were accurately distinguished among white blood cells via high-resolution SERS mapping images and stable Raman ***,CTCs blood samples obtained from the triple negative breast cancer patients were also successfully recognized compared to that of health people,indicating IO@AR@PDA-a PD-L1 SERS bioprobe possessed great potential for CTCs detection in liquid ***,IO-based bioprobe exhibited excellent dual-modal imaging abilities of high-resolution SERS imaging mode and microimaging magnetic resonance imaging *** two highly complementary imaging modes endowed IO-based bioprobes unrivalled capacity in tumor boundary differentiation,supporting tumor accurate resection and precise *** our best knowledge,this is the first time that biocompatible IO-based SERS bioprobes without noble metal element were reported not only for CTCs accurate detection,but also for precise tumor boundary delineation,showing great advantages in tumor diagnosis and treatment.

关键词： Circulating tumor cells Surface-enhanced Raman scattering PD-L1 Iron oxide bioprobe Dual-modal imaging Tumor boundaries delineation

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Surface-enhanced Raman scattering on nanomaterials for cancer and pathogens diagnosis

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Nano Research 2025年第2期18卷 650-674页

作者： Jingjing Wu Baohong Zhang Lei Xu Yanyu Zhao Tao Chen Jie Lin Anran Li School of Engineering Medicine Beihang UniversityBeijing 100191China key Laboratory of Big Data-Based Precision Medicine Ministry of Industry and Information Technology of the People’s Republic of ChinaBeihang UniversityBeijing 100191China School of Optics and Photonics Beijing Institute of TechnologyBeijing 100089China Shanxi Lu'an Taihang Lubricant Technology Co. Ltd.Changzhi 046204China Cixi Institute of Biomedical Engineering Ningbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo 315201China

Surface-enhanced Raman scattering(SERS)is a non-invasive spectroscopic technique that provides specific chemical fingerprint information for biomarkers in cancer and pathogen ***,the SERS strategies are limited by the non-specific interactions between substrates and co-existing substances in biological matrices and the challenges of obtaining molecular fingerprint information from the complex vibrational *** recent years,the rapid development of novel substrates with high SERS activity has opened up new opportunities for their applications in cancer and pathogen *** aim of this review is to present the recent progress and perspectives of novel SERS-based substrates for cancer and pathogen diagnostic ***,we will introduce recently developed SERS-active nanomaterials and discuss the influencing factors of the SERS ***,the advantages of SERS in the diagnosis of cancer and pathogens will be ***,we will review the latest breakthroughs in cancer and pathogen detection research with SERS technology,as well as the new opportunities for SERS applications brought about by artificial intelligence(Al)*** addition,the novel microfluidic-SERS platforms for cancer and pathogens diagnosis will also be ***,we will summarize the challenges and future perspectives of SERS technology in the field of early cancer diagnosis and rapid pathogen *** is highly expected that this review could benefit a comprehensive understanding of the research status of the SERS-active nanomaterials and arouse the research enthusiasm for them,leading to accelerated clinical translation of SERS technology in cancer and pathogen diagnosis.

关键词： surface-enhanced Raman scattering(SERS) SERS-active nanomaterials cancer and pathogen diagnosis artificial intelligence(Al)technology

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Bioinspired tactile perception platform with information encryption function

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Chinese Physics B 2022年第9期31卷 636-643页

作者： Zhi-Wen Shi Zheng-Yu Ren Wei-Sheng Wang Hui Xiao Yu-Heng Zeng Li-Qiang Zhu School of Physical Science and Technology Ningbo UniversityNingbo 315211China ningbo Institute of Materials Technology and Engineering Chinese Academy of SciencesNingbo 315201China

Mimicking tactile perception is critical to the development of advanced interactive neuromorphic *** by cutaneous perceptual functions,a bionic tactile perceptual platform is ***-based tactile sensors act as bionic skin touch *** indium tin oxide neuromorphic transistors fabricated with a single-step mask pro-cessing act as artificial ***,the tactile perceptual platform possesses the ability of information ***,the flexible tactile perception platform can find applications in information encryption and *** adoption of cipher,signal transmitted by the perception platform is ***,the security of information transmis-sion is effectively *** flexible tactile perceptual platform would have potentials in cognitive wearable devices,advanced human-machine interaction system,and intelligent bionic robots.

关键词： flexible oxide neuromorphic transistor tactile perception platform information encryption

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Pocket Modification of x-Amine Transaminase AtATA for Overcoming the Trade-Off Between Activity and Stability Toward 1-Acetonaphthone

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Engineering 2023年第11期30卷 203-214页

作者： Jiaren Cao Fangfang Fan Changjiang Lyu Sheng Hu Weirui Zhao Jiaqi Mei Shuai Qiu Lehe Mei Jun Huang key Laboratory of Chemical and Biological Processing Technology for Farm Products of Zhejiang Province Zhejiang Provincial Collaborative Innovation Center of Agricultural Biological Resources Biochemical ManufacturingSchool of Biological and Chemical EngineeringZhejiang University of Science and TechnologyHangzhou 310023China School of Biological and Chemical Engineering Ningbo Tech UniversityNingbo 315100China Hangzhou Huadong Medicine Group Co.Ltd. Hangzhou 310011China College of Chemical and Biological Engineering Zhejiang UniversityHangzhou 310027China Jinhua Advanced Research Institute Jinhua 321019China

Amine transaminases(ATAs)catalyze the asymmetric amination of prochiral ketones or aldehydes to their corresponding chiral ***,the trade-off between activity and stability in enzyme engineering represents a major obstacle to the practical application of *** this trade-off is important for developing robustly engineered enzymes and a universal approach for ***,we modified the binding pocket of co-ATA from Aspergillus terreus(AtATA)to identify the key amino acid residues controlling the activity and stability of AtATA toward *** discovered a structural switch comprising four key amino acid sites(R128,V149,L182,and L187),as well as the"best"mutant(AtATAD224K/V149A/L182 F/L187F;termed M4).Compared to the parent enzyme AtATAD224K(AtATAPa),M4 increased the catalytic efficiency(k_(cat)/K_(m)^(1-acetonaphthone),where kcatis the constant of catalytic activities and is 10.1 min^(-1),K_(m)^(1-acetonaphthoneis) Michaelis-Menten constant and is 1.7 mmol·L^(-1))and half-life(t1/2)by 59-fold to 5.9 L·min^(-1)·mmol-1and by 1.6-fold to 46.9 min,***,using M4 as the biocatalyst,we converted a 20 mmol·L^(-1)aliquot of 1-acetonaphthone in a 50 mL scaled-up system to the desired product,(R)-(+)-1(1-naphthyl)ethylamine((R)-NEA),with 78%yield and high enantiomeric purity(R>99.5%)within 10 h.M4 also displayed significantly enhanced activity toward various 1-acetonaphthone *** related structural properties derived by analyzing structure and sequence information of robust ATAs illustrated their enhanced activity and *** of intramolecular interactions and expansion of the angle between the substratebinding pocket and the pyridoxal 5’-phosphate(PLP)-binding pocket contributed to synchronous enhancement of ATA thermostability and ***,this pocket engineering strategy successfully transferred enhanced activity and thermostability to three other ATAs,which exhibited 8%-22%sequence simila

关键词： Trade-off Co-evolution Amine transaminase (R)-(+)-1(1-naphthyl)ethylamine

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Non-associative learning behavior in mixed proton and electron conductor hybrid pseudo-diode

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Journal of Materials Science & Technology 2023年第29期160卷 204-213页

作者： Zhi Wen Shi Wei Sheng Wang Ling Ai Yan Li Xin Li Chen Hui Xiao Yu Heng Zeng Li Qiang Zhu School of Physical Science and Technology Ningbo UniversityNingbo 315211China ningbo Institute of Materials Technology and Engineering Chinese Academy of SciencesNingbo 315201China

With inherent ionic priorities, mixed ion and electron conductor hybrid devices have been proposed for brain-inspired neuromorphic system applications, demonstrating interesting neuromorphic functions. Here, mixed proton and electron conductor (MPEC) hybrid oxide neuromorphic transistor is proposed by adopting aqueous solution-processed mesoporous silica coating (MSC)-based electrolyte as gate dielec- tric. With optical and electrical synergetic coupling behaviors, the device demonstrates typical synap- tic responses and transition between short-term plasticity and long-term plasticity. With unique field- configurable proton self-modulation behaviors, a pseudo-diode operation mode is demonstrated on the MPEC hybrid transistor. Moreover, the device demonstrates interesting non-associative learning, including habituation and sensitization behavior. The results show that the proposed MPEC hybrid oxide neuromor- phic transistor has great potential in the field of neuromorphic engineering and would have potential in the bionic visual perception platform .

关键词： Mixed proton and electron conductor hybrid Oxide neuromorphic transistors Non-associative learning Pseudo-diode

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High Performance Bio-based Polyurethane Elastomers： Effect of Different Soft and Hard Segments

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Chinese Journal of Polymer Science 2016年第7期34卷 901-909页

作者： Bin Cui Qing-Yun Wu 顾林 Liang Shen 余海斌 key Laboratory of Marine Materials and Related Technologies Key Laboratory of Marine Materials and Protective Technologies of Zhejiang Province Ningbo Institute of Materials Technology and EngineeringChinese Academy of Sciences Department of Polymer and Coating Jiangxi Science & Technology Normal University Department of Polymer Science and Engineering Faculty of Materials Science and Chemical EngineeringNingbo University

In this work, a series of high performance bio-based polyurethanes（bio-PUs） were synthesized from polylactide（PLA）-based diols, different diisocyanates（TDI, MDI, HDI, IPDI） and chain extender 1,4-butanediol, in which different soft and hard segments are used to adjust their transition temperatures and mechanical properties. Poly（lactide-co-caprolactone）copolymer diols（co-PLAols） instead of PLA diols as the soft segment improved the thermal stability and mechanical properties of the synthesized bio-PUs. Among them, MDI-based bio-PUs have the highest T_g（43.8 °C）, tensile strength（23.5 MPa） and modulus（380.8 MPa）, while HDI-based bio-PUs have the lowest T_g（21.4 °C） and highest elongation at break（580%）. Especially, the bio-PUs synthesized from co-PLAols and MDI demonstrate better mechanical properties,closed to petroleum-based commodities. Furthermore, the obtained bio-PUs display good shape memory properties at body temperature and cytocompatibility. Therefore, these bio-PUs are promising for applications in biomedical fields.

关键词： Polylactide diols Bio-based polyurethane Shape memory Biocompatibility

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Multi-terminal pectin/chitosan hybrid electrolyte gated oxide neuromorphic transistor with multi-mode cognitive activities

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Frontiers of physics 2024年第5期19卷 117-127页

作者： Yan Li You Jie Huang Xin Li Chen Wei Sheng Wang Xin Huang Hui Xiao Li Qiang Zhu School of Physical Science and Technology Ningbo UniversityNingbo 315211China ningbo Institute of Materials Technology and Engineering Chinese Academy of SciencesNingbo 315201China

In order to fulfill the urgent requirements of functional products,circuit integration of different functional devices are commonly ***,issues including production cycle,cost,and circuit crosstalk will get *** computing aims to break through the bottle neck of von Neumann *** devices with multi-operation modes,especially neuromorphic devices with multi-mode cognitive activities,would provide interesting ***,pectin/chitosan hybrid electrolyte gated oxide neuromorphic transistor was *** extremely strong proton related interfacial electric-double-layer coupling,the device can operate at low voltage of below 1 *** device can also operate at multi-operation mode,including bottom gate mode,coplanar gate and pseudo-diode ***,the artificial synapse can work at low voltage of only 1 mV,exhibiting extremely low energy consumption of~7.8 fJ,good signal-to-noise ratio of~229.6 and sensitivity of~23.6 *** inhibitory and excitatory synaptic responses were mimicked on the pseudo-diode,demonstrating spike rate dependent plasticity ***,a linear classifier is proposed on the oxide neuromorphic transistor under synaptic metaplasticity *** results suggest great potentials of the oxide neuromorphic devices with multi-mode cognitive activities in neuromorphic platform.

关键词： pectin/chitosan hybrid electrolyte pseudo-diode function multi-mode cognitive activities ultrasensitive oxide neuromorphic device linear data classifier

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Semitransparent Organic Solar Cells with Superior Thermal/Light Stability and Balanced Efficiency and Transmittance

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Energy & Environmental Materials 2024年第4期7卷 215-222页

作者： Zhipeng Yin Huan Zhao Yang Liu Xunwen Xiao Yong Zhang Huahang Lai Ning Li Hai-Qiao Wang School of Materials Science and Engineering NingboTech UniversityNingbo 315100China State key Laboratory of Luminescent Materials and Devices Institute of Polymer Optoelectronic Materials and DevicesSchool of Materials Science and EngineeringSouth China University of Technology381 Wushan RoadGuangzhou 510640China E-mail:ningli2022@scut.edu ningbo University of Technology Ningbo 315211China ningbo Institute of Technology Beihang UniversityNingbo 315800China Hangna Nanofabrication Equipment Co. Ltd.Hangzhou 311215China

Semitransparent organic solar cells show attractive potential in the application of building-integrated photovoltaics,agrivoltaics,floating photovoltaics,and wearable electronics,as their multiple functionalities of electric power generation,photopermeability,and color *** and exploration of semitransparent organic solar cells with optimal and balanced efficiency and average visible light transmittance and simultaneously high stability are in great *** this work,based on a layer-by-layer-processed active layer and an ultrathin metal electrode,inverted semitransparent organic solar cells(ITO/AZO/PM6/BTP-eC9/MoO_(3)/Au/Ag)were *** and balanced efficiency and average visible light transmittance were demonstrated,and simultaneously promising thermal and light stability were achieved for the obtained *** power conversion efficiency of 13.78-12.29%and corresponding average visible light transmittance of 14.58-25.80%were recorded for the ST-OSC devices with 25-15 nm thick Ag electrodes,*** thermal and light stability with~90%and~85%of initial efficiency retained in 400 h under 85°C thermal stress and AM1.5 solar illumination were demonstrated,respectively.

关键词： organic solar cell semitransparent thermal/light stability

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The continuous wavelet projections algorithm: A practical spectral-feature-mining approach for crop detection

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The Crop Journal 2022年第5期10卷 1264-1273页

作者： Xiaohu Zhao Jingcheng Zhang Ruiliang Pu Zaifa Shu Weizhong He Kaihua Wu College of Artificial Intelligence Hangzhou Dianzi UniversityHangzhou 310018ZhejiangChina School of Geosciences University of South FloridaTampaFL 33620USA Lishui Institute of Agriculture and Forestry Sciences Lishui 323000ZhejiangChina

Spectroscopy can be used for detecting crop characteristics. A goal of crop spectrum analysis is to extract effective features from spectral data for establishing a detection model. An ideal spectral feature set should have high sensitivity to target parameters but low information redundancy among ***, feature-selection methods that satisfy both requirements are lacking. To address this issue,in this study, a novel method, the continuous wavelet projections algorithm(CWPA), was developed,which has advantages of both continuous wavelet analysis(CWA) and the successive projections algorithm(SPA) for generating optimal spectral feature set for crop detection. Three datasets collected for crop stress detection and retrieval of biochemical properties were used to validate the CWPA under both classification and regression scenarios. The CWPA generated a feature set with fewer features yet achieving accuracy comparable to or even higher than those of CWA and SPA. With only two to three features identified by CWPA, an overall accuracy of 98% in classifying tea plant stresses was achieved, and high coefficients of determination were obtained in retrieving corn leaf chlorophyll content(R^(2)= 0.8521)and equivalent water thickness(R^(2)= 0.9508). The mechanism of the CWPA ensures that the novel algorithm discovers the most sensitive features while retaining complementarity among features. Its ability to reduce the data dimension suggests its potential for crop monitoring and phenotyping with hyperspectral data.

关键词： Hyperspectral Crop parameters Crop phenotyping Continuous wavelet analysis Successive projections algorithm

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Inner alkyl chain modulation of small molecular acceptors enables molecular packing optimization and efficient organic solar cells

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Science China Chemistry 2023年第2期66卷 500-507页

作者： Yuntong Guo Zhenyu Chen Jinfeng Ge Jinna Zhang Lin Xie Ruixiang Peng Wei Ma Ziyi Ge Zhejiang Engineering Research Center for Energy Optoelectronic Materials and Devices Ningbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo315201China School of Chemical Engineering Zhejiang University of TechnologyHangzhou310014China State key Laboratory for Mechanical Behavior of Materials Xi’an Jiaotong UniversityXi’an710049China

With the generation of Y6,organic solar cells have reached remarkable achievement of over 19%*** chain is of importance to modulate intermolecular stacking and possibly enhance optoelectronic properties of small molecule acceptors(SMAs).Three alkyl chains of 2-ethylhexyl,2-butylocyl and 3-ethylheptyl were selected to obtain G6-EH,G6-BO and G6-EHep molecules,*** to G6-EH and G6-BO,G6-EHep was found inducing unfavourable large domain ***,we discover that 2-butyloctyl effectively inhibits monomolecular and bimolecular recombination,improves molecular packing,generates more balanced carrier mobility and enhances exciton *** SMA with 2-butyloctyl alkyl chains(G6-BO)shows the best electrical and morphological characteristics,achieving a higher power conversion efficiency(PCE)of 17.06%,with an open circuit voltage of 0.912 V,a short-circuit current of 24.22 m A cm-2and a fill factor of 77.25%.Finally,using the ternary strategy by incorporating the G6-BO acceptor into PM6:BTP-e C9,we achieved a higher PCE of18.13%with enhanced electron transport.

关键词： alkyl chain small molecular acceptors molecular packing ternary strategy

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