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宁夏大学学报（自然科学版） 2011年第1期32卷 8-10,14页

作者：万静雯王金平宁波大学理学院数学系浙江宁波315211

讨论了实函数指数型Radon变换的一些性质,并将其推广到复函数的情形,最后给出了参数为纯虚数时指数型Radon变换的反演公式.

关键词：指数型Radon变换反演公式复函数

Study on the Synergistic Catalytic Oxidation of Landfill Leachate by O3 /H2O2 System

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Meteorological and Environmental Research 2016年第4期7卷 56-58页

作者： Teng Lihua Wang Chenyi Wang Jianping Zhejiang Wanli University Ningbo 315100 China ningbo Academy of Ocean and Fishery Ningbo 315012 China

The characteristics of water quality had significant effects on the oxidative degradation of O_3/H_2O_2 *** this study,iron supported on activated carbon catalyst was prepared firstly,and then the treatment of landfill leachate by O_3/H_2O_2/catalyst system was analyzed,especially the roles of H_2O_2 in the oxidation of landfill leachate by O_3/H_2O_2 *** results showed that at room temperature,when the dosage of the catalyst was 1.0g,the removal rate of COD from the landfill leachate reached 79.8% after 50 ml of the landfill leachate(pH=3)was oxidized by O_3(its flow rate was 5g/h)for 50 *** 0.3ml of H_2O_2 was added to the landfill leachate,the removal rate of COD increased from 79.8%to 88.7%.It showed that the landfill leachate with the characteristics of complex composition and difficult biodegradation could be effectively degraded by the O_3/H_2O_2 system.

关键词： Landfill leachate Oxidative degradation O3/H2O2 system china

Heme oxygenase-1 and gut ischemia/reperfusion injury: A short review

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World Journal of Gastroenterology 2013年第23期19卷 3555-3561页

作者： Yu-Feng Liao Wei Zhu Dong-Pei Li Xiao Zhu Department of Laboratory Medicine Ningbo No.2 Hospital Molecular Pathology Platform Key Laboratory of Molecular Diagnosis Guangdong Medical College Institute of Molecular Medicine and Genetics Georgia Health Sciences University

Ischemia/reperfusion (I/R) injury of the gut is a significant problem in a variety of clinical settings and is associated with a high morbidity and mortality. Although the mechanisms involved in the pathogenesis of gut I/R injury have not been fully elucidated, it is generally believed that oxidative stress with subsequent inflammatory injury plays an important role. Heme oxygenase (HO) is the rate-limiting enzyme in the catabolism of heme, followed by production of CO, biliverdin, and free iron. The HO system is believed to confer cytoprotection by inhibiting inflammation, oxidation, and apoptosis, and maintaining microcirculation. HO-1, an inducible form of HO, serves a vital metabolic function as the rate-limiting step in the heme degradation pathway, and affords protection in models of intestinal I/R injury. HO-1 system is an important player in intestinal I/R injury condition, and may offer new targets for the management of this condition.

关键词： Heme oxygenase Ischemia/reperfusion injury Oxidative stress Cytoprotection Gut

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关于周期神经网络逼近阶的研究(英文)

运筹学学报 2005年第4期9卷 21-30页

作者：盛宝怀周观珍刘三阳绍兴文理学院数学系宁波大学数学系西安电子科技大学应用数学系

借助于有关Fourier级数的Riesz平均构造出了一类含有一个隐含层的周期神经网络与平移网络,与已有的讨论相比较,在获得相同的逼近阶的情况下,此类网络的隐层单元要求较少的神经元个数．

关键词：运筹学周期神经网络逼近阶神经元个数

PCN-Fe(Ⅲ)-PTX nanoparticles for MRI guided high efficiency chemo-photodynamic therapy in pancreatic cancer through alleviating tumor hypoxia

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Nano Research 2020年第1期13卷 273-281页

作者： Tao Zhang Zhenqi Jiang Libin Chen Chunshu Pan Shan Sun Chuang Liu Zihou Li Wenzhi Ren Aiguo Wu Pintong Huang Department of Ultrasound The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou310009China Cixi Institute of Biomedical Engineering CAS Key Laboratory of Magnetic Materials and Devices&Key Laboratory of Additive Manufacturing Materials of Zhejiang ProvinceNingbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo315201China University of Chinese Academy of Sciences Beijing100049China Department of Ultrasound Ningbo First HospitalNingbo315010China Key Laboratory of Diagnosis and Treatment of Digestive System Tumors of Zhejiang Province Ningbo315016China

As nanomedicine-based clinical strategies have continued to develop,the possibility of combining chemotherapy and singlet oxygen-dependent photodynamic therapy(PDT)to treat pancreatic cancer(PaC)has emerged as a viable therapeutic *** efficacy of such an approach,however,is likely to be constrained by the mechanisms of drug release and tumor oxygen *** the present study,we developed an Fe(Ⅲ)-complexed porous coordination network(PCN)which we then used to encapsulate PTX(PCN-Fe(Ⅲ)-PTX)nanoparticles(NPs)in order to treat PaC via a combination of chemotherapy and *** resultant NPs were able to release drug in response to both laser irradiation and pH changes to promote drug accumulation within ***,through a Fe(Ⅲ)-based Fenton-like reaction these NPs were able to convert H2O2 in the tumor site to O2,thereby regulating local hypoxic conditions and enhancing the efficacy of PDT *** these NPs were suitable for use as a T1-MRI weighted contrast agent,making them viable for monitoring therapeutic efficacy upon *** results in both cell line and animal models of PaC suggest that these NPs represent an ideal agent for mediating effective MRI-guided chemotherapy-PDT,giving them great promise for the clinical treatment of PaC.

关键词： hypoxia porous-coordination polymers MRI imaging photodynamic therapy chemocherapy

Black TiO_(2) nanoprobe-mediated mild phototherapy reduces intracellular lipid levels in atherosclerotic foam cells via cholesterol regulation pathways instead of apoptosis

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Bioactive Materials 2022年第11期7卷 18-28页

作者： Ting Dai Wenming He Shuangshuang Tu Jinru Han Bo Yuan Chenyang Yao Wenzhi Ren Aiguo Wu Department of Cardiology The Affiliated Hospital of Medical SchoolNingbo University247 Renmin RoadJiangbei DistrictNingboZhejiang Province315020China Cixi Institute of Biomedical Engineering International Cooperation Base of Biomedical Materials Technology and ApplicationCAS Key Laboratory of Magnetic Materials and Devices&Zhejiang Engineering Research Center for Biomedical MaterialsNingbo Institute of Materials Technology and EngineeringChinese Academy of Sciences1219 ZhongGuan West RoadNingbo315201China University of Chinese Academy of Sciences No.1 Yanqihu East RoadHuairou DistrictBeijing101408China Advanced Energy Science and Technology Guangdong Laboratory Huizhou516000China

Given that apoptosis increases the risk of plaque rupture, strategies that reduce intracellular lipid levels without killing foam cells are warranted for safe and effective treatment of atherosclerosis. In this study, a mild pho-totherapy strategy is carried out to achieve the hypothesis. Foam cell-targeted nanoprobes that allow photo-thermal therapy (PTT) and/or photodynamic therapy (PDT) were prepared by loading hyaluronan and porphine onto black TiO_(2) nanoparticles. The results showed that when temperatures below 45 ◦C, PTT alone and PTT +PDT significantly reduced the intracellular lipid burden without inducing evidently apoptosis or necrosis. In contrast, the use of PDT alone resulted in only a slight reduction in lipid levels and induced massive apoptosis or necrosis. The protective effect against apoptosis or necrosis after mild-temperature PTT and PTT + PDT was correlated with the upregulation of heat shock protein 27. Further, mild-temperature PTT and PTT + PDT attenuated intracellular cholesterol biosynthesis and excess cholesterol uptake via the SREBP2/LDLR pathway, and also triggered ABCA1-mediated cholesterol efflux, ultimately inhibiting lipid accumulation in foam cells. Our results offer new insights into the mechanism of lipid regulation in foam cells and indicate that the black TiO_(2) nanoprobes could allow safer and more effective phototherapy of atherosclerosis.

关键词： Atherosclerosis Black TiO_(2)nanoparticles Phototherapy Cholesterol homeostasis

Enhancing health-promoting isothiocyanates in Chinese kale sprouts via manipulating BoESP

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Horticulture Research 2023年第4期10卷 124-134页

作者： Huiying Miao Chuchu Xia Shunhao Yu Jiansheng Wang Yanting Zhao Qiaomei Wang Key Laboratory of Horticultural Plant Growth Development and Quality ImprovementDepartment of HorticultureZhejiang UniversityHangzhou 310058China Institute of Vegetables Zhejiang Academy of Agricultural SciencesHangzhou 310021China

Glucosinolates(GSLs)are a group of sulfur-containing secondarymetabolites,which are abundant in Brassica *** breakdown products(GBPs),especially isothiocyanates(ITCs)benefit human *** kale is a native Brassica vegetable in china,and its sprouts are rich in GSLs and nutritional *** are the predominant GBPs while alternative products are formed in the presence of specifier ***,fewer ITCs are formed in the ***(ESP)promotes the formation of epithionitriles at the expense of ITCs in Arabidopsis,but a systematic study of different isoforms of ESPs in most vegetables is still *** this study,changes in the content of GBPs and the precursor GSLs,as well as thiols per plant were monitored during sprout *** proportions of epithionitriles and ITCs in total GBPs were found to be increased and decreased,***-seq showed enhanced expression of numerous genes involved in GSLs biosynthesis and degradation,as well as sulfur assimilation in sprouts compared to *** copies of BoESPs were isolated and BoESP2 was the most abundant ***,transcription of BoESPs showed a strong response to abscisic acid and gibberellin,and consequently epithionitriles increased under these *** of BoESP2 expression through virus-induced gene silencing system could effectively increase total ITCs and decrease total ***,dynamic GSL metabolic f lux exists in the sprouting period,and the expression of BoESPs determines the pattern of GBPs,suggesting that improving the health-promoting ITCs in Chinese kale sprouts through manipulating BoESPs by metabolic engineering is feasible.

关键词： ESP ITC vegetables

Influence of Al addition on solidification path and hot tearing susceptibility of Mg-2Zn-(3+0.5 x)Y-x Al alloys

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Journal of Magnesium and Alloys 2019年第2期7卷 272-282页

作者： Guojia Zhang Yue Wang Zheng Liu Shimeng Liu School of Materials Science and Engineering Shenyang University of technologyShenyang 110870P.R.China

Hot tearing susceptibility(HTS)of Mg-2Zn-(3+0.5 x)Y-x Al(x=0,2 and 3 at%)alloys is predicted by using modified Clyne-Davies’model(CSC^(∗)).The solidification path,solidification characteristic temperatures and dendritic coherency solid fraction have been studied by double-thermocouple thermal *** solidification contraction stress ***(and time)curves are measured by using a“T”type hot tearing *** results reveal that the CSC^(∗)prediction values are in good agreement with the experimental ***,Al_(2)Y phase acts as the heterogeneous nucleation core ofα-Mg and significantly influences the grain *** has been observed that minimum grain size,optimal dendritic coherency and minimum HTS are exhibited by Mg-2Zn-(3+0.5 x)Y-x Al alloy(x=2).Furthermore,when Al content was increased to 3 at%,Al_(2)Y phase exhibited a peritectic reaction and transformed into a mixed structure of Al_(2)Y and Al+Al_(3)Y phases,which increased the HTS of the alloy due to reduced fine-grained Al_(2)Y content.

关键词： Mg-Zn-Y-Al alloys Hot tearing susceptibility(HTS) Solidification path Clyne-Davies’model(CSC^(∗)) Dendritic coherency

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全球海啸相关研究进展综述（英文）

Journal of Marine Science and Application 2023年第1期 14-24页

作者：程思学刘海江 Faculty of Mechanical Engineering and Mechanics Ningbo University College of Civil Engineering and Architecture Zhejiang University

With the advancement of the global economy, the coastal region has become heavily developed and densely populated and suffers significant damage potential considering various natural disasters, including tsunamis, as indicated by several catastrophic tsunami disasters in the 21st century. This study reviews the up-to-date tsunami research from two different viewpoints: tsunamis caused by different generation mechanisms and tsunami research applying different research approaches. For the first issue, earthquake-induced, landslide-induced, volcano eruption-induced, and meteorological tsunamis are individually reviewed, and the characteristics of each tsunami research are specified. Regarding the second issue, tsunami research using post-tsunami field surveys, numerical simulations, and laboratory experiments are discussed individually. Research outcomes from each approach are then summarized. With the extending and deepening of the understanding of tsunamis and their inherent physical insights, highly effective and precise tsunami early warning systems and countermeasures are expected for the relevant disaster protection and mitigation efforts in the coastal region.

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Controllable synthesis of layered black bismuth oxidechloride nanosheets and their applications in internal tumor ablation

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Regenerative Biomaterials 2022年第1期9卷 501-510页

作者： Qianlan Fang Yu Xu Lijia Luo Chuang Liu Zihou Li Jie Lin Tianxiang Chen Aiguo Wu Cixi Institute of Biomedical Engineering International Cooperation Base of Biomedical Materials Technology and ApplicationChinese Academy of Science(CAS)Key Laboratory of Magnetic Materials and Devices and Zhejiang Engineering Research Center for Biomedical MaterialsNingbo Institute of Materials Technology and EngineeringCASNingbo 315201P.R.China University of Chinese Academy of Sciences Beijing 100049P.R.China Advanced Energy Science and Technology Guangdong Laboratory Huizhou 516000P.R.China

The recently emerging bismuth oxyhalide(BiOX)nanomaterials are promising indirect band gap photosensitizer for ultraviolet(UV)light-triggered phototherapy due to their unique layered nanosheet ***,the low absorption and poor photothermal conversion efficiency have always impeded their further applications in cancer clinical ***,BiOCl rich in oxygen vacancies has been reported to have fullspectrum absorption properties,making it possible to achieve photothermal property under near-infrared *** 808nm irradiation,the photothermal conversion efficiency of black BiOCl nanosheets(BBNs)is up to 40%.BBNs@PEG can effectively clear primary subcutaneous tumors and prevent recurrence,achieving good synergistic treatment *** results not only broke the limitation of UV on the BiOCl material and provided a good template for other semiconductor materials,but also represent a promising approach to fabricate BBN@PEG a novel,potent and multifunctional theranostic platform for precise photothermal therapy and prognostic evaluation.

关键词： black bismuth oxidechloride nanosheet photothemal therapy tumor photothermal conversion efficiency