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印度传统药用植物可因氏越橘的研究综述(英文)

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中西医结合学报 2011年第8期9卷 824-833页

作者： Priyanka Gupta Alok Nahata Vinod K.Dixit Department of Pharmaceutical Sciences Dr.Hari Singh Gour University

可因氏越橘又名调料九里香(Murraya koenigii,芸香科,九里香属),是一种常用的药用植物,在印度阿育吠陀医学中有数百年的使用历史。这种植物的叶子、果实、根及树皮均富含咔唑生物碱。已有的很多研究报道这些生物碱具有多种药理活性如抗... 详细信息

可因氏越橘又名调料九里香(Murraya koenigii,芸香科,九里香属),是一种常用的药用植物,在印度阿育吠陀医学中有数百年的使用历史。这种植物的叶子、果实、根及树皮均富含咔唑生物碱。已有的很多研究报道这些生物碱具有多种药理活性如抗肿瘤、抗病毒、抗炎、止泻、利尿、抗氧化等。除了这些药理活性,该植物还具有多种多样的生物活性。可因氏越橘作为一种能够治疗多种疾病的有价值的药用植物,有关其植物化学及药理学的研究数量众多,因此有必要对其作一系统的综述。本文对有关可因氏越橘的植物化学、药理学、临床及基础研究进行了系统的整理,以期更全面地发掘其作为药用植物的价值。

关键词：芸香科九里香属医学印度传统植物提取物综述

蚝菇提取物对老年大鼠肝肾组织内过氧化物酶表达及蛋白质氧化的影响(英文)

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中西医结合学报 2010年第8期8卷 774-780页

作者： Thanasekaran Jayakumar Philip Aloysius Thomas Mathivanan Isai Pitchairaj Geraldine Department of Animal Science School of Life SciencesBharathidasan UniversityTiruchirappalli 620 024 Institute of Ophthalmology Joseph Eye HospitalTiruchirappalli 620 001

目的:探讨蚝菇提取物对老年大鼠(24月龄)肝肾组织内过氧化物酶基因表达及蛋白质羰基含量的影响。方法:18只大鼠被分为3组,每组6只。组1为健康年轻大鼠(4月龄)对照组;组2为健康老年大鼠(24月龄)对照组;组3为健康老年大鼠(24月龄)蚝菇提... 详细信息

目的:探讨蚝菇提取物对老年大鼠(24月龄)肝肾组织内过氧化物酶基因表达及蛋白质羰基含量的影响。方法:18只大鼠被分为3组,每组6只。组1为健康年轻大鼠(4月龄)对照组;组2为健康老年大鼠(24月龄)对照组;组3为健康老年大鼠(24月龄)蚝菇提取物干预组,干预措施为每天腹腔注射蚝菇提取物200 mg/kg体质量,连续注射30 d。第31天处死全部大鼠并取出肝肾组织。使用逆转录聚合酶链反应及分光光度测定法分别测定大鼠肝肾组织内过氧化物酶基因表达情况及蛋白质羰基的含量。结果:组3老年大鼠注射蚝菇提取物后,其肝肾组织内过氧化物酶基因表达显著高于组2老年大鼠,且组3老年大鼠肝肾组织内蛋白羰基含量显著低于组2老年大鼠。结论:蚝菇提取物能够增加老年大鼠肝肾组织内抗氧化酶基因的表达并减少自由基引起的蛋白质氧化,对于自由基引起的年龄相关性疾病可能有保护作用。

关键词：蚝菇过氧化氢酶活性氧逆转录聚合酶链反应蛋白质羰基大鼠

comSeedling growth of five tropical dry forest tree species in relation to light and nitrogen gradients

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Journal of Plant Ecology 2014年第3期7卷 250-263页

作者： S.N.Tripathi A.S.Raghubanshi Ecosystems Analysis Laboratory Department of BotanyBanaras Hindu UniversityVaranasiUttar Pradesh 221005India Deen Dayal Upadhyaya College University of DelhiShivaji MargKarampuraNew Delhi 110015India Institute of Environment and Sustainable Development Banaras Hindu UniversityVaranasiUttar Pradesh 221005India

Aims Increasing anthropogenic nitrogen(N)deposition has been claimed to induce changes in species composition and community dynamics.A greenhouse experiment was conducted to examine the effect of increased N availability on growth and functional attributes of seedlings of five tree species with different life history characteristics under varying *** following questions have been addressed:(i)how do the pioneer and non-pioneer species respond in absolute growth and relative growth rate(RGR)to the interaction of light and nitrogen?(ii)how does the interaction between irradiance and nitrogen availability modulate growth attributes(*** attributes)?(iii)is there any variation in growth responses between leguminous and non-leguminous species along the light and nitrogen gradients?Methods Seedlings of five tree species(Acacia catechu,Bridelia retusa,Dalbergia sissoo,Lagerstroemia parviflora and Terminalia arjuna)were subjected to twelve combinations of irradiance and N *** growth traits,including height(HT),basal area(BA),whole plant dry biomass(MD),leaf mass per unit area(LMA),leaf area ratio(LAR),net assimilation rate(NAR),RGR,biomass fractions,root-toshoot ratio(R:S)and leaf nitrogen content,were studied to analyse intra-and inter-specific responses to interacting light and N *** Findings Significant interactions for irradiance and N availability for majority of growth attributes indicates that growth and biomass allocation of seedlings were more responsive to N availability under high ***,species responded differentially to N addition and they did not follow successional *** growers(***,a shade-tolerant species and ***,a light demander)exhibited greater response to N enrichment than the fast growers(***,*** and ***).However,N-mediated increment in growth traits was greater in non-legumes(***,*** and ***)compared with that of legumes(*** and D

关键词： tropical dry forest irradiance nitrogen biomass allocation relative growth rate net assimilation rate

Antioxidant enzyme profile of two clinical isolates of Entamoeba histolytica varying in sensitivity to antiamoebic drugs

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World Journal of Clinical Infectious Diseases 2017年第2期7卷 21-31页

作者： Lakshmi Rani Iyer Neha Banyal Shailendra Naik Jaishree Paul School of Life Sciences Jawaharlal Nehru University

AIM To study the sensitivity and antioxidant enzyme response in two clinical isolates of Entamoeba histolytica(E. histolytica) during treatment with antiamoebic drugs,auranofin and metronidazole. METHODS E. histolytica were isolated from stool samples and maintained in Robinson's biphasic culture medium. Clinial isolates were maintained in xenic culture medium,and harvested for determination of minimum inhibitory concentrations to the two antiamoebic drugs,Metronidazole and Auranofin using microtiter plate tests. The percent survival of the two isolates were determined using the trypan blue cell count. Isolate 980 was treated with 70 μmol/L and 2 μmol/L while isolate 989 was treated with 20 μmol/L and 0.5 μmol/L of metronidazole and auranofin respectively for 24 h. Fifty thousand cells of each isolate were harvested after 24 h of treatment for analysis of the mRNA expressions of the antioxidant enzymes,thioredoxin reductase,peroxiredoxin and FeSOD using the specific primers. Cell lysate was used for determination of enzyme activity of thioredoxin reductase by measuring DTNB reduction spectrophotometrically at412 *** Minimum inhibitory concentration of the clinical isolates 980 and 989 for auranofin was 3 μmol/L and 1 μmol/L respectively while that for metronidazole was 80 μmol/L and 30 μmol/L respectively. Thioredoxin reductase,peroxiredoxin and FeSOD expression levels were significantly reduced in the isolate 980 when treated with Auranofin. Metronidazole treatment showed a down regulation of thioredoxin reductase. Though not significant both at the mRNA and the enzyme activity levels. Peroxiredoxin and FeSOD however remained unchanged. Auranofin treatment of isolate 989,showed an upregulation in expression of thioredoxin reductase while Peroxiredoxin and FeSOD did not show any change in expression. Upon treatment with metronidazole,isolate 989 showed an increase in thioredoxin reductase expression. Peroxiredoxin and FeSOD expressions however remain unchange

关键词： Metronidazole Entamoeba histolytica Amoebiasis Thioredoxin reductase Minimum inhibitory concentrations Auranofin

A defect in the activities of △~6 and △~5 desaturases and pro-resolution bioactive lipids in the pathobiology of non-alcoholic fatty liver disease

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World Journal of Diabetes 2011年第11期2卷 176-188页

作者： Undurti N Das UND Life Sciences School of Biotechnology Jawaharlal Nehru Technological University Bio-Science Research Centre Gayatri Vidya Parishad College of Engineering Visakhapatnam-530 048

Non-alcoholic fatty liver disease (NAFLD) is a low-grade systemic inflammatory condition, since liver and adipose tissue tumor necrosis factor-α (TNF-α) and TNF receptor 1 transcripts and serum TNF-α levels are increased and IL-6-/-mice are less prone to NAFLD. Fatty liver damage caused by high-fat diets is associated with the generation of pro-inflammatory prostaglandin E2 (PGE2). A decrease in the levels of arachidonic acid (AA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and the usefulness of EPA and DHA both in the prevention and management of NAFLD has been reported. AA, EPA and DHA and their anti-inflammatory products lipoxins (LXs), resolvins and protectins suppress IL-6 and TNF-α and PGE2 production. These results suggest that the activities of △6 and △5 desaturases are reduced in NAFLD and hence, the dietary essential fatty acids, linoleic acid (LA) and α-linolenic acid (ALA) are not metabolized to their long-chain products AA, EPA and DHA, the precursors of anti-inflammatory molecules, LXs, resolvins and protectins that could prevent NAFLD. This suggests that an imbalance between proand anti-inflammatory bioactive lipids contribute to NAFLD. Hence, it is proposed that plasma and tissue levels of AA, EPA, DHA and LXs, resolvins and protectins could be used as predictors and prognostic biomarkers of NAFLD. It is suggested that the synthesis and use of more stable analogues of LXs, resolvins and protectins need to be explored in the prevention and management of NAFLD.

关键词： Prostaglandins Lipids Arachidonic acid Eicosapentaenoic acid Non-alcoholic fatty liver disease Docosahexaenoic acid Lipoxins Resolvins Protectins Cytokines Free radicals Hyperlipidemia

China’s 1-3-7 surveillance and response strategy for malaria elimination: Is case reporting, investigation and foci response happening according to plan?

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Infectious Diseases of Poverty 2015年第1期4卷 465-473页

作者： Shui-Sen Zhou Shao-Sen Zhang Li Zhang Aafje ECRietveld Andrew RRamsay Rony Zachariah Karen Bissell Rafael Van den Bergh Zhi-Gui Xia Xiao-Nong Zhou Richard ECibulskis National Institute of Parasitic Diseases Chinese Center for Disease Control and PreventionKey Laboratory of Parasite and Vector BiologyMOHWHO Collaborating Centre for Tropic DiseasesNational Center for International Research on Tropical Diseases207 Rui Jin Er RoadShanghai200025People’s Republic of China Global Malaria Programme World Health Organization20 Avenue AppiaCH-1211Geneva 27Switzerland Special Programme for Research and Training in Tropical Diseases(TDR) 20 Avenue AppiaCH-1211Geneva 27Switzerland Médecins Sans Frontieres Brussels Operational CentreLuxembourgLuxembourg International Union Against Tuberculosis and Lung Disease ParisFrance

Background:The China’s 1-3-7 strategy was initiated and extensively adopted in different types of counties(geographic regions)for reporting of malaria cases within 1 day,their confirmation and investigation within 3 days,and the appropriate public health response to prevent further transmission within 7 *** the level of compliance to the 1-3-7 strategy at the county level is a first step towards determining whether the surveillance and response strategy is happening according to *** study assessed if the time-bound targets of the 1-3-7 strategy were being sustained over *** information would be useful to improve implementation of the 1-3-7 strategy in ***:This cross-sectional study involved country-wide programmatic data for the period January 1st 2013 to June 30th *** variables were extracted from the national malaria information system and included socio-demographic information,type of county,date of diagnosis,date of reporting,date of case investigation,case classification(indigenous,or imported,or unknown),focus investigation,date of reactive case detection(RACD),and date of indoor residual spraying(IRS).Summary statistics and proportions were used and comparisons between groups were assessed using the chi-square *** of significance was set at a P-value≤***:Of a total of 5,688 malaria cases from 731 counties,there were 55(1%)indigenous cases(only in Type 1 and Type 2 counties)and 5,633(99%)imported cases from all types of *** was no delay in reporting malaria cases by type of *** terms of case investigation,97.5%cases were investigated within 3 days with the proportion of delays(1.5%)in type 2 counties,being significantly lower than type 1 counties(4.1%).Regarding active foci,96.4%were treated by RACD and/or ***:The performance of 1-3-7 strategy was encouraging but identified some challenges that if addressed can further improve implementation.

关键词： 1-3-7 strategy Malaria elimination Surveillance and response

Effects of histamine HlR-H4R-agonist on the airway epithelium of rabbits

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Asian Pacific Journal of Tropical Medicine 2010年第5期3卷 367-370页

作者： Naushad A Dilkash Trivendra Tripathi Aijaz Ahmed Khan Mohd Shahid Haris M Khan Mashiatullah Siddiqui Rahat Ali Khan Department of Anatomy Faculty of MedicineJawaharlal Nehru Medical College & HospitalAligarh Muslim University Department of Biochemistry Faculty of MedicineJawaharlal Nehru Medical College & HospitalAligarh Muslim University Department of Microbiology Faculty of MedicineJawaharlal Nehru Medical College & HospitalAligarh Muslim University Department of Pharmacology Faculty of MedicineJawaharlal Nehru Medical College & HospitalAligarh Muslim University

Objective:To explore the exact role of histamine receptors in respiratory ***: The cohort comprised of six groups(group I control and groupⅡ—Ⅳtreated) containing five rabbits in each ***-group received vehicle(sterile distilled water) and treated groups received subcutaneous histamine(100μg/kg,b.i.d.),and H1R-agonist(HTMT),H2R-agonist (amthamine),H3R-agonist(R-(-)-α-methylhistamine) and H4R-agonist(clobenpropit) each in a dose of 10μg/kg,*** 30 subsequent *** completion of treatment,animals were euthanized and perfused with 10% buffered *** tissue blocks of trachea and lungs were processed for paraffin *** were recorded in sample photomicrographs taken from 10μm *** and eosin stained ***:It was observed that trachea and bronchi from histamine,H1R and H4R groups had only patches of hyperplastic and hypertrophied epithelium and in general,cells in the affected region were taller heaped up. The bronchiolar epithelia from all treated groups showed hypertrophy and hyperplasia throughout with most of the cells having rounded profile and appeared to bud out from the basal cells. Conclusions:It is concluded that histamine receptors on induction via its specific agonist can induce hypertrophy,hyperplasia of respiratory tract epithelia suggesting its role akin to growth stimulating factor and warranting further long-term study.

关键词： Rabbit Airway epithelium Histamine receptors-agonist Hyperplasia Hypertrophy

Two new records of hydnoid fungi from the Western Ghats of India

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Studies in Fungi 2016年第1期1卷 135-141页

作者： Karun NC Sridhar KR Department of Biosciences Mangalore UniversityMangalagangotriMangalore 574199KarnatakaIndia

During inventory of macrofungi in the forests of Western Ghats,two hitherto unrecorded rare hydnoid taxa,Gyrodontium sacchari(Spreng.)Hjortstam(Agaricomycetes,Boletales,Coniophoraceae)and Hericium cirrhatum(Pers.)Nikol.(Agaricomycetes,Russulales,Hariciaceae)were recovered on decaying *** are reported from North-Eastern India,thus the present report constitutes the first report for the Western Ghats of *** communication embodies brief systematic accounts with illustrations,substrates,distributions and economic value of these hydnoid fungi.

关键词： forest Gyrodontium sacchari Hericium cirrhatum macrofungi wood

Effects of environmental factors and host characteristics on diversity and distribution of wood-rotting fungi of Mount Puliebadze,Nagaland

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Studies in Fungi 2018年第1期3卷 241-247页

作者： Chuzho K Dkhar MS Microbial Ecology Laboratory Centre for Advanced Studies in BotanyNorth-Eastern Hill UniversityShillong campus 793022MeghalayaIndia

The study on the effects of environmental factors and host characteristics on diversity and distribution of wood-rotting fungi Mount Puliebadze,Nagaland was carried out for a period of two successive years(January 2015 to December 2016).A total of 46 wood-rotting fungi belonging to 16 families were *** occurrence of wood-rotting fungi demonstrated a decreasing trend with increase in elevations and correlation between the two variables showed a strong negative correlation with Pearson’s correlation coefficient(r)value *** zone with lowest elevation(zone 1)comprised maximum number of species(25 species)whereas the zone with highest elevation(zone 4)comprised minimum number of species(05 species).Highest species similarity percentage(25.9%)was observed between zone 2 and *** way ANOVA showed significant variations between the occurrence of wood-rotting fungi with different seasons,light intensity,type of substrata and decay stage of ***’s diversity index(H’)of zone 1 was highest(H’=3.073)and that of zone 4 was lowest(H’=1.242).

关键词： Correlation ecology elevation Non-matric Multidimensional Scaling