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Recent development in electrode design for wide-temperature supercapacitors

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science china Chemistry 2025年第1期68卷 96-117页

作者： Jianhong Liu Qiang Zhou Yuxiao Lin Xinsheng Zhao Guangmin Zhou Xiaoxiao Li School of Physics and Electronic Engineering Jiangsu Normal UniversityXuzhou 221116China Tsinghua-Berkeley Shenzhen Institute&Tsinghua Shenzhen International Graduate School Tsinghua UniversityShenzhen 518055China

An ever-increasing market demand has stimulated the soaring enthusiasm of researchers to develop wide-temperature supercapacitors(SCs).The active electrode is one of the most important parts of SC,which is directly related to the energy density,power transmission and long-term cyclability of the device in the wide-temperature *** with the SC electrodes aimed for room-temperature application,the SC electrodes for operating at wide-temperature scene often face greater *** this review,the main challenges of SC electrodes under various temperature conditions,including low,high and cross-fade temperatures,are *** relevant performance decay and failure mechanisms of wide-temperature SC electrodes are *** addition,this review deals with the recent studies and developments in robust wide-temperature SC electrodes with respect to the rational design of electrode structures and the exploitation of advanced active ***,the future directions for exploring reliable wide-temperature SCs are also proposed.

关键词： supercapacitor wide-temperature electrode design active materials

CDK9 inhibitor elicits APC through a synthetic lethal effect in colorectal cancer cells

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GENES & DISEASES 2025年第1期12卷 101220页

作者： Liang, Tingming Luo, Lulu Xu, Xinru Du, Yajing Yang, Xinbing Xiao, Jiahui Huang, Xiaoyan Yang, Huiying Wang, Siyu Guo, Li Nanjing Normal Univ Sch Life Sci Jiangsu Key Lab Mol & Med Biotechnol Nanjing 210023 Jiangsu Peoples R China Nanjing Univ Posts & Telecommun State Key Lab Organ Elect & Informat Displays Nanjing 210023 Jiangsu Peoples R China Nanjing Univ Posts & Telecommun Inst Adv Mat IAM Nanjing 210023 Jiangsu Peoples R China

Colorectal cancer(CRC)is a significant global health concern,ranking third in incidence and second in mortality among all cancer-related diseases.1 Therefore,it is imperative to prioritize research efforts focused on CRC prevention and treatment to effectively reduce the associated incidence and mortality *** lethality(SL)refers to the phenomenon in which cells harboring two specific gene mutations simultaneously undergo cell death,whereas cells with a single mutation in either of the genes can survive *** strategies are widely concerned in personalized cancer treatment,with the application of PARP inhibitors marking a significant milestone.

关键词： mortality prevention treatment

Control upconversion decay dynamics from perspective of collective response

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Journal of Rare Earths 2025年第1期43卷 57-63,I0003页

作者： Yingdong Han Yutong Pan Tong Wei Yu Ma Xingxing Zhang Lei Jiang Kai Chen Liwei Wu Jiao Cui Chao Gao College of science Civil Aviation University of ChinaTianjin300300China School of Inspection and Testing Certification Changzhou Vocational Institute of EngineeringChangzhou213164China School of Chemical and Physical sciences Victoria University of WellingtonWellington6012New Zealand Robinson research Institute Faculty of EngineeringVictoria University of WellingtonWellington6012New Zealand

Very recently,upconversion luminescence(UCL)lifetime,as a powerful optical dimension,has attracted tremendous research interest due to its advantages of high information capacity and high photophysical *** the implementation and emergence of endlessly fascinating UCL features,it is particularly meaningful to understand the photophysical mechanisms inside UCL materials to enable rational subdivision-level structure design,which is however currently far from *** this work,we take an ordinary upconversion nanoparticle as an example to prove that the UCL decay curves and corresponding lifetimes are indeed a collective response of the entire UCL system to excitations,that exhibits correlated,yet quite different properties from individual ions.A specially developed theoretical random walk model combined with an experimental lifetime control for Yb^(3+)/Er^(3+)UCL demonstrates that ene rgy diffusion principally alters the decay ***,the different extent of the influence of energy diffusion on the emissions of ^(2)H_(11/2)/^(4)S_(3/2)(green)and ^(4)F_(9/2)(red)leads to an extremely uncommon crossover comparison of decay *** work provides new ideas for understanding decay dynamics and practical UCL lifetime manipulation methods.

关键词： Upconversion Lifetime Collective response Decaycurves Random walk model Rare earths

Approved delivery strategies for biopharmaceuticals

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Chinese Chemical Letters 2025年第2期36卷 69-79页

作者： Makhloufi Zoulikha Zhongjian Chen Jun Wu Wei He School of Pharmacy China Pharmaceutical University Shanghai Skin Disease Hospital Tongji University School of Medicine Department of Geriatric Cardiology Jiangsu Provincial Key Laboratory of Geriatrics The First Affiliated Hospital of Nanjing Medical University

In recent years, biopharmaceuticals have witnessed remarkable advancements, transforming the landscape of therapeutic interventions. Biopharmaceuticals encompassing therapeutics generated through cutting-edge biotechnological methods have shown promising therapeutic outcomes. However, their clinical success hinges significantly on overcoming drug delivery challenges related to stability, intracellular delivery, immunogenicity, and pharmacokinetic properties. Herein, we provide an overview of various marketed macromolecules, including nucleic acids, and immunotherapeutic agents such as cytokines and monoclonal antibodies, as well as other therapeutic peptides/proteins like enzymes, hormones, and coagulation factors. Our primary focus is on elucidating the delivery challenges associated with these macromolecules and highlighting the pivotal role played by drug delivery platforms in the development of currently marketed products, offering valuable insights for both scientific research and the pharmaceutical industry.

关键词： Biopharmaceuticals Drug delivery Monoclonal antibodies Nucleic acids Proteins

Emerging progress:photochemical transformation of nitroso compounds

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science china Chemistry 2025年第1期68卷 118-133页

作者： Ze-Le Chen Qiang-Qiang Li Armido Studer Jun Xuan Anhui Province Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials School of Chemistry&Chemical EngineeringAnhui UniversityHefei 230601China Organisch-Chemisches Institut Universitat MünsterMunster 48149Germany

Nitroso compounds have emerged as highly valuable reaction partners or reagents in organic synthesis due to their rich *** versatile profile of these compounds allows them to function as electrophiles,nucleophiles,diradicals,and radical acceptors in diverse *** recent years,notable progress has been made in harnessing photochemical reactions with nitroso compounds to prepare N,O-containing structures using mild and eco-friendly *** nitroso compounds like nitrosoarenes,acyloxy nitroso compounds,N-nitrosoamines and nitrites have received significant attention for their ability to introduce NO moieties into complex molecules that are otherwise difficult to *** this review,we provide an overview of the recent advancements in the visible light-induced conversion of nitroso compounds,with particular emphasis on their role as bifunctional reagents and acceptors of radicals,carbenes and nitrenes.

关键词： nitroso compounds photochemistry radical reaction carbene transformation nitrosoarenes

miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration research 2025年第1期20卷 277-290页

作者： Meng Cong Jing-Jing Hu Yan Yu Xiao-Li Li Xiao-Ting Sun Li-Ting Wang Xia Wu Ling-Jie Zhu Xiao-Jia Yang Qian-Ru He Fei Ding Hai-Yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of jiangsu and Ministry of education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

Mole-inspired Forepaw Design and Optimization Based on Resistive Force Theory

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JOURNAL OF BIONIC ENGINEERING 2025年第1期22卷 171-180页

作者： Zhang, Tao Liang, Zhaofeng Zheng, Hongmin Chen, Zibiao Zheng, Kunquan Xu, Ran Liu, Jiabin Zhu, Haifei Guan, Yisheng Xu, Kun Ding, Xilun Beihang Univ Sch Mech Engn & Automat Beijing 100191 Peoples R China Guangdong Univ Technol Sch Electromech Engn Guangzhou 510006 Peoples R China

Moles exhibit highly effective capabilities due to their unique body structures and digging techniques, making them ideal models for biomimetic research. However, a major challenge for mole-inspired robots lies in overcoming resistance in granular media when burrowing with forelimbs. In the absence of effective forepaw design strategies, most robotic designs rely on increased power to enhance performance. To address this issue, this paper employs Resistive Force Theory to optimize mole-inspired forepaws, aiming to enhance burrowing efficiency. By analyzing the relationship between geometric parameters and burrowing forces, we propose several forepaw design variations. Through granular resistance assessments, an effective forepaw configuration is identified and further refined using parameters such as longitudinal and transverse curvature. Subsequently, the Particle Swarm Optimization algorithm is applied to determine the optimal forepaw design. In force-loading tests, the optimized forepaw demonstrated a 79.44% reduction in granular lift force and a 22.55% increase in propulsive force compared with the control group. In robotic burrowing experiments, the optimized forepaw achieved the longest burrow displacement (179.528 mm) and the lowest burrowing lift force (0.9355 mm/s), verifying its effectiveness in reducing the lift force and enhancing the propulsive force.

关键词： Resistive force theory Mole-inspired forepaw design Structural optimization Bioinspired robot

Recent progress on artificial intelligence-enhanced multimodal sensors integrated devices and systems

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Journal of Semiconductors 2025年第1期46卷 179-192页

作者： Haihua Wang Mingjian Zhou Xiaolong Jia Hualong Wei Zhenjie Hu Wei Li Qiumeng Chen Lei Wang College of Integrated Circuit science and Engineering Nanjing University of Posts and TelecommunicationsNanjing 210023China Nantong Institute of Nanjing University of Posts and Telecommunications Nantong 226021China

Multimodal sensor fusion can make full use of the advantages of various sensors,make up for the shortcomings of a single sensor,achieve information verification or information security through information redundancy,and improve the reliability and safety of the *** intelligence(AI),referring to the simulation of human intelligence in machines that are programmed to think and learn like humans,represents a pivotal frontier in modern scientific *** the continuous development and promotion of AI technology in Sensor 4.0 age,multimodal sensor fusion is becoming more and more intelligent and automated,and is expected to go further in the *** this context,this review article takes a comprehensive look at the recent progress on AI-enhanced multimodal sensors and their integrated devices and *** on the concept and principle of sensor technologies and AI algorithms,the theoretical underpinnings,technological breakthroughs,and pragmatic applications of AI-enhanced multimodal sensors in various fields such as robotics,healthcare,and environmental monitoring are *** a comparative study of the dual/tri-modal sensors with and without using AI technologies(especially machine learning and deep learning),AI-enhanced multimodal sensors highlight the potential of AI to improve sensor performance,data processing,and decision-making ***,the review analyzes the challenges and opportunities afforded by AI-enhanced multimodal sensors,and offers a prospective outlook on the forthcoming advancements.

关键词： sensor multimodal sensors machine learning deep learning intelligent system

Influence of Al,Cu and Mn additions on diffusion behaviors in CoCrFeNi high-entropy alloys

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Transactions of Nonferrous Metals Society of china 2025年第1期35卷 184-193页

作者： Juan CHEN Zhen-zhong ZHANG Jin-kun XIAO Li-jun ZHANG Testing Center Yangzhou UniversityYangzhou 225009China School of Mechanical Engineering Yangzhou UniversityYangzhou 225009China State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083China

The interdiffusion coefficients in Al_(0.2)CoCrFeNi,CoCrCu_(0.2)FeNi,and CoCrFeMn_(0.2)Ni high-entropy alloys were efficiently determined by combining diffusion couple experiments and high-throughput determination of interdiffusion coefficients(HitDIC)software at 1273−1373 *** results show that the addition of Al,Cu,and Mn to CoCrFeNi high-entropy alloys promotes the diffusion of Co,Cr,and Fe *** comparison of tracer diffusion coefficients indicates that there is no sluggish diffusion in tracer diffusion on the thermodynamic temperature scale for the present Al_(0.2)CoCrFeNi,CoCrCu_(0.2)FeNi,and CoCrFeMn_(0.2)Ni high-entropy *** linear relationship between diffusion entropy and activation energy reveals that the diffusion process of atoms is unaffected by an increase in the number of components as long as the crystal structure remains unchanged.

关键词： Co−Cr−Fe−Ni high-entropy alloy diffusion interdiffusivity diffusion couple