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Tau truncation in the pathogenesis of Alzheimer's disease: a narrative review

Neural Regeneration Research 2024年第6期19卷 1221-1232页

作者： Dandan Chu Xingyue Yang Jing Wang Yan Zhou Jin-Hua Gu Jin Miao Feng Wu Fei Liu Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products Coinnovation Center of Neuroregeneration Nantong University 2. Department of Pharmacology School of Pharmacy Nantong University 3. Department of Biochemistry and Molecular Biology School of Medicine Nantong University 4. Department of Clinical Pharmacy Affiliated Maternity and Child Health Care Hospital of Nantong University Nantong University 5. Laboratory of Animal Center Nantong University Department of Neurochemistry Inge Grundke-Iqbal Research Floor New York State Institute for Basic Research in Developmental Disabilities

Alzheimer’s disease is characterized by two major neuropathological hallmarks—the extracellular β-amyloid plaques and intracellular neurofibrillary tangles consisting of aggregated and hyperphosphorylated Tau protein. Recent studies suggest that dysregulation of the microtubuleassociated protein Tau, especially specific proteolysis, could be a driving force for Alzheimer’s disease neurodegeneration. Tau physiologically promotes the assembly and stabilization of microtubules, whereas specific truncated fragments are sufficient to induce abnormal hyperphosphorylation and aggregate into toxic oligomers, resulting in them gaining prion-like characteristics. In addition, Tau truncations cause extensive impairments to neural and glial cell functions and animal cognition and behavior in a fragment-dependent manner. This review summarizes over 60 proteolytic cleavage sites and their corresponding truncated fragments, investigates the role of specific truncations in physiological and pathological states of Alzheimer’s disease, and summarizes the latest applications of strategies targeting Tau fragments in the diagnosis and treatment of Alzheimer’s disease.

关键词： Alzheimer's disease cleavage site diagnosis marker neurofibrillary tangles phosphorylation Tau Tau aggregation therapy truncation

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Hybrid nanoarchitectonics of TiO_(2)/aramid nanofiber membranes with softness and durability for photocatalytic dye degradation

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Chinese Chemical Letters 2024年第7期35卷 188-191页

作者： Wenhao Wang Guangpu Zhang Qiufeng Wang Fancang Meng Hongbin Jia Wei Jiang Qingmin Ji Herbert Gleiter Institute for Nanoscience School of Materials Science and Engineering Nanjing University of Science and TechnologyNanjing 210094China School of Chemical Engineering Nanjing University of Science&TechnologyNanjing 210094China nantong Junjiang Material science and Technology Co. Ltd.Haimen 226136China

TiO_(2)-based films are one of the most attractive photocatalysts owing to their highly cost-effective ***,most TiO_(2)-based photocatalytic films for dye degradation are in the form of robust films(without flexibility),TiO_(2)coatings on carbon matrix(with leakage risk),or surface-covered TiO_(2)hybrids(not favorite to contact with external molecules).Therefore,the development of durable and highly efficient TiO_(2)photocatalytic films for dye degradation is still ***,we fabricated soft photocatalytic hybrid membranes(TANFs)from TiO_(2)nanotubes(Ti NT)and aramid nanofiber(ANF)by a facile vacuum filtration *** similar morphology and dimension of Ti NT and ANF enable them intricately intertwine with each other in the membrane *** an appropriate mixing ratio,the TANF exhibited significantly improved optical and mechanical *** used for dye degradation,the membrane showed excellent photocatalytic performance and could keep stable activity and integrated state for repeated usage.

关键词： Titanium dioxide nanotube Aramid nanofiber Flexible hybrid membrane Photocatalysis Dye degradation

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Structure,ligands,and roles of GPR126/ADGRG6 in the development and diseases

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Genes & Diseases 2024年第1期11卷 294-305页

作者： Qi Li Anran Huo Mengqi Li Jiali Wang Qiao Yin Lumiao Chen Xin Chu Yuan Qin Yuwan Qi Yang Li Hengxiang Cui Qifei Cong Institute of Neuroscience and Jiangsu Key Laboratory of Neuropsychiatric Diseases Soochow UniversitySuzhouJiangsu215123China Department of Neurology and Clinical Research Center of Neurological Disease The Second Affliated Hospital of Soochow UniversitySuzhouJiangsu 215004China Department of Nephrology The Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu 215004China Department of Emergency Center The Second Affiliated Hospital of Nantong UniversityNantongJiangsu226001China Department of Neurology Huzhou Central HospitalThe Affiliated Huzhou HospitalZhejiang University School of MedicineHuzhouZhejiang 313000China Institute of Neuroscience State Key Laboratory of NeuroscienceCAS Center for Excellence in Brain Science and Intelligence TechnologyChinese Academy of SciencesShanghai 200031China Shanghai Key Laboratory of Psychotic Disorders Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghai 200030China

Adhesion G protein-coupled receptors(aGPCRs)are the second largest diverse group within the GPCR superfamily,which play critical roles in many physiological and patho-logical processes through cell-cell and cell-extracellular matrix *** adhesion GPCR Adgrg6,also known as GPR126,is one of the better-characterized ***126 was previously found to have critical developmental roles in Schwann cell maturation and its mediated myelination in the peripheral nervous system in both zebrafish and *** studies have extended our understanding of GPR126-mediated roles during develop-ment and in human *** this review,we highlighted these recent advances in GPR126 in expression profile,molecular structure,ligand-receptor interactions,and associated physiological and pathological functions in development and diseases.

关键词： Adhesion G protein-coupled receptor Function GPR126/Adgrg6 Ligand Structure

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Bionic peptide scaffold in situ polarization and recruitment of M2 macrophages to promote peripheral nerve regeneration

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Bioactive Materials 2023年第12期30卷 85-97页

作者： Pengxiang Yang Yong Peng Xiu Dai Jing Jie Deling Kong Xiaosong Gu Yumin Yang Key Laboratory of Neuroregeneration of Jiangsu Province and Ministry of Education Co-Innovation Center of NeuroregenerationNMPA Key Laboratory for Researchand Evaluation of Tissue Engineering Technology ProductsNantong University226001NantongPR China Institute of Cancer Prevention and Treatment Heilongjiang Academy of Medical ScienceHarbin Medical University150081HarbinPR China Department of Clinical Laboratory The Second Affiliated Hospital of Nantong University226001NantongPR China State Key Laboratory of Medicinal Chemical Biology College of Life SciencesNankai UniversityTianjin300071PR China

Tissue regeneration requires exogenous and endogenous signals,and there is increasing evidence that the exogenous microenvironment may play an even more dominant role in the complex process of coordinated multiple *** short-distance peripheral nerve showed a spontaneous regenerative phenomenon,which was initiated by the guiding role of ***,it cannot sufficiently restore long-distance nerve injury by *** on this principle,we firstly constructed a proinflammatory model to prove that abnormal M2 expression reduce the guidance and repair effect of long-distance ***,a bionic peptide hydrogel scaffold based on self-assembly was developed to envelop M2-derived regenerative cytokines and extracellular vesicles(EVs).The cytokines and EVs were quantified to mimic the guidance and regenerative microenvironment in a direct and mild *** bionic scaffold promoted M2 transformation in situ and led to proliferation and migration of Schwann cells,neuron growth and motor function ***,the peptide scaffold combined with CX3CL1 recruited more blood-derived M2 macrophages to promote long-distance nerve recon***,we systematically confirmed the important role of M2 in regulating and restoring the injury peripheral *** bionic peptide hydrogel scaffold mimicked and remodeled the local environment for M2 transformation and recruitment,favoring long-distance peripheral nerve *** can help to explicate regulative effect of M2 may be a cause not just a consequence in nerve repair and tissue integration,which facilitating the development of pro-regenerative biomaterials.

关键词： Bionic peptide scaffolds Peripheral nerve regeneration Macrophages Conditional media Immune microenvironment

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Interleukin 17A deficiency alleviates neuroinflammation and cognitive impairment in an experimental model of diabetic encephalopathy

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Neural Regeneration Research 2022年第12期17卷 2771-2777页

作者： Xiao-Xia Fang Fen-Fen Xu Zhan Liu Bei-Bei Cao Yi-Hua Qiu Yu-Ping Peng Department of Physiology School of Medicineand Co-innovation Center of NeuroregenerationNantong UniversityNantongJiangsu ProvinceChina

Interleukin 17A(IL-17A)was previously shown to be a key pro-inflammatory factor in diabetes mellitus and associated ***,the role of IL-17A in diabetic encephalopathy remains poorly *** this study,we established a mouse model of diabetic encephalopathy that was deficient in IL-17A by crossing Il17a-/-mice with spontaneously diabetic Ins2^(Akita)(Akita)*** glucose levels and body weights were monitored from 2-32 weeks of *** mice were 32 weeks of age,behavioral tests were performed,including a novel object recognition test for assessing short-term memory and learning and a Morris water maze test for evaluating hippocampus-dependent spatial learning and ***-17A levels in the serum,cerebrospinal fluid,and hippocampus were detected with enzyme-linked immunosorbent assays and real-time quantitative polymerase chain ***,proteins related to cognitive dysfunction(amyloid precursor protein,β-amyloid cleavage enzyme 1,p-tau,and tau),apoptosis(caspase-3 and-9),inflammation(inducible nitric oxide synthase and cyclooxygenase 2),and occludin were detected by western blot ***-inflammatory cytokines including tumor necrosis factor-α,interleukin-1β,and interferon-γin serum and hippocampal tissues were measured by enzyme-linked immunosorbent *** activation and hippocampal neuronal apoptosis were detected by immunofluorescent *** with that in wild-type mice,mice with diabetic encephalopathy had higher IL-17A levels in the serum,cerebrospinal fluid,and hippocampus;downregulation of occludin expression;lower cognitive ability;greater loss of hippocampal neurons;increased microglial activation;and higher expression of inflammatory factors in the serum and ***-17A knockout attenuated the abovementioned changes in mice with diabetic *** findings suggest that IL-17A participates in the pathological process of diabetic ***,IL-17A deficiency reduces

关键词： Akita mice apoptosis cognitive impairment diabetic encephalopathy hippocampus interleukin 17A mice microglia neuroinflammation neuron targeted treatment

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Assembly of selenoniobate-vanadoniobate double-anion heteropolyoxoniobate:synthesis,structure,and magnetic property

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Tungsten 2023年第1期5卷 75-80页

作者： Zhi-Jie Liang Nan Li Hai-Bing Cheng Wei-Xin Du Guan Wang Dong-Di Zhang School of Textiles and Clothing Nantong UniversityNantong 226019China Henan Key Laboratory of Polyoxometalate Chemistry College of Chemistry and Chemical EngineeringHenan UniversityKaifeng 475004China

Recently,continuous interests and persisting efforts on heteropolyniobate have been dedicated to its preparation and *** this work,a novel Se-centred heteropolyniobate,[H2SeNb12(VO)4O40][Cu(en)2]2{[VNb12(VO)4O40][Cu(en)2]4}0.5·39H2O(en=ethanediamine),was *** compound was synthesized in aqueous solution by reacting the K7HNb6O19·13H2O with a mixture of vanadate(Ⅴ) and selenite(Ⅳ) source,which consists of two polyanions,i.e.,V-centred one and Se-centred *** architecture was characterized by infrared spectra,thermogravimetric analysis,X-ray powder diffraction spectroscopy,ultraviolet-visible and X-ray photoelectron ***,the magnetic property shows the antiferromagnetic interaction of the compound.

关键词： Heteropolyniobate Crystal structure Double-anion Self-assembly Magnetic property

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Integrated analysis reveals the protective mechanism and therapeutic potential of hyperbaric oxygen against pulmonary fibrosis

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Genes & Diseases 2023年第3期10卷 1029-1039页

作者： Yuan Yuan Guoqiang Qiao Jiajiao Zhou Yilu Zhou Yali Li Xia Li Zhenglin Jiang Yihua Wang Department of Neurophysiology and Neuropharmacology Institute of Special Environmental Medicine and Co-innovation Center of NeuroregenerationNantong UniversityNantongJiangsu 226019China Biological sciences Faculty of Environmental and Life SciencesUniversity of SouthamptonSouthamptonSO171BJUnited Kingdom Institute for Life sciences University of SouthamptonSouthamptonSO171BJUnited Kingdom

Idiopathic pulmonary fibrosis (IPF) is a dreadful, chronic, and irreversibly progressive disease leading to death with a few effective treatments. Our previous study suggested that repetitive hyperbaric oxygen (HBO) treatment alleviates bleomycin-induced pulmonary fibrosis in mice. Here, we investigated the protective mechanism of HBO treatment against pulmonary fibrosis using an integrated approach. Analyzing publicly available expression data from the mouse model of bleomycin-induced pulmonary fibrosis as well as IPF patients, several potential mechanisms of relevance to IPF pathology were identified, including increased epithelial-to-mesenchymal transition (EMT) and glycolysis. High EMT or glycolysis scores in bronchoalveolar lavage were strong independent predictors of mortality in multivariate analysis. These processes were potentially driven by hypoxia and blocked by HBO treatment. Together, these data support HBO treatment as a viable strategy against pulmonary fibrosis.

关键词： Epithelial-mesenchymal transition Hyperbaricoxygen Hypoxia Pulmonary fibrosis Systematic analysis

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Dihydroartemisinin ameliorates palmitate-induced apoptosis in cardiomyocytes via regulation on miR-133b/Sirt1 axis

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BIOCELL 2022年第4期46卷 989-998页

作者： LONGJU QI XIAOYING XU BIN LI BO CHANG SHENGCUN WANG CHUN LIU LIUCHENG WU XIAODI ZHOU QINGHUA WANG Affiliated nantong Hospital 3 of nantong university Nantong UniversityNantong226001China Comparative Medicine Institution of nantong university Nantong UniversityNantong226001China Department of Gynecology and Obstetrics Hai’an Hospital Affiliated to Nantong UniversityNantong UniversityNantong226001China Department of Paediatric Affiliated Hospital of Nantong UniversityNantong UniversityNantong226001China Department of Internal Cardiovascular Medicine the 6th People’s Hospital of Nantong CityNantong226001China

Excessive fat ectopically deposited in the non-adipose tissues is considered as one of the leading causes of *** aim of this study was to investigate the role of Dihydroartemisinin(DHA)in palmitate(PAL)-incubated H9c2 cells(lipotoxicity-induced cell injury model).Cell viability of PAL-treated cells was determined by MTT assay,and apoptotic regulators were examined by qRT-PCR and western blot analysis,in the absence or in the presence of DHA,*** levels of miR-133b and Sirt1 were also evaluated by qRT-PCR and western blotting *** decreased the viability of H9c2 cells and enhanced the expression of apoptotic *** reversed the effect of PAL on cell viability and lowed the level of Caspase3 and *** also lowered the expression of miR-133b,while enhanced the expression of ***1 was revealed as target of miR-133b through transcriptional regulation and the process was affected by *** partially protected against the PAL-induced lipotoxicity by influencing the expression of miR-133b that hindered the activity of *** may be used as a potential treatment in clinical management for lipotoxicity induced heart complications.

关键词： microRNA-133b Palmitate acid Cardiomyocytes Sirt1 Dihydroaretemisinin

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Ultralight and compressive SiC nanowires aerogel for high-temperature thermal insulation

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Rare Metals 2023年第10期42卷 3354-3363页

作者： Jun-Xiong Zhang Jing Zhang Xin-Li Ye Xiao-Ming Ma Rong Liu Qi-Long Sun Yun-Lei Zhou School of Textile and Clothing Nantong UniversityNantong226019China School of Civil Aviation Northwestern Polytechnical UniversityXi’an710072China National Equipment New Materials&Technology(Jiangsu)Co. LtdSuzhou215101China Hangzhou Institute of Technology Xidian UniversityHangzhou311231China

Aerogels with excellent properties combination of ultralow density and great thermal insulation are drawing attention to applications in harsh *** aerogels,however,are usually constructed with nanoparticles with a weakness in physical *** silicon carbide nano wire(SiC_(NW)) is a kind of one-dimensional(1D) nano wire possessing the promising properties of flexibility,great thermal insulation,and stability at high *** aerogel constructed by the SiC_(NW) will produce a great material with a promising material,the amazing SiC_(NW) ***,a novel SiC_(NW) aerogel was fabricated consisting of quantities of β-SiC_(NW) of15-40 nm in diameter and tens to hundreds of micrometers in *** SiC_(NW) aerogel possessed an ultralow density of 5.82 mg·cm^(-3),high-temperature resistance,and great thermal insulation with its thermal conductivities of0.063 W·m^(-1)·K^(-1) at 100℃ and 0.243 W·m^(-1)·K^(-1) at900℃ in ***,the thermal insulation applicability of this aerogel was *** study provides a promising way for designing and fabricating other multifunctional nanowire aerogels for high-temperature thermal insulation.

关键词： SiC nanowires Aerogel Thermal insulation Thermal conductivity

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Multi-site anchoring of single-molecule for efficient and stable perovskite solar cells with lead shielding

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Journal of Energy Chemistry 2023年第12期87卷 390-399,I0010页

作者： Zhengyan He Shufang Zhang Yushuang Gao Quanming Geng Xiangrui Jia Shuo Yang Zhiqiang Zhang Yanpu Zheng Yanqiang Hu Changlin Yao Qi Zhang School of Physics and Photoelectronic Engineering Ludong UniversityYantai 264025ShandongChina College of Chemistry and Chemical Engineering Nantong UniversityNantong 226001JiangsuChina

The emergence of perovskite solar cells(PSCs) has greatly promoted the progress of photovoltaic *** rapid development of PSCs has been driven by the advances in optimizing perovskite films and their adjacent ***,the polycrystalline perovskite layers in most highly efficient PSCs still contain various defects that greatly limit photovoltaic performance and stability of the ***,we introduce a multifunctional additive ethylene diamine tetra methylene phosphonic sodium(EDTMPS) with multiple anchor points into the precursor of perovskite to improve the efficiency and stability of PSCs and provide in-situ protection of lead *** addition of EDTMPS acts as a crystal growth controller and passivation agent for perovskite films,thereby slowing down the crystallization rate of the film and obtaining high-quality perovskite *** study also provides an insight into how the modifier modulate the interfacial energy level arrangement as well as affect transfer of charge carriers and their recombination under photoinduced *** a result,the power conversion efficiency(PCE) of single subcell with a working area of 0.255 cm^(2) increases significantly from 20.03% to 23.37%.Moreover,we obtained a PCE of 19.16% for the 25 cm^(2) ***,the unencapsulated EDTMP-modified PSCs exhibit better operational and thermal stability,as well as in-situ absorption of leaked lead ions.

关键词： Perovskite solar cell Organic additive Defect passivation Crystallization process Lead leakage

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