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Julolidinyl aza-BODIPYs as NIR-Ⅱ fluorophores for the bioimaging of nanocarriers

Acta Pharmaceutica Sinica B 2024年第7期14卷 3155-3168页

作者： Chang Liu Yifan Cai Zichen Zhang Yi Lu Quangang Zhu Haisheng He Zhongjian Chen Weili Zhao Wei Wu shanghai Skin Disease Hospital Tongji University School of MedicineShanghai 200443China Key Laboratory of Smart Drug Delivery of MOE School of PharmacyFudan UniversityShanghai 201203China Department of MediChinal Chemistry School of PharmacyFudan UniversityShanghai 201203China

The aggregation-caused quenching(ACQ)rationale has been employed to improve the fluorescence imaging accuracy of nanocarriers by precluding free probe-derived ***,its usefulness is undermined by limited penetration and low spatiotemporal resolution of NIR-Ⅰ(700-900 nm)bioimaging owing to absorption and diffraction by biological tissues and tissue-derived *** study aimed to develop ACQ-based NIR-Ⅱ(1000-1700 nm)probes to further improve the imaging resolution and *** strategy employed is to install highly planar and electron-rich julolidine into the 3,5-position of aza-BODIPY based on the larger substituent *** newly developed probes displayed remarkable photophysical properties,with intense absorption centered at approximately 850 nm and bright emission in the 950-1300 nm *** with the NIR-Ⅰ counterpart P2,the NIR-Ⅱ probes demonstrated superior water sensitivity and quenching ***1 and ACQ6 exhibited more promising ACQ effects with absolute fluorescence quenching at water fractions above 40% and higher quenching stability with less than 2.0% fluorescence reillumination in plasma after 24 h of *** calculations verified that molecular planarity is more important than hydrophobicity for ACQ ***,in vivo and ex vivo reillumination studies revealed less than 2.5% signal interference from prequenched ACQ1,in contrast to 15% for P2.

关键词： 3,5-Julolidinyl Aza-BODIPY Nanocarriers Near-infraredⅡ Fluorescence imaging Aggregation-caused quenching Polymeric micelles Polymeric nanoparticles

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Danhongqing formula alleviates cholestatic liver fibrosis by downregulating long non-coding RNA H19 derived from cholangiocytes and inhibiting hepatic stellate cell activation

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Journal of Integrative Medicine 2024年第2期22卷 188-198页

作者： Meng Li Yang Zhou Hui Zhu Lie-ming Xu Jian Ping Institute of Liver Diseases Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai 201203China Preventive Treatment Center Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200437 China Department of Gastroenterology Suzhou Traditional Chinese Medicine HospitalSuzhou 215000Jiangsu ProvinceChina shanghai Key Laboratory of Traditional Chinese Medicine Shanghai 201203China Key Laboratory of Liver and Kidney Diseases(Ministry of Education) Shanghai 201203China

Objective:This study explores the mechanism of action of Danhongqing formula(DHQ),a compoundbased Chinese medicine formula,in the treatment of cholestatic liver ***:In vivo experiments were conducted using 8-week-old multidrug resistance protein 2 knockout(Mdr2-/-)mice as an animal model of cholestatic liver *** was administered orally for 8 weeks,and its impact on cholestatic liver fibrosis was evaluated by assessing liver function,liver histopathology,and the expression of liver fibrosis-related ***-time polymerase chain reaction,Western blot,immunohistochemistry and other methods were used to observe the effects of DHQ on long non-coding RNA H19(H19)and signal transducer and activator of transcription 3(STAT3)phosphorylation in the liver tissue of Mdr2-/-*** addition,cholangiocytes and hepatic stellate cells(HSCs)were cultured in vitro to measure the effects of bile acids on cholangiocyte injury and H19 *** overexpressing H19 were constructed,and a conditioned medium containing H19 was collected to measure its effects on STAT3 protein expression and cell *** intervention effect of DHQ on these processes was also *** overexpressing H19 were constructed to measure the impact of H19 on cell activation and assess the intervention effect of ***:DHQ alleviated liver injury,ductular reaction,and fibrosis in Mdr2-/-mice,and inhibited H19expression,STAT3 expression and STAT3 *** formula also reduced hydrophobic bile acid-induced cholangiocyte injury and the upregulation of H19,inhibited the activation of HSCs induced by cholangiocyte-derived conditioned medium,and decreased the expression of activation markers in *** overexpression of H19 in a human HSC line confirmed that H19 promoted STAT3 phosphorylation and HSC activation,and DHQ was able to successfully inhibit these ***:DHQ effectively alleviated spontaneous cholestatic liver fibrosis in Md

关键词： Liver cirrhosis biliary Long non-coding RNA H19 Danhongqing formula Cholangiocyte Hepatic stellate cells STAT3 transcription factor

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Long-time Asymptotics for the Reverse Space-time Nonlocal Hirota Equation with Decaying Initial Value Problem:without Solitons

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Acta Mathematicae Applicatae Sinica 2024年第3期40卷 708-727页

作者： Wei-qi PENG Yong CHEN School of Mathematical sciences East China Normal UniversityShanghai 200241China College of Mathematics and Systems science Shandong University of Science and TechnologyQingdao 266590China

In this work,we mainly consider the Cauchy problem for the reverse space-time nonlocal Hirota equation with the initial data rapidly decaying in the solitonless *** from the Lax pair,we first construct the basis Riemann-Hilbert problem for the reverse space-time nonlocal Hirota ***,using the approach of Deift-Zhou nonlinear steepest descent,the explicit long-time asymptotics for the reverse space-time nonlocal Hirota is *** the reverse space-time nonlocal Hirota equation,since the symmetries of its scattering matrix are different with the local Hirota equation,the v(λ_(i))(i=0,1)would like to be imaginary,which results in theδ_(λi)^(0)contains an increasing t(±Imv(λ_(i)))/2,and then the asymptotic behavior for nonlocal Hirota equation becomes differently.

关键词： Riemann-Hilbert problem reverse space-time nonlocal Hirota equation long-time asymptotics nonlinear steepest descent method

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The Coarse l^(p)-Novikov Conjecture and Banach Spaces with Property(H)

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Chinese Annals of Mathematics,Series B 2024年第2期45卷 193-220页

作者： Huan WANG Qin WANG Research Center for Operator Algebras School of Mathematical SciencesEast China Normal UniversityShanghai 200241China Key Laboratory of MEA Ministry of Educationand Shanghai Key Laboratory of PMMPEast China Normal UniversityShanghai 200241China

In this paper,for 1 authors show that the coarse l^(p)-Novikov conjecture holds for metric spaces with bounded geometry which are coarsely embeddable into a Banach space with Kasparov-Yu’s Property(H).

关键词： The coarse l^(p)-Novikov conjecture Banach spaces with Property(H) Coarse geometry K-Theory

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High-order Soliton Matrix for the Third-order Flow Equation of the Gerdjikov-Ivanov Hierarchy Through the Riemann-Hilbert Method

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Acta Mathematicae Applicatae Sinica 2024年第2期40卷 358-378页

作者： Jin-yan ZHU Yong CHEN School of Mathematical sciences Shanghai Key Laboratory of Pure Mathematics and Mathematical PracticeEast China Normal UniversityShanghai 200062China College of Mathematics and Systems science Shandong University of Science and TechnologyQingdao 266590China

The Gerdjikov-Ivanov(GI)hierarchy is derived via recursion operator,in this article,we mainly investigate the third-order flow GI *** the framework of the Riemann-Hilbert method,the soliton matrices of the third-order flow GI equation with simple zeros and elementary high-order zeros of Riemann-Hilbert problem are constructed through the standard dressing *** advantage of this result,some properties and asymptotic analysis of single soliton solution and two soliton solution are discussed,and the simple elastic interaction of two soliton are *** with soliton solution of the classical second-order flow,we find that the higher-order dispersion term affects the propagation velocity,propagation direction and amplitude of the ***,by means of a certain limit technique,the high-order soliton solution matrix for the third-order flow GI equation is derived.

关键词： Gerdjikov-Ivanov hierarchy third-order flow GI equation Riemann-Hilbert method high-order soliton

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Engineering the Interface Between Au Nanoparticles and CoO-Ov to Enhance the Catalytic Performance of 5-Hydroxymethylfurfural(HMF)to 2,5-Dimethylfuran(DMF)

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Chemical Research in Chinese Universities 2024年第1期40卷 47-54页

作者： XIANG Shuang GUO Yong LIU Xiaohui WANG Yanqin Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering Feringa Nobel Prize Scientist Joint Research CenterResearch Institute of Industrial CatalysisSchool of Chemistry and Molecular EngineeringEast China University of Science and TechnologyShanghai 200237P.R.China

The interface between Au and support has attracted extensive interest because of its unique catalytic ability for hydrogen activation in catalytic hydrogenation/hydrogenolysis ***,we create the Au-CoO-OV interface in the 1.0%Au/Co3O4-Rod-250 catalyst,which could dissociate H2 via the heterolytic way to yield rich hydride species and achieve excellent catalytic performance in the hydrogenolysis of biomass-derived 5-hydroxymethylfurfural(HMF)to 2,5-dimethylfuran(DMF).The XRD and HRTEM analyses show that Au nanoparticles are uniformly dispersed on CoO-OV surface and in situ DRIFTS spectra show the enhancement of heterolytic dissociation of hydrogen(signals of Au-D and O-D vibration)compared with bare CoO(Co3O4-Rod-250).This work provides insights for fabricating highly active Au-support catalysts for catalytic hydrogenation/hydrogenolysis reactions.

关键词： Au-CoO-OV interface Hydride species Heterolytic dissociation 5-Hydroxymethylfurfural(HMF) 2 5-Dimethylfuran(DMF)

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Environmental Conditions Conducive to the Formation of Multiple Tropical Cyclones over the Western North Pacific

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Advances in Atmospheric sciences 2024年第10期41卷 2027-2042页

作者： Yining GU Ruifen ZHAN Xiaomeng LI Department of Atmospheric and Oceanic sciences/Institute of Atmospheric sciences Fudan UniversityShanghai 200438China CMA-FDU Joint Laboratory of Marine Meteorology Shanghai 200030China Institute of Desert and Meteorology China Meteorological AdministrationUrumqi 830002China

There is limited understanding regarding the formation of multiple tropical cyclones(MTCs).This study explores the environmental conditions conducive to MTC formation by objectively determining the atmospheric circulation patterns favorable for MTC formation over the western North *** on 199 MTC events occurring from June to October 1980–2020,four distinct circulation patterns are identified:the monsoon trough(MT)pattern,accounting for 40.3%of occurrences,the confluence zone(CON)pattern at 26.2%,the easterly wave(EW)pattern at 17.8%,and the monsoon gyre(MG)pattern at 15.7%.The MT pattern mainly arises from the interaction between the subtropical high and the monsoon trough,with MTCs forming along the monsoon trough and its *** CON pattern is affected by the subtropical high,the South Asian high,and the monsoon trough,with MTCs emerging at the confluence zone where the prevailing southwesterly and southeasterly flows *** EW pattern is dominated by easterly flows,with MTCs developing along the easterly wave *** in the MG pattern arise within a monsoon vortex characterized by strong southwesterly flows.A quantitative analysis further indicates that MTC formation in the MT pattern is primarily governed by mid-level vertical velocity and low-level vorticity,while mid-level humidity and vertical velocity are significantly important in the other *** meridional shear and convergence of zonal winds are essential in converting barotropic energy from the basic flows to disturbance kinetic energy,acting as the primary source for eddy kinetic energy growth.

关键词： multiple tropical cyclones western North Pacific circulation pattern monsoon trough barotropic energy conversion

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Multi-dimensional multiplexing optical secret sharing framework with cascaded liquid crystal holograms

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Opto-Electronic Advances 2024年第1期7卷 28-35页

作者： Keyao Li Yiming Wang Dapu Pi Baoli Li Haitao Luan Xinyuan Fang Peng Chen Yanqing Lu Min Gu Institute of Photonic Chips University of Shanghai for Science and TechnologyShanghai 200093China Centre for Artificial-Intelligence Nanophotonics School of Optical-Electrical and Computer EngineeringUniversity of Shanghai for Science and TechnologyShanghai 200093China National Laboratory of Solid State Microstructures and College of Engineering and Applied SciencesNanjing UniversityNanjing 210093China

Secret sharing is a promising technology for information encryption by splitting the secret information into different ***,the traditional scheme suffers from information leakage in decryption process since the amount of available information channels is ***,we propose and demonstrate an optical secret sharing framework based on the multi-dimensional multiplexing liquid crystal(LC)*** LC holograms are used as spatially separated shares to carry secret *** polarization of the incident light and the distance between different shares are served as secret keys,which can significantly improve the information security and ***,the decryption condition is also restricted by the applied external voltage due to the variant diffraction efficiency,which further increases the information *** implementation,an artificial neural network(ANN)model is developed to carefully design the phase distribution of each LC *** the advantage of high security,high capacity and simple configuration,our optical secret sharing framework has great potentials in optical encryption and dynamic holographic display.

关键词： holographic encryption optical secret sharing cascaded liquid crystal hologram multi-dimensional multiplexing

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Neighborhood garden's age shapes phyllosphere microbiota associated with respiratory diseases in cold seasons

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Environmental science and Ecotechnology 2024年第2期18卷 114-123页

作者： Chang Zhao Xinxin Liu Haoxin Tan Shan Yin Lantian Su Baoming Du Muhammad Khalid Aki Sinkkonen Nan Hui School of Agriculture and Biology Shanghai Jiao Tong University800 Dongchuan Rd.200240ShanghaiChina shanghai Yangtze River Delta Eco-Environmental Change and Management Observation and Research Station Ministry of Science and TechnologyMinistry of Education800 Dongchuan Rd.200240ShanghaiChina shanghai Urban Forest Ecosystem Research Station National Forestry and Grassland Administration800 Dongchuan Rd.200240ShanghaiChina Department of Biology College of Science and TechnologyWenzhou-Kean UniversityWenzhouChina Department of Garden Technologies Horticulture TechnologiesNatural Resources Institute FinlandHelsinkiFinland Ecosystems and Environment Research Programme Faculty of Biological and Environmental SciencesUniversity of HelsinkiLahtiFinland

Neighborhood gardens serve as sensitive sites for human microbial encounters,with phyllosphere microbes directly impacting our respiratory ***,our understanding remains limited on how factors like season,garden age,and land use shape the risk of respiratory diseases(RDs)tied to these garden *** we examined the microbial communities within the phyllosphere of 72 neighborhood gardens across shanghai,spanning different seasons(warm and cold),garden ages(old and young),and locales(urban and rural).We found a reduced microbial diversity during the cold season,except for Gammaproteobacteria which exhibited an inverse *** land use influenced the microbial composition,urban and rural gardens had strikingly similar microbial ***,young gardens in the cold season hosted a substantial proportion of RDs-associated species,pointing towards increased respiratory inflammation *** essence,while newer gardens during colder periods show a decline in microbial diversity,they have an increased presence of RDs-associated microbes,potentially escalating respiratory disease *** underscores the pivotal role the garden age plays in enhancing both urban microbial diversity and respiratory health.

关键词： Neighborhood gardens Phyllosphere microbial communities Seasonal variation Garden age Respiratory diseases

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Morphological design and tunable mechanical properties of 3D spinodal membrane structures:adaptive coarse-grained modelling

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Acta Mechanica Sinica 2024年第8期40卷 166-178页

作者： Yujie Xiang Jie Tian Keke Tang Xianqiao Wang Zheng Zhong School of Aerospace Engineering and Applied Mechanics Tongji UniversityShanghai200092China Key Laboratory of AI-aided Airworthiness of Civil Aircraft Structures Civil Aviation Administration of ChinaTongji UniversityShanghai200092China School of School of Environmental CivilAgricultural and Mechanical EngineeringUniversity of GeorgiaAthensGA30602USA School of science Harbin Institute of TechnologyShenzhen518055China

The spinodal decomposition method emerges as a promising methodology,showcasing its potential in exploring the design space for metamaterial ***,spinodal structures design is still largely limited to regular structures,due to their relatively easy parameterization and *** predicting the mechanical properties of 3D spinodal membrane structure remains a challenge,given that the features of the membrane necessitate adaptive mesh through the modelling *** paper proposes an integrated approach for morphological design with customized mechanical properties,incorporating the spinodal decomposition method and adaptive coarse-grained modeling,which can produce various morphologies such as lamellar,columnar,and cubic ***-periodic parameterβand orientational parameterΘ(θ_(1),θ_(2),θ_(3))are identified to achieve the optimal goal of anisotropic mechanical *** analysis is conducted to reveal the correlation between the customized spinodal structure and mechanical *** work provides an integrated approach for morphological variation and tuning mechanical properties,paving the way for the design and development of customized functional materials similar to 3D spinodal membrane structures.

关键词： Morphological design Spinodal decomposition Adaptive coarse-grained modeling Mechanical properties Parametric design

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