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Salsolinol as an RNA m~6A methylation inducer mediates dopaminergic neuronal death by regulating YAP1 and autophagy

Neural Regeneration Research 2025年第3期20卷 887-899页

作者： Jianan Wang Yuanyuan Ran Zihan Li Tianyuan Zhao Fangfang Zhang Juan Wang Zongjian Liu Xuechai Chen Beijing International science and Technology Cooperation Base for Antiviral Drugs College of Chemistry and LifeBeijing University of TechnologyBeijingChina Department of Rehabilitation Beijing Rehabilitation HospitalCapital Medical UniversityBeijingChina

Salsolinol(1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline,Sal)is a catechol isoquinoline that causes neurotoxicity and shares structural similarity with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine,an environmental toxin that causes Parkinson's ***,the mechanism by which Sal mediates dopaminergic neuronal death remains *** this study,we found that Sal significantly enhanced the global level of N~6-methyladenosine(m~6A)RNA methylation in PC12 cells,mainly by inducing the downregulation of the expression of m~6A demethylases fat mass and obesity-associated protein(FTO)and alk B homolog 5(ALKBH5).RNA sequencing analysis showed that Sal downregulated the Hippo signaling *** m~6A reader YTH domain-containing family protein 2(YTHDF2)promoted the degradation of m~6A-containing Yes-associated protein 1(YAP1)mRNA,which is a downstream key effector in the Hippo signaling ***,downregulation of YAP1 promoted autophagy,indicating that the mutual regulation between YAP1 and autophagy can lead to *** findings reveal the role of Sal on m~6A RNA methylation and suggest that Sal may act as an RNA methylation inducer mediating dopaminergic neuronal death through YAP1 and *** results provide greater insights into the neurotoxic effects of catechol isoquinolines compared with other studies and may be a reference for assessing the involvement of RNA methylation in the pathogenesis of Parkinson's disease.

关键词： ALKBH5 autophagy FTO Hippo pathway m~6A Parkinson's disease RNA methylation salsolinol YAP1 YTHDF2

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Ultrastrong room-temperature phosphorescence in cucurbit[8]uril-mediated crystalline supramolecules for ratiometric detection of phenethylamine

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science China Chemistry 2025年

作者： Qingyu Niu Yingxiang Ye Lingna Su Xu He Zhiqiang Li Yu Liu School of Chemical Engineering and Technology Hebei University of Technology Fujian Provincial Key Laboratory of Polymer Materials College of Chemistry and Materials Science Fujian Normal University Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education) Nankai University College of Chemistry State Key Laboratory of Elemento-Organic Chemistry Nankai University

It is a great challenge to modulate purely organic fluorescence-phosphorescence dual emission in aqueous solution because the excited singlet and triplet states are in competition with each other. Herein, we report a crystalline 1:2 host-guest formed by selfassembly of 4-(4-bromophenyl)-pyridinium derivatives and cucurbit[8]uril, in which a rigid environment rich in weak interactions is directly demonstrated. Due to the inhibition of non-radiative transition and stabilization of triplet exciton in the crystalline environment, the crystalline inclusion complex exhibits ultralong room-temperature phosphorescence lifetime of 3.21 ms with an room-temperature phosphorescence(RTP) quantum yield up to 16.29%. Interestingly, the crystalline 1:2 hostguest complex demonstrates the ability of rapid identification and sensitive fluorescence-phosphorescence ratiometric detection behavior toward phenethylamine, a drug analogue, with a limit of detection as low as 27.5 nM. We believe that this study will undoubtedly broaden the utilizing scopes of RTP and offer a novel avenue for psychoactive substances monitoring.

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Tailor-made high elasticity and low-hysteresis hydrogels based on asymmetric H-bonding crosslinking for wearable applications

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science China Chemistry 2025年

作者： Xiaofang Shi Nan Shi Miaomiao Dang Chengyu Ji Yingjie Li Peiyi Wu Zhiguo Hu Collaborative Innovation Centre of Henan Province for Green Manufacturing of Fine Chemicals Henan Engineering Laboratory of Chemical Pharmaceutical and Biomedical Materials School of Chemistry and Chemical Engineering Henan Normal University State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Chemistry Chemical Engineering and Biotechnology & Center for Advanced Low-dimension Materials Donghua University

The conventional method of fabricating hydrogels constantly confronts the conflict between elasticity and toughness, limiting their repetitive application. Achieving the desired elasticity through a simple and low-cost approach is a significant challenge for hydrogels, particularly through rational molecular design. Here, low-hysteresis and high-toughness hydrogels are developed from the design of a new feature monomer, N-acryloylethylsemicarbazide (NACE). Based on a concept of “asymmetric Hbonding design”, the unique double and triple H-bonding of NACE can result in a novel asymmetric crosslinking polymer with alternating strong and weak H-bonding regions. The NACE is copolymerized with acrylamide (AM) to regulate the mechanical properties of hydrogel via H-bonding density. The P(NACE-AM) ionic hydrogels are obtained simply and rapidly via one-step photopolymerization without a chemical cross-linking agent. The P(NACE-AM) hydrogels combine superb mechanical elasticity and toughness, and excellent ionic conductivity, showing great potential as durable ionic conductive devices for wearable utilization.

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一种便携、低成本乳酸测量系统(英文)

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Journal of Measurement science and Instrumentation 2025年

作者：王晴晴潘玉余传信王妍延张凯凯刘升淮北师范大学计算机科学与技术学院认知行为智能计算与应用工程研究中心(淮北)

乳酸作为代谢产物，在医学诊断、运动生理学和食品科学等领域扮演重要角色。传统的乳酸检测技术通常配备昂贵且笨重的仪器。本文开发了一种便携式、低成本的乳酸测量系统，包括可独立检测的硬件电路和用户友好的嵌入式软件、电脑及手机... 详细信息

乳酸作为代谢产物，在医学诊断、运动生理学和食品科学等领域扮演重要角色。传统的乳酸检测技术通常配备昂贵且笨重的仪器。本文开发了一种便携式、低成本的乳酸测量系统，包括可独立检测的硬件电路和用户友好的嵌入式软件、电脑及手机应用程序。实验验证了装置电路检测电流相对误差低于1%，电化学性能通过对[Fe（CN）6]3-/[Fe（CN）6]4-溶液的测量，与台式电化学工作站CHI660E进行比较，得到了近乎一致的CA曲线。使用修饰的两种（ELS和NLS）乳酸传感器对乳酸进行CA测试，在0.1 -20 mmol/L的浓度范围内，乳酸浓度与稳态电流均呈现良好的线性关系，相关系数(R2)大于0.99，且重复性良好，体现了所研制装置的可靠性。本研究开发的乳酸测量系统在提供优异的检测性能和可靠性的同时，实现了便携性和低成本，为乳酸测量提供了一种新的解决方法。

关键词：乳酸测量便携式设备嵌入式开发乳酸传感器电化学分析

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An accurate three-dimensional potential energy surface for the He-Na_2 complex

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science China Chemistry 2008年第6期51卷 539-544页

作者： WANG Yue,HUANG WuYing,FENG ErYin& CUI ZhiFeng Department of Physics,anhui Normal University,Wuhu 241000,China Department of Physics Anhui Normal University Wuhu China

An accurate three-dimensional potential energy surface(PES) for the He-Na2 van der Waals comple was calculated at the coupled cluster singles-and-doubles with noniterative inclusion of connecte triple(CCSD(T)) level of theory.A mixed basis set,aug-cc-pVQZ for the He atom and cc-pCVQZ for th sodium atom,and an additional(3s3p2d1f) set of midbond functions were *** computed inte action energies in 819 configurations were fitted to a 96-parameter analytic potential model by leas squares *** PES has two shallow wells corresponding to the T-shaped structure and the linea configuration,which are located at 12.5a0 and 14 a0 with depths of 1.769 and 1.684 cm-1,respectivel The whole potential energy surface exhibits weak *** on the fitted PES,state-to-stat differential cross sections were calculated.

关键词： van der Waals complex potential energy surface ab initio calculation

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STUDY ON THE SURFACE MODIFICATION OF NANO-TiO_2 BY GRAFTING PMMA/PBMA AND ITS THERMAL STABILITY

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Chinese Journal of Polymer science 2005年第3期23卷 243-247页

作者：宇海银 Jia-shanGu JunDu Ming-yunGuan CollegeofChemistryandMaterialsscience AnhuiNormalUniversityWuhu241000China

The surface of nano-TiO_2 was encapsulated with hydroxyl-propyl-methyl cellulose(HPMC),and then cograftedwith *** of absorbing and grafting have been *** nano-TiO_2 particles were characterized byFT-IR spectra,TEM and TG *** was convinced from FT-IR studies that both methyl methacrylate(MMA)and butyl-methacrylate(BMA)were co-grafted onto the surface of nano-TiO_2 *** images show that the surface of nano-TiO_2 particles was successfully modified by a thick layer of film-like *** results demonstrate that the decompositiontemperature of HPMC-g-PMMA/PBMA,which has been grafted onto the surface of nano-TiO_2,is 56.9 K higher than that ofHPMC-g-PMMA/PBMA.

关键词： Hydroxyl-propyl-methyl cellulose Nano-TiO_2 particles Surface modification Cograft polymerization Thermal stability.

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Existence Results of Damped Second Order Impulsive Functional Differential Equations with Infinite Delay

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Acta Mathematicae Applicatae Sinica 2019年第3期35卷 564-579页

作者： Sheng-li XIE Yi-ming XIE School of Mathematics&Physics Urban Construction CollegeAnhui Jianzhu University School of Civil Engineering Anhui Jianzhu UniversityHefei 230601China

Using the Monch fixed point theorem and progressive estimation method,we study the existence,uniqueness and regularity of mild solutions for damped second order impulsive functional differential equations with infinite delay in Banach *** compactness assumption on associated family of operators and the impulsive term,some restrictive conditions on a priori estimation,noncompactness measure estimation and the impulsive term have not been used,our results are different from some known ***,a noncompact semigroup example explains the obtained results.

关键词： damped second order impulsive functional differential equations mild solution strong solution classical solution measure of noncompactness

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A Generalization of Strongly Nil Clean Rings

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Algebra Colloquium 2018年第4期25卷 585-594页

作者： Jian Cui Xiaobin Yin Department of Mathematics Anhui Normal UniversityWuhuAnhui 241002China

Generalizing the notion of strongly nil clean rings,we introduce strongly quasinil clean *** fundamental properties and equivalent characterizations of this class of rings are *** means of g-Drazin inverses,Cline's fo... 详细信息

关键词： strongly quasi-nil clean ring strongly nil clean ring strongly clean ring g-Drazin inverse

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Blue/red-shift of the p-Phenylene-ethynylene Oligomers Absorption Spectra

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Chinese Journal of Structural Chemistry 2017年第4期36卷 549-561页

作者：王素凡黄玉成周涛 College of Chemistry and Materials science Anhui Normal University

The absorption spectra of the p-phenylene-ethynylene（p-PPE） oligomers（up to n = 12） were estimated by DFT and TD-DFT methods. The effective conjugation length（ECL） of the corresponding polymer was obtained by extrapolating the first excitation energies of the oligmers to infinite chain length with an alternative exponential function. The absorption spectral red-shift mainly depends on the ？-conjugation segment of oligomers resulting from the planarization of the backbone. The excitation mechanism of the rotamer has been investigated sufficiently by analyzing the orbital density variation upon the conformational rotations around the cylindrical triple-bonded carbon which is believed to impact significantly on the optical spectrum. The calculated results further indicate that rotation about the cylindrical triple bond interrupts the conjugation of rod-like oligomers to lead an angle-dependence of the corresponding excitation energy. The results are helpful to interpret the conformational-dependent spectroscopic phenomena of p-phenyleneethynylene and derivatives oligomers and polymers observed in ensemble and single molecule spectroscopy.

关键词： p-phenylene-ethynylene conjugation absorption spectrum oligomer

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Magnetic/Magnetostrictive Properties Together with Resistivity and Corrosion Behaviors of CoFe_2 and Its Composite with CoFe_2N

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Journal of Materials science & Technology 2017年第7期33卷 744-750页

作者： B.Q.Geng Y.Q.Ma M.Wang Z.L.Ding W.H.Song B.C.Zhao Key Laboratory of Materials Physics Institute of Solid State Physics Chinese Academy of Sciences Hefei 230031 China

The CoFe_2alloy（CF） was prepared by reducing CoFe_2O_4 in the H_2 ambient. Subsequently the CF sample was nitrided in the NH_3 atmosphere to produce the composite of CoFe_2N and CoFe_2. The magnetostriction, thermal expansion, resistivity and corrosion resistance of CF sample and the nitrided sample（CFN）at 1000？C were investigated. The saturation magnetostriction coefficiency λ_s and thermal expansion coefficient ？ at 300 K for the nitrided CFN were 50 ppm and 10 ppm/K, respectively, approximately equal to those for the CF sample. However, compared with CF, CFN presents a decrease in temperature coefficient R_λ（300 K） of magnetostriction by 11%. The smaller resistivity and improved corrosion resistance in the H_2SO_4 solution may expand the applications of the CoFe_2 in the fields needing lower resistivity or in the acidic environment.

关键词： CoFe alloy CoFe_2N alloy Magnetostriction Resistivity Corrosion resistance

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