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Aortic Dissection Research in china:Analysis of Studies Funded by the national natural science foundation of china

Current Medical science 2023年第1期43卷 206-212页

作者： Zhang YUE Da-shuai WANG Sheng LE Jia-hong XIA Ping YE Xiao-fan HUANG Department of Cardiovascular Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Department of Cardiovascular Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou450052China Department of Cardiology The Central Hospital of WuhanTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430014China

Objective The national natural science foundation of china(NSFC)has made great progress in promoting the development of aortic dissection research in recent years.This study aimed to examine the development and research status of aortic dissection research in china so as to provide references for future research.Methods The NSFC projects data from 2008 to 2019 were collected from the Internet-based science Information System and other websites utilized as search engines.The publications and citations were retrieved by Google Scholar,and the impact factors were checked by the InCite Journal Citation Reports database.The investigator’s degree and department were identified from the institutional faculty profiles.Results A total of 250 grant funds totaling 124.3 million Yuan and resulting in 747 publications were analyzed.The funds in economically developed and densely populated areas were more than those in underdeveloped and sparsely populated areas.There was no significant difference in the amount of funding per grant between different departments’investigators.However,the funding output ratios of the grants for cardiologists were higher than those for basic science investigators.The amount of funding for clinical researchers and basic scientific researchers in aortic dissection was also similar.Clinical researchers were better in terms of the funding output ratio.Conclusion These results suggest that the medical and scientific research level of aortic dissection in china has been greatly improved.However,there are still some problems that urgently need to be solved,such as the unreasonable regional allocation of medical and scientific research resources,and the slow transition from basic science to clinical practice.

关键词： national natural science foundation of china aortic dissection grant funding funding output ratio

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Progress in osteoarthritis research by the national natural science foundation of china

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Bone Research 2022年第3期10卷 409-420页

作者： Yusheng Li Wenqing Xie Wenfeng Xiao Dou Dou Deparment of Orthopedics Xiangya HospitalCentral South UniversityChangsha 410008 HunanChina national Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangsha 410008 HunanChina Department of Health sciences National Natural Science Foundation of ChinaBeijing 100085China

Osteoarthritis(OA) in china is gradually becoming an important scientific research area that has had a significant impact on research and development(R&D) activities in the OA field worldwide. This article summarizes the R&D progress related to OA in china in recent years. The national natural science foundation of china(NSFC) is a national funding institution for basic research and plays a critical role in promoting and supporting Chinese scholars’ R&D activities. We collected and analyzed information on NSFC funding in the field of OA from 2010 to 2019, including the amount, the level and the program categories of the funded projects. The data fully demonstrate the important and positive role of the NSFC in supporting free exploration, cultivating research teams and young talent, and boosting OA R&D. In this article, we outline and discuss hot topics in focused areas, key advances in this field and the prospects for progress in OA research in china.

关键词： NSFC supporting becoming

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the national natural science foundation of china(41877029,41961130383);Royal SocietyNewton Advanced Fellowship(NAF\R1\191017);Wuhan science and Technology Bureau(2019020701011469).

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Soil Ecology Letters 2022年第3期4卷 224-236页

作者： Shuzhen Li Xiongfeng Du Kai Feng Yueni Wu Qing He Zhujun Wang Yangying Liu Danrui Wang Xi Peng Zhaojing Zhang Arthur Escalas Yuanyuan Qu Ye Deng CAS Key Laboratory of Environmental Biotechnology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China Key Laboratory of Industrial Ecology and Environmental Engineering(Ministry of Education) School of Environmental Science and TechnologyDalian University of TechnologyDalian116024China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China Institute for Marine science and Technology Shandong UniversityQingdao 266237China MARBEC Universitéde MontpellierCNRSIRDIFREMERMontpellier Cedex 534090France

Due to the tremendous diversity of microbial organisms in topsoil,the estimation of saturated richness in a belowground ecosystem is still challenging.Here,we intensively surveyed the 16S rRNA gene in four 1 m2 sampling quadrats in a typical grassland,with 141 biological or technical replicates generating over 11 million sequences per quadrat.Through these massive data sets and using both non-asymptotic extrapolation and non-parametric asymptotic approaches,results revealed that roughly 15919±193,27193±1076 and 56985±2347 prokaryotic species inhabited in 1 m2 topsoil,classifying by DADA2,UPARSE(97%cutoff)and Deblur,respectively,and suggested a huge difference among these clustering tools.Nearly 500000 sequences were required to catch 50%species in 1 m2,while any estimator based on 500000 sequences would still lose about a third of total richness.Insufficient sequencing depth will greatly underestimate both observed and estimated richness.At least~911000,~3461000,and~1878000 sequences were needed for DADA2,UPARSE,and Deblur,respectively,to catch 80%species in 1 m2 topsoil,and the numbers of sequences would be nearly twice to three times on this basis to cover 90%richness.In contrast,α-diversity indexes characterized by higher order of Hill numbers,including Shannon entropy and inverse Simpson index,reached saturation with fewer than 100000 sequences,suggesting sequencing depth could be varied greatly when focusing on exploring differentα-diversity characteristics of a microbial community.Our findings were fundamental for microbial studies that provided benchmarks for the extending surveys in large scales of terrestrial ecosystems.

关键词： Grassland Topsoil Prokaryote Richness α-diversity Hill number

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Achievements in cancer research supported by national natural science foundation of china

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Chinese science Bulletin 2013年第1期58卷 39-43页

作者： HONG Wei LI Cui ZHANG LiPing XU YanYing ZHANG Jun HU Hai DONG ErDan Department of Health sciences National Natural Science Foundation of China

For the past two decades,great achievements have been made in cancer research of china and the majority of them were supported by the national natural science foundation of china(NSFC).In this article,we reviewed the funding history of NSFC including the number of proposals,the amount of grants,distribution of supported program categories during the period of 1987 to 2012 and the representative achievements made by continuous support of NSFC.Also,the impacts of NSFC support on discipline development and talent fostering were analyzed.From 1987 to 2012,a total of 8738 proposals related to cancer research were funded by NSFC.The percentages of the Research Program,Talent-Training Program,and the Research Environment Program were 61.19%,36.32%,and 2.49%,respectively.Under the support of NSFC,cancer research in china has achieved a significantly rapid and balanced development in both disciplines and scientist resources.

关键词：国家自然科学基金委员会癌症中国 NSFC 人才培养环境计划人才培训科学家

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The authors acknowledge the financial support from the national natural science foundation of china(project No.31971247).

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International Journal of Oral science 2021年第2期13卷 148-155页

作者： Yan Wei Guixin Zhu Zifan Zhao Chengcheng Yin Qin Zhao Hudi Xu Jinyang Wang Jinglun Zhang Xiaoxin Zhang Yufeng Zhang Haibin Xia The State Key Laboratory Breeding Base of Basic science of Stomatology(Hubei-MOST)&Key Laboratory of Oral Biomedicine Ministry of Education School&Hospital of StomatologyWuhan UniversityWuhanChina Department of Oral Implantology School and Hospital of StomatologyWuhan UniversityWuhanChina

Mineralized tissue regeneration is an important and challenging part of the field of tissue engineering and regeneration.At present,autograft harvest procedures may cause secondary trauma to patients,while bone scaffold materials lack osteogenic activity,resulting in a limited application.Loaded with osteogenic induction growth factor can improve the osteoinductive performance of bone graft,but the explosive release of growth factor may also cause side effects.In this study,we innovatively used platelet-rich fibrin(PRF)-modified bone scaffolds(Bio-Oss®)to replace autograft,and used cytokine(BMP-2)to enhance osteogenesis.Encouragingly,this mixture,which we named“Autograft Mimic(AGM)”,has multiple functions and advantages.(1)The fiber network provided by PRF binds the entire bone scaffold together,thereby shaping the bone grafts and maintaining the space of the defect area.(2)The sustained release of BMP-2 from bone graft promoted bone regeneration continuously.(3)AGM recruited bone marrow mesenchymal stem cells(BMSCs)and promote their proliferation,migration,and osteogenic differentiation.Thus,AGM developed in this study can improve osteogenesis,and provide new guidance for the development of clinical bone grafts.

关键词： sustained graft replace

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supported by the national natural science foundation of china(Nos.62172051,61772085,and 61877005)and Jiangsu Agriculture science and Technology Innovation Fund(No.CX(18)3054).

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Tsinghua science and Technology 2023年第1期28卷 82-92页

作者： Jinghui Zhang Yuchen Wang Tianyu Huang Fang Dong Wei Zhao Dian Shen School of Computer science and Engineering Southeast UniversityNanjing 211189China Hefei Comprehensive national science Center Hefei 231299China School of Computer science and Technology Anhui University of TechnologyHefei 230026China Department of Computer science&Engineering The Chinese University of Hong KongHong Kong 999077China

Numerous neural network(NN)applications are now being deployed to mobile devices.These applications usually have large amounts of calculation and data while requiring low inference latency,which poses challenges to the computing ability of mobile devices.Moreover,devices’life and performance depend on temperature.Hence,in many scenarios,such as industrial production and automotive systems,where the environmental temperatures are usually high,it is important to control devices’temperatures to maintain steady operations.In this paper,we propose a thermal-aware channel-wise heterogeneous NN inference algorithm.It contains two parts,the thermal-aware dynamic frequency(TADF)algorithm and the heterogeneous-processor single-layer workload distribution(HSWD)algorithm.Depending on a mobile device’s architecture characteristics and environmental temperature,TADF can adjust the appropriate running speed of the central processing unit and graphics processing unit,and then the workload of each layer in the NN model is distributed by HSWD in line with each processor’s running speed and the characteristics of the layers as well as heterogeneous processors.The experimental results,where representative NNs and mobile devices were used,show that the proposed method can considerably improve the speed of the on-device inference by 21%–43%over the traditional inference method.

关键词： neural network inference mobile device temperature adjustment channel-wise parallelization

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This work was supported by grants from the national natural science foundation of china(Nos.81625020,81402736,and 81902791)and the Key Research and Development Program of Shaanxi Province(No.2019sf-079).

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International Journal of Dermatology and Venereology 2021年第3期4卷 152-162页

作者： Jia-Hui Jin Yu-Yan Jiang Yan Wang Zhao-Wei Meng Di-Hua Li Lei Zhang Hao Wang Yan-Jun Zhang Graduate School Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Nuclear General Tianjin Medical University General HospitalTianjin 300052China College of Pharmaceutical Engineering of Traditional Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Research Institute Tianjin NanKai HospitalTianjin 300100China Research and Development Department Tianjin ShangMei Cosmetics Co.Ltd.Tianjin 300380China School of Chinese Materia Medica Tianjin University of Traditional Chinese MedicineTianjin 301617China

Objective:This study was performed to investigate the relationship between the human melanogenesis and antioxidant systems and to further confirm the synergistic effect of oxyresveratrol(OXYR)and resveratrol(RES)in human epidermal melanocyte cell line.Methods:The human epidermal melanocyte line PIG1 cells were divided into the UV groups and control group,treated with different doses of UVB and without UVB,respectively.MTT assay and flow cytometry were used to detect cell viability and apoptosis.The expression of Nrf2/HO-1 and melanogenesis-associated proteins/genes was measured by Western blotting and real-time qPCR(RT-qPCR).pCMV6-XL5-Nrf2 was used to upregulate the expression of Nrf2.Subsequently,the proteins/genes levels of Nrf2/HO-1 and tyrosinase(TYR),melanin/eumelanin content,and reactive oxygen species(ROS)were analyzed.Isobologram analysis and cell experiment were used to analyze whether OXYR and RES inhibit TYR synergistically.Western blotting,RT-qPCR,and NaOH splitting method were used to determine the Nrf2/HO-1 and melanogenesis-associated proteins/genes expression and melanin content to evaluate the efficacy of OXYR and RES.Results:The activated Nrf2 and HO-1 eliminated ROS produced by UVB irradiation.The melanogenesis-associated proteins/genes of melanocyte-inducing transcription factor(MITF,P<0.01 on protein expression),TYR(both P<0.01),TYR-related protein(TRP)-1(both P<0.05),and TRP2(P<0.05 on mRNA expression)were activated in PIG1 cells by UVB irradiation.Simultaneously,the upregulation of Nrf2 significantly reduced melanogenesis formation(P<0.001)and TYR level(P<0.01 on protein expression).Moreover,OXYR and RES synergistically inhibited TYR activity(P<0.001)and reduced melanin content(P<0.001).Conclusions:A microbalance exists between Nrf2/HO-1 signaling and melanogenesis production in the UVBinduced responses of melanocytes.Simultaneously,OXYR enhances the ability of RES to inhibit melanin production.

关键词： melanin Nrf2/HO-1 oxyresveratrol reactive oxygen species resveratrol tyrosinase

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Joint Funds of national natural science foundation of china:Strategy,Practice and Development

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science foundation in china 2012年第1期20卷 32-36,31页

作者： Du Quansheng Ren Zhiguang Zhang Zhimin Xiong Xiaoqing Han Zhiyong General Office National Natural Science Foundation of China President's office Hangzhou Dianzi UniversityXiasha Higher Education Zone

中国(NSFC ) 的国家自然科学基础的联合资金被不同股东开始，它试图起一个更好的指导作用在特定的区域和方向支持基本研究。他们形成了资助系统的国家自然科学的重要部分，它负责在膨胀边疆推进科技。文章将简短总结联合资金在过去的十... 详细信息

中国(NSFC ) 的国家自然科学基础的联合资金被不同股东开始，它试图起一个更好的指导作用在特定的区域和方向支持基本研究。他们形成了资助系统的国家自然科学的重要部分，它负责在膨胀边疆推进科技。文章将简短总结联合资金在过去的十年的战略目标，程序实现和成就，并且在他们的未来开发提供一个观点。

关键词：国家自然科学基金委员会中国利益相关者 NSFC 基础研究科学发展组成部分执行情况

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Progress of basic research in Parkinson’s disease in china: data mini-review from the national natural science foundation

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Translational Neurodegeneration 2013年第1期2卷 119-123页

作者： Heqi Cao Gang Chen Erdan Dong Department of Medical science National Natural Science Foundation of ChinaBeijing 100085China Department of Neurosurgery The First Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina

This review is to analyze the role of national natural science foundation of china(NSFC)on the development of basic research of Parkinson’s disease from 1990 to 2012.Data on the total number of projects and funding of NSFC allocated to Parkinson’s disease,as well as hotspots in western countries,papers published,awards,personnel training,subject construction were collected,and the role of NSFC on other sources of funding was evaluated.Over the past 23 years,a full range of continuous funding from NSFC has led to fruitful results and a strong impetus to the progress of basic research of Parkinson’s disease.

关键词： NSFC funding fruitful

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Metabolomic Analysis in Saliva and Different Brain Regions of Older Mice with Postoperative Delirium Behaviors

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Biomedical and Environmental sciences 2024年第2期37卷 133-145页

作者： LIU Xiao CAO Ying LIN Xiao Wan GAO Dan Yang MIAO Hui Hui LI Tian Zuo Department of Anesthesiology Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China

Objective Postoperative delirium(POD)has become a critical challenge with severe consequences and increased incidences as the global population ages.However,the underlying mechanism is yet unknown.Our study aimed to explore the changes in metabolites in three specific brain regions and saliva of older mice with postoperative delirium behavior and to identify potential non-invasive biomarkers.Methods Eighteen-month-old male C57/BL6 mice were randomly assigned to the anesthesia/surgery or control group.Behavioral tests were conducted 24 h before surgery and 6,9,and 24 h after surgery.Complement C3(C3)and S100 calcium-binding protein B protein(S100beta)levels were measured in the hippocampus,and a metabolomics analysis was performed on saliva,hippocampus,cortex,and amygdala samples.Results In total,43,33,38,and 14 differential metabolites were detected in the saliva,hippocampus,cortex,and amygdala,respectively.“Pyruvate”“alpha-linolenic acid”and“2-oleoyl-1-palmitoy-snglycero-3-phosphocholine”are enriched in one common pathway and may be potential non-invasive biomarkers for POD.Common changes were observed in the three brain regions,with the upregulation of 1-methylhistidine and downregulation of D-glutamine.Conclusion Dysfunctions in energy metabolism,oxidative stress,and neurotransmitter dysregulation are implicated in the development of POD.The identification of changes in the level of salivary metabolite biomarkers could aid in the development of noninvasive diagnostic methods for POD.

关键词： Metabolomic Postoperative delirium(POD) Mechanism Biological marker

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