检索结果-南通市图书馆

Irisin attenuates intestinal injury,oxidative and endoplasmic reticulum stress in mice with L-arginine-induced acute pancreatitis

引用

World Journal of Gastroenterology 2019年第45期25卷 6653-6667页

作者： Yi-Fan Ren Meng-Zhou Wang Jian-Bin Bi Jia Zhang Lin Zhang Wu-Ming Liu Sha-Sha Wei Yi Lv Zheng Wu Rong-Qian Wu national Local Joint Engineering Research Center for Precision Surgery&Regenerative Medicine Shaanxi Provincial Center for Regenerative Medicine and Surgical EngineeringFirst Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina Department of Hepatobiliary Surgery First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina

BACKGROUND Acute pancreatitis(AP)is often associated with intestinal injury,which in turn exaggerates the progression of *** recent study has shown that a low level of serum irisin,a novel exercise-induced hormone,is associated with poor outcomes in patients with AP and irisin administration protects against experimental ***,the role of irisin in intestinal injury in AP has not been *** To investigate the effect of irisin administration on intestinal injury in experimental *** AP was induced in male adult mice by two hourly intraperitoneal injections of *** 2 h after the last injection of L-arginine,irisin(50 or 250μg/kg body weight)or 1 mL normal saline(vehicle)was administered through intraperitoneal *** animals were sacrificed at 72 h after the induction of *** injury,apoptosis,oxidative and endoplasmic reticulum(ER)stress were *** Administration of irisin significantly mitigated intestinal damage,reduced apoptosis,and attenuated oxidative and ER stress in AP *** addition,irisin treatment also effectively downregulated serum tumor necrosis factor-alpha and interleukin-6 levels and alleviated injury in the pancreas,liver and lung of AP *** Irisin-mediated multiple physiological events attenuate intestinal injury following an episode of *** has a great potential to be further developed as an effective treatment for patients with AP.

关键词： Irisin Intestinal injury Oxidative stress Endoplasmic reticulum stress Acute pancreatitis Mouse model

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

T-tube vs no T-tube for biliary tract reconstruction in adult orthotopic liver transplantation:An updated systematic review and metaanalysis

引用

World Journal of Gastroenterology 2021年第14期27卷 1507-1523页

作者： Jun-Zhou Zhao Lin-Lan Qiao Zhao-Qing Du Jia Zhang Meng-Zhou Wang Tao Wang Wu-Ming Liu Lin Zhang Jian Dong Zheng Wu Rong-Qian Wu Department of Hepatobiliary Surgery First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina national Local Joint Engineering Research Center for Precision Surgery and Regenerative Medicine First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina

BACKGROUND Whether to use a T-tube for biliary anastomosis during orthotopic liver transplantation(OLT)remains a debatable *** surgeons chose to use a T-tube because they believed that it reduces the incidence of biliary *** in surgical techniques during the last decades have significantly decreased the overall incidence of postoperative biliary *** using a T-tube during OLT is still associated with the reduced incidence of biliary strictures needs to be *** To provide an updated systematic review and meta-analysis on using a T-tube during adult *** In the electronic databases MEDLINE,PubMed,Scopus,***,the Cochrane Library,the Cochrane Hepato-Biliary Group Controlled Trails Register,and the Cochrane Central Register of Controlled Trials,we identified 17 studies(eight randomized controlled trials and nine comparative studies)from January 1995 to October *** data of the studies before and after 2010 were separately *** chose the overall biliary complications,bile leaks or fistulas,biliary strictures(anastomotic or non-anastomotic),and cholangitis as *** ratios(ORs)with 95%confidence intervals(CIs)were calculated to describe the results of the ***,the test for overall effect(Z)was used to test the difference between OR and 1,where P≤0.05 indicated a significant difference between OR value and *** A total of 1053 subjects before 2010 and 1346 subjects after 2010 were included in this *** pooled results showed that using a T-tube reduced the incidence of postoperative biliary strictures in studies before 2010(P=0.012,OR=0.62,95%CI:0.42-0.90),while the same benefit was not seen in studies after 2010(P=0.60,OR=0.76,95%CI:0.27-2.12).No significant difference in the incidence of overall biliary complications(P=0.37,OR=1.41,95%CI:0.66-2.98),bile leaks(P=0.89,OR=1.04,95%CI:0.63-1.70),and cholangitis(P=0.27,OR=2.00,95%CI:0.59-6.84)was obse

关键词： Orthotopic liver transplantation T-tube Biliary tract reconstruction Biliary complications Biliary strictures Meta-analysis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

手法及中药辅助治疗腰椎间盘突出症慢性阶段的病例对照研究

引用

中国骨伤 2011年第11期24卷 926-929页

作者：张宇吴冠男李星章永东黎作旭马明雷仲民李俊杰中国中医科学院望京医院脊柱一科北京100102 北京中医医院北京电力医院

目的:观察以手法配合中药和以牵引配合西药两种治疗手段对腰椎间盘突出症(LDH)慢性阶段的治疗效果,对比两者疗效。方法:采用多中心、中央区组的研究方法,对2008年11月28日至2010年5月7日收治的200例LDH患者进行临床研究,其中治疗组100例... 详细信息

目的:观察以手法配合中药和以牵引配合西药两种治疗手段对腰椎间盘突出症(LDH)慢性阶段的治疗效果,对比两者疗效。方法:采用多中心、中央区组的研究方法,对2008年11月28日至2010年5月7日收治的200例LDH患者进行临床研究,其中治疗组100例,男45例,女55例;平均年龄(43.43±9.18)岁;应用"手法加中药导入加口服汤药"治疗,疗程3周。对照组100例,脱落5例,男38例,女57例;平均年龄(42.29±9.78)岁,应用"牵引加理疗加口服西药"治疗,疗程3周。应用VAS、M-JOA、LMS及分级疗效评定进行组间及治疗前后观察指标比较和疗效评价。结果:治疗前后比较:治疗组治疗后较治疗前VAS及M-JOA改善,治疗前后LMS差异无统计学意义;对照组治疗后较治疗前VAS及M-JOA改善,治疗前后LMS差异无统计学意义。组间比较:治疗后治疗组VAS及M-JOA的改善优于对照组,两组间LMS差异无统计学意义。疗效评价:治疗组优41例,良34例,可13例,差12例;对照组优35例,良16例,可19例,差25例,治疗组疗效优于对照组。结论:两种治疗方法均能改善LDH患者的VAS及M-JOA,且治疗组的改善情况好于对照组,两种治疗方法对下肢肌力的改善均不明显。

关键词：椎间盘移位手法骨科牵引术中草药前瞻性研究病例对照研究

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Current Technologies of Synthetic Biosensors for Disease Detection:Design,Classification and Future Perspectives

引用

Chinese Medical sciences Journal 2018年第4期33卷 240-251页

作者： Xue Chen Yi Lv Rongqian Wu national-Local Joint Engineering Research Center for Precision Surgery&Regenerative Medicine Shaanxi Provincial Center for Regenerative Medicine and Surgical EngineeringInstitute of Advanced Surgical Technology and Engineeringthe First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an710061China

Synthetic biology aims to endow living cells with new functions by incorporating functional gene networks into *** overexpressing,blocking and rewiring native gene pathways,synthetic biologists have harnessed this promising technology to reprogram cells to perform diverse tasks such as drug discovery,biopharmaceutical manufacturing,gene therapy and tissue engineering,*** this review,we focus on current technologies of synthetic biosensors for disease *** start with the design principle of synthetic *** we move towards the characteristics of simple synthetic biosensors,which can respond to a single input signal,and complex synthetic biosensors including Boolean gate biosensors,cascade biosensors,time-delay biosensors,oscillator biosensors and hysteretic biosensors,which can respond to more than two input signals and perform complex *** biosensor has showed great potential in disease detection,but it is still in its infancy *** efforts should be made in identifying and constructing clinically relevant regulation *** tools are also needed in the design process in order to guarantee the precision of the synthetic *** ultimate goal of a synthetic biosensor is to act as a therapeutic sensor-effector device that connects diagnostic input with therapeutic output and therefore provides all-in-one diagnostic and therapeutic solutions for future gene-and cell-based therapies.

关键词： synthetic biosensor gene circuit disease detection

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Compromised immune status of patients with post-liver transplant biliary complications

引用

Chinese Medical Journal 2020年第21期133卷 2622-2624页

作者： Hong Lei Min Tian Xiao-Gang Zhang Lie-Su Meng Wen-Hua Zhu Xue-Min Liu Meng-Zhou Wang Tao Wang Peng-Kang Chang Huan Chen Bo Wang Rong-Qian Wu Yi Lyu national Local Joint Engineering Research Center for Precision Surgery and Regenerative Medicine The First Affiliated Hospital of Xi'an Jiaotong UniversityXi'anShaanxi 710061China Department of Hepatobiliary Surgery The First Affiliated Hospital of Xi'an Jiaotong UniversityXi'anShaanxi 710061China Department of Biochemistry and Molecular Biology School of Basic Medical SciencesXi'an Jiaotong UniversityXi'anShaanxi 710061China

Immunosuppression(IS)is indispensable for liver trans-plant(LTx)patients to control the unwanted alloimmune responses,which are mainly mediated by T ***,antigen-independent homeostasis of T cells is vital for sustaining long-lived T cell-mediated immunity,and excessive IS may increase the risk of opportunistic infections and ***,IS therapy for LTx patients should be tailored to the immune status of the individual patient.[1]Biliary complications(BC),including biliary strictures with cholangitis,are the most common complications after ***,the immunological characteristics especially T cell-mediated immunity of these patients are unknown yet.

关键词： patients immunity complications

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：