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Chinese science Bulletin 2010年第21期55卷 2197-2197页

作者： LI ChuanYou LI JiaYang State Key Laboratory of Plant Genomics National Centre for Plant Gene Research Institute of Genetics and Developmental Biology Chinese Academy of Sciences Beijing 100101 China

Decades of physiological and molecular studies have demonstrated that plants rely on a diverse set of small molecule hormones to regulate every aspect of their biological processes including development,growth and ada... 详细信息

关键词：国家自然科学基金委员会植物激素分子机制 nsfc 资助中国分子生物学植物生物学

Progress in osteoarthritis research by the national natural science foundation of china

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Bone Research 2022年第3期10卷 409-420页

作者： Yusheng Li Wenqing Xie Wenfeng Xiao Dou Dou Deparment of Orthopedics Xiangya HospitalCentral South UniversityChangsha 410008 HunanChina national Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangsha 410008 HunanChina Department of Health sciences National Natural Science Foundation of ChinaBeijing 100085China

Osteoarthritis(OA) in china is gradually becoming an important scientific research area that has had a significant impact on research and development(R&D) activities in the OA field worldwide. This article summarizes the R&D progress related to OA in china in recent years. The national natural science foundation of china(nsfc) is a national funding institution for basic research and plays a critical role in promoting and supporting Chinese scholars’ R&D activities. We collected and analyzed information on nsfc funding in the field of OA from 2010 to 2019, including the amount, the level and the program categories of the funded projects. The data fully demonstrate the important and positive role of the nsfc in supporting free exploration, cultivating research teams and young talent, and boosting OA R&D. In this article, we outline and discuss hot topics in focused areas, key advances in this field and the prospects for progress in OA research in china.

关键词： nsfc supporting becoming

MOF-encapsulated copper-doped carbon dots nanozymes with excellent biological activity promote diabetes wound healing

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Regenerative Biomaterials 2025年第1期4卷 156-169页

作者： Sheng Dai Lang Jiang Luying Liu Zhaogui Su Li Yao Ping Yang Nan Huang Institute of Biomedical Engineering College of MedicineSouthwest Jiaotong UniversityChengduSichuan 610031China Key Laboratory of Advanced Technologies of Materials Ministry of Education School of Materials Science and EngineeringSouthwest Jiaotong UniversityChengduSichuan 610031China Air Force Medical Center PLABeijing 100074China Shandong Provincial Engineering Research Center of Novel Pharmaceutical Excipients and Controlled Release Preparations College of Medicine and NursingDezhou UniversityDezhou 253023China

Poor wound healing in diabetics is primarily caused by persistently high levels of inflammation and recurrent bacterial *** catalytic therapy technique based on nanozyme medicine has emerged as a beacon of hope for patients with diabetic ***,the use of a single-atom nanozyme may still have limitations,including nanozyme burst release,immunological clearance and insufficient antibacterial *** address the aforementioned problems,we provide a new nano-catalytic therapeutic agent for diabetic skin ulcers that incorporates a single-atom nanozyme with high antioxidant activity into a metal–organic framework(ZIF-Cu/C-dots).First,a Cu single-atom nanozyme supported by ultra-small carbon dots(Cu/C-dots)with high antioxidant activity was created.A nanozyme-integrated metal–organic framework was then created,utilizing Cu/C-dots as ligands and Zn2þas the core ***/C-dots have good oxidase-like activity,shielding the biological system from ROS damage and reducing the expression of TNF-αand IL-1β.Zn2þalso has good antibacterial activity(the antibacterial rate was more than 90%).This integrated technique prevents nanozyme aggregation,improves nanozyme biocompatibility,slows down the breakdown of ZIF and allows for the regulated release of Cu/C-dots and Zn2þas ***,in vivo studies have shown that ZIF-Cu/C-dots can effectively alleviate inflammation at the site of diabetic wounds,accelerate vascular regeneration,promote collagen deposition and enhance tissue remodeling,serving as a novel nano-catalytic platform for the treatment of wounds that are difficult to heal.

关键词： diabetic wounds single-atom nanozyme antioxidant activity antibacterial activity nano-catalytic platform

Machine learning model-based prediction of postpancreatectomy acute pancreatitis following pancreaticoduodenectomy:A retrospective cohort study

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World Journal of Gastroenterology 2025年第8期31卷 9-23页

作者： Ji-Ming Ma Peng-Fei Wang Liu-Qing Yang Jun-Kai Wang Jian-Ping Song Yu-Mei Li Yan Wen Bing-Jun Tang Xue-Dong Wang Hepatopancreatobiliary Center Beijing Tsinghua Changgung HospitalBeijing 102218China Department of Information Administration Beijing Tsinghua Changgung HospitalBeijing 102218China Department of Radiology Beijing Tsinghua Changgung HospitalBeijing 102218China Organ Transplantation Qilu HospitalCheeloo College of MedicineShandong UniversityJinan 250012Shandong ProvinceChina Department of Otorhinolaryngology Xiangyang No.1 People’s HospitalXiangyang 441000Hubei ProvinceChina

BACKGROUND The International Study Group of Pancreatic Surgery has established the defi-nition and grading system for postpancreatectomy acute pancreatitis(PPAP).There are no established machine learning models for predicting PPAP following pancreaticoduodenectomy(PD).AIM To explore the predictive model of PPAP,and test its predictive efficacy to guide the clinical *** Clinical data from consecutive patients who underwent PD between 2016 and 2024 were retrospectively *** analysis of PPAP risk factors was performed,various machine learning algorithms[logistic regression,random forest,gradient boosting decision tree,extreme gradient boosting,light gradient boosting machine,and category boosting(CatBoost)]were utilized to develop predictive *** feature elimination was employed to select several variables to achieve the optimal machine *** The study included 381 patients,of whom 88(23.09%)developed *** patients exhibited a significantly higher incidence of postoperative pancreatic fistula(55.68%vs 14.68%,P C postoperative pancreatic fistula(9.09%vs 1.37%,P=0.001).The CatBoost algorithm outperformed other algorithms with a mean area under the receiver operating characteristic curve of 0.859[95%confidence interval(CI):0.814-0.905]in the training cohort and 0.822(95%CI:0.717-0.927)in the testing *** to shapley additive explanations analysis,pancreatic texture,main pancreatic duct diameter,body mass index,estimated blood loss,and surgery time were the most important variables based on recursive feature *** CatBoost algorithm based on selected variables demonstrated superior performance,with an area under the receiver operating characteristic curve of 0.837(95%CI:0.788-0.886)in the training cohort and 0.812(95%CI:0.697-0.927)in the testing *** We developed the first machine learning-based predictive model for PPAP following *** predictive model can assist surgeons in an

关键词： Pancreaticoduodenectomy Postoperative complication Acute pancreatitis Machine learning Predictive value

Recent progress on surface chemistryⅡ:Property and characterization

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Chinese Chemical Letters 2025年第1期36卷 8-57页

作者： Xin Li Zhen Xu Donglei Bu Jinming Cai Huamei Chen Qi Chen Ting Chen Fang Cheng Lifeng Chi Wenjie Dong Zhenchao Dong Shixuan Du Qitang Fan Xing Fan Qiang Fu Song Gao Jing Guo Weijun Guo Yang He Shimin Hou Ying Jiang Huihui Kong Baojun Li Dengyuan Li Jie Li Qing Li Ruoning Li Shuying Li Yuxuan Lin Mengxi Liu Peinian Liu Yanyan Liu Jingtao Lü Chuanxu Ma Haoyang Pan JinLiang Pan Minghu Pan Xiaohui Qiu Ziyong Shen Qiang Sun Shijing Tan Bing Wang Dong Wang Li Wang Lili Wang Tao Wang Xiang Wang Xingyue Wang Xueyan Wang Yansong Wang Yu Wang Kai Wu Wei Xu Na Xue Linghao Yan Fan Yang Zhiyong Yang Chi Zhang Xue Zhang Yang Zhang Yao Zhang Xiong Zhou Junfa Zhu Yajie Zhang Feixue Gao Yongfeng Wang Center for Carbon-based Electronics and Key Laboratory for the Physics and Chemistry of Nanodevices School of ElectronicsPeking UniversityBeijing 100871China Spin-X Institute School of MicroelectronicsSouth China University of TechnologyGuangzhou 511442China School of Materials and Energy Guangzhou Key Laboratory of Low-Dimensional Materials and Energy Storage DevicesGuangdong University of TechnologyGuangzhou 510006China Faculty of Materials science and Engineering Kunming University of Science and TechnologyKunming 650093China i-Lab CAS Key Laboratory of Nanophotonic Materials and DevicesSuzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhou 215123China CAS Key Laboratory of Molecular Nanostructure and Nanotechnology CAS Research/Education Center for Excellence in Molecular SciencesBeijing National Laboratory for Molecular Sciences(BNLMS)Institute of ChemistryChinese Academy of SciencesBeijing 100190China State Key Laboratory for Organic Electronics and Information Displays&Jiangsu Key Laboratory for Biosensors Institute of Advanced MaterialsJiangsu National Synergetic Innovation Center for Advanced MaterialsNanjing University of Posts and TelecommunicationsNanjing 210023China Institute of Functional Nano and Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials and DevicesSoochow UniversitySuzhou 215123China Hefei national Research Center for Physical sciences at the Microscale and Synergetic Innovation Center of Quantum Information and Quantum Physics University of Science and Technology of ChinaHefei 230026China Institute of Physics&University of Chinese Academy of sciences Beijing 100190China State Key Laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China College of Chemistry Beijing Normal UniversityBeijing 100875China Beijing national Laboratory for Molecular sciences(BNLMS) College of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China School

Surface with well-defined components and structures possesses unique electronic,magnetic,optical and chemical *** a result,surface chemistry research plays a crucial role in various fields such as catalysis,energy,materials,quantum,and *** science mainly investigates the correspondence between surface property and *** probe microscopy(SPM)techniques are important tools to characterize surface properties because of the capability of atomic-scale imaging,spectroscopy and manipulation at the single-atom *** this review,we summarize recent advances in surface electronic,magnetic and optical properties characterized mainly by SPM-based *** focus on elucidating theπ-magnetism in graphene-based nanostructures,construction of spin qubits on surfaces,topology properties of surface organic structures,STM-based light emission,tip-enhanced Raman spectroscopy and integration of machine learning in SPM studies.

关键词： Surface chemistry Scanning probe microscopy π-Magnetism Spin qubits Tip-enhanced Raman spectroscopy

Degradation of bisphenol F by peroxymonosulfate activated with palladium-based catalysts

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Journal of Environmental sciences 2025年第4期150卷 54-65页

作者： Xiaomei Zhou Minghui Li Jifei Hou Jingya Sun Shourong Zheng Yingjun Chen Qingxin Guan College of Chemistry Nankai UniversityTianjin 300071China School of Environment Nanjing UniversityNanjing 210023China

In this study,supported Pd catalysts were prepared and used as heterogeneous catalysts for the activation of peroxymonosulfate(PMS)which successfully degrade bisphenol F(BPF).Among the supported catalysts(i.e.,Pd/SiO_(2),Pd/CeO_(2),Pd/TiO_(2)and Pd/Al2O3),Pd/TiO_(2)exhibited the highest catalytic activity due to the high isoelectric point and high Pd0 ***/TiO_(2)prepared by the deposition method leads to high Pd dispersion,which are the key factors for efficient BPF *** influencing factors were investigated during the reaction process and two possible degradation pathways were *** functional theory(DFT)calculations demonstrate that stronger BPF adsorption and BPF degradation with lower reaction barrier occurs on smaller Pd *** catalytic activities are strongly dependent on the structural features of the *** experiments and theoretical calculations prove that the reaction is actuated by electron transfer rather than radicals.

关键词： Supported Pd catalysts Peroxymonosulfate activation Bisphenol F DFT calculations Mechanism

Change-point detection with deep learning:A review

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工程管理前沿（英文） 2025年第1期12卷 154-176页

作者： Ruiyu XU Zheren SONG Jianguo WU Chao WANG Shiyu ZHOU Department of Industrial Engineering and Management Peking UniversityBeijing 100871China Department of Industrial and Systems Engineering University of IowaIowa CityIA 52242USA Department of Industrial and Systems Engineering University of Wisconsin-MadisonMadisonWI53706USA

Recent advances in deep learning have led to the creation of various methods for change-point detection(CPD).These methods enhance the ability of CPD tech-niques to handle complex,high-dimensional data,making them more adaptable and less dependent on strict assump-tions about data *** methods have also demonstrated high accuracy and have been applied across various fields,including manufacturing,healthcare,activity monitoring,finance,and environmental *** review provides an overview of how these methods are applied,the data sets they use,and how their performance is *** also organizes techniques into supervised and unsupervised categories,citing key ***,we explore ongoing challenges and suggest directions for future research to improve interpretability,generalizability,and real-world implementation.

关键词： change-point detection deep learning supervised learning unsupervised learning time-series analysis

"Design nature":A color interpretation of Bauhaus school building in Dessau and its conceptual origins

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建筑学研究前沿（英文版） 2025年第1期14卷 32-61页

作者： Yuan Meng Wei Liu School of Urban Design Wuhan UniversityWuhan 430072China School of Urban Design Wuhan UniversityWuhan 430072China Carbon Neutral Strategic Planning and Spatial Design Research Center Wuhan UniversityWuhan 430072China

In modernist architecture,color serves as a crucial tool in shaping spatial ***,due to historical reasons,the color design of early modernist architecture has not been fully *** paper focuses on the iconic modernist work,the Bauhaus school building in *** historical investigation and theoretical research,it elu-cidates the evolution of color cognition from the perspectives of color theory development,architectural color characteristics,and the interaction between visual perception and *** this basis,it explores the color theory origins of the Bauhaus and Gropius,dissecting the conceptual framework and methods behind the color design of the Bauhaus school building in ***,this article analyzes the spatial characteristics of architectural color from an experiential *** paper argues that Gropius conveyed his concept of"natural perspective"through color design,emphasizing the eternal value of natural inter-nal *** Bauhaus redefined the role of color in architectural expression,based on nat-ural laws,and deduced a scientifically designed method related to perception,promoting a shift in color design from subjective to objective and injecting deeper connotations into architectural color.

关键词： Dessau Bauhaus Walter Gropius Architectural space color design Educational philosophy Origin tracing research

ICU-acquired muscle weakness in COVID-19 patients who underwent lung transplantation

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World Journal of Emergency Medicine 2025年第1期16卷 94-96页

作者： Juan Chen Bingqing Yue Jingyu Chen Man Huang General Intensive Care Unit the Second Affi liated Hospital of Zhejiang University School of MedicineHangzhou 310014China Lung Transplantation Laboratory the Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310014China Department of Lung Transplantation the Second Affi liated Hospital of Zhejiang University School of MedicineHangzhou 310014China Key Laboratory of Multiple Organ Failure(Zhejiang University) Ministry of EducationHangzhou 310014China Wuxi Lung Transplant Center Wuxi People's Hospital Affi liated to Nanjing Medical UniversityWuxi 214043China

Lung transplantation (LT)has emerged as a crucial life-saving option for critically ill patients with severe coronavirus disease 2019 (COVID-19)-related acute respiratory distress syndrome (ARDS) or irreversible lung injury.[1]Intensive care unit-acquired weakness (ICU-AW)is a prevalent complication in critically ill patients.[2] The recovery of recipients undergoing LT for COVID-19-related respiratory failure may face impediments due to ICU-AW,which negatively affects early mobilization and functional improvement. This study describes two cases of successful bilateral LT for severe COVID-19-related ARDS with the occurrence of ICU-AW and subsequent successful discharge.

关键词： patients lung respiratory

Multi-scale correlation analysis between geometric parameters and solar radiation in high density urban environment——Case study in Nanjing

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建筑学研究前沿（英文版） 2025年第1期14卷 248-266页

作者： Jingjin Li Xinxin Cui Jianmin Yang School of Architecture Southeast UniversityNanjing 210096China

This study explores the impact of multi-scale urban morphology on solar radiation in high-density environments,focusing on Nanjing as a case *** Grasshopper,the research decomposed urban models into four scales—district,block group,block,and plot—and analyzed eight morphological indicators,including site coverage(SC),floor area ratio(FAR),and block sur-face ratio(BSR).Solar radiation was simulated for the entire year,the summer solstice,and the winter *** findings reveal that different scales exhibit varying influences on solar *** the district scale,BSR shows the highest correlation with annual solar radiation(R2=0.96),while at the neighborhood cluster scale,the minimum distance between buildings(DBmin)is most correlated(R2=0.7).At the block scale,BSR significantly correlates with sum-mersolar radiation(R2=0.55).At the plot scale,no single indicator strongly correlates with solar radiation,but a combination of indicators is more *** findings enable rapid solar per-formance assessments in urban design,promoting efficient solar energy use.

关键词： Multi-scale High density Urban form Solar radiation