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Aggregate 2023年第3期4卷 94-101页

作者： Shujun Wu Yujiao Yang Yao Cheng Shuodong Wang Zhibiao Zhou Pei Zhang Xinqi Zhu Baodui Wang Hua Zhang Sheng Xie Zebing Zeng Ben Zhong Tang Shenzhen research Institute of Hunan University Nanshan DistrictShenzhenState Key Laboratory of Chemo/Biosensing and ChemometricsCollege of Chemistry and Chemical EngineeringHunan UniversityChangshaChina Shanghai Institute of Optics and Fine Mechanics Chinese Academy of SciencesShanghaiChina University of Chinese Academy of Sciences BeijingChina State key Laboratory of Applied Organic Chemistry and key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province Lanzhou UniversityGansuChina State key Laboratory of Environmental Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyangChina AIE Institute Guangzhou Development DistrictHuangpuChina School of Science and Engineering Shenzhen Key Laboratory of Functional Aggregate MaterialsThe Chinese University of Hong KongShenzhenChina

A“turn-on”fluorescent sensing strategy was developed for ultrasensitive detection of heavy metal mercury ion(Hg2+)directly in *** utilized an aqueous soluble aggregation-induced emission(AIE)-active probe,named 1,1,2,2-tetrakis(4-(1Htetrazol-5-yl)phenyl)ethene(TPE-4TA),composing of a luminescent tetraphenylene core and multiple anionic tetrazolate *** probe retained dark when molecularly dissolved in ***,mercury ions can ligate with multiple tetrazolate groups to form infinite coordination polymer particles spontaneously,thus inducing a fluorogenic AIE response for in situ ***,by embedding this AIE sensing molecules in a hydrophilic polyvinyl alcohol substrate,the resulting hydrogel film allowed in situ detection of Hg^(2+)on a laser-induced fluorescence analysis setup in aqueous *** strategy worked effectively in common aqueous environments with pH from 4 to 7.5 and showed high sensitivity(limit of detection down to 0.38 ppb/1.9 nM),good selectivity and a wide linearity range for *** work may lead to a reliable and promising platform for on-site environmental water analysis.

关键词： aggregation-induced emission heavy metal detection hydrogel

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Spiro-fused bicyclo[3,2,2]octatriene-cored triptycene:synthesis,molecular packing,and functional aggregates

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Science china Chemistry 2021年第11期64卷 1976-1984页

作者： Qing Liu Xian Chen Zhibiao Zhou Tingting Huang Yanpei Wang Sheng Xie Zebing Zeng Ben Zhong Tang State key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangsha410082China Aggregation-Induced Emission(AIE)Institute Guangzhou Development DistrictHuangpuGuangzhou510530China Shenzhen Institute of Aggregate Science and Technology School of Science and EngineeringThe Chinese University of Hong KongShenzhen518172China

Aggregate science has led to the existence of functional properties at the aggregate level that significantly differs from those of corresponding single-molecule species,leading to a number of novel conceptual materials with state-dependent *** developing such materials,new molecular scaffolds that allow modulating the structural and functional properties of aggregates in a controlled manner could be extremely *** this study,we report a class of spiro-fused bicyclo[3,2,2]octatriene triptycene derivatives with a unique 3 D molecular scaffolding structure that displays aggregation-induced emission(AIE)activity with bright solid-state blue *** core scaffold features a Y-shaped bicyclo[3,2,2]octatriene backbone and a vertical crossover arrangement of adjacent spiro-conjugated *** classic bicyclo[2,2,2]octatrienes with high rigidity,this stereoscopic bicyclo[3,2,2]octatriene containing a seven-membered ring allows retaining certain flexibility in the molecular scaffold,which results in a weak fluorescence in dilute solutions(Φ_(F)<10%).However,the corresponding molecular aggregates emit intense fluorescence(Φ_(F)=50%-75%)and show prominent AIE activity because of the restriction of intramolecular scaffold ***,in principle,these stereoscopic scaffold constructions with partially restricted flexibility facilitate the assembly of multiple different crystalline packing structures in both porous and nonporous forms depending on the growth conditions of crystalline *** obtained crystals with regular voids(12.85×6.89Aeach)show reversible luminescence in response to the adsorption/desorption of iodine *** materials based on an unusual 3 D scaffold exhibit a high degree of structural modulation at the aggregate level and demonstrate potential applications in chemical sensing and flexible optoelectronics,which may open up the exploration of highly stereoscopic molecular building blocks for developing functi

关键词： aggregate science triptycene aggregation-induced emission organic porous material

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Sequence matching enhanced 3D place recognition using candidate rearrangement

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IET Cyber-Systems and Robotics 2022年第3期4卷 189-199页

作者： Chi Li Fei Yan Yan Zhuang School of Control Science and Engineering Dalian University of TechnologyDalianChina

Deep‐learning‐based 3D place recognition has received more attention since the data‐driven fashion is widely used for the 3D point cloud *** of the existing deep‐learning‐based 3D place recognition methods only utilise a single scene for place ***,a single scene may have measurement noise or observable dy-namic object differences,which may lead to a reduction in recognition *** improve the performance of 3D place recognition,a sequence matching based rear-rangement method is *** sequence matching method is based on an assignment algorithm and guides the candidate rearrangement in searching for a similar *** global descriptor extraction adapts the effective sparse tensor representation and a simple pooling layer to obtain the global descriptor.A new loss function com-bination is employed to train the *** proposed approach is evaluated on the popular 3D place recognition benchmarks,which proves the effectiveness of the proposed approach.

关键词： matching Deep recognition

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Harness the functions of gut microbiome in tumorigenesis for cancer treatment

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Cancer Communications 2021年第10期41卷 937-967页

作者： Mong-Hong Lee research Institute of Gastroenterology Sun Yat-sen University GuangzhouGuangdong 510020P.R.China Guangdong Provincial key laboratory of Colorectal and Pelvic Floor Disease the Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong 510020P.R.China

It has been shown that gut microbiota dysbiosis leads to physiological changes and links to a number of diseases,including ***,many cancer categories and treatment regimens should be investigated in the context of the *** to the availability of metagenome sequencing and multiomics studies,analyses of species characterization,host genetic changes,and metabolic profile of gut microbiota have become feasible,which has facilitated an exponential knowledge gain about microbiota composition,taxonomic alterations,and host interactions during ***,the complexity of the gut microbiota,with a plethora of uncharacterized host-microbe,microbemicrobe,and environmental interactions,still contributes to the challenge of advancing our knowledge of the microbiota-cancer *** interactions manifest in signaling relay,metabolism,immunity,tumor development,genetic instability,sensitivity to cancer chemotherapy and *** review summarizes current studies/molecular mechanisms regarding the association between the gut microbiota and the development of cancers,which provides insights into the therapeutic strategies that could be harnessed for cancer diagnosis,treatment,or prevention.

关键词： cancer biomarkers chemotherapy fecal microbiota transplantation gut microbiome immunotherapy microbiota probiotics

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PDGFA-associated protein 1 is a novel target of c-Myc and contributes to colorectal cancer initiation and progression

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Cancer Communications 2022年第8期42卷 750-767页

作者： Hong-Yong Cui Wei Wei Mei-Rui Qian Ruo-Fei Tian Xin Fu Hong-Wei Li Gang Nan Ting Yang Peng Lin Xi Chen Yu-Meng ZhuBin Wang Xiu-Xuan Sun Jian-Hua Dou Jian-Li Jiang Ling Li Shi-Jie Wang Zhi-Nan Chen national Translational Science Center for Molecular Medicine&Department of Cell Biology Fourth Military Medical UniversityXi’anShaanxi 710032P.R.China State key Laboratory of Cancer Biology and national Clinical research Center for Digestive Diseases Xijing Hospital of Digestive DiseasesFourth Military Medical UniversityXi’anShaanxi 710032P.R.China Department of Clinical Medicine Medical College of Yan’an UniversityYan’anShaanxi 716000P.R.China key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education College of Chemistry and Materials ScienceNorthwest UniversityXi’anShaanxi 710127P.R.China

Background:The mechanism underlying colorectal cancer(CRC)initiation and progression remains elusive,and overall survival is far from *** studies have shown that PDGFA-associated protein 1(PDAP1)is upregulated in several cancers including ***,we aimed to identify the cause and consequence of PDAP1 dysregulation in CRC and evaluate its role as a potential therapeutic ***:Multi-omics data analysis was performed to identify potential key players in CRC initiation and ***(IHC)staining was applied to determine the expression pattern of PDAP1 in CRC ***1 conditional knockout mice were used to establish colitis and CRC mouse *** sequencing,a phosphoprotein antibody array,western blotting,histological analysis,5-bromo-2′-deoxyuridine(BrdU)incorporation assay,and interactome analysis were applied to identify the underlying mechanisms of PDAP1.A human patient-derived xenograft(PDX)model was used to assess the potential of PDAP1 as a therapeutic ***:PDAP1 was identified as a potential key player in CRC development using multi-omics data ***1 was overexpressed in CRC cells and correlated with reduced overall *** investigation showed that PDAP1 was critical for the regulation of cell proliferation,migration,invasion,and ***,depletion of Pdap1in intestinal epithelial cells impaired mucosal restitution in dextran sulfate sodium salt-induced colitis and inhibited tumor initiation and growth in colitis-associated *** studies showed that c-Myc directly transactivated PDAP1,which contributed to the high PDAP1 expression in CRC ***1 interacted with the juxtamembrane domain of epidermal growth factor receptor(EGFR)and facilitated EGFRmitogen-activated protein kinase(MAPK)signaling activation,which resulted in FOS-related antigen 1(FRA-1)expression,thereby facilitating CRC progres***,silencing of PDAP1 could hinder the

关键词： carcinogenesis colorectal cancer FRA-1 PDAP1 c-Myc

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Real-world data on ALK rearrangement test in Chinese advanced non-small cell lung cancer(RATICAL):a nationwide multicenter retrospective study

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Cancer Communications 2024年第9期44卷 992-1004页

作者： Lin Li Wencai Li ChunyanWu Yanfeng Xi Lei Guo Yuan Ji Lili Jiang Ji Li Jingping Yun Gang Chen Yuan Li Yueping Liu DianbinMu Yuchen Han Leina Sun Qingxin Xia Xiaodong Teng Nanying Che WeiWu Xueshan Qiu Chao Liu Xiaochu Yan Daiqiang Li Zhihong Zhang ZheWang Yujun Li ZhengWang Lingchuan Guo Xiu Nie Jingshu Geng Jianhua Zhou Jianming Ying Department of Pathology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking UnionMedical CollegeBeijingP.R.China Department of Pathology the First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenanP.R.China Department of Pathology Shanghai Pulmonary HospitalSchool of MedicineTongji UniversityShanghaiP.R.China Department of Pathology Cancer Hospital Affiliated to Shanxi Medical UniversityShanxi Province Cancer HospitalShanxi Hospital Affiliated to Cancer HospitalChinese Academy of Medical SciencesTaiyuanShanxiP.R.China Department of Pathology Zhongshan HospitalFudan UniversityShanghaiP.R.China Department of Pathology West China Hospital of Sichuan UniversityChengduSichuanP.R.China Department of Pathology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingP.R.China Department of Pathology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdongP.R.China Department of Pathology Fujian Cancer HospitalFujian Medical University Cancer HospitalFuzhouFujianP.R.China Department of Pathology Department of OncologyFudan University Cancer CenterShanghaiMedical College of Fudan UniversityShanghaiP.R.China Department of Pathology The Fourth Hospital of Hebei Medical UniversityShijiazhuangHebeiP.R.China Department of Pathology Shandong Cancer HospitalJinanShandongP.R.China Department of Pathology Shanghai Chest HospitalShanghai Jiao Tong UniversityShanghaiP.R.China Department of Pathology Tianjin Medical University Cancer Institute and HospitalTianjinP.R.China Department of Pathology the Affiliated Cancer Hospital of Zhengzhou UniversityHenan Provincial Cancer HospitalZhengzhouHenanP.R.China Department of Pathology the First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhouZhejiangP.R.China Department of Pathology Bei

Background:Anaplastic lymphoma kinase(ALK)test in advanced non-small cell lung cancer(NSCLC)can help physicians provide target therapies for patients harboring ALK gene *** study aimed to investigate the real-world test patterns and positive rates of ALK gene rearrangements in advanced ***:In this real-world study(ChiCTR2000030266),patientswith advanced NSCLC who underwent an ALK rearrangement test in 30 medical centers in china between October 1,2018 and December 31,2019 were retrospectively *** training was conducted before the study was *** controls were performed at participating centers using immunohistochemistry(IHC)-*** positive ALK gene rearrangement rate and consistency rate were *** associated clinicopathological characteristics of ALK gene rearrangement were investigated as ***:The overall ALK gene rearrangement rate was 6.7%in 23,689 patients with advanced NSCLC and 8.2%in 17,436 patients with advanced lung *** quality control analysis of IHC-VENTANA-D5F3 revealed an intrahospital consistency rate of 98.2%(879/895)and an inter-hospital consistency rate of 99.2%(646/651).IHC-VENTANA-D5F3 was used in 53.6%,real-time polymerase chain reaction(RT-PCR)in 25.4%,next-generation sequencing(NGS)in 18.3%,and fluorescence in-situ hybridization(FISH)in 15.9%in the adenocarcinoma *** specimens tested with multiple methods,the consistency rates confirmed by IHC-VENTANA-D5F3 were 98.0%(822/839)for FISH,98.7%(1,222/1,238)forNGS,and 91.3%(146/160)for *** overall ALK gene rearrangement rateswere higher in females,patients of≤35 years old,never smokers,tumor cellularity of>50,and metastatic specimens used for testing in the total NSCLC population and adenocarcinoma subgroup(all P<0.05).Conclusions:This study highlights the real-world variability and challenges of ALK test in advanced NSCLC,demonstrating a predominant use of IHCVENTANA-D5F3 with high co

关键词： anaplastic lymphoma kinase diagnosis gene fusion non-small cell lung cancer

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Positron emission tomography-adapted therapy in low-risk diffuse large B-cell lymphoma:results of a randomized,phase Ⅲ,non-inferiority trial

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Cancer Communications 2023年第8期43卷 896-908页

作者： Qing Shi Yang He Hong-Mei Yi Rong-Ji Mu Xu-Feng Jiang Di Fu Lei Dong Wei Qin Peng-Peng Xu Shu Cheng Qi Song Sai-Juan Chen Li Wang Wei-Li Zhao State key Laboratory of Medical Genomics National Research Center for Translational Medicine at ShanghaiShanghai Institute of HematologyRuijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiP.R.China Department of Pathology Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiP.R.China Clinical research Institute Shanghai Jiao Tong University School of MedicineShanghaiP.R.China Department of Nuclear Medicine Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiP.R.China Department of Radiology Ruijin Hospital affiliated to Shanghai Jiao Tong University School of MedicineShanghaiP.R.China Laboratory of Molecular Pathology Pole de Recherches Sino-Francis en Science du Vivant et GénomiqueShanghaiChina

Background:The current standard of care for non-bulky diffuse large B-cell lymphoma(DLBCL)patients with an International Prognostic Index(IPI)of 0 is four cycles of rituximab plus cyclophosphamide,doxorubicin,vincristine and prednisone(R-CHOP)but whether the same efficacy can be achieved with reduced chemotherapy regimen of four cycles for non-bulky DLBCL patients with an IPI of 1 remains *** study compared four cycles versus six cycles of chemotherapy in non-bulky low-risk DLBCL patients with negative interim positron emission tomography with computed tomography(PET-CT,Deauville 1-3),irrespective of age and other IPI risk factors(IPI 0-1).Methods:This was an open-label,randomized,phaseⅢ,non-inferiority *** aged 14-75 years with newly diagnosed low-risk DLBCL,according to IPI,achieving PET-CT confirmed complete response(CR)after four cycles of R-CHOPwere randomized(1:1)between four cycles of rituximab(4R-CHOP+4R arm)or two cycles of R-CHOP plus two cycles of rituximab(6R-CHOP+2R arm).The primary endpoint was 2-year progression-free survival(PFS),conducted in the intention-to-treat *** was assessed in patients with at least one cycle of assigned *** non-inferiority margin was-8%.Results:A total of 287 patients were included in the intention-to-treat analysis,the median follow-up was 47.3 months,and the 2-year PFS rate was 95%(95%confidence interval[CI],92%to 99%)and 94%(95%CI,91%to 98%)for the 4R-CHOP+4R and 6R-CHOP+2R *** absolute difference in 2-year PFS between the two arms was 1%(95%CI,-5%to 7%),supporting the non-inferiority of 4R-CHOP+*** 3-4 neutropenia was lower in the last four cycles of rituximab alone in the 4R-CHOP+4R arm(16.7%versus 76.9%),with decreased risk of febrile neutropenia(0.0%versus 8.4%)and infection(2.1%versus 14.0%).Conclusions:For newly diagnosed low-risk DLBCL patients,interim PET-CT after four cycles of R-CHOP was effective in identifying patients with Deauville 1-3 who would have a goo

关键词： diffuse large B-cell lymphoma low-risk positron emission tomography randomized phaseⅢtrial

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Contribution of phylogenetics to understanding the evolution and epidemiology of dengue virus

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Animal Models and Experimental Medicine 2022年第5期5卷 410-417页

作者： Xi Yu Gong Cheng Tsinghua-Peking Center for Life Sciences School of MedicineTsinghua UniversityBeijingChina Institute of Infectious Diseases Shenzhen Bay LaboratoryShenzhenChina Institute of Pathogenic Organisms Shenzhen Center for Disease Control and PreventionShenzhenChina School of Life Sciences Tsinghua UniversityBeijingChina

Dengue virus(DENV)is one of the most important arboviral pathogens in the tropics and subtropics,and nearly one-third of the world's population is at risk of *** transmission of DENV involves a sylvatic cycle between nonhuman primates(NHP)and Aedes genus mosquitoes,and an endemic cycle between human hosts and predominantly Aedes *** belongs to the genus Flavivirus of the family Flaviviridae and consists of four antigenically distinct serotypes(DENV-1-4).Phylogenetic analyses of DENV have revealed its origin,epidemiology,and the drivers that determine its molecular evolution in *** review discusses how phyloge-netic research has improved our understanding of DENV evolution and how it affects viral ecology and improved our ability to analyze and predict future DENV emergence.

关键词： dengue virus(DENV) evolution flavivirus phylogenetics

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Strain-Insensitive Hierarchically Structured Stretchable Microstrip Antennas for Robust Wireless Communication

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Nano-Micro Letters 2021年第8期13卷 1-12页

作者： Jia Zhu Senhao Zhang Ning Yi Chaoyun Song Donghai Qiu Zhihui Hu Bowen Li Chenghao Xing Hongbo Yang Qing Wang Huanyu Cheng Department of Engineering Science and Mechanics The Pennsylvania State UniversityUniversity ParkPA 16802USA Division of Life Sciences and Medicine School of Biomedical Engineering(Suzhou)University of Science and Technology of ChinaHefei 230022People’s Republic of China Institute of Biomedical Engineering and Technology Chinese Academy of ScienceSuzhou 215011People’s Republic of China Department of Materials Science and Engineering The Pennsylvania State UniversityUniversity ParkPA 16802USA School of Engineering and Physical Sciences Heriot-Watt UniversityUniversity ParkEdinburgh EH144ASScotlandUK Department of Electrical Engineering The Pennsylvania State UniversityUniversity ParkPA 16802USA

As the key component of wireless data transmission and powering,stretchable antennas play an indispensable role in flexible/stretchable ***,they often suffer from frequency detuning upon mechanical deformations;thus,their applications are limited to wireless sensing with wireless transmission capabilities remaining ***,a hierarchically structured stretchable microstrip antenna with meshed patterns arranged in an arched shape showcases tunable resonance frequency upon deformations with improved overall *** almost unchanged resonance frequency during deformations enables robust on-body wireless communication and RF energy harvesting,whereas the rapid changing resonance frequency with deformations allows for wireless *** proposed stretchable microstrip antenna was demonstrated to communicate wirelessly with a transmitter(input power of−3 dBm)efficiently(i.e.,the receiving power higher than−100 dBm over a distance of 100 m)on human bodies even upon 25%*** flexibility in structural engineering combined with the coupled mechanical-electromagnetic simulations,provides a versatile engineering toolkit to design stretchable microstrip antennas and other potential wireless devices for stretchable electronics.

关键词： Stretchable microstrip antennas Strain-insensitive resonance frequency Wireless communication RF energy harvesting Wearable and bio-integrated electronics

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A preliminary study of the mechanism of compound hearing loss caused by ototoxic drugs combined with impulse noise

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iLABMED 2024年第1期2卷 38-52页

作者： Xin Qiu Qing‐qing Jiang Wei‐wei Guo Ning Yu Shi‐ming Yang Senior Department of Otolaryngology Head and Neck Surgery Chinese PLA General HospitalChinese PLA Medical SchoolBeijingChina State key Laboratory of Hearing and Balance Science BeijingChina national Clinical research Center for Otolaryngologic Diseases BeijingChina key Laboratory of Hearing Science Ministry of EducationBeijingChina Beijing key Laboratory of Hearing Impairment Prevention and Treatment BeijingChina Chinese PLA Medical School BeijingChina

Background:Hearing loss(HL)is becoming increasingly common and is more commonly caused by noise,ototoxic substances,or a combination of ototoxic ***,so far,few studies have examined the mechanism by which compound factors cause *** only relevant study is about occupational ototoxic substances combined with environmental noise at 85-110 dB *** this study,to address the shortcomings of existing research,we innovatively focused on HL induced by loud noise(impulse noise,>160 dB SPL)combined with common ototoxic *** aim of this study was to establish and validate a mature animal model,and then to compare the characteristics of audiology,pathomorphology and molecular features,and to preliminarily predict pathogenesis in compound *** and Methods:We selected guinea pigs to construct in vivo HL model groups for different extents of exposure,including a blank control group,a single-drug group,a single-impulse noise group,and a compound *** animal model of the mature compound HL group was established using gentamicin combined with impulse *** then performed audio-logical and pathological *** analyzed the auditory brainstem response(ABR),pathological morphology of the cochlea,and molecules(including important self-radicals,cytokines,and apoptosis signal trans-duction pathway proteins in the pathogenesis of drug-and noise-induced HL),compared the effect of different extents of exposure on HL,and preliminarily predict the pathogenic mechanism of compound ***:Four groups of animal models were established successfully and verified by audiology and *** audiology,there were no sig-nificant differences in the ABR thresholds before exposure(p>0.05),but differences emerged among the groups after ***,after 3,7,and 14 days of exposure,there were significant differences in the ABR thresholds between the compound group and both the drug and noise groups(p<0.01),and after 14 days,the HL of the compoun

关键词： auditory brainstem response gentamicin hearing loss impulse noise molecular mechanisms pathomorphology

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