检索结果-南通市图书馆

Association of chromosome 7 aneuploidy measured by fluorescence in situ hybridization assay with muscular invasion in bladder cancer

引用

Cancer Communications 2020年第4期40卷 167-180页

作者： Xiayao Diao Jinhua Cai Junjiong Zheng Jianqiu Kong Shaoxu Wu Hao Yu Hao Huang Weibin Xie Xiong Chen Chengran Huang Lifang Huang Haide Qin Jian Huang Tianxin Lin Department of Urology Sun Yat-sen Memorial HospitalSun Yat-senUniversityGuangzhouGuangdong510120P.R.China Guangdong Provincial key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhouGuangdong510120P.R.China Department of Neurology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouGuangdong510120P.R.China State key Laboratory of Oncology in South china GuangzhouGuangdong510120P.R.China

Background:The preoperative prediction of muscular invasion status is important for adequately treating bladder cancer(BC)but nevertheless,there are some existing dilemmas in the current preoperative diagnostic accuracy of BC with muscular ***,we investigated the potential association between the fluorescence in situ hybridization(FISH)assay and muscular invasion among patients with BC.A cytogenetic-clinical nomogram for the individualized preoperative differentiation of muscle-invasive BC(MIBC)from non-muscle-invasive BC(NMIBC)is also ***:All eligible BC patients were preoperatively tested using a FISH assay,which included 4 sites(chromosome-specific centromeric probe[CSP]3,7,and 17,and gene locus-specific probe[GLP]-p16 locus).The correlation between the FISH assay and BC muscular invasion was evaluated using the Chi-square *** the training set,univariate and multivariate logistic regression analyses were used to develop a cytogenetic-clinical nomogram for preoperative muscular invasion ***,we assessed the performance of the nomogram in the training set with respect to its discriminatory accuracy and calibration for predicting muscular invasion,and clinica usefulness,which were then validated in the validation ***,model comparison was set to evaluate the discrimination and clinical usefulness between the nomogram and the individual variables incorporated in the ***:Muscular invasion was more prevalent in BC patients with positive CSP3,CSP7 and CSP17 status(OR[95%CI],2.724[1.555 to 4.774],P<0.001;3.406[1.912 to 6.068],P<0.001 and 2.483[1.436 to 4.292],P=0.001,respectively).Radiologydetermined tumor size,radiology-determined clinical tumor stage and CSP7 status were identified as independent risk factors of BC muscular invasion by the multivariate regression analysis in the training ***,a cytogenetic-clinical nomogram incorporating these three independent risk factors was constructed and was observed

关键词： chromosome aneuploidy fluorescence in situ hybridization muscular invasion nomogram preoperative prediction urinary bladder neoplasms

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Electrohydrodynamic printing for high resolution patterning of flexible electronics toward industrial applications

引用

InfoMat 2024年第2期6卷 28-56页

作者： Zhouping Yin Dazhi Wang Yunlong Guo Zhiyuan Zhao Liqiang Li Wei Chen Yongqing Duan State key Laboratory of Intelligent Manufacturing Equipment and Technology Huazhong University of Science and TechnologyWuhanthe People's Republic of China Optics Valley Laboratory Wuhanthe People's Republic of China key Laboratory for Micro/Nano Technology and System of Liaoning Province Dalian University of TechnologyDalianthe People's Republic of China Beijing national Laboratory for Molecular Sciences Key Laboratory of Organic SolidsInstitute of ChemistryChinese Academy of SciencesBeijingthe People's Republic of China Institute of Molecular Aggregation Sciences Tianjin UniversityTianjinthe People's Republic of China

Electrohydrodynamic(EHD)printing technique,which deposits micro/nanostructures through high electric force,has recently attracted significant research interest owing to their fascinating characteristics in high resolution(key technologies for promoting printing efficiency/*** we summarize the recent progress of EHD printing in fabrication of displays,organic field-effect transistors(OFETs),transparent electrodes,and sensors and ***,a brief summary and the outlook for future research effort are presented.

关键词： display electrohydrodynamic printing flexible electronics organic field-effect transistor printhead

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

PD-1/L1 inhibitors can improve but not replace chemotherapy for advanced urothelial carcinoma:A systematic review and network meta-analysis

引用

Cancer Innovation 2023年第3期2卷 191-202页

作者： Longkun Mao Meihua Yang Xinxiang Fan Wenjie Li Xiaodong Huang Wang He Tianxin Lin Jian Huang Guangdong Provincial key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Medical Research CenterSun Yat-Sen Memorial HospitalSun Yat-Sen(Zhongshan)UniversityGuangzhouChina Department of Urology Sun Yat-sen Memorial HospitalSun Yat-sen(Zhongshan)UniversityGuangzhouChina Guangdong Provincial Clinical research Center for Urological Diseases GuangzhouChina The First Affiliated Hospital of Nanchang University NanchangChina

Background:programmed cell death-1/ligand 1 inhibitors are a new treatment strategy for advanced urothelial ***,a comparative evaluation of their efficacy and toxicity compared with chemotherapy is ***:We comprehensively searched PubMed,Web of Science,Embase,and Cochrane Library databases and performed a meta-analysis of randomized controlled trials up to July *** considered overall survival as the primary outcome,and progression-free survival,objective response rate,and treatment-related adverse events as secondary ***:Overall,3584 patients from five studies were *** with first-line chemotherapy,programmed cell death-1/ligand 1 inhibitors were significantly associated with worse progression-free survival(pprogrammed cell death-1/ligand 1 inhibitors significantly improved overall survival(pprogrammed cell death-1/ligand 1 inhibitors were well tolerated(first-line chemotherapy:pprogrammed cell death-1/ligand 1 inhibitors in patients with advanced urothelial carcinoma is not superior to that of first-line platinum-based chemotherapy but is better than second-line chemotherapy;however,programmed cell death-1/ligand 1 inhibitors are safer than first-and second-line chemotherapy and have a broader prospect for use in combination therapy.

关键词： chemotherapy efficacy immune checkpoint inhibitors safety urinary bladder neoplasms

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

HSF1 facilitates the multistep process of lymphatic metastasis in bladder cancer via a novel PRMT5-WDR5-dependent transcriptional program

引用

Cancer Communications 2022年第5期42卷 447-470页

作者： Ming Huang Wen Dong Ruihui Xie Jilin Wu Qiao Su Wuguo Li Kai Yao Yuelong Chen Qianghua Zhou Qiang Zhang Wenwen Li Liang Cheng Shengmeng Peng Siting Chen Jian Huang Xu Chen Tianxin Lin Department of Urology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouGuangdong 510120P.R.China Guangdong Provincial key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouGuangdong 510120P.R.China Guangdong Provincial Clinical research Center for Urological Diseases GuangzhouGuangdong 510120P.R.China Animal Experiment Center The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong 510080P.R.China Department of Urology Sun Yat-sen University Cancer CenterGuangzhouGuangdong 510060P.R.China

Background:Lymphatic metastasis has been associated with poor prognosis in bladder cancer patients with limited therapeutic *** evidence shows that heat shock factor 1(HSF1)drives diversified transcriptome to promote tumor growth and serves as a promising therapeutic ***,the roles of HSF1 in lymphatic metastasis remain largely ***,we aimed to illustrate the clinical roles and mechanisms of HSF1 in the lymphatic metastasis of bladder cancer and explore its therapeutic ***:We screened the most relevant gene to lymphatic metastasis among overexpressed heat shock factors(HSFs)and heat shock proteins(HSPs),and analyzed its clinical relevance in three *** in vitro and in vivo assays were performed in HSF1-silenced and-regained *** also used Coimmunoprecipitation to identify the binding proteins of HSF1 and chromatin immunoprecipitation and dual-luciferase reporter assays to investigate the transcriptional program directed by *** pharmacological inhibitor of HSF1,KRIBB11,was evaluated in popliteal lymph node metastasis models and patientderived xenograft models of bladder ***:HSF1 expression was positively associated with lymphatic metastasis status,tumor stage,advanced grade,and poor prognosis of bladder ***,HSF1 enhanced the epithelial-mesenchymal transition(EMT)of cancer cells in primary tumor to initiate metastasis,proliferation of cancer cells in lymph nodes,and macrophages infiltration to facilitate multistep lymphatic ***,HSF1 interacted with protein arginine methyltransferase 5(PRMT5)and jointly induced the monomethylation of histone H3 at arginine 2(H3R2me1)and symmetric dimethylation of histone H3 at arginine 2(H3R2me2s).This recruited the WD repeat domain 5(WDR5)/mixed-lineage leukemia(MLL)complex to increase the trimethylation of histone H3 at lysine 4(H3K4me3);resulting in upregulation of lymphoid enhancer-binding factor 1(LEF1),matrix me

关键词： HSF1 PRMT5 KRIBB11 transcriptional program bladder cancer lymphatic metastasis prognostic factor targeted therapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Design of bionic water jet thruster with double-chamber driven by electromagnetic force

引用

International Journal of Mechanical System Dynamics 2024年第3期4卷 292-302页

作者： Chong Cao Yasong Zhang Chengchun Zhang Chun Shen Wen Cheng Zhenjiang Wei Zhengyang Wu Luquan Ren key Laboratory of Bionic Engineering(Ministry of Education) Jilin UniversityChangchunChina Weihai Junming Power Technology Co.Ltd. WeihaiChina

In response to the limitations of the single-chamber water jet thruster used in underwater vehicles mimicked by natural cephalopods,a novel approach involving a double-chamber water jet thruster has been *** thruster utilizes electromagnetic force to manipulate the diaphragm,thereby altering the volume of the upper and lower chambers to achieve water jet *** investigations were conducted to determine the tensile length-force characteristics of the diaphragm made of ***,key parameters of essential propulsion components,such as solenoid coils,electromagnets,and currents,were established based on the tensile length-force curve,and the propulsion capabilities of the system were evaluated through theoretical *** assessments indicate that the system does not produce reverse thrust regardless of whether the coil moves up or *** experimental results demonstrate that the maximum peak propulsion force generated by the dual-chamber water jet thruster within a 3-s cycle is 0.253N.

关键词： water jet thruster diaphragm electromagnetic force

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

An HGF-dependent positive feedback loop between bladder cancer cells and fibroblasts mediates lymphangiogenesis and lymphatic metastasis

引用

Cancer Communications 2023年第12期43卷 1289-1311页

作者： Yuting Li Hanhao Zheng Yuming Luo Yan Lin Mingjie An Yao Kong Yue Zhao Yina Yin Le Ai Jian Huang Changhao Chen Department of Oncology Sun Yat-sen Memorial Hospital Guangzhou Guangdong P. R. China Cancer Center Renmin Hospital of Wuhan University Wuhan Hubei P. R. China Department of Urology Sun Yat-sen Memorial Hospital Sun Yat-sen University Guangzhou Guangdong P. R. China Guangdong Provincial key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat-sen Memorial Hospital State Key Laboratory of Oncology in South China Guangzhou Guangdong P. R. China Department of General Surgery Guangdong Provincial People's Hospital Guangdong Academy of Medical Sciences Guangzhou Guangdong P. R. China

Background Cancer-associated fibroblasts (CAFs) play a vital role in facilitating tumor progression through extensive reciprocal interplay with cancer cells. Tumor-derived extracellular vesicles (EVs) are the critical mediators involved in the crosstalk between cancer cells and stromal cells, contributing to the metastasis of cancers. Yet, the biological mechanisms of tumor-derived EVs in triggering CAFs phenotype to stimulate the lymph node (LN) metastasis of bladder cancer (BCa) are largely unknown. Here, we aimed to explore the effects and molecular mechanisms of tumor-derived EV-mediated CAFs phenotype in regulating BCa LN metastasis. Methods The high-throughput sequencing was utilized to identify the crucial long non-coding RNA (lncRNA) associated with CAF enrichment in BCa. The functional role of the transition of fibroblasts to CAFs induced by LINC00665-mediated EVs was investigated through the in vitro and in vivo assays. Chromatin isolation by RNA purification assays, fluorescence resonance energy transfer assays, cytokine profiling and patient-derived xenograft (PDX) model were performed to explore the underlying mechanism of LINC00665 in the LN metastasis of BCa. Results We found that CAFs are widely enriched in the tumor microenvironment of BCa, which correlated with BCa lymphangiogenesis and LN metastasis. We then identified a CAF-associated long non-coding RNA, LINC00665, which acted as a crucial mediator of CAF infiltration in BCa. Clinically, LINC00665 was associated with LN metastasis and poor prognosis in patients with BCa. Mechanistically, LINC00665 transcriptionally upregulated RAB27B expression and induced H3K4me3 modification on the promoter of RAB27B through the recruitment of hnRNPL. Moreover, RAB27B-induced EVs secretion endowed fibroblasts with the CAF phenotype, which reciprocally induced LINC00665 overexpression to form a RAB27B-HGF-c-Myc positive feedback loop, enhancing the lymphangiogenesis and LN metastasis of BCa. Importantly, we dem

关键词： bladder cancer Cancer-associated fibroblasts extracellular vesicles HGF lymphangiogenesis lymph node metastasis long non-coding RNA positive feedback loop

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Harness the functions of gut microbiome in tumorigenesis for cancer treatment

引用

Cancer Communications 2021年第10期41卷 937-967页

作者： Mong-Hong Lee research Institute of Gastroenterology Sun Yat-sen University GuangzhouGuangdong 510020P.R.China Guangdong Provincial key laboratory of Colorectal and Pelvic Floor Disease the Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong 510020P.R.China

It has been shown that gut microbiota dysbiosis leads to physiological changes and links to a number of diseases,including ***,many cancer categories and treatment regimens should be investigated in the context of the *** to the availability of metagenome sequencing and multiomics studies,analyses of species characterization,host genetic changes,and metabolic profile of gut microbiota have become feasible,which has facilitated an exponential knowledge gain about microbiota composition,taxonomic alterations,and host interactions during ***,the complexity of the gut microbiota,with a plethora of uncharacterized host-microbe,microbemicrobe,and environmental interactions,still contributes to the challenge of advancing our knowledge of the microbiota-cancer *** interactions manifest in signaling relay,metabolism,immunity,tumor development,genetic instability,sensitivity to cancer chemotherapy and *** review summarizes current studies/molecular mechanisms regarding the association between the gut microbiota and the development of cancers,which provides insights into the therapeutic strategies that could be harnessed for cancer diagnosis,treatment,or prevention.

关键词： cancer biomarkers chemotherapy fecal microbiota transplantation gut microbiome immunotherapy microbiota probiotics

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in the pathogenesis of Rett syndrome using cell models

引用

Animal Models and Experimental Medicine 2022年第6期5卷 532-541页

作者： Sijia Lu Yongchang Chen Zhengbo Wang State key Laboratory of Primate Biomedical research Institute of Primate Translational MedicineKunming University of Science and TechnologyKunmingChina Yunnan key Laboratory of Primate Biomedical research KunmingChina

Rett syndrome(RTT)is a progressive neurodevelopmental disorder that occurs mainly in girls with a range of typical symptoms of autism spectrum ***2 protein loss-of-function in neural lineage cells is the main cause of RTT *** it is still hard to understand the mechanism of RTT on the basis of only clinical patients or animal models,cell models cultured in vitro play indispensable *** we reviewed the research progress in the pathogenesis of RTT at the cellular level,summarized the preclinical-research-related applications,and prospected potential future development.

关键词： cell models MeCP2 pathogenesis Rett syndrome

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Microalbuminuria sensitive near-infrared AIE probe for point-of-care evaluating kidney diseases

Aggregate

引用

Aggregate 2024年第3期5卷 421-428页

作者： Zhirong Zhu Xiaoyan Chen Hongze Liao Li Li Haojian Yang Qi Wang Wei-Hong Zhu Shanghai key Laboratory of Functional Materials Chemistry Key Laboratory for Advanced Materials and Institute of Fine ChemicalsJoint International Research Laboratory of Precision Chemistry and Molecular EngineeringFeringa Nobel Prize Scientist Joint Research CenterFrontiers Science Center for Materiobiology and Dynamic ChemistrySchool of Chemistry and Molecular EngineeringEast China University of Science and TechnologyShanghaiChina Department of Pathology Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina research Center for Marine Drugs Department of PharmacyRen Ji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Laboratory Medicine Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina

Urinary microalbumin(mALB)serves as an exceptionally sensitive indicator for the early detection of kidney damage,playing a pivotal role in identifying chronic renal failure and kidney lesions in ***,the currentﬂuores-cent methodologies for point-of-care(POC)diagnosis of mALB in real urine still exhibit suboptimal ***,the development and synthesis of QM-N2,an albumin-activated near-infrared(NIR)aggregation-induced emission(AIE)ﬂuorescent probe,are *** strategic incorporation and positioning of quaternary ammonium salts within the quinoline-malononitrile(QM)scaffold sig-niﬁcantly inﬂuence solubility and luminescence ***ﬁcally,the quaternary ammonium salt-free variant,QM-OH,and the quaternary ammonium salt integrated at the donor function group(DFG)site,QM-N1,display limited solubility in aqueous solutions while demonstrating a distinctﬂuorescence ***,the incorporation of quaternary ammonium salt at the conformational functional group(CFG)site in QM-N2 imparts superior dispersibility in water and reduces the initialﬂ***,the integration of a well-deﬁned D-π-A struc-ture within QM-N2 enables itself with near-infrared emission,which is crucial for mitigating interference from autoﬂuorescence present in urine *** inter-action with albumin,QM-N2 forms a tight bond with the IIA site of the subdomain of human serum albumin(HSA),inducing alterations in protein conﬁguration and constraining the intrinsic motion ofﬂuorescent *** interaction inducesﬂuorescence,facilitating the sensitive detection of trace ***,QM-N2 is applied for POC testing of mALB using portable equipment,particularly in the diagnosis of mALB-related diseases,notably chronic renal *** positioning underscores its potential as an ideal candidate for self-health measurement at home or in community hospitals.

关键词： AIE-active probe kidney disease microalbuminuria point-of-care testing

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Anode interfacial modification for non-fullerene polymer solar cells:Recent advances and prospects

引用

InfoMat 2022年第12期4卷 33-73页

作者： Nafees Ahmad Guangxing Liang Ping Fan Huiqiong Zhou Shenzhen key Laboratory of Advanced Thin Films and Applications Key Laboratory of Optoelectronic Devices and SystemsCollege of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhenPeople's Republic of China CAS key Laboratory of Nanosystem and Hierarchical Fabrication National Center for Nanoscience and TechnologyBeijingPeople's Republic of China

Recently,the power conversion efficiency(PCE)of single-junction non-fullerene polymer solar cells(NF-PSCs)has surpassed 19%due to the fast development of novel donor polymers,NF-acceptors,device engineering,and interlayer *** anode interlayer(AIL)plays a vital role in improving the efficiency and stability of *** challenges and opportunities in this research area encourage researchers to pursue great innovation in developing new materials and strategies for highly efficient *** review summarizes the recent development of AIL materials and their modification strategies in single-junction ***,a brief introduction,key functions,basic requirements,and peculiar features of AILs when employed in NF-PSCs are ***,the impact of AIL materials(including organic,inorganic,and hybrid materials)on the PCE and the stability of NF-PSCs are ***,the fabrication of large-area devices and related issues are *** summary and the future challenges regarding efficient AIL are summarized in the last section of this review.

关键词： anode interlayer efficiency hole extraction non-fullerene polymer solar cells stability

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：